Familial aggregation of lone atrial fibrillation in young persons
Open accessAbstract
Objectives This study investigated whether an individual's risk of developing lone atrial fibrillation (AF) before age 60 years is associated with lone AF in relatives.Background Genetic factors may play a role in the development of lone AF.Methods Using Danish national registers, a cohort was established of ~4 million persons born between 1950 and 2008, and those with a family history of lone AF (AF without preceding cardiovascular/endocrine diagnoses) were identified. Individuals were followed up until the first diagnosis of lone AF. Poisson regression was used to estimate incidence rate ratios (IRRs).Results In ~92 million person-years of follow-up, 9,507 persons were identified as having lone AF. The IRRs for lone AF given an affected first- or second-degree relative were 3.48 (95% confidence interval [CI]: 3.08 to 3.93) and 1.64 (95% CI: 1.04 to 2.59), respectively. IRRs were higher for men than for women but were not associated with the affected relative's sex. IRR for lone AF was 6.24 (95% CI: 2.59 to 15.0), given at least 2 first-degree relatives affected with lone AF. The IRR for lone AF in persons aged <40 years given a first-degree relative affected at age <40 years was 5.42 (95% CI: 3.80 to 7.72), and 8.53 (95% CI: 3.82 to 19.0) in persons age <30 years given a first-degree relative affected at age <30 years.Conclusions A family history of lone AF is associated with substantial risk of lone AF, with the strongest risks associated with young age at onset, multiple affected relatives, and in first-degree relatives. These results suggest routine evaluation of the families of at least certain types of patients with lone AF.
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AF, especially early-onset AF, has a strong heritable component, independent of concomitant cardiovascular conditions.
“AF, especially early-onset AF, has a strong heritable component, independent of concomitant cardiovascular conditions.58,59”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [59]
Some studies have suggested differences in AF genetics between women and men.
“some studies have suggested differences in AF genetics between women and men7–9.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [8]
Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.
“Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.8,9,50–55”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [8]
The evidence for a differential AF risk dependent on the sex of the affected family member is ambiguous.
“The evidence for a differential AF risk dependent on the sex of the affected family member is more ambiguous (Supplementary Table S5).”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [8]
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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- Authors
- Øyen, N., Ranthe, M. F., Carstensen, L., Boyd, H. A., Olesen, M. S., Olesen, S.-P., Wohlfahrt, J., & Melbye, M.
- Affiliations
- Statens Serum Institut (DK)
- Rigshospitalet (DK)
- University of Copenhagen (DK)
- Corresponding author
- Øyen, Nina
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 60
- Issue
- 10
- Pages
- 917-921
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2047592374
- Cited by
- 126
- References
- 11
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 16 · 2017: 10 · 2016: 14 · 2015: 8 · 2014: 7 · 2013: 16 · 2012: 2
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Hjerteforeningen (10-04-R78-A2912-22619)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- lone atrial fibrillation, familial aggregation, family history (medicine), genetic risk factors, young adults, age of onset, first-degree relatives, second-degree relatives, sex differences, incidence rate ratio
- MeSH terms
- Adolescent, Adult, Atrial Fibrillation, Child, Child, Preschool, Denmark, Family, Female, Humans, Infant, Male, Medical History Taking, Middle Aged, Registries, Research Design, Risk, Risk Factors, Cohort Studies, Confounding Factors, Epidemiologic, Incidence, Poisson Distribution, Odds Ratio, Age of Onset, Genetic Predisposition to Disease
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