Association Between Cardiovascular Risk Factors and Aortic Stenosis
Open accessAbstract
Background Few longitudinal studies have delineated the association between traditional cardiovascular risk factors and development of aortic stenosis (AS).Objectives The authors examined the association between traditional cardiovascular risk factors and incident severe AS in a large, unselected elderly population.Methods This observational cohort study used multiple linked health care population-based databases of individuals older than 65 years on April 1, 2002, without prior valvular disease, coronary artery disease, heart failure, cardiac arrhythmia, cerebrovascular disease, congenital heart disease, or admissions with cardiac symptoms. The relationship between hypertension (HTN), diabetes, dyslipidemia, and incident severe AS requiring hospitalization or surgical or interventional treatment was examined.Results Among 1.12 million individuals followed for a median of 13 years, 20,995 subjects developed severe AS. Overall absolute incidence was 144 per 100,000 person-years (169 and 127 per 100,000 person-years in men and women, respectively). In cause-specific hazard models, HTN (adjusted hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.66 to 1.76), diabetes (HR: 1.49; 95% CI: 1.44 to 1.54), and dyslipidemia (HR: 1.17; 95% CI: 1.14 to 1.21) were all significantly associated with increased risk of developing severe AS (all p < 0.001). There was a positive dose-response relationship between the number and duration of cardiac risk factors and risk of AS. In the Fine-Gray model, all 3 risk factors were independently associated with a higher incidence of AS. The population-attributable risk of AS associated with 3 cardiac risk factors was 34.4% (95% CI: 32.8 to 36.0).Conclusions HTN, diabetes, and dyslipidemia have independent and dose-response associations with incident AS in an unselected population of older individuals, and together accounted for approximately one-third of the incidence of severe AS.
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Observational cohort studies have reported associations between dyslipidemia and increased risk of aortic stenosis or aortic valve calcification.
“Observational cohort studies have reported associations between dyslipidemia and increased risk of AS or aortic valve calcification.3,4”
From Rare Genetic Variants in <i>LDLR</i> , <i>APOB</i> , and <i>PCSK9</i> Are Associated With Aortic Stenosis (2024) · cites this paper as [4]
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Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,479 · see citing works
Guidelines on the management of valvular heart disease
Vahanian, A. S., Baumgartner, H., Bax, J. J., Butchart, E., Dion, R., Filippatos, G. S., Flachskampf, F., Hall, R., Iung, B., Kasprzak, J. D., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl428 · Cited by 3,579 · see citing works
Guidelines on the management of valvular heart disease (version 2012)
Authors/Task Force Members, Vahanian, A., Alfieri, O., Andreotti, F., Antunes, M. J., Barón-Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., De Bonis, M., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs109 · Cited by 3,559 · see citing works
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Guyton, R. A., O’Gara, P. T., Ruiz, C. E., Skubas, N. J., Sorajja, P., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.536 · Cited by 3,523 · see citing works
Introduction to the Analysis of Survival Data in the Presence of Competing Risks
Austin, P. C., Lee, D. S., & Fine, J. P. (2016) · Circulation · doi:10.1161/circulationaha.115.017719 · Cited by 2,653 · see citing works
Self-citationNishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Guyton, R. A., O’Gara, P. T., Ruiz, C. E., Skubas, N. J., Sorajja, P., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000029 · Cited by 2,566 · see citing works
Clinical Factors Associated With Calcific Aortic Valve Disease
Stewart, B. F., Siscovick, D., Lind, B. K., Gardin, J. M., Gottdiener, J. S., Smith, V. E., Kitzman, D. W., & Otto, C. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00563-3 · Cited by 2,029 · see citing works
Guidelines on the management of valvular heart disease (version 2012)
Authors Task Force Members, Vahanian, A. S., Alfieri, O., Andreotti, F., Antunes, M. J., Barón‐Esquivias, G., Baumgartner, H., Borger, M. A., Carrel, T. P., Bonis, M. D., et al. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs455 · Cited by 2,000 · see citing works
Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis
Rossebø, A. B., Pedersen, T. R., Boman, K., Brudi, P., Chambers, J. B., Egstrup, K., Gerdts, E., Gohlke-Bärwolf, C., Holme, I., Kesäniemi, Y. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804602 · Cited by 1,644 · see citing works
2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary
Nishimura, R. A., Otto, C. M., Bonow, R. O., Carabello, B. A., Erwin, J. P., Guyton, R. A., O'Gara, P. T., Ruiz, C. E., Skubas, N. J., Sorajja, P., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.537 · Cited by 1,642 · see citing works
Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis
Makkar, R., Fontana, G. P., Jilaihawi, H., Kapadia, S. R., Pichard, A. D., Douglas, P. S., Thourani, V. H., Babaliaros, V. C., Webb, J. G., Herrmann, H. C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202277 · Cited by 1,341 · see citing works
Hux, J. E., Ivis, F. J., Flintoft, V. F., & Bica, A. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.512 · Cited by 1,290 · see citing works
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
Cowell, S. J., Newby, D. E., Prescott, R. J., Bloomfield, P., Reid, J., Northridge, D. B., & Boon, N. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043876 · Cited by 1,146 · see citing works
Genetic Associations with Valvular Calcification and Aortic Stenosis
Thanassoulis, G., Campbell, C. Y., Owens, D. S., Smith, J. G., Smith, A. V., Peloso, G. M., Kerr, K. F., Pechlivanis, S., Budoff, M. J., Harris, T. B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109034 · Cited by 1,008 · see citing works
Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction
Otto, C. M., & Prendergast, B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1313875 · Cited by 631 · see citing works
Accuracy of administrative databases in identifying patients with hypertension.
Tu, K., Campbell, N. R. C., Chen, Z., Cauch‐Dudek, K., & McAlister, F. A. (2007) · PubMed Central · Cited by 553 · see citing works
Identifying Patients with Physician‐Diagnosed Asthma in Health Administrative Databases
Gershon, A. S., Wang, C., Guan, J., Vasilevska-Ristovska, J. Z., Cicutto, L. C., & To, T. M. (2009) · Canadian Respiratory Journal · doi:10.1155/2009/963098 · Cited by 428 · see citing works
Joosten, M. M., Pai, J. K., Bertoia, M. L., Rimm, E. B., Spiegelman, D. L., Mittleman, M. A., & Mukamal, K. J. (2012) · JAMA · doi:10.1001/jama.2012.13415 · Cited by 338 · see citing works
Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms
Miller, J. D., Weiss, R. M., & Heistad, D. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.234138 · Cited by 321 · see citing works
Spiegelman, D., Hertzmark, E., & Wand, H. C. (2007) · Cancer Causes & Control · doi:10.1007/s10552-006-0090-y · Cited by 298 · see citing works
Katz, R., Wong, N. D., Kronmal, R. A., Takasu, J., Shavelle, D. M., Probstfield, J. L., Bertoni, A. G., Budoff, M. J., & O’Brien, K. D. (2006) · Circulation · doi:10.1161/circulationaha.105.598086 · Cited by 282 · see citing works
Prevalence and incidence of hypertension from 1995 to 2005: a population-based study
Tu, K., Chen, Z., & Lipscombe, L. L. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.071283 · Cited by 254 · see citing works
Smith, J. G., Luk, K., Schulz, C.-A., Engert, J. C., Do, R., Hindy, G., Rukh, G., Dufresne, L., Almgren, P., Owens, D. S., et al. (2014) · JAMA · doi:10.1001/jama.2014.13959 · Cited by 238 · see citing works
Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease?
Agmon, Y., Khandheria, B. K., Meissner, I., Sicks, J. D., O’Fallon, W. M., Wiebers, D. O., Whisnant, J. P., Seward, J. B., & Tajik, A. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01422-x · Cited by 224 · see citing works
Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice
Weiss, R. M., Ohashi, M., Miller, J. D., Young, S. G., & Heistad, D. D. (2006) · Circulation · doi:10.1161/circulationaha.106.634139 · Cited by 222 · see citing works
Messika–Zeitoun, D., Bielak, L. F., Peyser, P. A., Sheedy, P. F., Turner, S. T., Nkomo, V. T., Breen, J. F., Maalouf, J. F., Scott, C. G., Tajik, A. J., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000255952.47980.c2 · Cited by 206 · see citing works
The Cardiovascular Health in Ambulatory Care Research Team (CANHEART)
Tu, J. V., Chu, A., Donovan, L. R., Ko, D. T., Booth, G. L., Tu, K., Maclagan, L. C., Guo, H., Austin, P. C., Hogg, W. E., et al. (2015) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.114.001416 · Cited by 187 · see citing works
Self-citationCurrent Management of Calcific Aortic Stenosis
Lindman, B. R., Bonow, R. O., & Otto, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.111.300084 · Cited by 175 · see citing works
Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice
Miller, J. D., Weiss, R. M., Serrano, K. M., Brooks, R. M., Berry, C. J., Zimmerman, K., Young, S. G., & Heistad, D. D. (2009) · Circulation · doi:10.1161/circulationaha.108.834614 · Cited by 153 · see citing works
Population-Wide Trends in Aortic Stenosis Incidence and Outcomes
Bonow, R. O., & Greenland, P. (2015) · Circulation · doi:10.1161/circulationaha.115.014846 · Cited by 135 · see citing works
Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease
Gould, S. T., Srigunapalan, S., Simmons, C. A., & Anseth, K. S. (2013) · Circulation Research · doi:10.1161/circresaha.112.300154 · Cited by 130 · see citing works
Incidence of Major Cardiovascular Events in Immigrants to Ontario, Canada
Tu, J. V., Chu, A., Rezai, M. R., Guo, H., Maclagan, L. C., Austin, P. C., Booth, G. L., Manuel, D. G., Chiu, M., Ko, D. T., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.015345 · Cited by 126 · see citing works
Self-citationPeltier, M., Trojette, F., Enriquez-Sarano, M. L., Grigioni, F., Slama, M., & Tribouilloy, C. M. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03010-2 · Cited by 120 · see citing works
Teo, K. K., Corsi, D. J., Tam, J. W., Dumesnil, J. G., & Chan, K. L. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.03.012 · Cited by 118 · see citing works
Self-citationTemporal Trends in the Incidence and Prognosis of Aortic Stenosis
Martinsson, A., Li, X., Andersson, C., Nilsson, J., Smith, J. G., & Sundquist, K. (2015) · Circulation · doi:10.1161/circulationaha.114.012906 · Cited by 114 · see citing works
Administrative Hospitalization Database Validation of Cardiac Procedure Codes
Lee, D. S., Stitt, A., Wang, X., Yu, J. S., Gurevich, Y., Kingsbury, K., Austin, P. C., & Tu, J. V. (2011) · Medical Care · doi:10.1097/mlr.0b013e3182329778 · Cited by 114 · see citing works
Self-citationFibrocalcific Aortic Valve Disease
Weiss, R. M., Miller, J. D., & Heistad, D. D. (2013) · Circulation Research · doi:10.1161/circresaha.113.300153 · Cited by 102 · see citing works
Relations of Inflammation and Novel Risk Factors to Valvular Calcification
Fox, C. S., Guo, C., Larson, M. G., Vasan, R. S., Parise, H., O’Donnell, C. J., D’Agostino, R. B., Keaney, J. F., & Benjamin, E. J. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.11.086 · Cited by 70 · see citing works
Berry, C., Lloyd, S. M., Wang, Y., MacDonald, A., & Ford, I. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs339 · Cited by 64 · see citing works
Time to Treat Hypertension in Patients With Aortic Stenosis
Lindman, B. R., & Otto, C. M. (2013) · Circulation · doi:10.1161/circulationaha.113.005275 · Cited by 40 · see citing works
Lipid Lowering in Aortic Stenosis
Helske, S., & Otto, C. M. (2009) · Circulation · doi:10.1161/circulationaha.109.864421 · Cited by 30 · see citing works
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Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Self-citationHeart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784 · see citing works
Martin, S. S., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Barone Gibbs, B., Beaton, A. Z., Boehme, A. K., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001209 · Cited by 2,800 · see citing works
Self-citationGlobal epidemiology of valvular heart disease
Coffey, S., Roberts-Thomson, R., Brown, A. D. H., Carapetis, J. R., Chen, M., Enriquez-Sarano, M. L., Zuhlke, L. J., & Prendergast, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00570-z · Cited by 791 · see citing works
Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases
Larsson, S. C., Wallin, A., Håkansson, N., Stackelberg, O., Bäck, M., & Wolk, A. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.03.099 · Cited by 213 · see citing works
Management of Patients With Aortic Valve Stenosis
Kanwar, A., Thaden, J. J., & Nkomo, V. T. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.01.020 · Cited by 177 · see citing works
Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study
Nazarzadeh, M., Pinho-Gomes, A.-C., Bidel, Z., Dehghan, A., Canoy, D., Hassaine, A., Ayala Solares, J. R., Salimi-Khorshidi, G., Smith, G. D., Otto, C. M., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa070 · Cited by 163 · see citing works
The Global Burden of Valvular Heart Disease: From Clinical Epidemiology to Management
Santangelo, G., Bursi, F., Faggiano, A., Moscardelli, S., Simeoli, P. S., Guazzi, M., Lorusso, R., Carugo, S., & Faggiano, P. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062178 · Cited by 168 · see citing works
Systolic Blood Pressure and Risk of Valvular Heart Disease
Nazarzadeh, M., Pinho‐Gomes, A., Smith-Byrne, K., Canoy, D., Raimondi, F. E. D., Solares, J. R. A., Otto, C. M., & Rahimi, K. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.2202 · Cited by 108 · see citing works
Elevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults
Rahimi, K., Mohseni, H., Kiran, A., Tran, J., Nazarzadeh, M., Rahimian, F., Woodward, M., Dwyer, T., MacMahon, S. W., & Otto, C. M. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy486 · Cited by 98 · see citing works
Development of calcific aortic valve disease: Do we know enough for new clinical trials?
Kostyunin, A. E., Yuzhalin, A. E., Ovcharenko, E. A., & Кутихин, А. Г. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.016 · Cited by 95 · see citing works
Current Therapeutic Options in Aortic Stenosis
Boskovski, M. T., & Gleason, T. G. (2021) · Circulation Research · doi:10.1161/circresaha.121.318040 · Cited by 81 · see citing works
Racial and Ethnic Differences in Treatment and Outcomes of Severe Aortic Stenosis
Wilson, J., Jackson, L. R., Ugowe, F. E., Jones, T., Yankey, G. S., Marts, C., & Thomas, K. L. (2020) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.08.056 · Cited by 70 · see citing works
Aortic stenosis and diabetes mellitus: An ominous combination
Banovic, M. D., Athithan, L., & McCann, G. P. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118820657 · Cited by 69 · see citing works
Risk factors for valvular calcification
Chen, H. Y., Engert, J. C., & Thanassoulis, G. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000471 · Cited by 66 · see citing works
Tilley, E., Psaltis, P. J., Loetscher, T., Davis, D. H. J., Harrison, S. L., Kim, S., & Keage, H. A. D. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.08.037 · Cited by 63 · see citing works
A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou, E. K., Holste, G., Yuan, N., Coppi, A. C., McNamara, R. L., Haynes, N., Vora, A. N., Velazquez, E. J., Li, F., Menon, V., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2024.0595 · Cited by 62 · see citing works
Toshima, T., Watanabe, T., Narumi, T., Otaki, Y., Shishido, T., Aono, T., Goto, J., Watanabe, K., Sugai, T., Takahashi, T., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz210 · Cited by 57 · see citing works
Comparative study of bicuspid vs. tricuspid aortic valve stenosis
Huntley, G. D., Thaden, J. J., Alsidawi, S., Michelena, H. I., Maleszewski, J. J., Edwards, W. D., Scott, C. G., Pislaru, S. V., Pellikka, P. A., Greason, K. L., et al. (2017) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jex211 · Cited by 56 · see citing works
Chen, J., Ren, T., Xie, L., Hu, H., Li, X., Maitusong, M., Zhou, X., Hu, W., Xu, D., Qian, Y. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44726-0 · Cited by 52 · see citing works
Aortic Valve Stenosis Treatment Disparities in the Underserved
Batchelor, W., Anwaruddin, S., Ross, L., Alli, O. O., Young, M. N., Horne, A., Cestoni, A., Welt, F. G. P., & Mehran, R. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.08.1035 · Cited by 51 · see citing works
Lindman, B. R., Arnold, S. V., Bagur, R., Clarke, L., Coylewright, M. J., Evans, F., Hung, J., Lauck, S., Peschin, S., Sachdev, V., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015975 · Cited by 51 · see citing works
Effect of Sodium-Glucose Cotransporter-2 Inhibitors on the Progression of Aortic Stenosis
Shah, T., Zhang, Z., Shah, H., Fanaroff, A. C., Nathan, A. S., Parise, H., Lutz, J., Sugeng, L., Bellumkonda, L., Redfors, B., et al. (2025) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2024.11.036 · Cited by 51 · see citing works
Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis
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Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients
Sengeløv, M., Cheng, S. C., Biering‐Sørensen, T., Matsushita, K., Konety, S., Solomon, S. D., Folsom, A. R., & Shah, A. M. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007234 · Cited by 49 · see citing works
Transcatheter Aortic Valve Replacement in Asia
Lee, C. H., Inohara, T., Hayashida, K., & Park, D. (2021) · JACC Asia · doi:10.1016/j.jacasi.2021.10.006 · Cited by 50 · see citing works
Ram, E., Kogan, A., Levin, S., Fisman, E. Z., Tenenbaum, A., Raanani, E., & Sternik, L. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0836-y · Cited by 41 · see citing works
Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults
Owens, D. S., Bartz, T. M., Bůžková, P., Massera, D., Biggs, M. L., Carlson, S., Psaty, B. M., Sotoodehnia, N., Gottdiener, J. S., & Kizer, J. R. (2021) · Heart · doi:10.1136/heartjnl-2021-319025 · Cited by 42 · see citing works
Biase, N. D., Mazzola, M., Punta, L. D., Fiore, V. D., Carlo, M. D., Giannini, C., Costa, G., Paneni, F., Mengozzi, A., Nesti, L., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.3018 · Cited by 40 · see citing works
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes
Rawshani, A., Sattar, N. A., McGuire, D. K., Wallström, O., Smith, U., Borén, J., Bergström, G. M. L., Ömerovic, E., Rosengren, A., Eliasson, B., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.058072 · Cited by 38 · see citing works
López‐de‐Andrés, A., Pérez-Farinós, N., de Miguel‐Díez, J., Hernández‐Barrera, V., Méndez‐Bailón, M., de Miguel-Yanes, J. M., & Jiménez‐García, R. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0780-2 · Cited by 35 · see citing works
Williams, M. C., Massera, D., Moss, A. J., Bing, R., Bularga, A., Adamson, P. D., Hunter, A. L., Alam, S. R., Shah, A. S. V., Pawade, T., et al. (2020) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeaa263 · Cited by 35 · see citing works
The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis
Sud, K., Narula, N., Aikawa, E. R., Arbustini, E., Pîbarot, P., Merlini, G., Rosenson, R. S., Seshan, S. V., Argulian, E., Ahmadi, A. A., et al. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00818-2 · Cited by 35 · see citing works
Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women
Perrot, N., Boekholdt, S. M., Mathieu, P., Wareham, N. J., Khaw, K., & Arsenault, B. J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.07.107 · Cited by 34 · see citing works
Aortic valve disease in diabetes: Molecular mechanisms and novel therapies
Mânduțeanu, I., Simionescu, D. T., Simionescu, A., & Simionescu, M. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16937 · Cited by 33 · see citing works
Large-scale assessment of aortic stenosis: facing the next cardiac epidemic?
Jiménez, J. R., Ruiz, J. M. M., González‐Alujas, T., Fuentes, M. E., Sitges, M., Peña, M. L. P., Carrasco‐Chinchilla, F., Echeverría, T., Bouzas‐Mosquera, A., Albertí, J. F. F., et al. (2017) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jex223 · Cited by 31 · see citing works
Diabetes Mellitus and Its Implications in Aortic Stenosis Patients
Mouriño-Álvarez, L., Corbacho-Alonso, N., Sastre-Oliva, T., Corros-Vicente, C., Solı́s, J., Tejerina, T., Padial, L. R., & Barderas, M. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126212 · Cited by 30 · see citing works
Liu, F., Chen, J., Hu, W., Gao, C., Zeng, Z., Cheng, S., Yu, K., Qian, Y. H., Xu, D., Zhu, G., et al. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.03.002 · Cited by 30 · see citing works
Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019
Yu, J., Wang, Z., Bao, Q., Lei, S., You, Y., Yin, Z., & Xie, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1003233 · Cited by 30 · see citing works
Harris, A. W., Pîbarot, P., & Otto, C. M. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.09.003 · Cited by 29 · see citing works
Diabetes mellitus as a risk factor for aortic stenosis: from new mechanisms to clinical implications
Natorska, J. (2021) · Kardiologia Polska · doi:10.33963/kp.a2021.0137 · Cited by 28 · see citing works
Selig, J. I., Ouwens, D. M., Raschke, S., Thoresen, G. H., Fischer, J. W., Lichtenberg, A., Akhyari, P., & Barth, M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.05.019 · Cited by 27 · see citing works
Tucureanu, M. M., Filippi, A., Alexandru, N., Constantinescu, C. A., Ciortan, L., Macarie, R. D., Vadana, M., Voicu, G., Frunza, S., Nistor, D., et al. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164119874469 · Cited by 27 · see citing works
Roifman, I., Han, L., Koh, M., Wijeysundera, H. C., Austin, P. C., Douglas, P. S., & Ko, D. T. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013824 · Cited by 25 · see citing works
Self-citationCelecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis
Bowler, M. A., Raddatz, M. A., Johnson, C. L., Lindman, B. R., & Merryman, W. D. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.12.003 · Cited by 24 · see citing works
Rämö, J. T., Jurgens, S. J., Kany, S., Choi, S. H., Wang, X., Smirnov, A. N., Friedman, S. F., Maddah, M., Khurshid, S., Ellinor, P. T., et al. (2024) · Circulation · doi:10.1161/circulationaha.124.070982 · Cited by 26 · see citing works
Aortic Stenosis, Aortic Regurgitation and Arterial Hypertension
Katsi, V. K., Georgiopoulos, G. A., Oikonomou, D., Aggeli, C., Grassos, C. A., Papadopoulos, D. P., Thomopoulos, C., Marketou, M. E., Dimitriadis, K. S., Toutouzas, K., et al. (2018) · Current Vascular Pharmacology · doi:10.2174/1570161116666180101165306 · Cited by 22 · see citing works
Ko, D. T., Khan, A. M., Kotrri, G., Austin, P. C., Wijeysundera, H. C., Koh, M., Chu, A., Jackevicius, C. A., Lawler, P. R., & Tu, J. V. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.010007 · Cited by 22 · see citing works
Self-citationTemporal trends in sudden cardiac death in Ontario, Canada
Shuvy, M., Qiu, F., Lau, G., Koh, M., Dorian, P., Géri, G., Lin, S., & Ko, D. T. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.01.010 · Cited by 22 · see citing works
Self-citationKontogeorgos, S., Thunström, E. Ö., Basic, C., Hansson, P., Zhong, Y., Ergatoudes, C., Morales, D. L. S., Mandalenakis, Z., Rosengren, A., Caidahl, K., et al. (2019) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2019.1685126 · Cited by 21 · see citing works
Yu, Q., Fu, Q., Ma, X., Wang, H., Xia, Y., Chen, Y., Li, P., Li, Y., & Yanqing, W. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02684-x · Cited by 24 · see citing works
Huang, N., Zhuang, Z., Liu, Z., & Huang, T. (2022) · Nutrients · doi:10.3390/nu14112273 · Cited by 21 · see citing works
Choi, Y., Son, J., Kim, E. K., Kim, I., Kim, H. Y., Seo, J.-S., Sun, B. J., Shim, C. Y., Yoon, S., Lee, S., et al. (2022) · Journal of Cardiovascular Imaging · doi:10.4250/jcvi.2022.0076 · Cited by 21 · see citing works
Yamamoto, K., Koretsune, Y., Akasaka, T., Kisanuki, A., Ohte, N., Takenaka, T., Takeuchi, M., Yoshida, K., Iwade, K., Okuyama, Y., et al. (2017) · Thrombosis Research · doi:10.1016/j.thromres.2017.10.027 · Cited by 21 · see citing works
Health care utilization prior to out-of-hospital cardiac arrest: A population-based study
Shuvy, M., Koh, M., Qiu, F., Brooks, S. C., Chan, T. C. Y., Cheskes, S., Dorian, P., Géri, G., Lin, S., Scales, D. C., et al. (2019) · Resuscitation · doi:10.1016/j.resuscitation.2019.04.033 · Cited by 21 · see citing works
Self-citationImaging aortic valve calcification: significance, approach and implications
Fletcher, A. J., Singh, T., Syed, M., & Dweck, M. R. (2020) · Clinical Radiology · doi:10.1016/j.crad.2020.04.007 · Cited by 20 · see citing works
Ljungberg, J., Johansson, B. H., Bergdahl, I. A., Holmgren, A., Näslund, U., Hultdin, J., & Söderberg, S. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1664761 · Cited by 20 · see citing works
Ko, D. T., Azizi, P., Koh, M., Chong, A. S., Austin, P. C., Stukel, T. A., & Jackevicius, C. A. (2019) · Open Heart · doi:10.1136/openhrt-2019-001010 · Cited by 19 · see citing works
Self-citationEffects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis
Trenkwalder, T., Nelson, C. P., Musameh, M. D., Mordi, I. R., Kessler, T., Pellegrini, C., Debiec, R., Rheude, T., Lazovic, V., Zeng, L., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.094 · Cited by 18 · see citing works
Molnár, A. Á., Pásztor, D. T., & Merkely, B. P. (2022) · Cells · doi:10.3390/cells11213389 · Cited by 18 · see citing works
Cheng, Y., Li, Z., Sui, Y., Long, T., Cheng, S., Guo, X., Jiang, C., Ma, H., Xu, H., Qian, J., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf050 · Cited by 19 · see citing works
Wang, A., Adeli, A., Kylhammar, D., Swahn, E., Engvall, J. E., Lind, L., Söderberg, S., Blomberg, A., Engström, G., Spaak, J., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf157 · Cited by 19 · see citing works
Andell, P., Li, X., Martinsson, A., Nilsson, P. M., Zöller, B., Smith, J. G., & Sundquist, K. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.06.034 · Cited by 15 · see citing works
Singh, G. K., van der Bijl, P., Goedemans, L., Vollema, E. M., Abou, R., Marsan, N. A., Bax, J. J., & Delgado, V. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.05.012 · Cited by 16 · see citing works
Jang, S. Y., Park, S., Kim, E. K., & Park, S. W. (2022) · ESC Heart Failure · doi:10.1002/ehf2.13957 · Cited by 15 · see citing works
Diabetes mellitus and cardiovascular mortality across the spectrum of aortic stenosis
Coisne, A., Montaigne, D., Ninni, S., Lamblin, N., Lemesle, G., Delsart, P., Filiot, A., Andrey, P., Balayé, P., Butruille, L., et al. (2022) · Heart · doi:10.1136/heartjnl-2022-320897 · Cited by 15 · see citing works
Prevalence and impact of diabetes in patients with valvular heart disease
Lu, Q., Lv, J., Ye, Y., Li, Z., Wang, W., Zhang, B., Zhao, Q., Zhao, Z., Zhang, H., Liu, Q., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109084 · Cited by 16 · see citing works
The Contribution of Whole Blood Viscosity to the Process of Aortic Valve Sclerosis
Serçelik, A., & Besnili, A. F. (2018) · Medical Principles and Practice · doi:10.1159/000487509 · Cited by 15 · see citing works
Han, K., Shi, D., Yang, L., Xie, M., Zhong, R., Wang, Z., Gao, F., Ma, X., & Zhou, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.812692 · Cited by 15 · see citing works
Kjeldsen, E. W., Thomassen, J. Q., Rasmussen, K. L., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Frikke‐Schmidt, R. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae177 · Cited by 12 · see citing works
Cecoltan, S., Ciortan, L., Macarie, R. D., Vadana, M., Mihaila, A. C., Tucureanu, M. M., Vlad, M.-L., Droc, I., Gherghiceanu, M., Simionescu, A., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.714573 · Cited by 13 · see citing works
Physical Activity Does Not Reduce Aortic Valve Stenosis Incidence
Sarajlic, P., Wolk, A., Bäck, M., & Larsson, S. C. (2018) · Circulation Journal · doi:10.1253/circj.cj-18-0598 · Cited by 13 · see citing works
Drugs for Prevention and Treatment of Aortic Stenosis: How Close Are We?
Afshar, M. S., Yazdan-Ashoori, S., Engert, J. C., & Thanassoulis, G. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.02.017 · Cited by 14 · see citing works
Guo, Y., Xu, S., Zhan, H., Chen, H., Hu, P., Zhou, D., Dai, H., Liu, X., Hu, W., Zhu, G., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020407 · Cited by 12 · see citing works
Song, X., Saito, N., Morimoto, T., Taniguchi, T., Shiomi, H., Andò, K., Nagao, K., Kanamori, N., Murata, K., Kitai, T., et al. (2020) · Circulation Journal · doi:10.1253/circj.cj-20-0681 · Cited by 12 · see citing works
Çelik, M., Milojevic, M., Durko, A. P., Oei, F. B. S., Bogers, A. J. J. C., & Mahtab, E. A. F. (2020) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezaa474 · Cited by 12 · see citing works
Chen, Y., Xiao, F., & Wang, R. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2301007 · Cited by 12 · see citing works
Dietary patterns, food groups, and incidence of aortic valve stenosis: A prospective cohort study.
Larsson, S., Wolk, A., & Bäck, M. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.007 · Cited by 12 · see citing works
Baran, J., Kleczyński, P., Niewiara, Ł., Podolec, J., Badacz, R., Gackowski, A., Pieniążek, P., Legutko, J., Zmudka, K. F., Przewłocki, T., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102109 · Cited by 12 · see citing works
Diabetes mellitus is associated with an increased incidence of aortic valve stenosis
Roderburg, C., Loosen, S. H., Luedde, T., Kostev, K., & Luedde, M. (2021) · Diabetes and Vascular Disease Research · doi:10.1177/14791641211033819 · Cited by 12 · see citing works
Moore, M. K., Jones, G. T., McCormick, S., Williams, M. J. A., & Coffey, S. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae100 · Cited by 11 · see citing works
Multimodality Imaging to Explore Sex Differences in Aortic Stenosis
Singh, G. K., & Delgado, V. (2022) · European Cardiology Review · doi:10.15420/ecr.2022.26 · Cited by 11 · see citing works
Movahed, M. R., Timmerman, B. D., & Hashemzadeh, M. (2023) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2023.07.008 · Cited by 11 · see citing works
Jain, H., Goyal, A., Khan, A. T. M. A., Khan, N. U., Jain, J., Chopra, S., Sulaiman, S. A., Reddy, M. M., Patel, K., Khullar, K., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002106 · Cited by 15 · see citing works
Park, D., Kwon, S.-S., Song, Y., Kim, Y. A., Jeong, B., Lee, W., & Park, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-93744-5 · Cited by 11 · see citing works
The year in cardiology 2017: valvular heart disease
Søndergaard, L., Saraste, A., Christersson, C., & Vahanian, A. S. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx772 · Cited by 11 · see citing works
Aortic stenosis: a review on acquired pathogenesis and ominous combination with diabetes mellitus
Wal, P., Rathore, S., Aziz, N., Singh, Y. K., & Gupta, A. K. (2023) · The Egyptian Heart Journal · doi:10.1186/s43044-023-00345-6 · Cited by 11 · see citing works
Okura, Y., Ishigaki, S., Sakakibara, S., Yumoto, C., Hashitate, M., Sekine, C., Fujita, T., Takayama, T., Ozaki, K., Sato, N., et al. (2018) · International Heart Journal · doi:10.1536/ihj.17-320 · Cited by 11 · see citing works
Calcific Aortic Valve Stenosis with Aging and Current Development in its Pathophysiology
Kodra, A., & Kim, M. (2022) · International Journal of Angiology · doi:10.1055/s-0042-1758382 · Cited by 10 · see citing works
Kaltoft, M., Afzal, S., Nordestgaard, B. G., Sigvardsen, P. E., Kühl, J. T., Fuchs, A., Køber, L., Kofoed, K. F., & Langsted, A. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf106 · Cited by 10 · see citing works
Liu, F., & Cai, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1583267 · Cited by 10 · see citing works
Ivert, T., Hammar, N., Talbäck, M., Malmström, H., Leander, K., & Walldius, G. (2021) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.12.005 · Cited by 10 · see citing works
Selig, J. I., Boulgaropoulos, J., Niazy, N., Ouwens, D. M., Preuß, K., Horn, P., Westenfeld, R., Lichtenberg, A., Akhyari, P., & Barth, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136976 · Cited by 10 · see citing works
Towards Personalized Therapy of Aortic Stenosis
Mazur, P. K., Kopytek, M., Ząbczyk, M., Undas, A., & Natorska, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121292 · Cited by 10 · see citing works
Dysglycaemia and incident aortic stenosis: a cohort study
Lind, V., Lundman, P., Friberg, L., Talbäck, M., Hammar, N., Walldius, G., Ding, M., & Norhammar, A. (2025) · Heart · doi:10.1136/heartjnl-2024-325150 · Cited by 9 · see citing works
Wang, A., Östgren, C. J., Norhammar, A., Kylhammar, D., Jernberg, T., Lind, L., Söderberg, S., Blomberg, A., Engström, G., Bergström, G. M. L., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02634-7 · Cited by 9 · see citing works
Trimaille, A., Hmadeh, S., Kikuchi, S., Mroueh, A., Carmona, A., Marchandot, B., Beras, F., Truong, D. P., Vu, M. C., Granier, A., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.041701 · Cited by 9 · see citing works
- Authors
- Yan, A. T., Koh, M., Chan, K. K., Guo, H., Alter, D. A., Austin, P. C., Tu, J. V., Wijeysundera, H. C., & Ko, D. T.
- Affiliations
- St. Michael's Hospital (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Corresponding author
- Yan, Andrew T.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 69
- Issue
- 12
- Pages
- 1523-1532
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2603952975
- Cited by
- 247
- References
- 43
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 33 · 2023: 26 · 2022: 37 · 2021: 26 · 2020: 21 · 2019: 22 · 2018: 20 · 2017: 12
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Institute for Clinical Evaluative Sciences
- Ontario Ministry of Health and Long-Term Care
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- aortic stenosis, cardiovascular risk factors, hypertension, diabetes mellitus, dyslipidemia, older adults, population attributable risk, dose-response relationship
- MeSH terms
- Aged, Aged, 80 and over, Aortic Valve Stenosis, Female, Humans, Male, Ontario, Risk Factors, Incidence
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