Mental health comorbidity in patients with atopic dermatitis
Open accessAbstract
Background Recent data, primarily from Europe, suggest children with atopic dermatitis may be at increased risk of developing mental health disorders. Objective We aimed to quantify the mental health burden associated with pediatric atopic dermatitis in the United States. Methods A cross-sectional study design was used analyzing data from the 2007 National Survey of Children's Health – a survey reporting on the health status of 92,642 non-institutionalized children ages 0-17. The lifetime prevalence of various provider-diagnosed mental health conditions was calculated for those with and without a history of atopic dermatitis. Results The odds of having attention-deficit/hyperactivity disorder was significantly increased in children with atopic dermatitis compared to non-atopic dermatitis controls, OR 1.87 (95% CI 1.54, 2.27) even after controlling for known confounders. The adjusted odds ratios for depression, anxiety, conduct disorder, and autism were 1.81 (95% CI 1.33,2.46) , 1.77 (95% CI 1.36, 2.29), 1.87 (1.46, 2.39), and 3.04 (95% CI 2.13, 4.34), respectively, and these estimates were all statistically significant. A clear dose-dependent relationship was observed between the prevalence of a mental health disorder and the reported severity of the skin disease. Conclusions Our data reveal a striking association between mental health disorders and atopic dermatitis in the U.S. pediatric population. The severity of the skin disease alters the strength of the association. Prospective cohort studies are needed to verify these associations and to explore underlying mechanisms. Strategies to prevent atopic dermatitis or to aggressively treat early skin inflammation may modify the risk of developing mental health disorders in at-risk children.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AD impacts the quality of life of patients and their families, whose chronic contingency manifests itself, neuropsychologically, in several ways, including anxiety, depression, disruptive behavior disorders, neurological development disorders, attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and suicidal ideation, with these associations especially striking in severe
“AD impacts the quality of life of patients and their families, whose chronic contingency manifests itself, neuropsychologically, in several ways, including anxiety, depression, disruptive behavior disorders, neurological development disorders, attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and suicidal ideation, with these associations especially striking in severe”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [109]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three
Odhiambo, J. A., Williams, H. C., Clayton, T. O., Robertson, C. F., & Asher, M. I. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.009 · Cited by 971 · see citing works
Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's Health
Shaw, T., Currie, G. P., Koudelka, C. W., & Simpson, E. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.251 · Cited by 721 · see citing works
Self-citationBeattie, P. E., & Lewis-Jones, M. S. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07185.x · Cited by 526 · see citing works
The Burden of Atopic Dermatitis: Impact on the Patient, Family, and Society
Carroll, C. L., Balkrishnan, R., Feldman, S. R., Fleischer, A. B., & Manuel, J. C. (2005) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2005.22303.x · Cited by 489 · see citing works
Atopic eczema: its impact on the family and financial cost
Su, J. C., Kemp, A. S., Varigos, G. A., & Nolan, T. M. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.76.2.159 · Cited by 425 · see citing works
The prevalence of atopic dermatitis in Oregon schoolchildren
Laughter, D., Istvan, J. A., Tofte, S. J., & Hanifin, J. M. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.107773 · Cited by 367 · see citing works
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., & Glaser, R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.229 · Cited by 340 · see citing works
Effects of Atopic Dermatitis on Young American Children and Their Families
Chamlin, S. L., Frieden, I. J., Williams, M. L. K., & Chren, M. (2004) · PEDIATRICS · doi:10.1542/peds.2004-0374 · Cited by 316 · see citing works
Cerebrospinal Fluid and Serum Markers of Inflammation in Autism
Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300 · see citing works
Patterns of Psychiatric Comorbidity with Attention-Deficit/Hyperactivity Disorder
Pliszka, S. R. (2000) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/s1056-4993(18)30105-6 · Cited by 257 · see citing works
Adverse associations of sleep problems in Australian preschoolers: national population study
Hiscock, H., Canterford, L., Ukoumunne, O. C., & Wake, M. (2007) · Pediatrics · doi:10.1542/peds.2006-1757 · Cited by 239 · see citing works
Vulnerability factors among children at risk for anxiety disorders
Merikangas, K. R., Avenevoli, S., Dierker, L., & Grillon, C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00172-9 · Cited by 229 · see citing works
Pollak, Y., & Yirmiya, R. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003152 · Cited by 215 · see citing works
Cost of atopic dermatitis and eczema in the United States
Ellis, C. N., Drake, L. A., Prendergast, M. M., Abramovits, W., Boguniewicz, M., Daniel, C. R., Lebwohl, M., Stevens, S. R., Whitaker-Worth, D. L., Cheng, J., et al. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.120528 · Cited by 211 · see citing works
Quality of life and disease severity are correlated in children with atopic dermatitis
Ben‐Gashir, M., Seed, P. T., & Hay, R. J. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05776.x · Cited by 209 · see citing works
Psychosocial adjustment in preschool children with atopic eczema.
Daud, L. R., Garralda, M. E., & David, T. J. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.69.6.670 · Cited by 203 · see citing works
Developmental comorbidity in attention-deficit/hyperactivity disorder
Taurines, R., Schmitt, J., Renner, T., Conner, A. C., Warnke, A., & Romanos, M. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0040-0 · Cited by 198 · see citing works
Is atopic disease a risk factor for attention‐deficit/hyperactivity disorder? A systematic review
Schmitt, J. M., Buske-Kirschbaum, A., & Roessner, V. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02449.x · Cited by 194 · see citing works
Romanos, M., Gerlach, M., Warnke, A., & Schmitt, J. M. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2009.093534 · Cited by 174 · see citing works
Schmitt, J. M. (2009) · JAMA · doi:10.1001/jama.2009.136 · Cited by 172 · see citing works
Psychological disturbance in atopic eczema: the extent of the problem in school‐aged children
Absolon, C. M., Cottrell, D. J., Eldridge, S. M., & Glover, M. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.18121896.x · Cited by 130 · see citing works
Stungo, E. (1951) · BMJ · doi:10.1136/bmj.2.4744.1405-b · Cited by 123 · see citing works
Sleep fragmentation in children with atopic dermatitis
Reuveni, H., Chapnick, G., Tal, A., & Tarasiuk, A. (1999) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.153.3.249 · Cited by 121 · see citing works
Atopic dermatitis in children: Who cares? Who pays?
Lapidus, C. S., Schwarz, D. F., & Honig, P. J. (1993) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(93)70096-c · Cited by 121 · see citing works
A Study of the Association between Sleep Habits and Problematic Behaviors in Preschool Children
Yokomaku, A., Misao, K., Omoto, F., Yamagishi, R., Tanaka, K., Takada, K., & Kohyama, J. (2008) · Chronobiology International · doi:10.1080/07420520802261705 · Cited by 118 · see citing works
The psychosocial burden of childhood atopic dermatitis
Chamlin, S. L. (2006) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2006.00060.x · Cited by 108 · see citing works
Principal pathogenetic components and biological endophenotypes in autism spectrum disorders
Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., Frolli, A., Lenti, C., Saccani, M., Elia, M., Reichelt, K.-L., et al. (2010) · Autism Research · doi:10.1002/aur.151 · Cited by 102 · see citing works
Anxiety accelerates T-helper 2-tilted immune responses in patients with atopic dermatitis
Hashizume, H., Horibe, T., Ohshima, A., Ito, T., Yagi, H., & Takigawa, M. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06449.x · Cited by 90 · see citing works
Anxiety in allergy and atopic dermatitis
Hashizume, H., & Takigawa, M. (2006) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000244793.03239.40 · Cited by 84 · see citing works
Emotional, developmental and behavioural co‐morbidities of children with chronic health conditions
Blackman, J. A., Gurka, M. J., Gurka, K. K., & Oliver, M. N. (2011) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2011.02044.x · Cited by 84 · see citing works
Immune allergic response in Asperger syndrome
Magalhães, E. S. D. S., Mariz, F. P., Bastos-Pinto, S., Pontes, A. T., Prado, E. A., & deAzevedo, L. C. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.09.015 · Cited by 69 · see citing works
Comorbidity in Atopic Dermatitis
Simpson, E. L. (2012) · Current Dermatology Reports · doi:10.1007/s13671-011-0003-5 · Cited by 67 · see citing works
Self-citationSuizidgedanken, Angst und Depression bei erwachsenen Neurodermitikern
Dieris-Hirche, J., Gieler, U., Kupfer, J., & Milch, W. E. (2009) · Der Hautarzt · doi:10.1007/s00105-009-1744-y · Cited by 65 · see citing works
Kramer, D., SchÄfer, Behrendt, et al. (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02561.x · Cited by 54 · see citing works
Allergic manifestations in autistic children: Relation to disease severity
Hamza, R. T., ElShahawi, H. H., & Mostafa, G. A. (2015) · Journal of Pediatric Neurology · doi:10.1055/s-0035-1557446 · Cited by 42 · see citing works
Yang, Y., Tseng, K. ‐., Chen, Y. ‐., & Yang, J. ‐. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02249.x · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110 · see citing works
Self-citationWeidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908 · see citing works
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y., & Williams, H. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.005 · Cited by 722 · see citing works
Self-citationPublic Health Burden and Epidemiology of Atopic Dermatitis
Silverberg, J. I. (2017) · Dermatologic Clinics · doi:10.1016/j.det.2017.02.002 · Cited by 400 · see citing works
Muskens, J. B., Velders, F. P., & Staal, W. G. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1020-0 · Cited by 232 · see citing works
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma
Andersen, Y. M. F., Egeberg, A., Skov, L., & Thyssen, J. P. (2017) · Current Dermatology Reports · doi:10.1007/s13671-017-0168-7 · Cited by 62 · see citing works
The link between atopic dermatitis and asthma-immunological imbalance and beyond
Yaneva, M., & Darlenski, R. (2021) · Asthma Research and Practice · doi:10.1186/s40733-021-00082-0 · Cited by 60 · see citing works
Lebrikizumab for the Treatment of Moderate-to-Severe Atopic Dermatitis
Bernardo, D., Bieber, T., & Torres, T. (2023) · American Journal of Clinical Dermatology · doi:10.1007/s40257-023-00793-5 · Cited by 43 · see citing works
Exposure-based cognitive behavior therapy for atopic dermatitis: an open trial
Hedman-Lagerlöf, E., Bergman, A., Lindefors, N., & Bradley, M. (2019) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2018.1504320 · Cited by 39 · see citing works
Hashimoto, O., Kuniishi, H., Nakatake, Y., Yamada, M., Wada, K., & Sekiguchi, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.013 · Cited by 17 · see citing works
- Authors
- Yaghmaie, P., Koudelka, C. W., & Simpson, E. L.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Simpson, Eric L.
- ORCID
- Simpson, Eric L.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 131
- Issue
- 2
- Pages
- 428-433
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC3565469
- OpenAlex
- W2029208193
- Semantic Scholar
- 9968471dd4a7ba5982ad28a6464618bd9cfa0b62
- Cited by
- 449
- References
- 36
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 39 · 2023: 47 · 2022: 38 · 2021: 39 · 2020: 37 · 2019: 37 · 2018: 41 · 2017: 32 · 2016: 31 · 2015: 27 · 2014: 22 · 2013: 11
- FWCI
- 23.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K23AR057486)
- National Center for Research Resources (KL2RR024141)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- atopic dermatitis, child mental health, comorbidities, attention deficit hyperactivity disorder, depression, anxiety, conduct disorder, autism spectrum disorder, skin disease severity, lifetime prevalence, National Survey of Children's Health
- MeSH terms
- Adolescent, Anxiety, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Mental Disorders, Child, Child, Preschool, Cross-Sectional Studies, Depression, Dermatitis, Atopic, Female, Humans, Infant, Infant, Newborn, Male, Mental Health, Risk Factors, United States, Comorbidity, Prevalence, Odds Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
