Cited by 111Allergic Rhinitis and SensitizationAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

Natural course and comorbidities of allergic and nonallergic rhinitis in children

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Westman, Marit, Stjärne, Pär, Asarnoj, Anna, Kull, Inger, van Hage, Marianne, Wickman, Magnus, Toskala, Elina·2012·Journal of Allergy and Clinical Immunology

Abstract

Background Not much data are available from large, unselected, birth cohort studies on the natural course and comorbidities of rhinitis in children.Objective To study phenotypes of rhinitis in relation to the natural course and comorbidities of allergic diseases in preschool-age and early school-age children.Methods We analyzed data from a birth cohort of 2024 children, for whom information on IgEs against 8 common inhaled allergens was available, collected at age 4 and 8 years. The children were assigned to groups of allergic rhinitis (rhinitis with sensitization to allergens), nonallergic rhinitis (rhinitis without sensitization), allergic sensitization but no rhinitis, or neither rhinitis nor sensitization.Results The proportion of children with allergic rhinitis increased from 5% to 14% from age 4 to 8 years, whereas the proportion of children with nonallergic rhinitis decreased slightly over the same period of development, from 8% to 6%. Of the children with allergic rhinitis when they were 4 years old, 12% underwent remission by the time they were 8 years old; of the children with nonallergic rhinitis, 73% underwent remission during this period of development. Among 4-year-olds without rhinitis who were sensitized to allergen, 56% had allergic rhinitis when they were 8 years old. Among 4- and 8-year-olds, allergic rhinitis and nonallergic rhinitis were associated with asthma, eczema, and food hypersensitivity. Twenty-five percent of 8-year-olds with allergic rhinitis also had oral allergy syndrome.Conclusions Fewer preschool-age children with allergic rhinitis undergo remission than do those with nonallergic rhinitis. Sensitization to inhaled allergens at an early age (4 years) precedes the development of allergic rhinitis, whereas symptoms of rhinitis do not. Oral allergy syndrome is common among 8-year-olds with allergic rhinitis.

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  1. Marinho S, Simpson A, Lowe L, Kissen P, Murray C, Custovic A. Rhinoconjunc- tivitis in 5-year-old children: a population-based birth cohort study. Allergy 2007; 62:385-93.

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Authors
Westman, M., Stjärne, P., Asarnoj, A., Kull, I., van Hage, M., Wickman, M., & Toskala, E.
Affiliations
  • Karolinska University Hospital (SE)
  • Karolinska Institutet (SE)
  • Children's Hospital of Philadelphia (US)
Corresponding author
Westman, Marit
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2012-02
Volume
129
Issue
2
Pages
403-408
ISSN
0091-6749 (ISSN-L)
OpenAlex
W1985793013
Cited by
111
References
30
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 13 · 2012: 4
FWCI
6.72
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Stockholms Läns Landsting
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
allergic rhinitis, non-allergic rhinitis, natural history (disease), remission, comorbidities, IgE, preschool children, younger schoolchildren, asthma, atopic dermatitis, food allergy, oral allergy syndrome, birth cohort
MeSH terms
Allergens, Child, Child, Preschool, Female, Humans, Immunoglobulin E, Male, Rhinitis, Rhinitis, Allergic, Perennial, Sweden, Cohort Studies, Comorbidity

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