Cited by 500Atrial Fibrillation Management and OutcomesCardiovascular Disease and AdiposityCardiovascular Function and Risk Factors

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The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

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Tedrow, Usha B., Conen, David, Ridker, Paul M., Cook, Nancy R., Koplan, Bruce A., Manson, JoAnn E., Buring, Julie E., Albert, Christine M.·2010·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2010.02.029PMC PMC2880879

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Abstract

Objectives The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women.Background Obesity and AF are increasing public health problems. The importance of dynamic obesity-associated AF risk is uncertain, and mediators are not well characterized.Methods Cases of AF were confirmed by medical record review in 34,309 participants in the Women's Health Study. Baseline and updated measures of BMI were obtained from periodic questionnaires.Results During 12.9 +/- 1.9 years of follow-up, 834 AF events were confirmed. BMI was linearly associated with AF risk, with a 4.7% (95% confidence interval [CI]: 3.4 to 6.1, p < 0.0001) increase in risk with each kilogram per square meter. Adjustment for inflammatory markers minimally attenuated this risk. When updated measures of BMI were used to estimate dynamic risk, overweight (hazard ratio [HR]: 1.22; 95% CI: 1.02 to 1.45, p = 0.03), and obesity (HR: 1.65; 95% CI: 1.36 to 2.00; p < 0.0001) were associated with adjusted short-term increases in AF risk. Participants becoming obese during the first 60 months had a 41% adjusted increase in risk of the development of AF (p = 0.02) compared with those maintaining BMI <30 kg/m(2). The prevalence of overweight and obesity increased over time. The adjusted proportion of incident AF attributable to short-term elevations in BMI was substantial (18.3%).Conclusions In this population of apparently healthy women, BMI was associated with short- and long-term increases in AF risk, accounting for a large proportion of incident AF independent of traditional risk factors. A strategy of weight control may reduce the increasing incidence of AF. (Women's Health Study [WHS]: A Randomized Trial of Low-Dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer; NCT00000479).

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Authors: Tedrow, U. B., Conen, D., Ridker, P. M., Cook, N. R., Koplan, B. A., Manson, J. E., Buring, J. E., & Albert, C. M.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Tedrow, Usha B.
ORCID: Tedrow, Usha B.
Conen, David
Ridker, Paul M.
Cook, Nancy R.
Koplan, Bruce A.
Manson, JoAnn E.
Buring, Julie E.
Albert, Christine M.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2010-05
Volume: 55
Issue: 21
Pages: 2319-2327
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2010.02.029
PMC: PMC2880879
OpenAlex: W1786577233
Cited by: 500
References: 35
Citations by year: 2026: 15 · 2025: 27 · 2024: 33 · 2023: 35 · 2022: 34 · 2021: 36 · 2020: 34 · 2019: 27 · 2018: 40 · 2017: 52 · 2016: 37 · 2015: 28 · 2014: 20 · 2013: 26 · 2012: 27
FWCI: 17.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1172 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Watkins and Harris Family Foundation
National Heart, Lung and Blood Institute (HL-093613, HL-043851, HL-080467)
National Cancer Institute (CA-047988)
The Donald W. Reynolds Foundation
Biosense Webster
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: atrial fibrillation, body mass index, obesity, overweight, weight gain, incident atrial fibrillation risk, women, inflammatory markers, weight management, Women's Health Study
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Electrocardiography, Female, Follow-Up Studies, Humans, Middle Aged, Obesity, Severity of Illness Index, Time Factors, Cohort Studies, Comorbidity, Body Mass Index, Incidence, Survival Rate, Women's Health, Treatment Outcome, Catheter Ablation, Risk Assessment, Overweight

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The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation

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