Cited by 260Lipid metabolism and disordersLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.

Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

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Rosenson, Robert S., Davidson, Michael H., Hirsh, Benjamin J., Kathiresan, Sekar, Gaudet, Daniel·2014·Journal of the American College of Cardiology

Abstract

Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.

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Metadata

Authors
Rosenson, R. S., Davidson, M. H., Hirsh, B. J., Kathiresan, S., & Gaudet, D.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Chicago (US)
  • Mount Sinai Hospital (US)
  • Harvard University (US)
  • Université de Montréal (CA)
Corresponding author
Rosenson, Robert S.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2014-12
Volume
64
Issue
23
Pages
2525-2540
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2005157832
Cited by
260
References
160
Citations by year
2026: 16 · 2025: 25 · 2024: 12 · 2023: 26 · 2022: 27 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 21 · 2017: 19 · 2016: 26 · 2015: 15
FWCI
3.23
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Amgen
  • Eli Lilly and Company
  • AstraZeneca
  • Sanofi
  • Regeneron Pharmaceuticals
  • Kowa Company
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
triglyceride-rich lipoproteins, atherosclerotic cardiovascular disease, triglycerides, genetic risk factors, causality, cardiovascular risk markers, triglyceride-lowering therapy, lipoprotein metabolism, omics, cardiovascular disease prevention
MeSH terms
Cardiovascular Diseases, Fasting, Humans, Inflammation, Intestinal Mucosa, Lipoproteins, Liver, Triglycerides, Genetic Variation, Hypertriglyceridemia, Fatty Acids, Omega-3, Sequence Analysis, DNA, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Postprandial Period, Atherosclerosis

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