European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans
Open accessAbstract
Background—: Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the higher risk is due to genetic or environmental factors. Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF. Methods and Results—: We studied whites (n=4543) and African Americans (n=822) in the Cardiovascular Health Study (CHS) and whites (n=10 902) and African Americans (n=3517) in the Atherosclerosis Risk in Communities (ARIC) Study (n=3517). Percent European ancestry in African Americans was estimated with 1747 ancestry informative markers from the Illumina custom ITMAT-Broad-CARe array. Among African Americans without baseline AF, 120 of 804 CHS participants and 181 of 3517 ARIC participants developed incident AF. A meta-analysis from the 2 studies revealed that every 10% increase in European ancestry increased the risk of AF by 13% (hazard ratio, 1.13; 95% confidence interval, 1.03 to 1.23; P =0.007). After adjustment for potential confounders, European ancestry remained a predictor of incident AF in each cohort alone, with a combined estimated hazard ratio for each 10% increase in European ancestry of 1.17 (95% confidence interval, 1.07 to 1.29; P =0.001). A second analysis using 3192 ancestry informative markers from a genome-wide Affymetrix 6.0 array in ARIC African Americans yielded similar results. Conclusions—: European ancestry predicted risk of incident AF. Our study suggests that investigating genetic variants contributing to differential AF risk in individuals of African versus European ancestry will be informative.
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A higher degree of European ancestry is associated with an increased predisposition to atrial fibrillation.
“Furthermore, recent reports indicate that higher degree of European ancestry is associated with an increased predisposition to AF.33”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [33]
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- Authors
- Marcus, G. M., Alonso, A., Peralta, C. A., Lettre, G., Vittinghoff, E., Lubitz, S. A., Fox, E. R., Levitzky, Y. S., Mehra, R., Kerr, K. F., Deo, R., Sotoodehnia, N., Akylbekova, M., Ellinor, P. T., Paltoo, D. N., Soliman, E. Z., Benjamin, E. J., Heckbert, S. R., & for the Candidate-Gene Association Resource (CARe) Study
- Affiliations
- University of Minnesota (US)
- From the Electrophysiology Section, Division of Cardiology (G.M.M.), Division of Nephrology (C.A.P.), and Department of Epidemiology and Biostatistics (E.V.), University of California, San Francisco; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (G.L.); Cardiovascular Research Center (S.A.L., P.T.E.) and Cardiac Arrhythmia Service (P.T.E.), Massachusetts...
- ORCID
- Venue
- Circulation
- Published
- 2010-11-16
- Volume
- 122
- Issue
- 20
- Pages
- 2009-2015
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3058884
- OpenAlex
- W1966857245
- Cited by
- 255
- References
- 42
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- 2026: 9 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 13 · 2021: 19 · 2020: 9 · 2019: 16 · 2018: 17 · 2017: 24 · 2016: 21 · 2015: 13 · 2014: 20 · 2013: 20 · 2012: 23
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
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- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
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- National Institutes of Health (n01hc95095-66-0-1, n01hc095100-000, n01hb097072-008, n01hb097073-003, n01hb073002-023, n01hb097062-006, n01hc95164-17-0-1, n01hc085082-026, n01hc085081-021, n01hc95170-30-0-1, n01hc045133-001, n01hb073005-020, n01hc48050-59-0-1, n01hc085079-024, n01hc015103-009, n01hc48048-58-0-1, n01hc085084-005, n01hb073003-018, 5rc1hl099452-02, n01hc55021-47-0-1, n01hc045134-008, n01hb072991-020, n01hb097064-007, n01hc085085-011, n01hc085083-027, n01hb073001-017, n01hc95165-34-0-1, n01hc48047-55-0-1, n01hc55020-39-0-0, n01hb073006-019, n01hc085080-026, n01hc55016-37-0-0, n01hb097054-006, n01hc055022-024, n01hb072982-018, n01hc95161-24-0-1, n01hb072993-015, n01hc095169-003, n01hb097051-002, n01hc95171-31-0-1, n01hc45205-9-0-0, n01hc005187-000, n01hb072992-017, n01hb072995-019, n01hc65226-6-0-0, n01hc95166-21-0-1, n01hc085086-022, n01hc48049-61-0-1, n01hc95162-31-0-1, n01hc55019-35-0-1, n01hc95168-27-0-1, n01hb072998-019, n01hc95160-18-0-1, n01hc45204-11-0-1, n01hb097070-004, n01hc095167-000, n01hb097068-005, n01hb097071-007, n01hb097058-006, n01hc55018-38-0-1, n01hb072997-020, 5u01hl053934-14, n01hb097061-007, n01hc25195-41-0-1, n01hc95163-22-0-1, n01hb073000-017, n01hc55222-0-0-0, n01hb097056-007, n01hb097069-007, n01hc95159-40-0-1, n01hb073004-021, n01hc075150-004, n01hc035129-010, n01hb072994-019, n01hb097053-007, n01hb072996-019, n01hb097066-008, n01hc95172-31-0-1, n01hb097060-002, n01hc55015-48-0-1)
- U.S. Public Health Service (HHSN 268200625226C)
- National Institute on Aging (R01AG028321)
- National Heart, Lung, and Blood Institute (N01-HC-85081, N01-HB-97054, R01HL071205, N01-HC55022, N01-HC-65226, N01 HC085086, N01HC48050, N01HC-85083, N01 HC-95159, N01-HC-95160, N01-HB-97056, N01 HC055016, N01-HC-55018, N01-HB-72997, N01-HC095169, N01-HB-72996, N01-HC045134, N01 HC-95168, N01-HB-97072, N01-HC-095165, N01-HB-97061, N01-HB-97064, U01HL053941, N01 HC 95095, N01-HB-97070, N01 HC95167, N01 HC 55020, N01 HC085079, N01-HB-97068, (N01-HC-95163, N01-HB-73004, N01 HC095163, U01HL053938, N01-HB-97053, N01-HB-72994, N01 HC085083, N01‐HC25195, N01-HB-97085, N01 HC 55019, R01HL088456, N01-HB-73002, N01HC85082, N01HC‐75150, N01 HC045205, N01 HC85086, R01 HL-59367, N01 HC-95161, N01-HB7-3000, N01 HC95165, N01HC95164, N01 HC085080, U01HL053937, N01 HC048048, RC1-HL01056, N01 HC095171, N01-HB-72998, N01-HC05187, N01 HC055020, N01 HC035129, R01HL046380, N01-HC-048049, N01HC85080, N01 HC045204, N01 HC095172, N01-HC-095159, N01 HC095168, R01HL104156, N01-HB-72992, N01 HC055018, N01-HC-095162, N01-HB-97071, N01 HC015103, N01-HC- 45204, N01-HB-97060, N01 HC095095, N01 HC55222, N01-HC-095161, N01 HC085085, U01HL064360, U01HL053916, N01HC95172, N01-HB-73006, N01-HB-7-2982, N01 HC048050, N01-HC-025195, N01-HB-97069, N01-HC-45205, N01-HC55016, HL053934, N01 HC095170, N01-HB-97058, N01 HC 95170, R01HL087641, N01 HC055022, N01 HC005187, N01-HB-72993, R01HL059367, N01 HC095167, N01HC085082, N01-HC-48-049, N01 HC065226, U01HL080295, L30 HL078035, N01-HC-095160, N01-HC-95100, R01HL076784, N01 HC055019, U01HL077813, N01 HC055222, N01 HC095166, N01-HB-97073, N01-HB-73005, N01-HB-73003, N01 HC095164, N01 HC048047, N01‐HC‐95166, HL 46380, U01HL063463, N01-HB-9-7062, Z01HL001056, N01-HC-480-47, N01 HC085081, N01-HB-97051, T32HL007575, N01-HB-97066, N01‐HC‐55015, N01 HC-95162, N01-HC55021, N01 HC075150, N01-HB-72995, N01 HC055021, K24HL105780, N01-HB-73001, N01 HC-95171, N01 HC085084, N01 HC055015, N01 HC045133, K23HL079114, N01-HB-72991, U01HL063429, U01-HL-053934, R01HL092577, R01HL086694, N01-HC85079, RC1-HL099452, N01 HC95169)
- National Institute on Drug Abuse (DA027021, R21DA027021)
- National Human Genome Research Institute (U01HG004402)
- National Institute of Neurological Disorders and Stroke (6R01NS17950, R01NS017950)
- National Center for Research Resources (M01RR000080, UL1RR025005, KL2RR024130, M01RR00080, K12RR023262)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- atrial fibrillation, European ancestry, African Americans, genetic ancestry, incident atrial fibrillation risk, ancestry informative markers, genetic risk factors
- MeSH terms
- Aged, Atrial Fibrillation, Black or African American, Female, Humans, Male, Middle Aged, Risk Factors, White People, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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