Cited by 2,606Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Adipose tissue, adipokines, and inflammation

Fantuzzi, Giamila·2005·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2005.02.023

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Abstract

White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.

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Authors: Fantuzzi, G.
Affiliations: University of Illinois Chicago (US)
Corresponding author: Fantuzzi, Giamila
ORCID: Fantuzzi, Giamila
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2005-05
Volume: 115
Issue: 5
Pages: 911-919
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2005.02.023
OpenAlex: W2158079900
Cited by: 2,606
References: 89
Citations by year: 2026: 45 · 2025: 67 · 2024: 96 · 2023: 117 · 2022: 119 · 2021: 127 · 2020: 112 · 2019: 121 · 2018: 123 · 2017: 145 · 2016: 112 · 2015: 132 · 2014: 139 · 2013: 184 · 2012: 148
FWCI: 16.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061483, DK-061483)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: white adipose tissue, adipokines, inflammation, adipose tissue macrophages, leptin, adiponectin, resistin, visfatin, TNF-α, interleukin-6, MCP-1, insulin resistance, obesity, cardiovascular disease, infection susceptibility, T cell response, malnutrition
MeSH terms: Adipose Tissue, Animals, Autoimmune Diseases, Hormones, Ectopic, Humans, Inflammation, Insulin Resistance, Macrophages, Obesity, Complement Factor D, Serine Endopeptidases, Cytokines, Adipocytes, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase

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Adipose tissue, adipokines, and inflammation

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