Adipose tissue, adipokines, and inflammation

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245

Novel Modulator for Endothelial Adhesion Molecules

Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid

Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756

Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans

Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,619

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

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Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,036

Adiponectin: More Than Just Another Fat Cell Hormone?

Chandran, M., Phillips, S. A., Ciaraldi, T. P., & Henry, R. R. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2442 · Cited by 1,013

Leptin in the regulation of immunity, inflammation, and hematopoiesis

Fantuzzi, G., & Faggioni, R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.4.437 · Cited by 980

Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

Wolf, A. M., Wolf, D. G. F., Rumpold, H. F., Enrich, B., & Tilg, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.145 · Cited by 821

Inflammatory pathways and insulin action

Hotamisligil, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802502 · Cited by 717

Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure

Kalantar‐Zadeh, K., Block, G., Horwich, T. B., & Fonarow, G. C. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.039 · Cited by 693

Resistin Promotes Endothelial Cell Activation

Verma, S., Li, S., Wang, C., Fedak, P. W. M., Li, R., Weisel, R. D., & Mickle, D. A. G. (2003) · Circulation · doi:10.1161/01.cir.0000084503.91330.49 · Cited by 670

FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family

Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A. L., Henzel, W. J., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 662

Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis

Jia, S. H., Li, Y., Parodo, J. C., Kapùs, A., Fan, L., Rotstein, O. D., & Marshall, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19930 · Cited by 617

From Blood Monocytes to Adipose Tissue-Resident Macrophages

Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600

Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages

Kumada, M., Kihara, S., Ouchi, N., Kobayashi, H., Okamoto, Y., Ohashi, K., Maeda, K., Nagaretani, H., Kishida, K., Maeda, N., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127953.98131.ed · Cited by 555

An Inflammatory Cascade Leading to Hyperresistinemia in Humans

Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., & Lazar, M. A. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010045 · Cited by 535

The Function of Leptin in Nutrition, Weight, and Physiology

Friedman, J. M. (2002) · Nutrition Reviews · doi:10.1301/002966402320634878 · Cited by 510

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

Ofei, F., Hurel, S. J., Newkirk, J., Sopwith, M., & Taylor, R. (1996) · Diabetes · doi:10.2337/diab.45.7.881 · Cited by 510

Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine–endothelial cell interactions

Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K., & Nagai, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.104 · Cited by 470

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

Maffei, M., Fei, H., Lee, G., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Négrel, R., Ailhaud, G. P., & Friedman, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6957 · Cited by 465

Adiponectin differentially regulates cytokines in porcine macrophages

Wulster-Radcliffe, M. C., Ajuwon, K. M., Wang, J., Christian, J. A., & Spurlock, M. E. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.130 · Cited by 464

The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss

Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects

Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 424

Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.

White, R. T., Damm, D. L., Hancock, N., Rosen, B. S., Lowell, B. B., Usher, P., Flier, J. S., & Spiegelman, B. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50409-4 · Cited by 409

Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice

Masaki, T., Chiba, S., Tatsukawa, H., Yasuda, T., Noguchi, H., Seike, M., & Yoshimatsu, H. (2004) · Hepatology · doi:10.1002/hep.20282 · Cited by 402

Pre–B-Cell Colony-enhancing Factor as a Potential Novel Biomarker in Acute Lung Injury

Ye, S. Q., Simon, B. A., Maloney, J. P., Zambelli-Weiner, A., Gao, L., Grant, A. V., Easley, R. B., McVerry, B. J., Tuder, R. M., Standiford, T. J., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200404-563oc · Cited by 381

Leptin-Deficient Mice Exhibit Impaired Host Defense in Gram-Negative Pneumonia

Mancuso, P., Gottschalk, A., Phare, S. M., Peters-Golden, M. L., Lukacs, N. W., & Huffnagle, G. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.8.4018 · Cited by 365

Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action

Sánchez‐Margalet, V., Martín-Romero, C., Santos‐Álvarez, J., Goberna, R., Najib, S., & González-Yanes, C. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02190.x · Cited by 364

Critical review of acylation-stimulating protein physiology in humans and rodents

Cianflone, K., Xia, Z., & Chen, L. Y. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00686-7 · Cited by 358

Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis

Matarese, G., Giacomo, A. D., Sanna, V., Lord, G. M., Howard, J. K., Tuoro, A. D., Bloom, S. R., Lechler, R. I., Zappacosta, S., & Fontana, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.10.5909 · Cited by 351

Effect of leptin on allergic airway responses in mice

Shore, S. A., Schwartzman, I. N., Mellema, M. S., Flynt, L., Imrich, A., & Johnston, R. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.10.007 · Cited by 330

A role for preadipocytes as macrophage‐like cells

Cousin, B., Muñoz, O., André, M., Fontanilles, A. M., Dani, C., Cousin, J. L., Laharrague, P. F., Casteilla, L., & Pénicaud, L. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.305 · Cited by 328

Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis

Busso, N., So, A. K.-L., Chobaz-Péclat, V., Morard, C., Martínez-Soria, E., Talabot‐Ayer, D., & Gabay, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.875 · Cited by 328

Leptin-deficient ( ob / ob ) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18

Faggioni, R., Jones‐Carson, J., Reed, D. A., Dinarello, C. A., Feingold, K. R., Grünfeld, C., & Fantuzzi, G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040561297 · Cited by 320

Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1

Waki, H., Yamauchi, T., Kamon, J., Kita, S., Ito, Y., Hada, Y., Uchida, S., Tsuchida, A., Takekawa, S., & Kadowaki, T. (2005) · Endocrinology · doi:10.1210/en.2004-1096 · Cited by 319

Adipose tissue, insulin action and vascular disease: inflammatory signals

Yudkin, J. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802496 · Cited by 311

Adipose Tissue Is a Major Source of Interleukin-1 Receptor Antagonist

Juge-Aubry, C. E., Somm, E., Giusti, V., Pernin, A., Chicheportiche, R., Verdumo, C., Rohner‐Jeanrenaud, F., Burger, D., Dayer, J., & Meier, C. A. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1104 · Cited by 305

Leptin deficiency enhances sensitivity to endotoxin-induced lethality

Faggioni, R., Fantuzzi, G., Gabay, C., Moser, A. H., Dinarello, C. A., Feingold, K. R., & Grünfeld, C. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r136 · Cited by 289

Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology

Wang, C. C. L., Goalstone, M. L., & Draznin, B. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2735 · Cited by 274

Adiponectin and resistin--new hormones of white adipose tissue.

Bełtowski, J. (2003) · PubMed · Cited by 267

Leptin: Does it have any role in childhood asthma?

Güler, N., Kirerleri, E., Öneş, Ü., Tamay, Z., Salmayenli, N., & Darendelıler, F. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.053 · Cited by 264

Complex interactions in complex traits: obesity and asthma.

Tantisira, K. G., & Weiss, S. T. (2001) · PubMed · Cited by 264

Leptin: A pivotal mediator of intestinal inflammation in mice

Siegmund, B., Lehr, H. A., & Fantuzzi, G. (2002) · Gastroenterology · doi:10.1053/gast.2002.33631 · Cited by 256

Weight loss reduces interleukin-18 levels in obese women

Esposito, K., Pontillo, A., Ciotola, M., Di Palo, C., Grella, E., Nicoletti, G., & Giugliano, D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8781 · Cited by 254

Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

Elmquist, J. K. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00613-8 · Cited by 249

High Expression of Complement Components in Omental Adipose Tissue in Obese Men

Gabrielsson, B. G., Johansson, J. M., Lönn, M., Jernås, M., Olbers, T., Peltonen, M., Larsson, I., Lönn, L., Sjöström, L., Carlsson, B., et al. (2003) · Obesity Research · doi:10.1038/oby.2003.100 · Cited by 218

Responses to ozone are increased in obese mice

Shore, S. A., Rivera-Sanchez, Y. M., Schwartzman, I. N., & Johnston, R. A. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00336.2003 · Cited by 198

The thymus gland is a target in malnutrition

Savino, W. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601485 · Cited by 196

Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor

Takahashi, N., Waelput, W., & Guisez, Y. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.207-a · Cited by 196

Unraveling the multiple roles of leptin in inflammation and autoimmunity

Cava, A. L., Alviggi, C., & Matarese, G. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0492-1 · Cited by 195

Influences of Ionomycin, Dibutyryl-cycloAMP and Tumour Necrosis Factor-alpha on Intracellular Amount and Secretion of apM1 in Differentiating Primary Human Preadipocytes

Kappes, A., & Löffler, G. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978684 · Cited by 193

Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men

Boudou, P., Sobngwi, E., Mauvais‐Jarvis, F., Vexiau, P., & Gautier, J. F. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490421 · Cited by 188

Natural vs Vaccine-Acquired Immunity to Cytomegalovirus—Reply

Schäffler, A., Ehling, A., Neumann, E., Herfarth, H. H., Tarner, I. H., Schölmerich, J., Müller‐Ladner, U., & Gay, S. (2003) · JAMA · doi:10.1001/jama.290.13.1709-c · Cited by 187

Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women

Ryan, A. S., Nicklas, B. J., Berman, D. M., & Elahi, D. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802387 · Cited by 174

Anorexia Nervosa Is Characterized by Increased Adiponectin Plasma Levels and Reduced Nonoxidative Glucose Metabolism

Pannacciulli, N., Vettor, R., Milan, G., Granzotto, M., Catucci, A., Federspil, G., Giacomo, P. D., GIORGINO, R., & Pergola, G. D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021215 · Cited by 171

Colonic leptin: source of a novel pro‐inflammatory cytokine involved in inflammatory bowel disease

Sitaraman, S. V., Liu, X., Charrier, L., Gu, L. H., Ziegler, T. R., Gewirtz, A. T., & Merlin, D. (2004) · The FASEB Journal · doi:10.1096/fj.03-0422fje · Cited by 165

The adaptive response of the immune system to the particular malnutrition of eating disorders

Nova, E., Samartı́n, S., Gómez, S., Morandé, G., & Marcos, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601482 · Cited by 150

Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases.

Barbier, M., Vidal, H., Desreumaux, P., Dubuquoy, L., Bourreille, A., Colombel, J.-F., Cherbut, C., & Galmiche, J. (2003) · PubMed · Cited by 144

Obesity and Asthma: Evidence For and Against a Causal Relation

Chinn, S. (2003) · Journal of Asthma · doi:10.1081/jas-120017202 · Cited by 127

Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis

Anders, H., Rihl, M., Heufelder, A. E., Loch, O., & Schattenkirchner, M. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90174-9 · Cited by 113

Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta

Batocchi, A. P., Rotondi, M., Caggiula, M., Frisullo, G., Odoardi, F., Nociti, V., Carella, C., Tonali, P. A., & Massimiliano Mirabella, A. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00154-1 · Cited by 102

Identification of RELMγ, a novel resistin-like molecule with a distinct expression pattern☆

Gerstmayer, B., Küsters, D., Gebel, S., Müller, T. H., Miert, E. V., Hofmann, K., & Bosio, A. (2003) · Genomics · doi:10.1016/s0888-7543(03)00070-3 · Cited by 96

Resistin: an adipocyte‐derived hormone. Has it a role in diabetes and obesity?

Rea, R., & Donnelly, R. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00334.x · Cited by 91

Leptin levels in the acute stage of ulcerative colitis

Tüzün, A., Uygun, A., Yeşilova, Z., Özel, M., Erdil, A., Yaman, H., Bağcı, S., Gülşen, M., Karaeren, N., & Dağalp, K. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2003.03300.x · Cited by 78

Leukocyte Migration in Adipose Tissue of Mice Null for ICAM‐1 and Mac‐1 Adhesion Receptors

Robker, R. L., Collins, R. G., Beaudet, A. L., Mersmann, H. J., & Smith, C. W. (2004) · Obesity Research · doi:10.1038/oby.2004.114 · Cited by 74

Effect of diet-induced obesity on ovalbumin-specific immune response in a murine asthma model

Mito, N., Kitada, C., Hosoda, T., & Sato, K. (2002) · Metabolism · doi:10.1053/meta.2002.35196 · Cited by 72

Plasma Leptin in Chronic Inflammatory Bowel Disease and HIV: Implications for the Pathogenesis of Anorexia and Weight Loss

Ballinger, A., Kelly, P. M., Hallyburton, E., Besser, R. E. J., & Farthing, M. J. G. (1998) · Clinical Science · doi:10.1042/cs0940479 · Cited by 72

Paracrine interactions of mammalian adipose tissue

Pond, C. M. (2002) · Journal of Experimental Zoology Part A Comparative Experimental Biology · doi:10.1002/jez.a.10215 · Cited by 71

Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

Bernotienė, E., Palmer, G., Talabot‐Ayer, D., Szalay‐Quinodoz, I., Aubert, M. L., & Gabay, C. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1174 · Cited by 66

Protective immunity against Helicobacter is characterized by a unique transcriptional signature

Mueller, A., O’Rourke, J., Chu, P., Kim, C. C., SUTTON, P. R. N., Lee, A., & Falkow, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635231100 · Cited by 62

Serum leptin levels in asthmatic children treated with an inhaled corticosteroid

Gürkan, F., Atamer, Y., Ece, A., Koçyiğit, Y., Tüzün, H., & Mete, N. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61501-3 · Cited by 61

Development of intestinal inflammation in double IL-10- and leptin-deficient mice

Siegmund, B., Sennello, J. A., Lehr, H. A., Batra, A., Fedke, I., Zeitz, M., & Fantuzzi, G. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404239 · Cited by 43

Leptin deficiency enhances myocardial necrosis and lethality in a murine model of viral myocarditis

Kanda, T., Takahashi, T., Kudo, S., Takeda, T., Tsugawa, H., & Takekoshi, N. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.03.012 · Cited by 39

Leptin and its soluble receptor in plasma of patients suffering from remitting–relapsing multiple sclerosis (MS)

Chatzantoni, K., Papathanasopoulos, P., Gourzoulidou, E., & Mouzaki, Α. (2004) · Journal of Autoimmunity · doi:10.1016/j.jaut.2004.05.007 · Cited by 38

Role of Leptin Deficiency in Early Acute Renal Failure during Endotoxemia in ob/ob Mice

Wang, W., Poole, B., Mitra, A., Falk, S. A., Fantuzzi, G., Lucia, S. M., & Schrier, R. W. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000113551.14276.0b · Cited by 37

An Immunologic Mechanism for the Association Between Obesity and Asthma

Varner, A. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.15.2395 · Cited by 24

CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases / STAT4 responsive to IL-12 stimulation in TCR-triggered T cells

Park, W.-R., Park, C.-S., Tomura, M., Ahn, H.-J., Nakahira, Y., 岩崎, 正., Gao, P. H., Abe, R., Hamaoka, T., & Fujiwara, H. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200105)31:5 · Cited by 20

[Leptin levels in patients with bronchial asthma and diabetes mellitus].

Babadzhanova, G. I., Nagornyĭ, A. B., Lebedin, I. S., & Chuchalin, A. G. (2003) · PubMed · Cited by 4

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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