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Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation
Open accessAbstract
Background The long-term outcome of atrial fibrillation (AF) ablation demonstrates attrition. This outcome may be due to failure to attenuate the progressive substrate promoted by cardiovascular risk factors.Objectives The goal of this study was to evaluate the impact of risk factor and weight management on AF ablation outcomes.Methods Of 281 consecutive patients undergoing AF ablation, 149 with a body mass index ≥27 kg/m(2) and ≥1 cardiac risk factor were offered risk factor management (RFM) according to American Heart Association/American College of Cardiology guidelines. After AF ablation, all 61 patients who opted for RFM and 88 control subjects were assessed every 3 to 6 months by clinic review and 7-day Holter monitoring. Changes in the Atrial Fibrillation Severity Scale scores were determined.Results There were no differences in baseline characteristics, number of procedures, or follow-up duration between the groups (p = NS). RFM resulted in greater reductions in weight (p = 0.002) and blood pressure (p = 0.006), and better glycemic control (p = 0.001) and lipid profiles (p = 0.01). At follow-up, AF frequency, duration, symptoms, and symptom severity decreased more in the RFM group compared with the control group (all p < 0.001). Single-procedure drug-unassisted arrhythmia-free survival was greater in RFM patients compared with control subjects (p < 0.001). Multiple-procedure arrhythmia-free survival was markedly better in RFM patients compared with control subjects (p < 0.001), with 16% and 42.4%, respectively, using antiarrhythmic drugs (p = 0.004). On multivariate analysis, type of AF (p < 0.001) and RFM (hazard ratio 4.8 [95% confidence interval: 2.04 to 11.4]; p < 0.001) were independent predictors of arrhythmia-free survival.Conclusions Aggressive RFM improved the long-term success of AF ablation. This study underscores the importance of therapy directed at the primary promoters of the AF substrate to facilitate rhythm control strategies.
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“Moderate or severe OSA (AHI ≥ 15) is reported in 20%–62%.330,704,706,710–715”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [330]
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“In studies, such as the ARREST-AF cohort study or the ACTIVE-AF trial, regular exercise programs exhibited a reduction in AF-related symptoms, AF incidence, and AF recurrence rates [76,77].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [76]
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“Other groups have studied the relationship between subjective (grade) or objective (volume/weight) tonsil evaluation and AHI and reported a trend toward significance328 or a significant association.318,329–334”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [330]
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“Given the high incidence of AF after CTI ablation for typical AFL”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [166]
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“Intensive weight-reduction management in addition to management of other cardiovascular risk factors (in the range of 10-15 kg weight loss achieved) led to fewer AF recurrences and symptoms compared with an approach based on general advice in obese patients with AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [203]
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Cites
(2007) · Cited by 6,530
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722
Self-citationMiyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
Self-citationAHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., Franklin, B. A., Goldstein, L. B., Greenland, P., Grundy, S. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020190.45892.75 · Cited by 1,837
Calkins, H. G., Kück, K., Cappato, R., Brugada, J., Camm, A. J., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Dimarco, J., et al. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,685
Self-citationCalkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456
Self-citationObesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427
Wilber, D. J., Pappone, C., Neuzil, P., De Paola, A., Marchlinski, F., Natale, A., Macle, L., Daoud, E. G., Calkins, H., Hall, B., et al. (2010) · JAMA · doi:10.1001/jama.2009.2029 · Cited by 1,170
Wazni, O. M., Marrouche, N. F., Martin, D. O., Verma, A., Bhargava, M., Saliba, W., Bash, D., Schweikert, R., Brachmann, J., Gunther, J., et al. (2005) · JAMA · doi:10.1001/jama.293.21.2634 · Cited by 1,121
Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation
Gami, A. S., Hodge, D. O., Herges, R. M., Olson, E. J., Nykodym, J., Kara, T., & Somers, V. K. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.060 · Cited by 1,104
Catheter Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation
Jaı̈s, P., CAUCHEMEZ, B., Macle, L., Daoud, E. G., Khairy, P., Subbiah, R. N., Hocini, M., Extramiana, F., Sacher, F., Bordachar, P., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772582 · Cited by 889
Ganesan, A. N., Shipp, N. J., Brooks, A. G., Kuklik, P., Lau, D. H., Lim, H. S., Sullivan, T., Roberts‐Thomson, K. C., & Sanders, P. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004549 · Cited by 800
Self-citationOuyang, F. O., Antz, M., Ernst, S., Hachiya, H., Mavrakis, H. E., Deger, F. T., Schaumann, A., Chun, K. R. J., Falk, P., Hennig, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000151289.73085.36 · Cited by 793
Abed, H. S., Wittert, G. A., Leong, D. P., Shirazi, M. G., Bahrami, B., Middeldorp, M. E., Lorimer, M. F., Lau, D. H., Antic, N. A., Brooks, A. G., et al. (2013) · JAMA · doi:10.1001/jama.2013.280521 · Cited by 776
Catheter Ablation for Atrial Fibrillation
Weerasooriya, R., Khairy, P., Litalien, J., Macle, L., Hocini, M., Sacher, F., Lellouche, N., Knecht, S., Wright, M. J., Nault, I., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.061 · Cited by 735
Long-Term Results of Catheter Ablation in Paroxysmal Atrial Fibrillation
Ouyang, F. O., Tilz, R. R., Chun, J., Schmidt, B., Wißner, E., Zerm, T., Neven, K. G. E. J., Köktürk, B., Konstantinidou, M., Metzner, A., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.946806 · Cited by 705
Madrid, A. H., Bueno, M. G., Rebollo, J. M. G., Marín, I., Peña, G., Bernal, E., Rodriguez, A., Cano, L., Cano, J. M., Cabeza, P., et al. (2002) · Circulation · doi:10.1161/01.cir.0000022665.18619.83 · Cited by 685
Pappone, C., Augello, G., Sala, S., Gugliotta, F., Vicedomini, G., Gulletta, S., Paglino, G., Mazzone, P., Sora, N., Greiss, I., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.037 · Cited by 685
Dorian, P., Jung, W., Newman, D., Paquette, M., Wood, K., Ayers, G. M., Camm, J., Akhtar, M., & Luderitz, B. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00886-x · Cited by 627
The Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation
Tedrow, U. B., Conen, D., Ridker, P. M., Cook, N. R., Koplan, B. A., Manson, J. E., Buring, J. E., & Albert, C. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.029 · Cited by 500
Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome
Wong, C. X. J., Abed, H. S., Molaee, P., Nelson, A. J., Brooks, A. G., Sharma, G., Leong, D. P., Lau, D. H., Middeldorp, M. E., Roberts‐Thomson, K. C., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.045 · Cited by 494
Self-citationOutcomes of long-standing persistent atrial fibrillation ablation: A systematic review
Brooks, A. G., Stiles, M. K., Laborderie, J., Lau, D. H., Kuklik, P., SHIPP, N. J., Hsu, L., & Sanders, P. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.01.017 · Cited by 488
Self-citationFein, A. S., Shvilkin, A., Shah, D., Haffajee, C. I., Das, S., Kumar, K., Kramer, D. B., Zimetbaum, P. J., Buxton, A. E., Josephson, M. E., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.052 · Cited by 447
Alcohol Consumption and Risk of Atrial Fibrillation
Larsson, S. C., Drca, N., & Wolk, A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.048 · Cited by 436
Abed, H. S., Samuel, C. S., Lau, D. H., Kelly, D. J., Royce, S. G., Alasady, M., Mahajan, R., Kuklik, P., Zhang, Y., Brooks, A. G., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.08.043 · Cited by 401
Self-citationVerma, A., Kılıçaslan, F., Pisanò, E., MARROUCHE, N. F., Fanelli, R., Brachmann, J., Geunther, J., Potenza, D. R., Martin, D. O., Cummings, J. E., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.533190 · Cited by 400
Paroxysmal Lone Atrial Fibrillation Is Associated With an Abnormal Atrial Substrate
Stiles, M. K., John, B., Wong, C. X. J., Kuklik, P., Brooks, A. G., Lau, D. H., Dimitri, H. R., Roberts‐Thomson, K. C., Wilson, L., Sciscio, P. D., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.054 · Cited by 326
Self-citationAtrial remodeling in obstructive sleep apnea: Implications for atrial fibrillation
Dimitri, H. R., Ng, M., Brooks, A. G., Kuklik, P., Stiles, M. K., Lau, D. H., Antic, N. A., Thornton, A., Saint, D. A., McEvoy, R. D., et al. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.10.017 · Cited by 325
Self-citationConen, D., Tedrow, U. B., Koplan, B. A., Glynn, R. J., Buring, J. E., & Albert, C. M. (2009) · Circulation · doi:10.1161/circulationaha.108.830042 · Cited by 312
Alcohol Consumption and Risk of Atrial Fibrillation
Kodama, S., Saito, K., Tanaka, S., Horikawa, C., Saito, A., Heianza, Y., Anasako, Y., Nishigaki, Y., Yachi, Y., Iida, K., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.08.641 · Cited by 303
Body Mass Index, Obstructive Sleep Apnea, and Outcomes of Catheter Ablation of Atrial Fibrillation
JONGNARANGSIN, K., CHUGH, A., GOOD, E., MUKERJI, S., DEY, S., CRAWFORD, T., SARRAZIN, J. F., KUHNE, M., CHALFOUN, N., WELLS, D., et al. (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01118.x · Cited by 219
Shah, A. N., Mittal, S., Sichrovsky, T., Cotiga, D., Arshad, A., Maleki, K., Pierce, W., & Steinberg, J. S. (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01101.x · Cited by 202
Lau, D. H., Mackenzie, L., Kelly, D. J., Psaltis, P. J., Brooks, A. G., Worthington, M. G., Rajendram, A., Kelly, D. R., Zhang, Y., Kuklik, P., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.05.010 · Cited by 200
Self-citationMohanty, S., Mohanty, P. K., Biase, L. D., Bai, R., Pump, A., Santangeli, P., BURKHARDT, D. J., Gallinghouse, J. G., Horton, R., Sánchez, J., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.051 · Cited by 158
Brooks, A. G. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.878 · Cited by 151
Pulmonary Vein Antral Isolation for Paroxysmal Atrial Fibrillation: Results from Long-Term Follow-Up
MEDI, C., SPARKS, P. B., Morton, J. B., Kistler, P. M., Halloran, K. M., Rosso, R., Vohra, J. K., Kumar, S., & Kalman, J. M. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01885.x · Cited by 151
Self-citationTeh, A. W., Kistler, P. M., Lee, G., MEDI, C., Heck, P. M., Spence, S. J., Morton, J. B., Sanders, P., & Kalman, J. M. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.11.013 · Cited by 151
Self-citationReverse Remodeling of the Atria After Treatment of Chronic Stretch in Humans
John, B., Stiles, M. K., Kuklik, P., Brooks, A. G., Chandy, S. T., Kalman, J. M., & Sanders, P. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.046 · Cited by 104
Self-citationVery long-term outcome after initially successful catheter ablation of atrial fibrillation
Steinberg, J. S., Palekar, R., Sichrovsky, T., Arshad, A., Preminger, M. W., Musat, D. L., Shaw, R. E., & Mittal, S. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.02.003 · Cited by 91
Wachtell, K., Gerdts, E., Aurigemma, G. P., Boman, K., Dahlöf, B., Nieminen, M. S., Olsen, M. H., Okin, P. M., Palmieri, V., Rokkedal, J. E., et al. (2010) · Blood Pressure · doi:10.3109/08037051.2010.481811 · Cited by 67
Fynn, S. P., TODD, D. M., Hobbs, W. J., Armstrong, K. L., Fitzpatrick, A. P., & Garratt, C. J. (2002) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2002.00135.x · Cited by 34
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Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,550
Self-citationHeart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Metadata
- Authors
- Pathak, R. K., Middeldorp, M. E., Lau, D. H., Mehta, A. B., Mahajan, R., Twomey, D., Alasady, M., Hanley, L., Antic, N. A., McEvoy, R. D., Kalman, J. M., Abhayaratna, W. P., & Sanders, P.
- Affiliations
- Royal Adelaide Hospital (AU)
- Australian National University (AU)
- Flinders University (AU)
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Sanders, Prashanthan
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 64
- Issue
- 21
- Pages
- 2222-2231
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W140098974
- Semantic Scholar
- f4c9c27c3ab3730d2c2ca09e8648704e91ba7fde
- Cited by
- 949
- References
- 44
- Citations by year
- 2026: 57 · 2025: 85 · 2024: 72 · 2023: 73 · 2022: 81 · 2021: 107 · 2020: 97 · 2019: 80 · 2018: 70 · 2017: 92 · 2016: 79 · 2015: 52 · 2014: 4
- FWCI
- 52.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Flinders Academic Commons (Flinders University) (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Funders
- ResMed
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- atrial fibrillation, catheter ablation, cardiovascular risk management, obesity, weight loss, blood pressure reduction, glycemic control, lipid profile, arrhythmia-free survival, atrial fibrillation substrate, antiarrhythmic drugs, atrial fibrillation recurrence
- MeSH terms
- Alcohol Drinking, Atrial Fibrillation, Blood Glucose, Blood Pressure, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Life Style, Lipids, Male, Middle Aged, Recurrence, Risk Factors, Severity of Illness Index, Cohort Studies, Body Mass Index, Case-Control Studies, Smoking Cessation, Catheter Ablation, Sleep Apnea, Obstructive, Dyslipidemias, Weight Reduction Programs
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