The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence
Open accessAbstract
Background Asthma is an inflammatory condition often punctuated by episodic symptomatic worsening, and accordingly, individuals with asthma may have waxing and waning adherence to controller therapy. Objective To measure changes in inhaled corticosteroid (ICS) adherence over time, and to estimate the effect of this changing pattern of use on asthma exacerbations. Methods ICS adherence was estimated from electronic prescription and fill information for 298 participants in the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE). For each individual we calculated a moving average of ICS adherence for each day of follow-up. Asthma exacerbations were defined as the need for oral corticosteroids, an asthma-related emergency department visit, or an asthma-related hospitalization. Proportional hazard models were used to assess the relationship between ICS medication adherence and asthma exacerbations. Results Adherence to ICS medications began to increase prior to the first asthma exacerbation and continued afterward. Adherence was associated with a reduction in exacerbations, but was only statistically significant among individuals whose adherence was >75% of the prescribed dose (hazard ratio [HR] 0.61; 95% confidence interval [CI] 0.41–0.90) when compared with individuals whose adherence was ≤25%. This pattern was largely confined to individuals whose asthma was not well controlled initially. An estimated 24% of asthma exacerbations were attributable to ICS medication non-adherence. Conclusions Inhaled corticosteroid adherence varies in the time period leading up to and following an asthma exacerbation, and non-adherence likely contributes to a large number of these exacerbations. High levels of adherence are likely required to prevent these events. [ClinicalTrials.gov number NCT01142947]
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Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD
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Digital interventions to improve adherence to maintenance medication in asthma
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Metadata
- Authors
- Williams, L. K., Peterson, E. L., Wells, K., Ahmedani, B. K., Kumar, R., Burchard, E. G., Chowdhry, V. K., Favro, D., Lanfear, D. E., & Pladevall, M.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 128
- Issue
- 6
- Pages
- 1185-1191.e2
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2062940257
- Cited by
- 347
- References
- 42
- FWCI
- 19.88
- Type
- journal article
- Language
- en
- Open access
- green
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