Cited by 1,028Aortic Disease and Treatment ApproachesCardiac Valve Diseases and TreatmentsCongenital Heart Disease Studies

The DOI matches its Crossref record; 140 of the 143 references it cites were found in a registry or an index.

Bicuspid Aortic Valve Disease

Open access

Siu, Samuel C., Silversides, Candice K.·2010·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2009.12.068

Open this paper in CoChat — free account Open PDF

Abstract

Bicuspid aortic valve (BAV) disease is the most common congenital cardiac defect. While the BAV can be found in isolation, it is often associated with other congenital cardiac lesions. The most frequent associated finding is dilation of the proximal ascending aorta secondary to abnormalities of the aortic media. Changes in the aortic media are present independent of whether the valve is functionally normal, stenotic, or incompetent. Although symptoms often manifest in adulthood, there is a wide spectrum of presentations ranging from severe disease detected in utero to asymptomatic disease in old age. Complications can include aortic valve stenosis or incompetence, endocarditis, aortic aneurysm formation, and aortic dissection. Despite the potential complications, 2 large contemporary series have demonstrated that life expectancy in adults with BAV disease is not shortened when compared with the general population. Because BAV is a disease of both the valve and the aorta, surgical decision making is more complicated, and many undergoing aortic valve replacement will also need aortic root surgery. With or without surgery, patients with BAV require continued surveillance. Recent studies have improved our understanding of the genetics, the pathobiology, and the clinical course of the disease, but questions are still unanswered. In the future, medical treatment strategies and timing of interventions will likely be refined. This review summarizes our current understanding of the pathology, genetics, and clinical aspects of BAV disease with a focus on BAV disease in adulthood.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2009.12.068

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,487
2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.007 · Cited by 2,245
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary
Warnes, C. A., Williams, R. G., Bashore, T. M., CHILD, J. S., Connolly, H. M., Dearani, J. A., del Nido, P. J., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,068
Clinical Factors Associated With Calcific Aortic Valve Disease
Stewart, B. F., Siscovick, D., Lind, B. K., Gardin, J. M., Gottdiener, J. S., Smith, V. E., Kitzman, D. W., & Otto, C. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00563-3 · Cited by 2,029
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.021 · Cited by 1,702
ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease
Warnes, C. A., Williams, R. G., Bashore, T. M., CHILD, J. S., Connolly, H. M., Dearani, J. A., del Nido, P. J., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.001 · Cited by 1,553
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Suggested standards for reporting on arterial aneurysms
Johnston, K. W., Rutherford, R. B., Tilson, M. D., Shah, D. M., Hollier, L. H., & Stanley, J. C. (1991) · Journal of Vascular Surgery · doi:10.1067/mva.1991.26737 · Cited by 1,369
Predictors of Outcome in Severe, Asymptomatic Aortic Stenosis
Rosenhek, R., Binder, T. M., Porenta, G., Lang, I. M., Christ, G., SCHEMPER, M., Maurer, G., & Baumgartner, H. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008313430903 · Cited by 1,332
A classification system for the bicuspid aortic valve from 304 surgical specimens
Sievers, H.-H., & Schmidtke, C. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.01.039 · Cited by 1,222

Show all 143 references

Research works printed but not linked: 4

Osler, 1886, The bicuspid condition of the aortic valve, Trans Assoc Am Physicians, 2, 185
Nadas, 1977, Report from the Joint Study on the Natural History of Congenital Heart Defects, Circulation, 56, I36
Bonow, 2006, J Am Coll Cardiol, 48, e1, 10.1016/j.jacc.2006.05.021 · DOI
Warnes, 2008, J Am Coll Cardiol, 52, e1, 10.1016/j.jacc.2008.10.002 · DOI

Sorted by citations

Items 401–500 of 999

Bicuspid Aortic Valve
Colombo, A., & Latib, A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.046 · Cited by 11
Concomitant cardiovascular malformations in isolated bicuspid aortic valve disease: a retrospective cross-sectional study and meta-analysis
Szöcs, K., Toprak, B., Schön, G., Rybczynski, M., Brinken, T., Mahlmann, A., Girdauskas, E., Blankenberg, S., & von Kodolitsch, Y. (2022) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-22-112 · Cited by 10
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve
Thériault, S., Holdcraft, J. A., Sharipova, D., Faucherre, A., Dębiec, R., Peloso, G. M., Al‐Kassou, B., Aranki, S. F., Swan, E. A., Ballotta, A., et al. (2026) · Circulation · doi:10.1161/circulationaha.125.074752 · Cited by 10
Long-term outcome of bicuspid aortic valve disease
Aschauer, J., Zilberszac, R., Gleiß, A., Colizzi, C., Binder, T. M., Bruno, P., Laufer, G., Massetti, M., Gabriel, H., & Rosenhek, R. (2023) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jead312 · Cited by 11
Evaluation of the Aortic Root With MRI and MDCT Angiography: Spectrum of Disease Findings
Hoey, E. T. D., Ganeshan, A., Nadar, S. K., & Gulati, G. S. (2012) · American Journal of Roentgenology · doi:10.2214/ajr.11.7848 · Cited by 10
Genetic Insights Into Bicuspid Aortic Valve Disease
Dębiec, R., Sall, H., Samani, N. J., & Bolger, A. P. (2017) · Cardiology in Review · doi:10.1097/crd.0000000000000147 · Cited by 10
Longer‐term outcomes after bicuspid aortic valve repair in 142 patients
Safari, M., Monsefi, N., Karimian‐Tabrizi, A., Miskovic, A., Linden, A. V., Žáček, P., Moritz, A., Walther, T., & Holubec, T. (2021) · Journal of Cardiac Surgery · doi:10.1111/jocs.16006 · Cited by 10
Device Failure in Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Implantation
Moriyama, N., Miyashita, H., Lehtola, H., Yamanaka, F., Vähäsilta, T., Piuhola, J., Saito, S., Niemelä, M. J., & Laine, M. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.04.037 · Cited by 10
Identification of Reference Genes for Quantitative Real Time PCR Assays in Aortic Tissue of Syrian Hamsters with Bicuspid Aortic Valve
Rueda-Martínez, C., Fernández, M. C., Soto‐Navarrete, M. T., Jiménez-Navarro, M. F., Durán, A. C., & Fernández, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164070 · Cited by 10
Diabetes, Incretin Therapy and Thoracic Aortic Aneurysm – What Does the Evidence Show?
Krizhanovskii, C., & Franco‐Cereceda, A. (2018) · Current Vascular Pharmacology · doi:10.2174/1570161116666180828155622 · Cited by 10
Effect of Aortic Wall Deformation with Healthy and Calcified Annulus on Hemodynamic Performance of Implanted On-X Valve
Sadipour, M., Hanafizadeh, P., Sadeghy, K., & Sattari, A. (2020) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-019-00453-y · Cited by 10
Multimodal Assessment of Vascular and Ventricular Function in Children and Adults With Bicuspid Aortic Valve Disease
Weismann, C. G., Ljungberg, S., Åkesson, A., & Hlebowicz, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.643900 · Cited by 10
Evaluation of the aortic and mitral valves with cardiac computed tomography and cardiac magnetic resonance imaging
Ko, S. M., Song, M. G., & Hwang, H. K. (2012) · International journal of cardiac imaging · doi:10.1007/s10554-012-0144-z · Cited by 10
Assessment of Aortic Valve Disease: Role of Imaging Modalities
Capoulade, R., & Pîbarot, P. (2015) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-015-0409-7 · Cited by 10
Prevalence and Impact of Coexistent Bicuspid Aortic Valve in Hypertrophic Cardiomyopathy
Padang, R., Gersh, B. J., Ommen, S. R., & Geske, J. B. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.01.020 · Cited by 10
Targeted next-generation sequencing identified ADAMTS5 as novel genetic substrate in patients with bicuspid aortic valve
Lin, X., Liu, X., Wang, L., Jiang, J., Ying-hao, S. U. N., Zhu, Q., Chen, Z., He, Y., Hu, P., Xu, Q., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.033 · Cited by 10
Ascending aortic size in aortic coarctation depends on aortic valve morphology: Understanding the bicuspid valve phenotype
Frandsen, E. L., Burchill, L. J., Khan, A. M., & Broberg, C. S. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.07.017 · Cited by 10
Educational Series in Congenital Heart Disease Congenital left-sided heart obstruction
Carr, M., Curtis, S., & Marek, J. (2018) · Echo Research and Practice · doi:10.1530/erp-18-0016 · Cited by 12
Native Valve Endocarditis due to Staphylococcus warneri Developing in a Patient with Type 1 Diabetes
Yamamoto, J., Endo, A., Sugawara, H., Izumi, T., Takahashi, K., Yamamoto, S., Akiyama, M., Adachi, O., Kaneko, K., Sawada, S., et al. (2020) · Internal Medicine · doi:10.2169/internalmedicine.4661-20 · Cited by 10
Bicuspid Aortic Valve in Children and Young Adults for Cardiologists and Cardiac Surgeons: State-of-the-Art of Literature Review
Nappi, F., Singh, S. S. A., & de Siena, P. M. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11100317 · Cited by 10
Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors
Derrick, C. J., Eley, L., Alqahtani, A., Henderson, D. J., & Chaudhry, B. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae230 · Cited by 9
“A Friend Among Strangers” or the Ambiguous Roles of Runx2
Azarkina, K., Gromova, E., & Malashicheva, A. (2024) · Biomolecules · doi:10.3390/biom14111392 · Cited by 10
Anatomy-derived 3D Aortic Hemodynamics Using Fluid Physics–informed Deep Learning
Berhane, H., Maroun, A., Dushfunian, D., Baraboo, J. J., Martinez, G., Jacobson, T., Bağcı, U., Allen, B. D., & Markl, M. (2025) · Radiology · doi:10.1148/radiol.240714 · Cited by 9
Stent frame deformation of self-expanding transcatheter heart valves in bicuspid aortic stenosis and impact on valve performance
Tirado‐Conte, G., Arslani, K., Zaid, S., Khokhar, A. A., Boiago, M., Costa, G., Bonnet, G., Mylotte, D., Carlo, M. D., McInerney, A., et al. (2025) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeaf195 · Cited by 9
Bicuspid aortic valve syndrome and fibrillinopathies: potential impact on clinical approach
Pepe, G., Cario, R. D., Sticchi, E., Giusti, B., Abbate, R., Gensini, G., & Nistri, S. (2015) · International Cardiovascular Forum Journal · doi:10.17987/icfj.v1i4.45 · Cited by 9
Insights into the genetic architecture of congenital heart disease from animal modeling
Zhu, W., Lo, C. W. Y., Lo, C. W., & 匹茨堡大学发育生物学系, 宾. 匹. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.463 · Cited by 9
Analysis of Fluid–Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve
Fringand, T., Macé, L. G., Cheylan, I., Lenoir, M., & Favier, J. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03566-1 · Cited by 9
Review of Molecular and Mechanical Interactions in the Aortic Valve and Aorta: Implications for the Shared Pathogenesis of Aortic Valve Disease and Aortopathy
Krishnamurthy, V. K., Godby, R. C., Liu, G. R., Smith, J. M., Hiratzka, L. F., Narmoneva, D. A., & Hinton, R. B. (2014) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9602-4 · Cited by 9
Thoracic aortic aneurysms: state of the art and current controversies
Ho, N. M., Mohadjer, A., & Desai, M. Y. (2017) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2017.1362983 · Cited by 9
MR Imaging of Thoracic Aortic Disease
Lichtenberger, J. P., Franco, D. F., Kim, J. S., & Carter, B. W. (2018) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000165 · Cited by 9
Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins
Pasipoularides, A. D. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.022 · Cited by 10
Clinical outcomes for congenital heart disease patients presenting with infective endocarditis
Filippo, S. D. (2020) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2020.1768847 · Cited by 9
Upregulated microRNA‑330‑3p promotes calcification in the bicuspid aortic valve via targeting CREBBP
Zheng, R., Liu, H., Gu, J., Ni, B., Sun, H., Guo, Y., Chen, S., He, K., Du, J., & Shao, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11297 · Cited by 9
The efficacy of sinus plication in aortic valvuloplasty for bicuspid aortic valve: experiments in a pulsatile flow simulation model
Arimura, S., Takada, J., Nishimura, G., Nakama, N., Kawasaki, E., Matsuhama, M., Iwasaki, K., Kasegawa, H., & Kunihara, T. (2021) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezab115 · Cited by 9
Transcatheter Aortic Valve Implantation in Sievers Type 0 vs. Type 1 Bicuspid Aortic Valve Morphology: Systematic Review and Meta-Analysis
Du, Y., Wang, Z., Liu, W., Guo, Y., Han, W., Shen, H., Jia, S., Yu, Y., Han, K., Shi, D., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.771789 · Cited by 9
Predictors of post-TAVI conduction abnormalities in patients with bicuspid aortic valves
Esposito, G., Kumar, N. S., Pugliese, F., Sayers, M. B., CHOW, A. W. C., Kennon, S. R. O., Ozkor, M., Mathur, A., Baumbach, A., Lloyd, G., et al. (2022) · Open Heart · doi:10.1136/openhrt-2022-001995 · Cited by 9
Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload
Hu, Y., Li, D., Zhou, C., Xiao, Y., Sun, S., Jiang, C., Chen, L., Liu, J., Zhang, H., Li, F., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.850248 · Cited by 9
Aortic dilatation and calcification in asymptomatic patients with bicuspid aortic valve: analysis in a Korean health screening population
Lee, M., Sung, J., Cho, S. J., Choi, S. H., Cho, S. W., Oh, J. K., Park, S. J., & Kim, D. (2012) · International journal of cardiac imaging · doi:10.1007/s10554-012-0116-3 · Cited by 9
Bicuspid and Unicuspid Aortic Valve: Fate of Moderate/Severe Mixed Aortic Valve Disease
Egbe, A. C., Connolly, H. M., Poterucha, J. T., & Warnes, C. A. (2016) · Congenital Heart Disease · doi:10.1111/chd.12391 · Cited by 9
Heart Valve Mechanobiology in Development and Disease
Zhong, A., & Simmons, C. A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-5617-3_12 · Cited by 9
Evidence of subannular and left ventricular morphological differences in patients with bicuspid versus tricuspid aortic valve stenosis: magnetic resonance imaging-based analysis
Disha, K., Dubslaff, G., Rouman, M., Fey, B., Borger, M. A., Barker, A. J., Kuntze, T., & Girdauskas, E. (2016) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivw363 · Cited by 9
Differences at surgery between patients with bicuspid and tricuspid aortic valves
Cozijnsen, L., van der Zaag–Loonen, H. J., Cozijnsen, M. A., Braam, R. L., Heijmen, R. H., Bouma, B. J., & Mulder, B. J. M. (2018) · Netherlands Heart Journal · doi:10.1007/s12471-018-1214-1 · Cited by 9
Biomechanical Cues Direct Valvulogenesis
Ahuja, N. H., Ostwald, P., Bark, D. L., & Garrity, D. M. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7020018 · Cited by 9
Early Valve Replacement for Severe Aortic Valve Disease: Effect on Mortality and Clinical Ramifications
Koerber, J. P., Bennetts, J. S., & Psaltis, P. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092694 · Cited by 9
Learning From Controversy: Contemporary Surgical Management of Aortic Valve Endocarditis
Nappi, F., Singh, S. S. A., & Timofeeva, I. (2020) · Clinical Medicine Insights Cardiology · doi:10.1177/1179546820960729 · Cited by 9
Medial tunica degeneration of the ascending aortic wall is associated with specific microRNA changes in bicuspid aortic valve disease
Pisano, C., Gammazza, A., Rappa, F., Barone, R., Allegro, R., Pitruzzella, A., Tagliavia, A., Agostara, V., Ruvolo, G., Cappello, F., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12516 · Cited by 9
Assessment of aortic valve disease - a clinician oriented review
Margulescu, A. D. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i6.481 · Cited by 9
The Heart’s Small Molecules: The Importance of MicroRNAs in Cardiovascular Health
Yildiz, M., Özkan, U., & Budak, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14217454 · Cited by 8
Transcatheter treatment of bicuspid aortic valve stenosis
Tchétché, D., Willemen, Y., Cesario, V., & Backer, O. D. (2025) · EuroIntervention · doi:10.4244/eij-d-24-01069 · Cited by 8
Sex-specific aortic root anatomy in patients with bicuspid aortic valve undergoing TAVR in a Chinese cohort
Du, F., Liu, X., Zhu, Q., He, Y., Jiang, J., Napawan, T., Jaiswal, S., Chen, Z., & Wang, J. (2018) · Herz · doi:10.1007/s00059-018-4740-0 · Cited by 8
Prognostic Implications of Bicuspid and Tricuspid Aortic Valve Phenotype on Progression of Moderate Aortic Stenosis and Ascending Aorta Dilatation
Chew, N., Phua, K., Ho, Y. J., Zhang, A. A. Y., Lin, N., Ngiam, J. N., Lau, Y. X., Teo, V. X. Y., Sia, C., Loh, P.-H., et al. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.08.050 · Cited by 8
Application of Machine Learning Methods to Analyze Occurrence and Clinical Features of Ascending Aortic Dilatation in Patients with and without Bicuspid Aortic Valve
Irtyuga, O. B., Kopanitsa, G., Kostareva, A. A., Metsker, O., Uspensky, V., Mikhail, G., Faggian, G. G., Sefieva, G., Derevitskii, I. V., Malashicheva, A., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050794 · Cited by 8
Transcatheter Aortic Valve Implantation for Bicuspid Aortic Valve Disease: Procedural Planning and Clinical Outcomes
Gutiérrez-Alonso, L., Boiago, M., Biase, C. D., Oliva, O., Laforgia, P. L., Feliachi, S., Beneduce, A., Dumonteil, N., & Tchétché, D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227074 · Cited by 9
3D Characterization of the Aortic Valve and Aortic Arch in Bicuspid Aortic Valve Patients
Yeats, B. B., Galvez, D., Sivakumar, S. K., Holst, K. A., Polsani, V. R., Yadav, P., Thourani, V. H., Yoganathan, A. P., & Dasi, L. P. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03527-8 · Cited by 8
Chronic cough: a herald symptom of thoracic aortic aneurysm in a patient with a bicuspid aortic valve
Miller, C. P., Firoozan, S., Woo, E. K., & Apps, A. P. (2014) · BMJ Case Reports · doi:10.1136/bcr-2014-205005 · Cited by 8
A new view on congenital heart disease: clinical burden prevision of changing patients
Daliento, L., Cecchetto, A., Bagato, F., & Bianco, L. D. (2011) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32834743cf · Cited by 8
Acute Care Medicine
Howard-Quijano, K. J., & Schwarzenberger, J. C. (2012) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3182456db9 · Cited by 8
Trans-catheter aortic valve implantation for non-classical indications.
Segev, A., Spiegelstein, D., Fefer, P., Shinfeld, A., Hay, I., Raanani, E., & Guetta, V. (2013) · PubMed · Cited by 8
Evaluation of left ventricular myocardial mechanics in patients with normally functioning bicuspid aortic valves: A systematic review and meta‐analysis
Chen, H., Liang, H., Wang, T., Zhao, H., Yang, J., & Chen, X. (2021) · Echocardiography · doi:10.1111/echo.15042 · Cited by 8
Impaction of regurgitation jet on anterior mitral leaflet is associated with diastolic dysfunction in patients with bicuspid aortic valve and mild insufficiency: a cardiovascular magnetic resonance study
Galea, N., Pambianchi, G., Cundari, G., Sturla, F., Marchitelli, L., Putotto, C., Versacci, P., Paulis, R. D., Francone, M., & Catalano, C. (2021) · International journal of cardiac imaging · doi:10.1007/s10554-021-02384-z · Cited by 8
Sex Differences in Aortopathy and Valve Diseases Among Patients Undergoing Cardiac Surgical Procedure
Vignac, M., Björck, H. M., Olsson, C., Eriksson, M. J., Jouven, X., Michos, E. D., Franco‐Cereceda, A., Eriksson, P. O., & Gaye, B. (2022) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2022.02.040 · Cited by 8
Semi-Automated Construction of Patient-Specific Aortic Valves from Computed Tomography Images
Lior, D., Puelz, C., Edwards, C., Molossi, S. M., Griffith, B. E., Birla, R. K., & Rusin, C. G. (2022) · Annals of Biomedical Engineering · doi:10.1007/s10439-022-03075-z · Cited by 8
SCUBA Diving in Adult Congenital Heart Disease
Kauling, R. M., Rienks, R., Cuypers, J. A. A. E., Jorstad, H. T., & Roos‐Hesselink, J. W. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10010020 · Cited by 8
Prognosis of Unrepaired Ascending Aorta after the Surgical Replacement of Bicuspid Aortic Valves
Shin, H. J., Kim, W. K., Kim, D. K., Kim, H. J., & Kim, J. B. (2023) · The Korean Journal of Thoracic and Cardiovascular Surgery · doi:10.5090/jcs.23.007 · Cited by 8
Congenital bicuspid aortic valve in an English bulldog
Visser, L. C., & Scansen, B. A. (2013) · Journal of Veterinary Cardiology · doi:10.1016/j.jvc.2012.12.001 · Cited by 8
Bicuspid aortic valve disease and lipoprotein(a)—A concept worth exploring?
Ker, J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.206 · Cited by 8
Is Bicuspid Aortic Valve Morphology Genetically Determined? A Family-Based Study
Tessler, I., Goudot, G., Albuisson, J., Reshef, N., Zwas, D. R., Carmi, S., Shpitzen, S., Levin, G., Kelman, G., Cheng, C., et al. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.09.051 · Cited by 8
Effects of acepromazine and buprenorphine on measured indices of the signal-averaged electrocardiogram in healthy dogs
Kushner, L. I., Calvert, C. A., & Boyle, C. R. (1996) · American Journal of Veterinary Research · doi:10.2460/ajvr.1996.57.10.1511 · Cited by 8
Aortic Pathology in Patients With Bicuspid Aortic Valve Assessed With Computed Tomography Angiography
Michałowska, I. M., Kruk, M. B. P., Kwiatek, P., Hryniewiecki, T., Kowalski, M., Furmanek, M. I., Oleksiuk, T., Waniewska, J., & Hoffmań, P. (2013) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000055 · Cited by 8
Fate Versus Flow
Spinale, F. G., & Bolger, A. F. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.002 · Cited by 8
Bicuspid aortic root spared during ascending aorta surgery: an update of long-term results
Russo, M., Saitto, G., Nardi, P., Bertoldo, F., Bassano, C., Scafuri, A., Pellegrino, A., & Ruvolo, G. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.05.83 · Cited by 8
Current Topics on Bicuspid Aortic Valve: Clinical Aspects and Surgical Management
Furukawa, H., & Tanemoto, K. (2015) · Annals of Thoracic and Cardiovascular Surgery · doi:10.5761/atcs.ra.15-00130 · Cited by 7
Medical Therapy to Prevent or Slow Progression of Aortic Stenosis: Current Evidence and Future Directions
Chong, T., Lan, N. S. R., Courtney, W., He, A., Strange, G. A., Playford, D. A., Dwivedi, G., Hillis, G. S., & Ihdayhid, A. R. (2023) · Cardiology in Review · doi:10.1097/crd.0000000000000528 · Cited by 7
Patent Foramen Ovale (PFO): History, Diagnosis, and Management
Maloku, A., Hamadanchi, A., Günther, A., Aftanski, P., Schulze, P. C., & Möbius‐Winkler, S. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2511422 · Cited by 8
Ascending Aortic Wall Cohesion: Comparison of Bicuspid and Tricuspid Valves
Benedı́k, J., Pilarczyk, K., Wendt, D., Indruch, J., Flek, R., Tsagakis, K., Alaeddine, S., & Jakob, H. G. (2012) · Cardiology Research and Practice · doi:10.1155/2012/180238 · Cited by 7
Evaluation of myocardial strain and aortic elasticity in patients with bicuspid aortic valve
Li, Y., Deng, Y., Bi, X.-J., Liu, Y., Zhang, J., Li, L., & Chen, B. (2016) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-016-1656-x · Cited by 7
Rare and Common Variants Uncover the Role of the Atria in Coarctation of the Aorta
Zhu, W., Williams, K., Young, C. B., Lin, J.-H. I., Teekakirikul, P., & Lo, C. W. Y. (2022) · Genes · doi:10.3390/genes13040636 · Cited by 7
Bicuspid Aortic Valve and Premature Ventricular Beats in Athletes
Modica, G., Sollazzo, F., Bianco, M., Cammarano, M., Pella, R., Monti, R., Palmieri, V., & Zeppilli, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912188 · Cited by 8
Conventional aortic root vs valve-sparing root replacement surgery in aortic dilatation syndromes: a comparison of mortality and postoperative complications
Rashid, H. N. Z., Chehab, O., Hurrell, H., Androshchuk, V., Sularz, A., Patterson, T., Lucchese, G., & Redwood, S. R. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2162039 · Cited by 7
Assessment of aortic valve area on cardiac computed tomography in symptomatic bicuspid aortic stenosis: Utility and differences from Doppler echocardiography
Kim, K., Lee, S. J., Seo, J., Suh, Y. J., Cho, I., Hong, G., Ha, J., Kim, Y. J., & Shim, C. Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1035244 · Cited by 7
4D FlowVersus2D Phase Contrast MRI in Populations With Bi- and Tricuspid Aortic Valves
HAUTANEN, S., Kiljander, T., Korpela, T., Saari, P., KOKKONEN, J., Mustonen, P., Sillanmäki, S., Ylä‐Herttuala, E., Husso, M., Hedman, M., et al. (2023) · In Vivo · doi:10.21873/invivo.13057 · Cited by 7
Stroke and Noninfective Native Valvular Disease
Mayfield, J. J., & Otto, C. M. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01855-0 · Cited by 7
Analysis of Prevalence and Clinical Features of Aortic Stenosis in Patients with and without Bicuspid Aortic Valve Using Machine Learning Methods
Irtyuga, O. B., Babakekhyan, M., Kostareva, A. A., Uspensky, V., Gordeev, M., Faggian, G. G., Malashicheva, A., Metsker, O., Shlyakhto, E. V., & Kopanitsa, G. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13111588 · Cited by 7
Preservación de la válvula aórtica bicúspide asociada a aneurismas de la raíz de aorta y aorta ascendente
Forteza, A., Vera, F., Centeno, J., López-Gude, M. J., de la Sota, E. P., Sánchez, V., López‐Melgar, B., Rufilanchas, J. J., & Cortina, J. M. (2013) · Revista Española de Cardiología · doi:10.1016/j.recesp.2013.04.006 · Cited by 7
Surgical and catheter procedures in adult congenital heart disease: simple national statistics of the UK tell us something
Uemura, H. (2013) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-013-0266-9 · Cited by 7
A retrospective analysis of mitral valve pathology in the setting of bicuspid aortic valves
van Rensburg, A., Herbst, P. G., & Doubell, A. (2017) · Echo Research and Practice · doi:10.1530/erp-17-0016 · Cited by 7
Looking for Optimal Implantation Height in Bicuspid Aortic Valve Patients Undergoing Transcatheter Aortic Valve Implantation: A Case Series
Giannini, F., Tzanis, G., Gallo, F., Mangieri, A., Laricchia, A., Mazzavillani, M., Fisicaro, A., Gallone, G., & Colombo, A. (2020) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2020.01.019 · Cited by 7
Outcomes of Florida Sleeve Procedure in Patients with Bicuspid Versus Tricuspid Aortic Valve
Aalaei‐Andabili, S. H., Beaver, T. M., Martin, T. D., Hess, P. J., & Arnaoutakis, G. J. (2020) · Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery · doi:10.1177/1556984520938470 · Cited by 7
Valvular Heart Disease in Athletes
Petek, B. J., & Baggish, A. L. (2021) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-021-00950-1 · Cited by 7
Point on the Aortic Bicuspid Valve
Bernard, C., Morgant, M., Guillier, D., Cheynel, N., & Bouchot, O. (2022) · Life · doi:10.3390/life12040518 · Cited by 7
Heart Disease in Pregnancy
Coulter, S., Lew, J., & Jenny, B. E. (2019) · Cardiovascular medicine · doi:10.1007/978-1-4471-2840-3_12 · Cited by 5
Aortopathy associated with bicuspid aortic valve: advances in clinical and hemodynamics research
Yang, M., Nie, Z., Yue, H., Liang, W., & Wu, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1576072 · Cited by 6
Calcium Fracture and Device Over Expansion in Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valves
Yeats, B. B., Sivakumar, S. K., Samaee, M., Polsani, V. R., Yadav, P., Thourani, V. H., Sellers, S., Sathananthan, J., & Dasi, L. P. (2023) · Annals of Biomedical Engineering · doi:10.1007/s10439-023-03246-6 · Cited by 6
Lipoprotein(a) As a Potential Predictive Factor for Earlier Aortic Valve Replacement in Patients with Bicuspid Aortic Valve
Krzesińska, A., Nowak, M. M., Mickiewicz, A., Chyła-Danił, G., Ćwiklińska, A., Koper‐Lenkiewicz, O. M., Kamińska, J., Matowicka-Karna, J., Gruchała, M., Jankowski, M., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11071823 · Cited by 6
Impact of Pacemaker Implantation After Transcatheter Aortic Valve Replacement on Long-Term Survival in Patients With Bicuspid Aortic Valve
Felice, F. D., Paolucci, L., Cesario, V., Musto, C., Nazzaro, M. S., Chin, D., Stio, R. E., Pennacchi, M., Gabrielli, D., Fiorina, C., et al. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.10.018 · Cited by 6
Impact of biological sex on valvular heart disease, interventions, and outcomes
Wiens, E. J., Kawa, K. L., Kass, M., & Shah, A. H. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0390 · Cited by 6
Three‐year clinical outcomes after transcatheter aortic valve implantation in patients with bicuspid aortic disease: Comparison between self‐expanding and balloon‐expandable valves
Boiago, M., Bellamoli, M., Biase, C. D., Beneduce, A., Gutiérrez-Alonso, L., Laforgia, P. L., Feliachi, S., Oliva, O., Dumonteil, N., & Tchétché, D. (2024) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.31041 · Cited by 6
Transcatheter aortic valve replacement in atypical valve anatomy using the Lotus valve
Xu, Q., Liu, X., Jiang, J., He, Y., Zhu, Q., Gao, F., Du, F., He, W., Cheng, J., Kong, M., et al. (2019) · Herz · doi:10.1007/s00059-018-4778-z · Cited by 6
Thoracic and Thoracoabdominal Aneurysms
Downey, R. T., & Aron, R. A. (2022) · Anesthesiology Clinics · doi:10.1016/j.anclin.2022.08.011 · Cited by 8
Pregnancy-related aortic complications in women with bicuspid aortic valve
Galián-Gay, L., Pijuan‐Domenech, A., Romero, J. C., Serrano, B., Goya, M., Maíz, N., Casellas‐Caro, M., Manrique, S., Suàrez-Edo, E., Miranda, B., et al. (2023) · Heart · doi:10.1136/heartjnl-2022-322328 · Cited by 6

Authors: Siu, S. C., & Silversides, C. K.
Affiliations: Western University (CA)
University Health Network (CA)
Corresponding author: Siu, Samuel C.
ORCID: Siu, Samuel C.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2010-06
Volume: 55
Issue: 25
Pages: 2789-2800
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2009.12.068
OpenAlex: W2121967184
Cited by: 1,028
References: 143
Citations by year: 2026: 37 · 2025: 62 · 2024: 59 · 2023: 85 · 2022: 68 · 2021: 100 · 2020: 71 · 2019: 61 · 2018: 63 · 2017: 79 · 2016: 69 · 2015: 67 · 2014: 64 · 2013: 49 · 2012: 57
FWCI: 7.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1178 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Scholarship@Western (Western University) (submittedVersion)
Funders: Heart and Stroke Foundation of Canada (NA 5927, NA 5662, T6085)
Canadian Institutes of Health Research (53030, 93722)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Keywords: bicuspid aortic valve, congenital heart disease, aortic root dilatation, aortic stenosis, aortic incompetence, infective endocarditis, aortic aneurysm, aortic dissection, aortic valve replacement, aortic root surgery, life expectancy, pathobiology, clinical course, surveillance (medicine), medical treatment, intervention timing
MeSH terms: Adult, Aortic Valve, Aortic Valve Insufficiency, Aortic Valve Stenosis, Cause of Death, Combined Modality Therapy, Female, Heart Defects, Congenital, Humans, Magnetic Resonance Imaging, Male, Mitral Valve, Prognosis, Severity of Illness Index, Survival Rate, Echocardiography, Transesophageal, Risk Assessment, Heart Valve Prosthesis Implantation, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bicuspid Aortic Valve Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks