CoChat
Sign Up
Cited by 404

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Anaphylaxis: Lessons from mouse models

Finkelman, Fred D.·2007·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2007.07.033
Open this paper in CoChat — free account

Abstract

Studies with mouse models demonstrate 2 pathways of systemic anaphylaxis: a classic pathway mediated by IgE, FcepsilonRI, mast cells, histamine, and platelet-activating factor (PAF) and an alternative pathway mediated by IgG, FcgammaRIII, macrophages, and PAF. The former pathway requires much less antigen and antibody than the latter. This is modified, however, by IgG antibodies that prevent IgE-mediated anaphylaxis by intercepting antigen before it binds to mast cell-associated IgE. Consequently, IgG antibodies block systemic anaphylaxis induced by small quantities of antigen but mediate systemic anaphylaxis induced by larger quantities. The importance of the alternative pathway in human subjects is unknown, but human IgG, IgG receptors, macrophages, mediators, and mediator receptors have appropriate properties to support this pathway if sufficient IgG and antigen are present. The severity of systemic anaphylaxis is increased by nitric oxide produced by the enzyme endothelial nitric oxide synthase and by the cytokines IL-4 and IL-13 and decreased by endogenous beta-adrenergic stimulation and receptors that contain ITIM that bind tyrosine phosphatases. Anaphylaxis is also suppressed by other receptors and ion channels that function through distinct mechanisms. Unlike systemic anaphylaxis, intestinal anaphylaxis (allergic diarrhea) is almost totally IgE and mast cell dependent and is mediated predominantly by PAF and serotonin. Some potent food allergens, including peanuts and…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2007.07.033

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 80

  1. Simons, 2007, Risk assessment in anaphylaxis: current and future approaches, J Allergy Clin Immunol, 120, S1, 10.1016/j.jaci.2007.05.016 · DOI
  2. Weiler, 1999, Anaphylaxis in the general population: a frequent and occasionally fatal disorder that is underrecognized, J Allergy Clin Immunol, 104, 271, 10.1016/S0091-6749(99)70363-5 · DOI
  3. Strait, 2002, Pathways of anaphylaxis in the mouse, J Allergy Clin Immunol, 109, 658, 10.1067/mai.2002.123302 · DOI
  4. Strait, 2006, IgG Blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and FcγRIIb crosslinking, J Clin Invest, 116, 833, 10.1172/JCI25575 · DOI · Paper page
  5. Ishizaka, 1983, Binding characteristics of human IgE receptors and initial triggering events in human mast cells for histamine release, Monogr Allergy, 18, 14
  6. Wastling, 1998, Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1, Am J Pathol, 153, 491, 10.1016/S0002-9440(10)65592-7 · DOI
  7. Lazar, 1994, Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade, Agents Actions, 41, C97, 10.1007/BF02007784 · DOI
  8. Jenei, 1991, Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and by gadolinium chloride (an agent blocking Kupffer cell function), Agents Actions, 32, 333, 10.1007/BF01980894 · DOI
  9. Hazenbos, 1996, Impaired IgG-dependent anaphylaxis and Arthus reaction in FcγRIII (CD16) deficient mice, Immunity, 5, 181, 10.1016/S1074-7613(00)80494-X · DOI
  10. Hazenbos, 1998, Murine IgG1 complexes trigger immune effector functions predominantly via FcγRIII (CD16), J Immunol, 161, 3026, 10.4049/jimmunol.161.6.3026 · DOI
  11. Terashita, 1987, A lethal role of platelet activating factor in anaphylactic shock in mice, J Pharmacol Exp Ther, 234, 378, 10.1016/S0022-3565(25)39247-5 · DOI
  12. Oettgen, 1994, Active anaphylaxis in IgE-deficient mice, Nature, 370, 367, 10.1038/370367a0 · DOI · Paper page
  13. Takai, 1996, Augmented humoral and anaphylactic responses in FcγRII-deficient mice, Nature, 379, 346, 10.1038/379346a0 · DOI
  14. Miyajima, 1997, Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and FcγRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1- dependent passive anaphylaxis, J Clin Invest, 99, 901, 10.1172/JCI119255 · DOI
  15. Ravetch, 2001, IgG Fc receptors, Annu Rev Immunol, 19, 275, 10.1146/annurev.immunol.19.1.275 · DOI
  16. Ha, 1986, Immune response potential of mast cell-deficient W/Wv mice, Int Arch Allergy Appl Immunol, 80, 85, 10.1159/000234031 · DOI
  17. Dombrowicz, 1997, Absence of FcɛRI α chain results in upregulation of FcγRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between FcɛRI and FcγRIII for limiting amounts of FcR β and γ chains, J Clin Invest, 99, 915, 10.1172/JCI119256 · DOI
  18. Takai, 1994, FcR γ chain deletion results in pleiotrophic effector cell defects, Cell, 76, 519, 10.1016/0092-8674(94)90115-5 · DOI
  19. Martin, 1993, Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice, J Immunol, 151, 367, 10.4049/jimmunol.151.1.367 · DOI
  20. Feuerstein, 1988, Platelet-activating factor and shock, Prog Biochem Pharmacol, 22, 181
  21. Fish, 2005, IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13, J Immunol, 174, 7716, 10.4049/jimmunol.174.12.7716 · DOI
  22. Nimmerjahn, 2005, Divergent Immunoglobulin G subclass activity through selective Fc receptor binding, Science, 310, 1510, 10.1126/science.1118948 · DOI
  23. Choi, 1998, Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice, J Exp Med, 188, 1587, 10.1084/jem.188.9.1587 · DOI
  24. Liu, 2002, Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23, J Clin Invest, 110, 1021, 10.1172/JCI0215488 · DOI
  25. Ujike, 1999, Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG, J Exp Med, 189, 1573, 10.1084/jem.189.10.1573 · DOI
  26. Bachelet, 2005, The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells, J Immunol, 175, 7989, 10.4049/jimmunol.175.12.7989 · DOI
  27. Maeda, 1998, Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptor γ chain, J Exp Med, 188, 991, 10.1084/jem.188.5.991 · DOI
  28. Udell, 2006, Fer and Fps/Fes participate in a Lyn-dependent pathway from FcɛRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation, J Biol Chem, 281, 20949, 10.1074/jbc.M604252200 · DOI
  29. Licht, 2005, Regulation of mast cells' secretory response by co-clustering the Type 1 Fcɛ receptor with the mast cell function-associated antigen, Eur J Immunol, 35, 1621, 10.1002/eji.200425964 · DOI
  30. Feldweg, 2003, gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo, Eur J Immunol, 33, 2262, 10.1002/eji.200323978 · DOI
  31. Takai, 2005, Paired immunoglobulin-like receptors and their MHC class I recognition, Immunology, 115, 433, 10.1111/j.1365-2567.2005.02177.x · DOI
  32. Zhang, 2004, Molecular mechanisms of CD200 inhibition of mast cell activation, J Immunol, 173, 6786, 10.4049/jimmunol.173.11.6786 · DOI
  33. Hua, 2007, Enhanced mast cell activation in mice deficient in the A2b adenosine receptor, J Exp Med, 204, 117, 10.1084/jem.20061372 · DOI
  34. Vennekens, 2007, Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4, Nat Immunol, 8, 312, 10.1038/ni1441 · DOI
  35. Franke, 1995, The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase, Cell, 81, 727, 10.1016/0092-8674(95)90534-0 · DOI
  36. Cauwels, 2006, Anaphylactic shock depends on PI3K and eNOS-derived NO, J Clin Invest, 116, 2244, 10.1172/JCI25426 · DOI
  37. Khodoun, 2004, Basophils initiate IL-4 production during a memory T-dependent response, J Exp Med, 200, 857, 10.1084/jem.20040598 · DOI
  38. Kaplan, 1996, Stat6 is required for mediating responses to IL-4 and for development of Th2 cells, Immunity, 4, 313, 10.1016/S1074-7613(00)80439-2 · DOI
  39. Strait, 2003, IL-4 exacerbates anaphylaxis, J Immunol, 170, 3835, 10.4049/jimmunol.170.7.3835 · DOI
  40. Breslow, 1991, Hyperadrenergic states, Crit Care Med, 19, 1566, 10.1097/00003246-199112000-00021 · DOI
  41. Sampson, 2003, Anaphylaxis and emergency treatment, Pediatrics, 111, 1601, 10.1542/peds.111.S3.1601 · DOI
  42. Lang, 1995, Anaphylactoid and anaphylactic reactions. Hazards of β-blockers, Drug Saf, 12, 299, 10.2165/00002018-199512050-00002 · DOI
  43. Cockcroft, 2000, β2-adrenoceptor polymorphism determines vascular reactivity in humans, Hypertension, 36, 371, 10.1161/01.HYP.36.3.371 · DOI
  44. Schafer, 2001, Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy, Allergy, 56, 1172, 10.1034/j.1398-9995.2001.00196.x · DOI
  45. Wood, 2003, The natural history of food allergy, Pediatrics, 111, 1631, 10.1542/peds.111.S3.1631 · DOI
  46. Li, 2000, A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses, J Allergy Clin Immunol, 106, 150, 10.1067/mai.2000.107395 · DOI
  47. Brandt, 2003, Mast cells are required for experimental oral allergen-induced diarrhea, J Clin Invest, 112, 1666, 10.1172/JCI19785 · DOI
  48. Birmingham, 2007, An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut, Int Arch Allergy Immunol, 144, 203, 10.1159/000103993 · DOI
  49. Sen, 2002, Protein structure plays a critical role in peanut allergen stability and may determine immunodominant IgE-binding epitopes, J Immunol, 169, 882, 10.4049/jimmunol.169.2.882 · DOI
  50. Maleki, 2000, Structure of the major peanut allergen Ara h 1 may protect IgE-binding epitopes from degradation, J Immunol, 164, 5844, 10.4049/jimmunol.164.11.5844 · DOI
  51. Sampson, 2000, Food anaphylaxis, Br Med Bull, 56, 925, 10.1258/0007142001903607 · DOI
  52. Shreffler, 2006, The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro, J Immunol, 177, 3677, 10.4049/jimmunol.177.6.3677 · DOI
  53. van Wijk, 2005, The effect of the food matrix on in vivo immune responses to purified peanut allergens, Toxicol Sci, 86, 333, 10.1093/toxsci/kfi187 · DOI
  54. Ovary, 1994, Immediate hypersensitivity. A brief, personal history, Arerugi, 43, 1375
  55. Ishizaka, 1970, Biological function of gamma E antibodies and mechanisms of reaginic hypersensitivity, Clin Exp Immunol, 6, 25
  56. Faquim-Mauro, 1999, Cutting edge: mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12, J Immunol, 163, 3572, 10.4049/jimmunol.163.7.3572 · DOI
  57. Park, 1997, Anti-IL-4 monoclonal antibody prevents antibiotics-induced active fatal anaphylaxis, J Immunol, 158, 5002, 10.4049/jimmunol.158.10.5002 · DOI
  58. Finkelman, 2005, Molecular mechanisms of anaphylaxis: lessons from studies with murine models, J Allergy Clin Immunol, 115, 449, 10.1016/j.jaci.2004.12.1125 · DOI
  59. Maurer, 1994, Expression of functional high affinity immunoglobulin E receptors (FcɛRI) on monocytes of atopic individuals, J Exp Med, 179, 745, 10.1084/jem.179.2.745 · DOI
  60. Dahinden, 1990, Growth factors, lipid mediators and effector cells, J Lipid Mediat, 2, S129
  61. Hosken, 1995, The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-αβ-transgenic model, J Exp Med, 182, 1579, 10.1084/jem.182.5.1579 · DOI
  62. Ring, 2002, Idiopathic anaphylaxis, Curr Allergy Asthma Rep, 2, 40, 10.1007/s11882-002-0036-8 · DOI
  63. Dybendal, 2003, Screening for mast cell tryptase and serum IgE antibodies in 18 patients with anaphylactic shock during general anaesthesia, Acta Anaesthesiol Scand, 47, 1211, 10.1046/j.1399-6576.2003.00237.x · DOI
  64. Golden, 2004, Patterns of anaphylaxis: acute and late phase features of allergic reactions, Novartis Found Symp, 257, 101, 10.1002/0470861193.ch9 · DOI
  65. Cheifetz, 2003, The incidence and management of infusion reactions to infliximab: a large center experience, Am J Gastroenterol, 98, 1315, 10.1111/j.1572-0241.2003.07457.x · DOI
  66. Stallmach, 2004, Severe anaphylactic reaction to infliximab: successful treatment with adalimumab—report of a case, Eur J Gastroenterol Hepatol, 16, 627, 10.1097/00042737-200406000-00018 · DOI
  67. Dreyfus, 2006, Characterization of an anaphylactoid reaction to omalizumab, Ann Allergy Asthma Immunol, 96, 624, 10.1016/S1081-1206(10)63560-0 · DOI
  68. Leung, 2003, Effect of anti-IgE therapy in patients with peanut allergy, N Engl J Med, 348, 986, 10.1056/NEJMoa022613 · DOI
  69. Gomez, 1999, Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study, Eur Respir J, 14, 622, 10.1034/j.1399-3003.1999.14c23.x · DOI
  70. Danko, 1988, Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis, Pharmacol Res Commun, 20, 785, 10.1016/S0031-6989(88)80717-3 · DOI
  71. Duschl, 1995, Antagonistic mutant proteins of interleukin-4, Behring Inst Mitt, 87
  72. Beckmann, 1990, Monoclonal antibodies block murine IL-4 receptor function, J Immunol, 144, 4212, 10.4049/jimmunol.144.11.4212 · DOI
  73. Lee, 2001, Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity, Clin Immunol, 101, 220, 10.1006/clim.2001.5122 · DOI
  74. Frossard, 2007, Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization, J Allergy Clin Immunol, 119, 952, 10.1016/j.jaci.2006.12.615 · DOI
  75. Zhu, 2002, A novel human immunoglobulin Fcγ Fcɛ bifunctional fusion protein inhibits FcɛRI-mediated degranulation, Nat Med, 8, 518, 10.1038/nm0502-518 · DOI
  76. Zhang, 2004, Inhibition of allergen-specific IgE reactivity by a human Ig Fcγ-Fcɛ bifunctional fusion protein, J Allergy Clin Immunol, 114, 321, 10.1016/j.jaci.2004.03.058 · DOI
  77. Bachelet, 2006, Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a, J Allergy Clin Immunol, 117, 1314, 10.1016/j.jaci.2006.04.031 · DOI
  78. Ong, 2007, Small molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells, Blood, 10.1182/blood-2007-03-079699 · DOI
  79. Buchanan, 2007, Egg oral immunotherapy in nonanaphylactic children with egg allergy, J Allergy Clin Immunol, 119, 199, 10.1016/j.jaci.2006.09.016 · DOI
  80. Nash, 2007, Oral peanut immunotherapy for peanut allergic patients, J Allergy Clin Immunol, 119, S158, 10.1016/j.jaci.2006.11.558 · DOI

Cited by

Sorted by citations

See all 404

Metadata

Authors
Finkelman, F. D.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2007-09
Volume
120
Issue
3
Pages
506-515
ISSN
0091-6749
DOI
10.1016/j.jaci.2007.07.033
Cited by
404
References
3
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Anaphylaxis: Lessons from mouse models. https://app.cochat.ai/papers/10.1016/j.jaci.2007.07.033
The paper
Finkelman, F. D. (2007). Anaphylaxis: Lessons from mouse models. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2007.07.033