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Cited by 159Cardiovascular Effects of ExerciseCardiovascular and exercise physiologyCardiomyopathy and Myosin Studies

Long-Term Clinical Consequences of Intense, Uninterrupted Endurance Training in Olympic Athletes

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Pelliccia, Antonio, Kinoshita, Norimitsu, Pisicchio, Cataldo, Quattrini, Filippo, DiPaolo, Fernando M., Ciardo, Roberto, Di Giacinto, Barbara, Guerra, Emanuele +4 more·2010·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2009.10.068
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Abstract

Objectives The aim of this study was to assess incidence of cardiac events and/or left ventricular (LV) dysfunction in athletes exposed to strenuous and uninterrupted training for extended periods of time. Background Whether highly intensive and uninterrupted athletic conditioning over a long period of time might be responsible for cardiac events and/or LV dysfunction is unresolved. Methods We assessed clinical profile and cardiac dimensions and function in 114 Olympic athletes (78% male; mean age 22 +/- 4 years), free of cardiovascular disease, participating in endurance disciplines, who experienced particularly intensive and uninterrupted training for 2 to 5 consecutive Olympic Games (total, 344 Olympic events), over a 4- to 17-year-period (mean 8.6 +/- 3 years). Results Over the extended period of training and competition, no cardiac events or new diagnoses of cardiomyopathies occurred in the 114 Olympic athletes. Global LV systolic function was unchanged (ejection fraction: 62 +/- 5% to 63 +/- 5%; p = NS), and wall motion abnormalities were absent. In addition, LV volumes (142 +/- 26 ml to 144 +/- 25 ml; p = 0.52) and LV mass index (109 +/- 21 g/m(2) to 110 +/- 22 g/m(2); p = 0.74) were unchanged, and LV filling patterns remained within normal limits, although left atrial dimension showed a mild increase (37.8 +/- 3.7 mm to 38.9 +/- 3.2 mm; p < 0.001). Conclusions In young Olympic athletes, extreme and uninterrupted endurance training over long periods of time (up to 17 years) was not associated with deterioration in LV function, significant changes in LV morphology, or occurrence of cardiovascular symptoms or events.

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  • Exercise is a powerful intervention in the prevention and treatment of cardiovascular disease across a wide range of exercise volumes and intensities, including among competitive athletes.

    “Exercise is a powerful intervention in the prevention and treatment of cardiovascular disease for which compelling evidence exists across a wide range of exercise volumes and intensities, including among competitive athletes.4,26,37”

    From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [4]

    The Conclusions (page not provided) report that prolonged, intense endurance training in young Olympic athletes was not associated with cardiovascular events or deterioration in left ventricular function. That supports a limited point about competitive athletes, but the study enrolled athletes free of cardiovascular disease and does not establish exercise as a prevention or treatment intervention across a wide range of volumes and intensities. (LLM, conf=0.86)

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Authors
Pelliccia, A., Kinoshita, N., Pisicchio, C., Quattrini, F., DiPaolo, F. M., Ciardo, R., Di Giacinto, B., Guerra, E., De Blasiis, E., Casasco, M., Culasso, F., & Maron, B. J.
Affiliations
  • National Research Council (IT)
  • Keio University (JP)
  • Sapienza University of Rome (IT)
  • Minneapolis Heart Institute Foundation (US)
Corresponding author
Pelliccia, Antonio
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2010-04
Volume
55
Issue
15
Pages
1619-1625
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2009.10.068
OpenAlex
W2104680346
Cited by
159
References
32
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 13 · 2017: 3 · 2016: 8 · 2015: 22 · 2014: 15 · 2013: 5 · 2012: 17
FWCI
10.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Keywords
endurance training, Olympic athletes, left ventricular dysfunction, left ventricular hypertrophy, left atrial enlargement, left ventricular ejection fraction, left ventricular mass, left ventricular filling, cardiomyopathy, cardiovascular events
MeSH terms
Echocardiography, Electrocardiography, Female, Follow-Up Studies, Humans, Italy, Male, Motor Activity, Cardiomyopathies, Physical Endurance, Reference Values, Risk Factors, Sports, Stroke Volume, Time Factors, Incidence, Ventricular Function, Left, Ventricular Dysfunction, Left, Young Adult, Athletes

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