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Cited by 368

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

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Amu, Sylvie, Saunders, Sean P., Kronenberg, Mitchell, Mangan, Niamh E., Atzberger, Ann, Fallon, Padraic G.·2010·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2010.01.018
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Abstract

BACKGROUND Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation and anaphylaxis via IL-10 and B cells. OBJECTIVE To identify and characterize the specific helminth-induced regulatory B-cell subpopulation and determine the mechanism by which these regulatory B cells suppress allergic airway inflammation. METHODS IL-10-producing B cells from the spleens of helminth-infected mice were phenotyped, isolated, and transferred to ovalbumin-sensitized mice, and their ability to modulate allergic airway inflammation was analyzed. RESULTS S mansoni infection induced IL-10-producing CD1d(high) regulatory B cells that could prevent ovalbumin-induced allergic airway inflammation following passive transfer to ovalbumin-sensitized recipients. The capacity of regulatory B cells to suppress allergic airway inflammation was dependent on the expression of CD1d, and they functioned via an IL-10-mediated mechanism. Regulatory B cells induced pulmonary infiltration of CD4(+)CD25(+) forkhead box protein 3(+) regulatory T cells, independent of TGF-beta, thereby suppressing allergic airway inflammation. Regulatory B cells that were generated ex vivo also suppressed the development of allergic airway inflammation. Furthermore, the transfer of regulatory B cells reversed established airway inflammation in ovalbumin-sensitized mice. CONCLUSION We have generated in vivo and ex vivo a regulatory B cell that can prevent or reverse allergen-induced airway inflammation via regulatory T cells.

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Metadata

Authors
Amu, S., Saunders, S. P., Kronenberg, M., Mangan, N. E., Atzberger, A., & Fallon, P. G.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2010-05
Volume
125
Issue
5
Pages
1114-1124.e8
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2010.01.018
OpenAlex
W2000326189
Cited by
368
References
72
FWCI
19.40
Type
journal article
Language
en
Open access
green

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Amu, S., Saunders, S. P., Kronenberg, M., Mangan, N. E., Atzberger, A., & Fallon, P. G. (2010). Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2010.01.018

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.