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Lipoprotein(a) Catabolism Is Regulated by Proprotein Convertase Subtilisin/Kexin Type 9 through the Low Density Lipoprotein Receptor
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Multiple studies in cells have provided support for an interaction between Lp(a) and LDLR.
“Indeed, multiple studies in cells have provided support for an interaction between Lp(a) and LDLR27-30.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [30]
Multiple studies of LDLR in cells, animal models, and humans have provided inconsistent or conflicting results.
“Multiple studies of the LDL receptor (LDLR) in cells27-34, animal models25,32,35,36, and humans10,28,37-48 have provided inconsistent or conflicting results.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [30]
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cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886 · cited 2×
“Apo(a) contains multiple copies of plasminogen-like kringle IV (KIV) sequences, followed by sequences closely resembling plasminogen kringle V (KV) and an inactive protease domain (3, 4).”
BackgroundPoirier, S., Mayer, G., Benjannet, S., Bergeron, E., Marcinkiewicz, J., Nassoury, N., Mayer, H., Nimpf, J., Prat, A., & Seidah, N. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708098200 · Cited by 477
Self-citationRohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455 · cited 1×
“However, plasma LDL is predominately cleared through the LDLR (37, 38).”
BackgroundARH Is a Modular Adaptor Protein That Interacts with the LDL Receptor, Clathrin, and AP-2
He, G., Gupta, S., Yi, M., Michaely, P., Hobbs, H. H., & Cohen, J. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208539200 · Cited by 232
Kosenko, T., Golder, M., Leblond, G., Weng, W., & Lagace, T. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.421370 · Cited by 181
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Metadata
- Authors
- Romagnuolo, R., Scipione, C. A., Boffa, M. B., Marcovina, S. M., Seidah, N. G., & Koschinsky, M. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 290
- Issue
- 18
- Pages
- 11649-11662
- ISSN
- 0021-9258
- Cited by
- 206
- References
- 5
- Language
- en
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