Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 552

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain

Open access
Hoffmann, Udo, Bamberg, Fabian, Chae, Claudia U., Nichols, John H., Rogers, Ian S., Seneviratne, Sujith K., Truong, Quynh A., Cury, Ricardo C., Abbara, Suhny, Shapiro, Michael D., Moloo, Jamaluddin, Butler, Javed, Ferencik, Maros, Lee, Hang, Jang, Ik-Kyung, Parry, Blair A., Brown, David F., Udelson, James E., Achenbach, Stephan, Brady, Thomas J., Nagurney, John T.·2009·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2009.01.052
Open this paper in CoChat — free account

Abstract

Objectives To determine the usefulness of coronary computed tomography angiography (CTA) in patients with acute chest pain. Background Triage of chest pain patients in the emergency department (ED) remains challenging. Methods Observational cohort study in chest pain patients with normal initial troponin and non-ischemic electrocardiogram. 64-slice coronary CTA was performed prior to admission to detect coronary plaque and stenosis (>50% luminal narrowing). Results were not disclosed. Endpoints were acute coronary syndrome (ACS) during index hospitalization and major adverse cardiac events (MACE) during 6- month follow-up. Results Among 368 patients (mean age 53±12 years, 61% male) 31 had ACS (8%). By coronary CTA, 50% of these patients were free of CAD, 31% had nonobstructive disease, and 19% had inconclusive or positive CT for significant stenosis. Sensitivity and negative predictive value (NPV) for ACS were 100% (n=183/368; 95% confidence interval [CI]: 98 to 100%) and 100% (95%-CI: 0.89–1.00) with the absence of CAD; and 77% (95% CI: 59–90%) and 98% (n=300/368, 95%-CI: 95–99%) with significant stenosis by coronary CTA. Specificity of presence of plaque and stenosis for ACS were 54% (95%-CI: 0.49–0.60) and 87% (95%-CI: 0.83–0.90); respectively. Only one ACS occurred in the absence of calcified plaque. Both, the extent of coronary plaque and presence of stenosis predicted ACS independently and incrementally to TIMI risk score (AUC: 0.88, 0.82 vs. 0.63; respectively, all p<0.0001). Conclusion Fifty percent of patients with acute chest pain and low to intermediate likelihood of ACS are free of CAD by CT and have no ACS. Given the large number of such patients early coronary CTA may significantly improve patient management in the emergency department.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2009.01.052

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 35 references

Cited by

See all 552

Metadata

Authors
Hoffmann, U., Bamberg, F., Chae, C. U., Nichols, J. H., Rogers, I. S., Seneviratne, S. K., Truong, Q. A., Cury, R. C., Abbara, S., Shapiro, M. D., Moloo, J., Butler, J., Ferencik, M., Lee, H., Jang, I.-K., Parry, B. A., Brown, D. F., Udelson, J. E., Achenbach, S., Brady, T. J., & Nagurney, J. T.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2009-05
Volume
53
Issue
18
Pages
1642-1650
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2009.01.052
OpenAlex
W2161621220
Cited by
552
References
35
FWCI
55.43
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain. https://app.cochat.ai/papers/10.1016/j.jacc.2009.01.052
The paper
Hoffmann, U., Bamberg, F., Chae, C. U., Nichols, J. H., Rogers, I. S., Seneviratne, S. K., Truong, Q. A., Cury, R. C., Abbara, S., Shapiro, M. D., Moloo, J., Butler, J., Ferencik, M., Lee, H., Jang, I.-K., Parry, B. A., Brown, D. F., Udelson, J. E., Achenbach, S., . . . Nagurney, J. T. (2009). Coronary Computed Tomography Angiography for Early Triage of Patients With Acute Chest Pain. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2009.01.052

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.