Epidemiology and natural history of atrial fibrillation: clinical implications
Open accessAbstract
With a substantial impact on morbidity and mortality, the growing "epidemic" of atrial fibrillation (AF) intersects with a number of conditions, including aging, thromboembolism, hemorrhage, hypertension and left ventricular dysfunction. Currently, the epidemiology and natural history of AF govern all aspects of its clinical management. The ongoing global investigative efforts toward understanding AF are also driven by epidemiologic findings. New developments, by affecting the natural history of the disease, could eventually alter the nature of decision making in patients with AF. The crucial issue of rate versus rhythm control awaits completion of the AF Follow-up Investigation of Rhythm Management trial. The processes of electrical and structural remodeling that perpetuate AF appear to be reversible. In the era of functional genomics, the molecular basis of this ubiquitous arrhythmia is in the process of being defined. Unraveling the molecular genetics of AF might provide new insights into the structural and electrical phenotypes resulting from genetic mutations and, as such, new approaches to treatment of this arrhythmia at the ion channel and cellular levels. Thus, current adverse trends are superimposed on a background of a rapidly developing knowledge base and potentially exciting new therapeutic options. Consequently, an understanding of the epidemiology and natural history of AF is crucial to the future allocation of resources and the utilization of an expanding range of therapies aimed at reducing the impact of this disease on a changing patient population.
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Atrial fibrillation is a growing epidemic.
“In view of the emergence of AF as a ‘growing epidemic’,15, 17 an assessment of the global burden of AF is warranted.”
From Worldwide Epidemiology of Atrial Fibrillation: A Global Burden of Disease 2010 Study (2014) · cites this paper as [15]
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- Authors
- Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Gersh, Bernard J
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 37
- Issue
- 2
- Pages
- 371-378
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1988911499
- Cited by
- 768
- References
- 85
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 20 · 2023: 20 · 2022: 22 · 2021: 39 · 2020: 28 · 2019: 30 · 2018: 30 · 2017: 35 · 2016: 47 · 2015: 45 · 2014: 40 · 2013: 49 · 2012: 44
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, epidemiology, natural history (disease), thromboembolism, hemorrhage, hypertension, left ventricular dysfunction, aging, electrical remodeling, structural remodeling, molecular genetics, ion channels, antiarrhythmic therapy
- MeSH terms
- Atrial Fibrillation, Cross-Sectional Studies, Electrocardiography, Humans, Risk Factors, Incidence
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