Cited by 281Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

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Guzik, Tomasz J., Chen, Wei, Gongora, Maria C., Guzik, Bartlomiej, Lob, Heinrich E., Mangalat, Deepa, Hoch, Nyssa, Dikalov, Sergey, Rudzinski, Pawel, Kapelak, Boguslaw, Sadowski, Jerzy, Harrison, David G.·2008·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2008.07.063PMC PMC2593790

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Abstract

Objectives This study sought to examine the expression and activity of the calcium-dependent nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in human atherosclerotic coronary arteries.Background The NOX-based NADPH oxidases are major sources of reactive oxygen species (ROS) in human vessels. Several NOX homologues have been identified, but their relative contribution to vascular ROS production in coronary artery disease (CAD) is unclear; NOX5 is a unique homolog in that it is calcium dependent and thus could be activated by vasoconstrictor hormones. Its presence has not yet been studied in human vessels.Methods Coronary arteries from patients undergoing cardiac transplantation with CAD or without CAD were studied; NOX5 was quantified and visualized using Western blotting, immunofluorescence, and quantitative real-time polymerase chain reaction. Calcium-dependent NADPH oxidase activity, corresponding greatly to NOX5 activity, was measured by electron paramagnetic resonance.Results Both Western blotting and quantitative real-time polymerase chain reaction indicated a marked increase in NOX5 protein and messenger ribonucleic acid (mRNA) in CAD versus non-CAD vessels. Calcium-dependent NADPH-driven production of ROS in vascular membranes, reflecting NOX5 activity, was increased 7-fold in CAD and correlated significantly with NOX5 mRNA levels among subjects. Immunofluorescence showed that NOX5 was expressed in the endothelium in the early lesions and in vascular smooth muscle cells in the advanced coronary lesions.Conclusions These studies identify NOX5 as a novel, calcium-dependent source of ROS in atherosclerosis.

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Authors: Guzik, T. J., Chen, W., Gongora, M. C., Guzik, B., Lob, H. E., Mangalat, D., Hoch, N., Dikalov, S., Rudzinski, P., Kapelak, B., Sadowski, J., & Harrison, D. G.
Affiliations: Jagiellonian University (PL)
Emory University (US)
Corresponding author: Harrison, David G.
ORCID: Guzik, Tomasz J.
Chen, Wei
Dikalov, Sergey
Sadowski, Jerzy
Harrison, David G.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2008-11
Volume: 52
Issue: 22
Pages: 1803-1809
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2008.07.063
PMC: PMC2593790
OpenAlex: W2138423356
Cited by: 281
References: 22
Citations by year: 2026: 4 · 2025: 10 · 2024: 15 · 2023: 12 · 2022: 13 · 2021: 11 · 2020: 28 · 2019: 15 · 2018: 14 · 2017: 20 · 2016: 13 · 2015: 14 · 2014: 20 · 2013: 23 · 2012: 24
FWCI: 10.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1718 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL039006, HL 39000 6, T32HL007745, P01HL058000)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase 5, NADPH oxidase, reactive oxygen species, oxidative stress, coronary artery disease, atherosclerosis, endothelium, vascular smooth muscle cells, heart transplantation, human coronary arteries
MeSH terms: NADPH Oxidase 5, Calcium, Coronary Artery Disease, Coronary Vessels, Endothelium, Female, Humans, Male, Membrane Proteins, Middle Aged, Pilot Projects, Risk Factors, RNA, Messenger, Calcium Channels, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Myocytes, Smooth Muscle

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Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

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