Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage
Open accessAbstract
Background Clinical trials applying catheter-based radiofrequency renal denervation (RDN) demonstrated a favorable safety profile with minimal acute or procedural adverse events. Whether ablation of renal nerves adversely affects compensatory responses to hemodynamic challenge has not been extensively investigated.Objectives The aim of this study was to examine the effect of RDN on mean arterial pressure, renal function, and the reflex response to hemorrhage in sheep with normotension (control) or with hypertensive chronic kidney disease (CKD).Methods Sheep underwent RDN (control-RDN, n = 8; CKD-RDN, n = 7) or sham procedures (control-intact, n = 6; CKD-intact, n = 7). Response to hemorrhage (20% loss of blood volume), including plasma renin activity, was assessed at 2 and 5 months post-procedure.Results RDN caused a complete reversal of hypertension and improved renal function in CKD-RDN sheep (p < 0.0001 for 2 and 5 months vs. pre-RDN). In response to hemorrhage, mean arterial pressure fell in all groups, with the fall being greater in the RDN than the intact group (2-month fall in mean arterial pressure: control-intact, -10 ± 1 mm Hg; control-RDN, -15 ± 1 mm Hg; p < 0.05; CKD-intact, -11 ± 3 mm Hg; CKD-RDN, -19 ± 9 mm Hg; p < 0.001). Hemorrhage increased heart rate and plasma renin activity in intact sheep, but these responses were significantly attenuated in control-RDN and CKD-RDN animals. Responses to hemorrhage were remarkably similar at 2 and 5 months post-RDN, which suggests that nerve function had not returned within this time frame.Conclusions In hypertensive CKD sheep, RDN reduced blood pressure and improved basal renal function but markedly compromised compensatory hemodynamic responses to hemorrhage. Therefore, the capacity to respond to a physiological challenge to body fluid homeostasis may be compromised following RDN.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preclinical studies in sheep and rat models show that renal denervation improves renal function and reduces blood pressure in chronic kidney disease, with effects beyond blood pressure reduction.
“However, the beneficial effects of RDN on CKD are not limited to its antihypertensive effects, with studies showing direct improvement in renal function following ablation of the renal nerves.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [111]
The Renal Function results (page not supplied) report that denervation lowered blood pressure and increased GFR and renal blood flow at five months in sheep with hypertensive CKD. The paper does not establish that the renal improvement was independent of blood-pressure reduction, and it does not report a comparable CKD finding in rats. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186 · see citing works
Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
Self-citationRenal Sympathetic-Nerve Ablation for Uncontrolled Hypertension
Schlaich, M. P., Sobotka, P. A., Krum, H., Lambert, E., & Esler, M. D. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0904179 · Cited by 772 · see citing works
Self-citationTranslational medicine: the antihypertensive effect of renal denervation
DiBona, G. F., & Esler, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00647.2009 · Cited by 432 · see citing works
Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals
Schadt, J. C., & Ludbrook, J. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.260.2.h305 · Cited by 424 · see citing works
Renal Denervation in Moderate to Severe CKD
Hering, D., Mahfoud, F., Walton, A. S., Krum, H., Lambert, G. W., Lambert, E. A., Sobotka, P. A., Böhm, M., Cremers, B., Esler, M. D., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011111062 · Cited by 361 · see citing works
Self-citationBöhm, M., Mahfoud, F., Ukena, C., Hoppe, U. C., Narkiewicz, K., Negoita, M., Ruilope, L. M., Schlaich, M. P., Schmieder, R. E., Whitbourn, R., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.05010 · Cited by 186 · see citing works
Self-citationBooth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P., & May, C. N. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04176 · Cited by 171 · see citing works
Self-citationAzizi, M., Pereira, H., Hamdidouche, I., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Mounier‐Véhier, C., Courand, P., Lantelme, P., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022922 · Cited by 153 · see citing works
Ukena, C., Mahfoud, F., Kindermann, I., Barth, C., Lenski, M., Kindermann, M., Brandt, M. C., Hoppe, U. C., Krum, H., Esler, M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.05.036 · Cited by 147 · see citing works
Importance of Blood Pressure Control in Chronic Kidney Disease
Ravera, M., Re, M., Deferrari, L., Vettoretti, S., & Deferrari, G. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121319 · Cited by 140 · see citing works
Ott, C., Mahfoud, F., Schmid, A., Toennes, S. W., Ewen, S., Ditting, T., Veelken, R., Ukena, C., Uder, M., Böhm, M., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000556 · Cited by 129 · see citing works
Ukena, C., Mahfoud, F., Spies, A., Kindermann, I., Linz, D., Cremers, B., Laufs, U., Neuberger, H., & Böhm, M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.07.027 · Cited by 129 · see citing works
Esler, M. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.06.001 · Cited by 127 · see citing works
The role of sympathetic nervous activity in renal injury and end-stage renal disease
Masuo, K., Lambert, G. W., Esler, M., Rakugi, H., Ogihara, T., & Schlaich, M. P. (2010) · Hypertension Research · doi:10.1038/hr.2010.35 · Cited by 107 · see citing works
Self-citationFunctional reinnervation and development of supersensitivity to NE after renal denervation in rats
Kline, R. L., & Mercer, P. F. (1980) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1980.238.5.r353 · Cited by 98 · see citing works
Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu048 · Cited by 89 · see citing works
The Transplanted Human Kidney Does Not Achieve Functional Reinnervation
Hansen, J. M., Abildgaard, U., Fogh‐Andersen, N., Kanstrup, I., Bratholm, P. S., Plum, I., & Strandgaard, S. (1994) · Clinical Science · doi:10.1042/cs0870013 · Cited by 87 · see citing works
Schlaich, M. P., Hering, D., Sobotka, P. A., Krum, H., Lambert, G. W., Lambert, É., & Esler, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00010 · Cited by 81 · see citing works
Self-citationContribution of renal nerves to renal blood flow variability during hemorrhage
Malpas, S. C., Evans, R. G., Head, G. A., & Lukoshkova, E. V. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1283 · Cited by 70 · see citing works
Self-citationDifferential control of intrarenal blood flow during reflex increases in sympathetic nerve activity
Leonard, B. L., Malpas, S. C., Denton, K. M., Madden, A. C., & Evans, R. G. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.1.r62 · Cited by 59 · see citing works
Self-citationRenal renin secretion as regulator of body fluid homeostasis
Damkjær, M., Isaksson, G. L., Stubbe, J., Jensen, B. L., Assersen, K. B., & Bie, P. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1171-2 · Cited by 47 · see citing works
Pöss, J., Ewen, S., Schmieder, R. E., Muhler, S., Vonend, O., Ott, C., Linz, D., Geisel, J., Rump, L. C., Schlaich, M. P., et al. (2015) · Clinical Research in Cardiology · doi:10.1007/s00392-015-0832-5 · Cited by 44 · see citing works
Self-citationTsioufis, C. P., Papademetriou, V., Dimitriadis, K. S., Tsiachris, D., Thomopoulos, C., Park, E., Hata, C., Papalois, A. E., & Stefanadis, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.038 · Cited by 43 · see citing works
Singh, R. R., Denton, K. M., Bertram, J. F., Jefferies, A. J., Head, G. A., Lombardo, P., Schneider, M. E., & Moritz, K. M. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831bc778 · Cited by 43 · see citing works
Self-citationOrthostatic function after renal sympathetic denervation in patients with resistant hypertension
Lenski, M., Mahfoud, F., Razouk, A., Ukena, C., Lenski, D., Barth, C., Linz, D., Laufs, U., Kindermann, I., & Böhm, M. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.10.017 · Cited by 34 · see citing works
Kim, B.-K., Böhm, M., Mahfoud, F., Mancia, G., Park, S., Hong, M.-K., Kim, H.-S., Park, S.-J., Park, C. G., Seung, K. B., et al. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.77 · Cited by 32 · see citing works
The neural regulation of the kidney in hypertension and renal failure
Johns, E. J. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.072686 · Cited by 31 · see citing works
Renal Effects of Hemorrhage in Normal Man
Stone, A. M., & Stahl, W. M. (1970) · Annals of Surgery · doi:10.1097/00000658-197011000-00007 · Cited by 31 · see citing works
Effect of hemorrhage rate on early hemodynamic responses in conscious sheep
Scully, C. G., Daluwatte, C., Marques, N. R., Khan, M., Salter, M. G., Wolf, J., Nelson, C., Salsbury, J. R., Enkhbaatar, P., Kinsky, M. P., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12739 · Cited by 29 · see citing works
Frithiof, R., Ramchandra, R., Hood, S. G., & May, C. N. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00930.2010 · Cited by 27 · see citing works
Self-citationLankadeva, Y. R., Singh, R. R., Moritz, K. M., Parkington, H. C., Denton, K. M., & Tare, M. (2014) · Circulation · doi:10.1161/circulationaha.114.013930 · Cited by 26 · see citing works
Self-citationEwen, S., Mahfoud, F., Linz, D., Pöss, J., Cremers, B., Kindermann, I., Laufs, U., Ukena, C., & Böhm, M. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01985 · Cited by 26 · see citing works
Anti-hypertensive effect of radiofrequency renal denervation in spontaneously hypertensive rats
Machino, T., Murakoshi, N., Sato, A., Xu, D., Hoshi, T., Kimura, T., & Aonuma, K. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.06.015 · Cited by 24 · see citing works
Booth, L. C., Schlaich, M. P., Nishi, E. E., Yao, S. T., Xu, J., Ramchandra, R., Lambert, G. W., & May, C. N. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.440 · Cited by 22 · see citing works
Self-citationEvans, R. G., Burke, S. L., Lambert, G. W., & Head, G. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00217.2007 · Cited by 19 · see citing works
Self-citationRenal denervation in the era of HTN-3. Comprehensive review and glimpse into the future
Silva, J., Costa, M. A. D. S., Gersh, B. J., & Gonçalves, L. M. M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.05.009 · Cited by 19 · see citing works
Salman, I. M., Sattar, M. Z. A., Abdullah, N. A., Ameer, O. Z., Basri, F., Khan, A. H., Yam, M. F., Swarup, K. R. L. A., Kazi, R. N. A., Salman, H. M., et al. (2010) · PubMed · Cited by 18 · see citing works
Singh, R. R., Jefferies, A. J., Lankadeva, Y. R., Lombardo, P., Schneider, M. E., Hilliard, L. M., Denton, K. M., & Moritz, K. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042400 · Cited by 17 · see citing works
Self-citationRenal responses to hemorrhage are age dependent in conscious sheep
Smith, F. G., Şener, A., Basati, R., & Abu‐Amarah, I. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00492.2003 · Cited by 7 · see citing works
Prochnau, D., Otto, S., Figulla, H. R., & Surber, R. (2016) · Netherlands Heart Journal · doi:10.1007/s12471-016-0839-1 · Cited by 6 · see citing works
Programming of the renin response to haemorrhage by mild maternal renal impairment in sheep
Brandon, A. E., Boyce, A. C., Lumbers, E. R., Kumarasamy, V., & Gibson, K. J. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05473.x · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Small Ruminants: Farmers’ Hope in a World Threatened by Water Scarcity
Akinmoladun, O. F., Muchenje, V., Fon, F. N., & Mpendulo, C. T. (2019) · Animals · doi:10.3390/ani9070456 · Cited by 112 · see citing works
Renal Denervation Update From the International Sympathetic Nervous System Summit
Kiuchi, M. G., Esler, M., Fink, G. D., Osborn, J. W., Banek, C. T., Böhm, M., Denton, K. M., DiBona, G. F., Everett, T. H., Grassi, G. M., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.015 · Cited by 103 · see citing works
Self-citationSingh, R. R., McArdle, Z. M., Iudica, M., Easton, L. K., Booth, L. C., May, C. N., Parkington, H. C., Lombardo, P., Head, G. A., Lambert, G., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12250 · Cited by 86 · see citing works
Self-citationPhysiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney
McArdle, Z. M., Schreuder, M. F., Moritz, K. M., Denton, K. M., & Singh, R. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00725 · Cited by 78 · see citing works
Self-citationEuropean Society of Hypertension position paper on renal denervation 2018
Schmieder, R. E., Mahfoud, F., Azizi, M., Pathak, A., Dimitriadis, K. S., Kroon, A. A., Ott, C., Scalise, F., Mancia, G., & Tsioufis, C. P. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001858 · Cited by 66 · see citing works
Ye, T., Lai, Y., Wang, Z., Zhang, X., Meng, G., Zhou, L., Zhang, Y., Zhou, Z., Deng, J., Wang, M., et al. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902128 · Cited by 55 · see citing works
Veiga, A. C., Milanez, M. I. O., Ferreira, G. R., Lopes, N. R., Santos, C. P., De Angelis, K., Garcia, M. L., Oyama, L. M., Gomes, G. N., Nogueira, F. N., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002304 · Cited by 49 · see citing works
Lopes, N. R., Milanez, M. I. O., Martins, B. S., Veiga, A. C., Ferreira, G. R., Gomes, G. N., Girardi, A. C. C., de Carvalho, P. M., Nogueira, F. N., Campos, R. R., et al. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02346-4 · Cited by 49 · see citing works
Renal nerves in physiology, pathophysiology and interoception
Evans, L. C., Dayton, A., & Osborn, J. W. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00893-3 · Cited by 46 · see citing works
Zhang, L., Guo, F., Xu, S., Deng, Q., Xie, M., Sun, J., Kwok, R. T. K., Lam, J. W. Y., Deng, H., Jiang, H., et al. (2023) · Advanced Materials · doi:10.1002/adma.202304620 · Cited by 40 · see citing works
Bruno, R. M., Taddei, S., Borghi, C., Colivicchi, F., Desideri, G., Grassi, G. M., Mazza, A., Muiesan, M. L., Parati, G., Pontremoli, R., et al. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00367-0 · Cited by 36 · see citing works
Nishi, E. E., de Almeida, V. R., do Amaral, F. G., Simon, K., Futuro-Neto, H. A., Filho, R. A. P., Céspedes, J. G., Campos, R. R., & Bergamaschi, C. T. (2019) · Hypertension Research · doi:10.1038/s41440-019-0301-z · Cited by 35 · see citing works
Renal denervation: where do we stand and what is the relevance to the nephrologist?
Schmieder, R. E. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa237 · Cited by 34 · see citing works
Singh, R. R., & Denton, K. M. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10265 · Cited by 30 · see citing works
Self-citationAutonomic Neuromodulation for Preventing and Treating Ventricular Arrhythmias
Lai, Y., Yu, L., & Jiang, H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00200 · Cited by 26 · see citing works
Neurocardiology: translational advancements and potential
Herring, N., Ajijola, O. A., Foreman, R. D., Gourine, A. V., Green, A. L., Osborn, J. W., Paterson, D. J., Paton, J. F. R., Ripplinger, C. M., Smith, C. E. R., et al. (2024) · The Journal of Physiology · doi:10.1113/jp284740 · Cited by 28 · see citing works
Renal and hypothalamic inflammation in renovascular hypertension: role of afferent renal nerves
Lauar, M. R., Evans, L. C., Van Helden, D., Fink, G. D., Banek, C. T., Menani, J. V., & Osborn, J. W. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2023 · Cited by 23 · see citing works
Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation
Esler, M., Osborn, J. W., & Schlaich, M. P. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21715 · Cited by 25 · see citing works
Self-citationRenal sympathetic denervation for resistant hypertension: where do we stand after more than a decade
Fontes, M. A. P., Marzano, L. A. S., Silva, C. C., & Silva, A. C. S. E. (2020) · Brazilian Journal of Nephrology · doi:10.1590/2175-8239-jbn-2018-0213 · Cited by 22 · see citing works
Singh, R. R., McArdle, Z. M., Booth, L. C., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P., & Denton, K. M. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16718 · Cited by 15 · see citing works
Self-citationRenal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure
Booth, L. C., de Silva, R. A. U., Filho, R. A. P., Yao, S. T., Hood, S. G., Lankadeva, Y. R., Kosaka, J., Eikelis, N., Lambert, G. W., Schlaich, M. P., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16054 · Cited by 15 · see citing works
Self-citationContribution of the Renal Nerves to Hypertension in a Rabbit Model of Chronic Kidney Disease
Sata, Y., Burke, S. L., Gueguen, C., Lim, K., Watson, A. M. D., Jha, J. C., Eikelis, N., Jackson, K. L., Lambert, G. W., Denton, K. M., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15769 · Cited by 13 · see citing works
Self-citationCarnagarin, R., Kiuchi, M. G., Goh, G. S., Adams, L. A., Cohen, N. D., Kavnoudias, H., Gan, S. K., van Schie, G., Esler, M., Matthews, V. B., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002839 · Cited by 11 · see citing works
Self-citationThe involvement of renal afferents in the maintenance of cardiorenal diseases
Veiga, A. C., Milanez, M. I. O., Campos, R. R., Bergamaschi, C. T., & Nishi, E. E. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00225.2020 · Cited by 11 · see citing works
Update on Renal Sympathetic Denervation for the Treatment of Hypertension
Rao, A., & Krishnan, N. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01753-x · Cited by 10 · see citing works
Vuignier, Y., Grouzmann, E., Müller, O., Vakilzadeh, N., Faouzi, M., Maillard, M. P., Qanadli, S. D., Burnier, M., & Wuerzner, G. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00042 · Cited by 8 · see citing works
McArdle, Z. M., Filho, R. A. P., Yao, S. T., Lankadeva, Y. R., Singh, R. R., Hood, S. G., Schlaich, M. P., May, C. N., & Booth, L. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2018 · Cited by 8 · see citing works
Self-citationMilanez, M. I. O., Martins, G. R., Nishi, E. E., Bergamaschi, C. T., & Campos, R. R. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172819 · Cited by 7 · see citing works
Effectiveness of renal denervation in the treatment of hypertension: a literature review
Shah, R. T., & Wang, B. (2022) · Clinical Hypertension · doi:10.1186/s40885-022-00194-6 · Cited by 8 · see citing works
Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports
Mahfoud, F., Kandzari, D. E., Schlaich, M. P., Schmieder, R. E., Lauder, L., Ruilope, L. M., Narkiewicz, K., Williams, B., Hettrick, D. A., Lung, T., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf368 · Cited by 6 · see citing works
Self-citationControversies in Hypertension IV: Renal Denervation
Filippone, E. J., Naccarelli, G. V., & Foy, A. (2023) · The American Journal of Medicine · doi:10.1016/j.amjmed.2023.05.010 · Cited by 5 · see citing works
Editorial: Function of Renal Sympathetic Nerves
Wang, Y., Lim, K., & Denton, K. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00642 · Cited by 5 · see citing works
Self-citationSingh, R. R., McArdle, Z., Booth, L. C., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P., & Denton, K. M. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.18354 · Cited by 4 · see citing works
Self-citationCarnagarin, R., Nolde, J. M., Lee, R., Lugo‐Gavidia, L. M., Ward, N. C., Lambert, G. W., Lambert, E. A., Esler, M. D., Walton, A., Kiuchi, M. G., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000003050 · Cited by 4 · see citing works
Self-citationA Novel Catheter-Based Method for Denervation of Afferent Renal Nerves in Sheep
de la Cruz-Lynch, A., Dailey-Krempel, B., Dayton, A., Nguyen, D. T., Tyshynsky, R., Helden, D. A. V., Lahti, M. T., Carney, J. P., Evans, L. C., Vulchanova, L., et al. (2025) · Cardiovascular Engineering and Technology · doi:10.1007/s13239-025-00786-x · Cited by 3 · see citing works
Singh, R. R., McArdle, Z. M., Singh, H., Booth, L. C., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P., & Denton, K. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-94221-5 · Cited by 3 · see citing works
Self-citationIs There a Role for Device Therapies in Resistant Hypertension?
Peixoto, A. J. (2020) · Kidney360 · doi:10.34067/kid.0000742019 · Cited by 2 · see citing works
Renal Denervation in Hypertension
Messerli, F. H., Bavishi, C., & Bangalore, S. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.048 · Cited by 2 · see citing works
The denervation or activation of renal sympathetic nerve and renal blood flow
Kharazmi, F., Hosseini-Dastgerdi, H., Pourshanazari, A., & Nematbakhsh, M. (2023) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_216_23 · Cited by 1 · see citing works
Renal Nerves: Roles in Homeostasis and Pathophysiology
Tyshynsky, R., Vulchanova, L., & Osborn, J. W. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_1 · Cited by 1 · see citing works
Are Important Components of Kidney Function Lost With Renal Denervation? ∗
Esler, M. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.002
Bloch, M. J. (2017) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2017.10.001
Renal Denervation: Physiology, Scope, and Current Evidence
Kiuchi, M. G., & Schlaich, M. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-45414-2_21
Self-citationZhang, S., Wang, M., Jiao, L., Liu, C., Chen, H., Zhou, L., Wang, Y., Wang, Y., Liu, Z., Liu, Z., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4068268
What Needs to Be Shown Before Renal Denervation Can Be Used in Clinical Practice?
Saxena, M., & Lobo, M. D. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_26
Renal Denervation for Chronic Kidney Disease
Kiuchi, M. G., Carnagarin, R., Lugo‐Gavidia, L. M., Hering, D., & Schlaich, M. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-38934-4_9
Self-citation
- Authors
- Singh, R. R., Sajeesh, V., Booth, L. C., McArdle, Z., May, C. N., Head, G. A., Moritz, K. M., Schlaich, M. P., & Denton, K. M.
- Affiliations
- Monash University (AU)
- The University of Melbourne (AU)
- Baker Heart and Diabetes Institute (AU)
- The University of Queensland (AU)
- Corresponding author
- Singh, Reetu R.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 69
- Issue
- 8
- Pages
- 951-964
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2591421489
- Cited by
- 46
- References
- 43
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 3 · 2017: 3
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
- Funders
- Servier
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- renal denervation, radiofrequency ablation, hemorrhage, hypotension, plasma renin activity, renal function, blood pressure regulation, fluid homeostasis, sheep model
- MeSH terms
- Animals, Disease Models, Animal, Hemorrhage, Hypertension, Renal Artery, Sheep, Sympathectomy, Catheter Ablation, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
