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Cited by 111Blood Pressure and Hypertension StudiesEicosanoids and Hypertension PharmacologyRenin-Angiotensin System Studies

Aspirin Administered at Bedtime, But Not on Awakening, Has an Effect on Ambulatory Blood Pressure in Hypertensive Patients

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Hermida, Ramón C., Ayala, Diana E., Calvo, Carlos, López, José E.·2005·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2004.08.071
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Abstract

Objectives The purpose of this research was to investigate in untreated hypertensive patients the effects on ambulatory blood pressure (BP) of aspirin (ASA) administered at different times of the day.Background Previous studies have shown that ASA produces an administration time-dependent inhibition of angiotensin II. Low-dose ASA has also been shown to reduce BP when administered before bedtime, as opposed to upon awakening, in normotensive and hypertensive volunteers, and in pregnant women at high risk for preeclampsia.Methods We studied 328 untreated patients with grade 1 hypertension, 44.0 +/- 12.6 years of age, randomly divided into three groups: nonpharmacological hygienic-dietary recommendations, the same recommendations and ASA (100 mg/day) on awakening, or the same recommendations and ASA before bedtime. Blood pressure was measured every 20 min during the day and every 30 min at night for 48 consecutive h before and after 3 months of intervention.Results After three months of nonpharmacological intervention, there was a small and nonsignificant reduction of BP (<0.2 mm Hg; p = 0.648). Blood pressure was slightly elevated after aspirin on awakening (2.6/1.6 mm Hg in the 24-h mean of systolic/diastolic BP; p = 0.002). A significant BP reduction, however, was observed in the patients who received aspirin before bedtime (6.8/4.6 mm Hg in systolic/diastolic BP; p < 0.001).Conclusions This prospective trial documents a significant administration time-dependent effect of low-dose ASA on BP in untreated hypertensive patients. The timed administration of low-dose ASA could provide a valuable approach, beyond the secondary prevention of cardiovascular disease, in the added BP control of patients with mild essential hypertension.

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  • In people with mild untreated hypertension, 100 mg aspirin at bedtime reduced 24-hour systolic blood pressure by an average of 7 mmHg and diastolic blood pressure by 5 mmHg, whereas a similar dose of aspirin upon awakening actually increased 24-hour systolic blood pressure by an average of 3 mmHg and diastolic blood pressure by 2 mmHg.

    “Interestingly, in people with mild untreated hypertension, 100 mg aspirin at bedtime reduced 24-hour systolic BP by an average of 7 mmHg and diastolic BP by 5 mmHg, whereas a similar dose of aspirin upon awakening actually increased 24-hour systolic BP by an average of 3 mmHg and diastolic BP by 2 mmHg (178).”

    From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [178]

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Authors
Hermida, R. C., Ayala, D. E., Calvo, C., & López, J. E.
Affiliations
  • Universidade de Vigo (ES)
  • Complejo Hospitalario Universitario de Santiago (ES)
Corresponding author
Hermida, Ramón C.
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2005-09
Volume
46
Issue
6
Pages
975-983
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2004.08.071
OpenAlex
W2055328140
Cited by
111
References
49
Citations by year
2026: 5 · 2025: 5 · 2024: 11 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 5
FWCI
3.65
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
aspirin, low-dose aspirin, bedtime administration, timing of drug administration, ambulatory blood pressure, essential hypertension, untreated hypertension, non-pharmacological treatment, blood pressure control
MeSH terms
Adult, Aged, Aspirin, Circadian Rhythm, Female, Humans, Hypertension, Male, Middle Aged, Prospective Studies, Blood Pressure Monitoring, Ambulatory

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