Racial and Ethnic Considerations in Patients With Atrial Fibrillation
Open accessAbstract
Atrial fibrillation (AF) affects at least 60 million individuals globally and is associated with substantial impacts on morbidity, mortality, and health care expenditures. This review focuses on how race and ethnicity influence AF epidemiology, risk prediction, treatment, and outcomes; knowledge gaps in these areas are identified. Most AF studies have predominantly included White populations, with an underrepresentation of racial and ethnic groups, including but not limited to Black, Hispanic, and Indigenous individuals. Enhancement and implementation of AF risk prediction, prevention, and management call for studies that will gather accurate race-based epidemiologic data and evaluate social determinants and genetic factors in the context of multiple races and ethnicities. Available studies highlight inequities in access to treatment as well as outcomes between White individuals and persons of other races/ethnicities. These inequities will need to be addressed by a renewed emphasis on structural and social determinants of health that contribute to AF.
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The highest incidence of AF is observed in the Caucasian population compared to other racial groups.
“Finally, studies indicate that the highest incidence of AF is observed in the Caucasian population compared to other racial groups [33,34].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [33]
The Epidemiology section says US longitudinal cohort studies found the highest AF incidence in White individuals, and UK data show higher incidence in White than in Asian or Black individuals. The claim is broader than those findings: the same section reports a California study in which American Indians had a higher adjusted risk of incident AF than White individuals. (LLM, conf=0.86)
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- [44]Chen LY, Norby FL, Chamberlain AM CHA2DS2-VASc score and stroke prediction in atrial fibrillation in whites, blacks, and Hispanics. Stroke 2019; 50: 28– 33. 30580712 PMC6541553
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“Finally, studies indicate that the highest incidence of AF is observed in the Caucasian population compared to other racial groups [33,34].”
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- Authors
- Norby, F. L., Benjamin, E. J., Alonso, A., & Chugh, S. S.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Boston University (US)
- Corresponding author
- Chugh, Sumeet S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 78
- Issue
- 25
- Pages
- 2563-2572
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC8688256
- OpenAlex
- W4200371995
- Cited by
- 46
- References
- 50
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 3 · 2022: 4 · 2021: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- American Heart Association (AHA_18SFRN34110082)
- National Institutes of Health (R01 HL092577, 1R01AG066010, R01 HL141434, R01AG066914)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- atrial fibrillation, racial and ethnic disparities, health equity, social determinants of health, risk prediction, treatment access, genetic factors, underrepresentation in clinical research, Black patients, Hispanic patients, Indigenous patients
- MeSH terms
- Heart Disease Risk Factors, Atrial Fibrillation, Humans, Mass Screening, Healthcare Disparities
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