CoChat
Sign Up
Cited by 302Cardiac Health and Mental HealthLipoproteins and Cardiovascular HealthCardiovascular and exercise physiology

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Reduction in C-reactive protein through cardiac rehabilitation and exercise training

Open access
Milani, Richard V, Lavie, Carl J, Mehra, Mandeep R·2004·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2003.10.041
Open this paper in CoChat — free account

Abstract

Objectives This study was designed to assess the effects of three-month formal phase II cardiac rehabilitation and exercise training programs on high-sensitivity C-reactive protein (HSCRP) levels in patients with coronary heart disease (CHD).Background High-sensitivity C-reactive protein is associated with abdominal adiposity and other CHD risk factors and is a potent independent predictor of CHD events. Although weight reduction and statin therapy reduce HSCRP levels, the independent effects of cardiac rehabilitation programs on HSCRP are not well established.Methods We analyzed plasma levels of HSCRP in 277 patients with CHD (235 consecutive patients before and after formal phase II cardiac rehabilitation and exercise training programs and 42 "control" patients who did not attend cardiac rehabilitation). Additionally, we determined the effects of cardiac rehabilitation on HSCRP independent of statin therapy and weight loss.Results Rehabilitation patients improved significantly in body fat, obesity indices, exercise capacity, and other cardiac risk factors. Mean (5.9 +/- 7.7 to 3.8 +/- 5.8 mg/l; -36%; p < 0.0001) and median levels of HSCRP (-41%; p = 0.002) decreased significantly in the rehabilitation group but not in the control population. Similar significant reductions in HSCRP occurred in the rehabilitation patients regardless of whether they received statin therapy or lost weight.Conclusions Therapeutic lifestyle changes effected through a three-month cardiac rehabilitation program significantly improved numerous cardiac risk factors. Through this holistic approach to secondary prevention, we observed significant reductions in HSCRP levels. These findings identify another clinical modality of reducing HSCRP beyond use of statin drugs and suggest an additional benefit of formal phase II cardiac rehabilitation and exercise training programs.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2003.10.041

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

See all 302

Related

See all

Metadata

Authors
Milani, R. V., Lavie, C. J., & Mehra, M. R.
Affiliations
  • Ochsner Health System (US)
  • Ochsner Medical Center (US)
Corresponding author
Milani, Richard V
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2004-03
Volume
43
Issue
6
Pages
1056-1061
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2003.10.041
OpenAlex
W2131340542
Cited by
302
References
54
Citations by year
2026: 3 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 15 · 2012: 22
FWCI
15.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
high-sensitivity C-reactive protein, cardiac rehabilitation, exercise training, coronary artery disease, statin therapy, weight loss, abdominal fat, secondary prevention, inflammation, cardiovascular risk factors
MeSH terms
Aged, Blood Glucose, C-Reactive Protein, Cholesterol, Coronary Artery Disease, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Exercise, Body Mass Index, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review