Impact of Obesity on Cardiac Geometry and Function in a Population of Adolescents
Open accessAbstract
Objectives The goal here was to examine left ventricular (LV) geometry and function in a large, unselected group of adolescents with different degrees of abnormal body build, and verify whether possibly higher LV mass is compensatory for increased cardiac workload.Background There is little information on how much the excess of body weight impacts LV geometry and function in populations of adolescents.Methods Anthropometric, laboratory, and Doppler echocardiographic parameters of cardiac geometry and function were obtained in 460 adolescent participants (age 14 to 20 years, 245 female participants, 27 hypertensive, 10 with diabetes) from the Strong Heart Study. Body build was classified based on 85th and 95th percentiles of body mass index (BMI)-for-age charts.Results Range of BMI was 16.3 to 56.5 kg/m2 (28.8 +/- 8.3 kg/m2); 114 participants (24.9%) fell within the 85th percentile of BMI distribution (normal weight [NW]), 113 (24.6%) fell between 85th and 95th percentile (overweight [OW]), and 223 (48.5%) fell above the 95th percentile (obese [OB]). Obese participants were older than OW and NW subjects (p < 0.01), without differences in heart rate. Both OW and OB had greater LV diameter and mass than NW (all p < 0.05). Left ventricular hypertrophy was more prevalent in the OB (33.5%) and OW (12.4%), as compared with NW participants (3.5%; p < 0.001), largely compensating increased cardiac workload. However, OB subjects had four-fold higher probability of carrying an LV mass exceeding values compensatory for their cardiac workload (p < 0.001), a feature associated with lower ejection fraction, myocardial contractility, and greater force developed by left atrium to complete LV filling (all p < 0.05).Conclusions While in OW adolescents increased levels of LV mass are appropriate to compensate their higher hemodynamic load, in OB increase in LV mass exceeds this need and is associated with mildly reduced LV myocardial performance and increased left atrial force to contribute to LV filling.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LVH and mild abnormalities of myocardial systolic function have been observed in obese children and adolescents, and the severity of the dysfunction is comparable to that seen in obese subjects in their 30s, 40s, and 50s.
“Interestingly, LVH and mild abnormalities of myocardial systolic function have been observed in obese children and adolescents (48, 367), and the severity of the dysfunction is comparable to that seen in obese subjects in their 30s, 40s, and 50s.”
From Cardiac remodeling in obesity (2008) · cites this paper as [48]
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110 · see citing works
Self-citationSahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) · PEDIATRICS · doi:10.1542/peds.114.2.s2.555 · Cited by 6,895 · see citing works
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
Self-citationCDC growth charts: United States.
Kuczmarski, R. J., Ogden, C. L., Grummer‐Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R. X., Mei, Z., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2000) · PubMed · Cited by 5,298 · see citing works
Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000
Ogden, C. L. (2002) · JAMA · doi:10.1001/jama.288.14.1728 · Cited by 4,060 · see citing works
(2004) · PsycEXTRA Dataset · doi:10.1037/e442802008-001 · Cited by 2,882 · see citing works
(1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410020010002 · Cited by 1,960 · see citing works
SIMONE, G. D., Daniels, S. R., Devereux, R. B., Meyer, R. A., Roman, M. J., DIVITIIS, O. D., & Alderman, M. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90385-z · Cited by 1,727 · see citing works
Self-citationMust, A., Dallal, G., & Dietz, W. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.839 · Cited by 1,343 · see citing works
Guo, S. S., Wu, W., Chumlea, W. C., & Roche, A. F. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.653 · Cited by 1,160 · see citing works
de Ferranti, S. D., Gauvreau, K., Ludwig, D. S., Neufeld, E. J., Newburger, J. W., & Rifai, N. (2004) · Circulation · doi:10.1161/01.cir.0000145117.40114.c7 · Cited by 1,123 · see citing works
Klein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y., & Eckel, R. H. (2004) · Circulation · doi:10.1161/01.cir.0000145546.97738.1e · Cited by 934 · see citing works
Cardiovascular Health in Childhood
Williams, C. L., Hayman, L. L., Daniels, S. R., Robinson, T. N., Steinberger, J., Paridon, S. M., & Bazzarre, T. L. (2002) · Circulation · doi:10.1161/01.cir.0000019555.61092.9e · Cited by 778 · see citing works
The predictive value of childhood body mass index values for overweight at age 35 y
Guo, S., Roche, A., Chumlea, W., Gardner, J., & Siervogel, R. M. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.4.810 · Cited by 737 · see citing works
THE STRONG HEART STUDY A STUDY OF CARDIOVASCULAR DISEASE IN AMERICAN INDIANS: DESIGN AND METHODS
Lee, E. T., Welty, T. K., Fabsitz, R. R., Cowan, L. D., Le, N., Oopik, A. J., Cucchiara, A. J., Savage, P. J., & Howard, B. V. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115757 · Cited by 613 · see citing works
Self-citationSIMONE, G. D., Devereux, R. B., Roman, M. J., Ganau, A., Saba, P. S., Alderman, M. H., & Laragh, J. H. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90390-5 · Cited by 604 · see citing works
Self-citationHanevold, C. D., Waller, J. L., Daniels, S. R., Portman, R. J., & Sorof, J. M. (2004) · PEDIATRICS · doi:10.1542/peds.113.2.328 · Cited by 383 · see citing works
Devereux, R. B., & Alderman, M. H. (1993) · Circulation · doi:10.1161/01.cir.88.4.1444 · Cited by 298 · see citing works
Self-citationDaniels, S. R., Kimball, T. R., Morrison, J. A., Khoury, P. R., Witt, S. A., & Meyer, R. A. (1995) · Circulation · doi:10.1161/01.cir.92.11.3249 · Cited by 274 · see citing works
Comparative accuracy of Doppler echocardiographic methods for clinical stroke volume determination
Dubin, J. D., Wallerson, D. C., Cody, R. J., & Devereux, R. B. (1990) · American Heart Journal · doi:10.1016/0002-8703(90)90168-w · Cited by 243 · see citing works
Self-citationCronk, C., & Roche, A. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.5.953 · Cited by 233 · see citing works
Daniels, S. R., Meyer, R. A., Liang, Y., & Bove, K. E. (1988) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(88)80060-3 · Cited by 229 · see citing works
Interaction Between Body Size and Cardiac Workload
SIMONE, G. D., Devereux, R. B., Kimball, T. R., Mureddu, G. F., Roman, M. J., Contaldo, F., & Daniels, S. R. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1077 · Cited by 219 · see citing works
Self-citationChildhood Adiposity as a Predictor of Cardiac Mass in Adulthood
Li, X., Li, S., Ulusoy, E., Chen, W., Srinivasan, S. R., & Berenson, G. S. (2004) · Circulation · doi:10.1161/01.cir.0000149713.48317.27 · Cited by 218 · see citing works
Relations of Left Ventricular Mass to Demographic and Hemodynamic Variables in American Indians
Devereux, R. B., Roman, M. J., SIMONE, G. D., O’Grady, M. J., Paranicas, M., Yeh, J. L., Fabsitz, R. R., & Howard, B. V. (1997) · Circulation · doi:10.1161/01.cir.96.5.1416 · Cited by 200 · see citing works
Self-citationUtility of Different Measures of Body Fat Distribution in Children and Adolescents
Daniels, S. R., Khoury, P. R., & Morrison, J. A. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.12.1179 · Cited by 197 · see citing works
Evaluation of Concentric Left Ventricular Geometry in Humans
SIMONE, G. D., Daniels, S. R., Kimball, T. R., Roman, M. J., Romano, C., Chinali, M., Galderisi, M., & Devereux, R. B. (2004) · Hypertension · doi:10.1161/01.hyp.0000150108.37527.57 · Cited by 196 · see citing works
Self-citationPrognosis of Inappropriate Left Ventricular Mass in Hypertension
SIMONE, G. D., Verdecchia, P., Pede, S., Gorini, M., & Maggioni, A. P. (2002) · Hypertension · doi:10.1161/01.hyp.0000034740.99323.8a · Cited by 161 · see citing works
Palmieri, V., SIMONE, G. D., Arnett, D. K., Bella, J. N., Kitzman, D. W., Oberman, A., Hopkins, P. N., Province, M. A., & Devereux, R. B. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02054-9 · Cited by 119 · see citing works
Self-citationIlercil, A., O’Grady, M. J., Roman, M. J., Paranicas, M., Lee, E. T., Welty, T. K., Fabsitz, R. R., Howard, B. V., & Devereux, R. B. (2001) · Journal of the American Society of Echocardiography · doi:10.1067/mje.2001.113258 · Cited by 112 · see citing works
Self-citationAlpert, M., Lambert, C. R., Terry, B. E., Cohen, M. V., Mukerji, V., Massey, C. V., Hashimi, M. W., & Panayiotou, H. (1995) · American Heart Journal · doi:10.1016/0002-8703(95)90210-4 · Cited by 97 · see citing works
Left ventricular chamber and wall mechanics in the presence of concentric geometry
SIMONE, G. D., Devereux, R. B., Celentano, A., & Roman, M. J. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917070-00017 · Cited by 93 · see citing works
Self-citationStolarczyk, L., Heyward, V., Hicks, V., & Baumgartner, R. (1994) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.964 · Cited by 79 · see citing works
Increased left ventricular mass in obese adolescents*1
Friberg, P. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.03.018 · Cited by 75 · see citing works
Left Ventricular Filling in Arterial Hypertension
Mureddu, G. F., SIMONE, G. D., Greco, R., Rosato, G. F., & Contaldo, F. (1997) · Hypertension · doi:10.1161/01.hyp.29.2.544 · Cited by 63 · see citing works
Relations of body composition to left ventricular geometry and function in children
Gutin, B., Treiber, F. A., Owens, S., & Mensah, G. A. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70402-0 · Cited by 58 · see citing works
Influence of Obesity on Left Ventricular Midwall Mechanics in Arterial Hypertension
SIMONE, G. D., Devereux, R. B., Mureddu, G. F., Roman, M. J., Ganau, A., Alderman, M. H., Contaldo, F., & Laragh, J. H. (1996) · Hypertension · doi:10.1161/01.hyp.28.2.276 · Cited by 54 · see citing works
Self-citationSIMONE, G. D., Devereux, R. B., Kizer, J. R., Chinali, M., Bella, J. N., Oberman, A., Kitzman, D. W., Hopkins, P. N., Rao, D. C., & Arnett, D. K. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.757 · Cited by 49 · see citing works
Self-citationSIMONE, G. D., Mureddu, G. F., Greco, R., Scalfi, L., Puente, A. E.-D., Franzese, A., Contaldo, F., & Devereux, R. B. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.377 · Cited by 38 · see citing works
Self-citationChinali, M., SIMONE, G. D., LIU, J., Bella, J. N., Oberman, A., Hopkins, P. N., Kitzman, D. W., Rao, D. C., Arnett, D. K., & Devereux, R. B. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.01.005 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Crowley, D. I., Khoury, P. R., Urbina, E. M., Ippisch, H. M., & Kimball, T. R. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.10.016 · Cited by 92 · see citing works
Lund, B. P., Gohlke-Bärwolf, C., Cramariuc, D., Rossebø, A. B., Rieck, Å. E., & Gerdts, E. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.12.069 · Cited by 51 · see citing works
von Haehling, S., Doehner, W., & Anker, S. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.003 · Cited by 22 · see citing works
- Authors
- Chinali, M., de Simone, G., Roman, M. J., Lee, E. T., Best, L. G., Howard, B. V., & Devereux, R. B.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- University of Oklahoma (US)
- Missouri Breaks Industries Research (United States) (US)
- MedStar Health Research Institute (US)
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 47
- Issue
- 11
- Pages
- 2267-2273
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1444124670
- Semantic Scholar
- b612539628457e05220ffab9bec36637b40b3dbe
- Cited by
- 248
- References
- 46
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 13 · 2015: 12 · 2014: 19 · 2013: 23 · 2012: 22
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U01HL041652, U01HL041654, U01 HL-41642, U01HL 41652, U01HL41654, U01HL041642)
- National Center for Research Resources (M10RR0047-34)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- adolescent obesity, left ventricular hypertrophy, left ventricular mass, left ventricular geometry, left ventricular function, cardiac workload, compensatory hypertrophy, ejection fraction, body mass index, adolescent overweight, Strong Heart Study
- MeSH terms
- Adaptation, Physiological, Adolescent, Adult, Anthropometry, Female, Heart, Hemodynamics, Humans, Indians, North American, Longitudinal Studies, Male, Obesity, Phenotype, Echocardiography, Doppler, Body Mass Index, Prevalence, Case-Control Studies, Hypertrophy, Left Ventricular, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
