Screening for undiagnosed atrial fibrillation in the community
Abstract
PURPOSE OF REVIEW: Recent years have seen significant advances in knowledge about the prevalence of 'silent' atrial fibrillation and the morbidity associated with this condition. Data are emerging on improved strategies for screening, and new technologies for detecting atrial fibrillation are becoming available, making a review of this field timely. RECENT FINDINGS: Studies suggest that, when screening is performed, undiagnosed atrial fibrillation is present in around 1% of the screened population, rising to 1.4% for those aged at least 65 years. The prevalence of silent atrial fibrillation is even higher in patients with additional risk factors (e.g. those aged 75 years, patients with heart failure). Prolonged monitoring of patients with hypertension and an implanted cardiac device showed subclinical atrial arrhythmias in at least 10% and these patients had a 2.5-fold increased risk of stroke or systemic embolism. The feasibility of screening for silent atrial fibrillation has been demonstrated in a number of populations and many new technologies for atrial fibrillation detection exist, which could improve the efficiency and cost-effectiveness of this process. SUMMARY: Increased attention is being directed towards screening for silent atrial fibrillation and our 'toolbox' for detecting it is expanding. Whether this will translate into improved outcomes for patients remains to be proven.
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The detection rate of asymptomatic AF by new technologies such as smartphone cases with ECG electrodes, smart watches, and blood pressure machines with AF detection algorithms has not yet been formally evaluated against an established arrhythmia detection method.
“The detection rate of asymptomatic AF by new technologies such as smartphone cases with ECG electrodes, smart watches, and blood pressure machines with AF detection algorithms, has not yet been formally evaluated against an established arrhythmia detection method.140”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [140]
Cites
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793 · see citing works
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs253 · Cited by 2,898 · see citing works
Subclinical atrial fibrillation and the risk of stroke
Healey, J. S., Connolly, S. J., Gold, M. R., Israel, C. W., Van Gelder, I. C., Capucci, A., Lau, C. P., Fain, E., Yang, S., Bailleul, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105575 · Cited by 2,100 · see citing works
Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study
Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D’Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000140263.20897.42 · Cited by 2,041 · see citing works
Glotzer, T. V., Daoud, E. G., Wyse, D. G., Singer, D. E., Ezekowitz, M. D., Hilker, C., Miller, C., Qi, D., & Ziegler, P. D. (2009) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.109.849638 · Cited by 879 · cited 1× · see citing works
“5 h of atrial fibrillation in a single day increased the risk of thromboembolism [12].”
BackgroundFuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859 · see citing works
Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy
Hart, R. G., Pearce, L. A., Rothbart, R. M., McAnulty, J. H., ASINGER, R. W., & Halperin, J. L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00489-1 · Cited by 662 · see citing works
Skanes, A. C., Healey, J. S., Cairns, J. A., Dorian, P., Gillis, A. M., McMurtry, M. S., Mitchell, L. B., Verma, A., & Nattel, S. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.01.021 · Cited by 494 · see citing works
Hohnloser, S. H., Pajitnev, D., Pogue, J. M., Healey, J. S., Pfeffer, M. A., Yusuf, S., & Connolly, S. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.076 · Cited by 459 · see citing works
Andersson, T., Magnuson, A., Bryngelsson, I., Fröbert, O., Henriksson, K. M., Edvardsson, N. G., & Poçi, D. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs469 · Cited by 450 · see citing works
Cognitive Impairment Associated With Atrial Fibrillation
Kalantarian, S., Stern, T. A., Mansour, M., & Ruskin, J. N. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-5-201303050-00007 · Cited by 424 · see citing works
BOTTO, G. L., PADELETTI, L., SANTINI, M., CAPUCCI, A., GULIZIA, M., ZOLEZZI, F., FAVALE, S., MOLON, G., RICCI, R., BIFFI, M., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01320.x · Cited by 380 · see citing works
Screening to identify unknown atrial fibrillation: A systematic review
Lowres, N., Neubeck, L., Redfern, J., & Freedman, S. B. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-02-0165 · Cited by 327 · see citing works
Lau, J. K., Lowres, N., Neubeck, L., Brieger, D. B., Sy, R. W., Galloway, C. D., Albert, D. E., & Freedman, S. B. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.220 · Cited by 326 · see citing works
Effect of Age on Stroke Prevention Therapy in Patients With Atrial Fibrillation
van Walraven, C., Hart, R. G., Connolly, S. J., Austin, P. C., Mant, J., Hobbs, R. F., Koudstaal, P. J., Petersen, P., Pérez-Gómez, F., Knottnerus, J. A., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.526988 · Cited by 312 · see citing works
Seet, R. C. S., Friedman, P. A., & Rabinstein, A. A. (2011) · Circulation · doi:10.1161/circulationaha.111.029801 · Cited by 274 · see citing works
McManus, D. D., Lee, J., Maitas, O., Esa, N., Pidikiti, R., Carlucci, A., Harrington, J., Mick, E., & Chon, K. H. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2012.12.001 · Cited by 253 · see citing works
Engdahl, J., Andersson, L., Mirskaya, M., & Rosenqvist, M. (2013) · Circulation · doi:10.1161/circulationaha.112.126656 · Cited by 233 · see citing works
Age as a Risk Factor for Stroke in Atrial Fibrillation Patients
Marinigh, R., Lip, G. Y. H., Fiotti, N., Giansante, C., & Lane, D. A. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.028 · Cited by 232 · see citing works
Davis, R. C., Hobbs, F. D. R., Kenkre, J. E., Roalfe, A. K., Iles, R., Lip, G. Y. H., & Davies, M. K. (2012) · Europace · doi:10.1093/europace/eus087 · Cited by 180 · see citing works
Shanmugam, N., Boerdlein, A., Proff, J., Ong, P., Valencia, O., Maier, S. K. G., Bauer, W. R., Paul, V. E., & Sack, S. (2011) · EP Europace · doi:10.1093/europace/eur293 · Cited by 178 · see citing works
Cowan, C., Healicon, R., Robson, I., Long, W. R., Barrett, J., Fay, M., Tyndall, K., & Gale, C. P. (2013) · Heart · doi:10.1136/heartjnl-2012-303472 · Cited by 142 · see citing works
Detection of Atrial Fibrillation Using a Modified Microlife Blood Pressure Monitor
Wiesel, J., Fitzig, L., Herschman, Y., & Messineo, F. C. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.98 · Cited by 120 · see citing works
Short-term ECG for out of hospital detection of silent atrial fibrillation episodes
Doliwa, P. S., Frykman, V., & Rosenqvist, M. (2009) · Scandinavian Cardiovascular Journal · doi:10.1080/14017430802593435 · Cited by 105 · see citing works
Kaleschke, G., Hoffmann, B., Drewitz, I., Steinbeck, G., Naebauer, M., Goette, A., Breithardt, G., & Kirchhof, P. (2009) · Europace · doi:10.1093/europace/eup262 · Cited by 81 · see citing works
Marazzi, G., Iellamo, F., Volterrani, M., Lombardo, M., Pelliccia, F., Righi, D., Grieco, F., Cacciotti, L., Iaia, L., Caminiti, G., et al. (2011) · Advances in Therapy · doi:10.1007/s12325-011-0087-0 · Cited by 69 · see citing works
Watkins, R. E., Elliott, E. J., Mutch, R. C., Payne, J., Jones, H. M., Latimer, J., Russell, E., Fitzpatrick, J. P., Hayes, L., Burns, L., et al. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001918 · Cited by 65 · see citing works
Wiesel, J., Abraham, S., & Messineo, F. C. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.01.331 · Cited by 58 · see citing works
Screening for atrial fibrillation above age 65 detects an asymptomatic subset at high risk of stroke
Deif, B., Lowres, N., & Freedman, S. B. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.08.002 · Cited by 26 · see citing works
Lowres, N., Freedman, S. B., Redfern, J., McLachlan, A. J., Krass, I., Bennett, A. A., Briffa, T. G., Bauman, A. E., & Neubeck, L. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001355 · Cited by 23 · see citing works
The use of antithrombotics in patients presenting with stroke and atrial fibrillation.
Burgess, C. D., Ingham, T. R., Woodbridge, M., Weatherall, M., & Nowitz, M. (2007) · PubMed Central · Cited by 10 · see citing works
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Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Ródenas, J., García, M., Alcaraz, R., & Rieta, J. J. (2015) · Entropy · doi:10.3390/e17096179 · Cited by 65 · see citing works
JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia
Takase, B., Ikeda, T., Shimizu, W., Abe, H., Aiba, T., Chinushi, M., Koba, S., KUSANO, K. F., Niwano, S., Takahashi, N., et al. (2023) · Circulation Journal · doi:10.1253/circj.cj-22-0827 · Cited by 67 · see citing works
Uittenbogaart, S. B., Gurp, N. V.-V., Erkens, P. M. G., Lucassen, W. A. M., Knottnerus, J. A., Winkens, B., van Weert, H. C. P. M., & Stoffers, J. (2015) · Trials · doi:10.1186/s13063-015-1006-5 · Cited by 33 · see citing works
Quinn, F. R., Gladstone, D. J., Ivers, N. M., Sandhu, R. K., Dolovich, L. R., Ling, A. L. H., Nakamya, J., Ramasundarahettige, C. F., Frydrych, P. A., Henein, S., et al. (2018) · CMAJ Open · doi:10.9778/cmajo.20180001 · Cited by 26 · see citing works
Self-citationHelms, T. M., Duong, G., Zippel‐Schultz, B., Tilz, R. R., Kück, K., & Karle, C. A. (2014) · The EPMA Journal · doi:10.1186/1878-5085-5-15 · Cited by 23 · see citing works
Kalarus, Z. F., Balsam, P., Bandosz, P., Grodzicki, T. K., Kaźmierczak, J., Kiedrowicz, R., Mitręga, K. A., Noczyński, M., Opolski, G., Rewiuk, K., et al. (2018) · Kardiologia Polska · doi:10.5603/kp.a2018.0193 · Cited by 24 · see citing works
Undiagnosing to prevent overprescribing
Page, A. T., & Etherton‐Beer, C. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.02.010 · Cited by 23 · see citing works
JCS / JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia
Takase, B., Ikeda, T., Shimizu, W., Abe, H., Aiba, T., Chinushi, M., Koba, S., KUSANO, K. F., Niwano, S., Takahashi, N., et al. (2024) · Journal of Arrhythmia · doi:10.1002/joa3.13052 · Cited by 20 · see citing works
Blanco, V. G., de Torres, L. Á. P., Rioboó, E. M., Adell, M. Á. M., Rejano, J. M. P., González-Lama, J., Moruno, J. R., Álvarez, R. M., García, J., de Castroviejo, J. R., et al. (2016) · Medicina Clínica · doi:10.1016/j.medcli.2016.07.036 · Cited by 16 · see citing works
He, S., Deng, H., Jiang, J., Liu, F., Liao, H., Xue, Y., Zheng, M., Li, H., & Wu, S. (2021) · BioMed Research International · doi:10.1155/2021/9982569 · Cited by 14 · see citing works
Left atrial volume and function in patients with atrial fibrillation
Leong, D. P., & Dokainish, H. (2014) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000088 · Cited by 13 · see citing works
Blanco, V. G., de Torres, L. Á. P., Rioboó, E. M., Adell, M. Á. M., Rejano, J. M. P., González-Lama, J., Moruno, J. R., Álvarez, R. M., García, J., de Castroviejo, J. R., et al. (2017) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.07.029 · Cited by 8 · see citing works
Lasek‐Bal, A., Urbanek, T., Puz, P., & Piekarski, M. (2015) · Kardiologia Polska · doi:10.5603/kp.a2015.0207 · Cited by 6 · see citing works
Concentration of apelin inversely correlates with atrial fibrillation burden
Böhm, A., Urban, L., Tóthová, Ľ., Bezák, B., Uher, T., Musil, P., Kyselovič, J., Lipton, J., Olejník, P., & Hatala, R. (2021) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2021_026 · Cited by 5 · see citing works
Riccardo, V. I. O., Giordani, A. S., ALTURKI, A., Čulić, V., VITALE, R., CHINA, P., THEMISTOCLAKIS, S., VANOLI, E., & PROIETTI, R. (2022) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.22.05894-x · Cited by 5 · see citing works
Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation
Bezák, B., Snopek, P., Tóthová, Ľ., Jajcay, N., Mojto, V., Farsky, S., Gmitterová, K., Krivošík, M., Stanková, S., Duraníková, O., et al. (2023) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2023_056 · Cited by 5 · see citing works
Review of Screening Studies for Atrial Fibrillation in Rural Populations of 11 Countries
Gavino, A., & McLachlan, C. S. (2017) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2017.11929615 · Cited by 5 · see citing works
Blood Pressure Control versus Atrial Fibrillation Management in Stroke Prevention
Savoia, C., Sada, L., & Volpe, M. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0553-1 · Cited by 5 · see citing works
Yang, X., Huang, J., Huang, Z., Xue, Y., Deng, H., & Cao, X. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm36262 · Cited by 2 · see citing works
Bilateral internal mammary artery grafting: Why, how and for whom
Raja, S. G. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.03.011 · Cited by 2 · see citing works
Remote ECG Interpretation: Guidelines and their Implementation
Simova, I. I., Predovski, M., Christov, I. I., & Simov, D. (2017) · Computing in cardiology · doi:10.22489/cinc.2017.366-095 · Cited by 1 · see citing works
Bilateral Internal Mammary Artery Grafting
Raja, S. G., & Taggart, D. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-24174-2_21 · Cited by 1 · see citing works
Sampson, M. G. (2017) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2017.12.6.265
Bierig, S. M., Arnold, A. M., Einbinder, L. C., Armbrecht, E. S., & Burroughs, T. (2017) · Journal of diagnostic medical sonography · doi:10.1177/8756479317737764
Pidanov, O. Y. (2017) · The Bulletin of Contemporary Clinical Medicine · doi:10.20969/vskm.2017.10(6).24-30
Atrial Fibrillation a Benign Condition? Quality of Life Approach
Ţică, O., Țica, O., Hatos, A., Pantea-Roșan, L. R., & Popescu, M. I. (2018) · Central European Journal of Clinical Research · doi:10.2478/cejcr-2018-0008
Diagnosis and prognostic value of asymptomatic atrial fibrillation
Pavlyk, N. S., Chernyaha-Royko, U., Sorokivskyy, M., Aker, A. V., & Zharinov, O. J. (2019) · Cardiac Surgery and Interventional Cardiology · doi:10.31928/2305-3127-2019.2.521
Detection of atrial fibrillation
Gurp, N. V.-V. (2022) · doi:10.26481/dis.20220325nv
Rakhmatullov, R. F., Melnikova, L. V., Moiseeva, I. Y., Rakhmatullov, F. K., & Бурмистрова, Л. Ф. (2022) · Современные проблемы науки и образования · doi:10.17513/spno.31517
Recurrent Acute Limb Ischemia and Successful Treatment with Endovascular Thrombectomy
Rheaume, B. A., Adeel, M. Y., Dahal, K. B., & Lee, J. (2024) · Yonsei Medical Journal · doi:10.3349/ymj.2023.0367
Souliotis, K. N., Golna, C., Gountas, I., Trafalis, D. T., Barmpouni, M., & Vemmos, K. N. (2024) · Cardiology and cardiovascular medicine. · doi:10.5772/intechopen.1006642
- Authors
- Quinn, F. R., & Gladstone, D.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Quinn, F. Russell
- ORCID
- Gladstone, David
- Venue
- Current Opinion in Cardiology
- Published
- 2014-01
- Volume
- 29
- Issue
- 1
- Pages
- 28-35
- ISSN
- 0268-4705 (ISSN-L)
- OpenAlex
- W2012180585
- Cited by
- 34
- References
- 31
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- silent atrial fibrillation, undiagnosed atrial fibrillation, atrial fibrillation screening, community-based screening, prevalence, stroke risk, systemic embolism, cardiac implantable electronic devices, hypertension, heart failure, cost-effectiveness
- MeSH terms
- Atrial Fibrillation, Electrocardiography, Humans, Mass Screening, Risk Factors, Electrocardiography, Ambulatory, Asymptomatic Diseases
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