COMORBIDITY AND DISEASE BURDEN IN THE NATIONAL COMORBIDITY SURVEY REPLICATION (NCS-R): Research Article: Comorbidity and Disease Burden in the NCS-R

Gadermann, Anne M.; Alonso, Jordi; Vilagut, Gemma; Zaslavsky, Alan M.; Kessler, Ronald C.

doi:10.1002/da.21924

Cited by 210Chronic Disease Management StrategiesMental Health Treatment and AccessHealth Systems, Economic Evaluations, Quality of Life

COMORBIDITY AND DISEASE BURDEN IN THE NATIONAL COMORBIDITY SURVEY REPLICATION (NCS-R): Research Article: Comorbidity and Disease Burden in the NCS-R

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Gadermann, Anne M., Alonso, Jordi, Vilagut, Gemma, Zaslavsky, Alan M., Kessler, Ronald C.·2012·Depression and Anxiety

DOI 10.1002/da.21924PMC PMC4005614

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Abstract

BACKGROUND: Disease burden estimates rarely consider comorbidity. Using a recently developed methodology for integrating information about comorbidity into disease burden estimates, we examined the comparative burdens of nine mental and 10 chronic physical disorders in the National Comorbidity Survey Replication (NCS-R). METHODS: Face-to-face interviews in a national household sample (n = 5,692) assessed associations of disorders with scores on a visual analog scale (VAS) of perceived health. Multiple regression analysis with interactions for comorbidity was used to estimate these associations. Simulation was used to estimate incremental disorder-specific effects adjusting for comorbidity. RESULTS: The majority of respondents (74.9%) reported one or more disorders. Of respondents with disorders, 73.8-98.2% reported having at least one other disorder. The best-fitting model to predict VAS scores included disorder main effects and interactions for number of disorders. Adjustment for comorbidity reduced individual-level disorder-specific burden estimates substantially, but with considerable between-disorder variation (0.07-0.69 ratios of disorder-specific estimates with and without adjustment for comorbidity). Four of the five most burdensome disorders at the individual level were mental disorders based on bivariate analyses (panic/agoraphobia, bipolar disorder, posttraumatic stress disorder, major depression) but only two based on multivariate analyses, adjusting for comorbidity (panic/agoraphobia, major depression). Neurological disorders, chronic pain conditions, and diabetes were the other most burdensome individual-level disorders. Chronic pain conditions, cardiovascular disorders, arthritis, insomnia, and major depression were the most burdensome societal-level disorders. CONCLUSIONS: Adjustments for comorbidity substantially influence estimates of disease burden, especially those of mental disorders, underlining the importance of including information about comorbidity in studies of mental disorders.

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“Depression is a mental disorder associated with significant morbidity and mortality (Gadermann et al., 2012).”
Background
Epidemiology of DSM-5 bipolar I disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions – III
Blanco, C., Compton, W. M., Saha, T. D., Goldstein, B. I., Ruan, W. J., Huang, B., & Grant, B. F. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.10.003 · Cited by 149 · see citing works
“Bipolar I disorder has been consistently associated with significant medical and psychiatric comorbidity (Gadermann et al., 2012; Grant et al., 2005; Roshanaei-Moghaddam et al., 2009; Vancampfort et al., 2013; Weber et al., 2011), premature mortality (Westman et al., 2013), high levels of…”
Background
Cardiovascular disease and osteoarthritis: common pathways and patient outcomes
Fernandes, G., & Valdes, A. M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12413 · Cited by 141 · see citing works
In pursuit of truth: A critical examination of meta-analyses of cognitive behavior therapy
Wampold, B. E., Flückiger, C., Re, A. C. D., Yulish, N. E., Frost, N. D., Pace, B. T., Goldberg, S. B., Miller, S. D., Baardseth, T. P., Laska, K. M., et al. (2016) · Psychotherapy Research · doi:10.1080/10503307.2016.1249433 · Cited by 133 · see citing works
“…motivated by Mayo-Wilson et al.’s (2014) focus on the reduction of symptoms for social anxiety, over 90% of individuals qualifying for a social phobia diagnosis qualified for another diagnosis and the mean number of other diagnoses for people with social phobia was 3.5 (Gadermann et al., 2012).”
BackgroundInfluential
Prevalence, associated factors and predictors of anxiety: a community survey in Selangor, Malaysia
Maideen, S. F. K., Sidik, S. M., Rampal, L., & Mukhtar, F. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0648-x · Cited by 128 · see citing works
The Affect Regulation Training (ART): a transdiagnostic approach to the prevention and treatment of mental disorders
Berking, M., & Lukas, C. A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.02.002 · Cited by 124 · see citing works
Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119 · see citing works
“In addition, depressive disorders have an estimated 93.5% comorbidity with other diseases, most commonly with chronic pain, anxiety, bipolar disorder, post-traumatic stress disorder, diabetes and neurological disorders (Gadermann et al., 2012).”
BackgroundInfluential
Genetics of Anxiety Disorders
Meier, S. M., & Deckert, J. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1002-7 · Cited by 182 · see citing works
Prevalence and correlates of DSM-IV-TR major depressive disorder, self-reported diagnosed depression and current depressive symptoms among adults in Germany
Maske, U. E., Buttery, A. K., Beesdo-Baum, K., Riedel-Heller, S., Hapke, U., & Busch, M. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.006 · Cited by 120 · see citing works
Anxiety disorders and medical comorbidity: Treatment implications
Meuret, A. E., Tunnell, N., & Roque, A. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9705-0_15 · Cited by 96 · see citing works
Panic Disorder Comorbidity with Medical Conditions and Treatment Implications
Meuret, A. E., Kroll, J. L., & Ritz, T. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-021815-093044 · Cited by 88 · see citing works
The American Psychiatric Association Practice Guidelines for the Psychiatric Evaluation of Adults
(2015) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890426760 · Cited by 119 · see citing works
Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies
Mohammadi, S., Seyedmirzaei, H., Salehi, M. A., Jahanshahi, A., Zakavi, S. S., Firouzabadi, F. D., & Yousem, D. M. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00772-8 · Cited by 87 · see citing works
“The high prevalence of depression comorbidities among people play a significant role in its pathophysiology (Gadermann et al., 2012).”
Background
Comorbidity of 9/11‐Related PTSD and Depression in the World Trade Center Health Registry 10–11 Years Postdisaster
Caramanica, K., Brackbill, R. M., Liao, T. S., & Stellman, S. D. (2014) · Journal of Traumatic Stress · doi:10.1002/jts.21972 · Cited by 87 · see citing works
Mental health stigma: Impact on mental health treatment attitudes and physical health
Sickel, A. E., Seacat, J. D., & Nabors, N. A. (2019) · Journal of Health Psychology · doi:10.1177/1359105316681430 · Cited by 82 · see citing works
“It is well established that mental illness has deleterious personal, social, and economic consequences for individuals, families, and society (Gadermann et al., 2012; Kessler et al., 2009; Levinson et al., 2010; Parks et al., 2006).”
Background
Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms
John, C. S., Sypek, E. I., Carlezon, W. A., Cohen, B. M., Öngür, D., & Bechtholt, A. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.16 · Cited by 83 · see citing works
Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana
Feingold, D., Brill, S., Goor‐Aryeh, I., Delayahu, Y., & Lev‐Ran, S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.026 · Cited by 80 · see citing works
Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear
Vollmer, L. L., Ghosal, S., McGuire, J. L., Ahlbrand, R. A., Li, K., Santin, J. M., Ratliff, C. A., Patrone, L. G. A., Rush, J. A., Lewkowich, I. P., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.022 · Cited by 74 · see citing works
Exploration of the Influence of Childhood Trauma, Combat Exposure, and the Resilience Construct on Depression and Suicidal Ideation Among U.S. Iraq/Afghanistan Era Military Personnel and Veterans
Youssef, N. A., Green, K. T., Dedert, E. A., Hertzberg, J. S., Calhoun, P. S., Dennis, M. F., Cen, M.-A. M. I. R. E. A. C., & Beckham, J. C. (2013) · Archives of Suicide Research · doi:10.1080/13811118.2013.776445 · Cited by 74 · see citing works
“Depression is a common cause of morbidity worldwide (Kessler et al., 2003; McKenna, Michaud, Murray, & Marks, 2005) and is associated with significant disease burden (Gadermann et al., 2012).”
Background
The association between severity of depression and prescription opioid misuse among chronic pain patients with and without anxiety: A cross-sectional study
Feingold, D., Brill, S., Goor-Aryeh, I., Delayahu, Y., & Lev-Ran, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.058 · Cited by 69 · see citing works
Risk of suicide ideation in comorbid substance use disorder and major depression
Onaemo, V. N., Fawehinmi, T. O., & D’Arcy, C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265287 · Cited by 69 · see citing works
“Suicide ideation among individuals with MD and comorbid SUDs tend to present with more severe mood symptoms, higher risk of suicide attempts, poor functioning, more psychiatric comorbidities, and increased mortality [75, 76].”
Background
Family Strain, Depression, and Somatic Amplification in Adults with Chronic Pain
Boone, D. M., & Kim, S. Y. (2019) · International Journal of Behavioral Medicine · doi:10.1007/s12529-019-09799-y · Cited by 66 · see citing works
Metacognitive therapy versus disorder-specific CBT for comorbid anxiety disorders: A randomized controlled trial
Johnson, S. U., Hoffart, A., Nordahl, H. M., & Wampold, B. E. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.06.004 · Cited by 67 · see citing works
Burden of Sexual Dysfunction
Balon, R. (2015) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2015.1113597 · Cited by 64 · see citing works
The association between depressive symptoms and fall accidents among middle-aged and elderly people in China
Ouyang, P., & Sun, W. (2018) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-018-0735-y · Cited by 64 · see citing works
Acid–base dysregulation and chemosensory mechanisms in panic disorder: a translational update
Vollmer, L. L., Strawn, J. R., & Sah, R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.67 · Cited by 64 · see citing works
Persistent post-surgical pain and experimental pain sensitivity in the Tromsø study: Comorbid pain matters
Johansen, A., Schirmer, H., Stubhaug, A., & Nielsen, C. S. (2013) · Pain · doi:10.1016/j.pain.2013.10.013 · Cited by 63 · see citing works
ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations
Johnson, L. A., Zuloaga, D. G., Bidiman, E., Marzulla, T., Weber, S., Wahbeh, H., & Raber, J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.95 · Cited by 69 · see citing works
EXPERIENCING CORE SYMPTOMS OF ANXIETY AND UNIPOLAR MOOD DISORDERS IN LATE ADOLESCENCE PREDICTS DISORDER ONSET IN EARLY ADULTHOOD: Symptoms of Disorders as Predictors of Later Onset of Disorders
Wolitzky-Taylor, K., Dour, H., Zinbarg, R., Mineka, S., Vrshek-Schallhorn, S., Epstein, A., Bobova, L., Griffith, J., Waters, A., Nazarian, M., et al. (2014) · Depression and Anxiety · doi:10.1002/da.22250 · Cited by 61 · see citing works
Patterns of Alcohol Abuse, Depression, and Intimate Partner Violence Among Township Mothers in South Africa Over 5 Years
Davis, E., Rotheram‐Borus, M. J., Weichle, T. W., Rezai, R., & Tomlinson, M. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1927-y · Cited by 61 · see citing works
Quality of life in anxious adolescents
Raknes, S., Pallesen, S., Himle, J. A., Bjaastad, J. F., Wergeland, G. J., Hoffart, A., Dyregrov, K., Håland, Å. T., & Haugland, B. S. M. (2017) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-017-0173-4 · Cited by 59 · see citing works
ADHD is comorbid to migraine in childhood: a population-based study
Arruda, M. A., Arruda, R., Guidetti, V., & Bigal, M. E. (2020) · Journal of Attention Disorders · doi:10.1177/1087054717710767 · Cited by 51 · see citing works
Psychological distress in French college students: demographic, economic and social stressors. Results from the 2010 National Health Barometer
Saïas, T., du Roscoät, E., Véron, L., Guignard, R., Richard, J., Legleye, S., Sauvade, F., Kovess–Masféty, V., & Beck, F. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-256 · Cited by 53 · see citing works
“First, the response rate obtained in the survey was 61%, which is satisfactory for such health surveys in France, but lower than the rates obtained in other epidemiological mental health surveys such as the NCS-R [45] or the NESARC [46].”
Result
Effectiveness of a collaborative care intervention for managing major depression and chronic musculoskeletal pain in primary care: A cluster-randomised controlled trial
Aragonès, E., Rambla, C., López-Cortacans, G., Tomé-Pires, C., Sánchez-Rodríguez, E., Caballero, A., & Miró, J. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.004 · Cited by 50 · see citing works
Antidepressant effectiveness of deep Transcranial Magnetic Stimulation (dTMS) in patients with Major Depressive Disorder (MDD) with or without Alcohol Use Disorders (AUDs): A 6-month, open label, follow-up study
Rapinesi, C., Curto, M., Kotzalidis, G. D., CASALE, A. D., Serata, D., Ferri, V. R., Pietro, S. D., Scatena, P., Bersani, F. S., Raccah, R. N., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.015 · Cited by 48 · see citing works
“Co-occurrence of AUD and MDD results in even greater diseaserelated burden than the separate disorders (Gadermann et al., 2012).”
Background
The Lingering Impact of Resolved PTSD on Subsequent Functioning
Bryant, R. A., McFARLANE, A. C., Silove, D. M., O'Donnell, M. L., Forbes, D., & Creamer, M. C. (2015) · Clinical Psychological Science · doi:10.1177/2167702615598756 · Cited by 47 · see citing works
Glutamatergic copy number variants and their role in attention‐deficit/hyperactivity disorder
Akutagava‐Martins, G. C., Salatino‐Oliveira, A., Genro, J. P., Contini, V., Polanczyk, G. V., Zeni, C., Chazan, R., Kieling, C., Anselmi, L., Menezes, A. M. B., et al. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32253 · Cited by 46 · see citing works
“Our analyses of anxiety disorders focused on agoraphobia, generalized anxiety, and social phobia since they represent those anxiety disorders with higher prevalence and clinical significance [Gadermann et al., 2012].”
Background
Functional Disability and Quality of Life Decrements in Mental Disorders: Results From the Mental Health Module of the German Health Interview and Examination Survey for Adults (Degs1-Mh)
Mack, S., Jacobi, F., Beesdo‐Baum, K., Gerschler, A., Strehle, J., Höfler, M., Busch, M. A., Maske, U., Hapke, U., Gäebel, W., et al. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.06.003 · Cited by 45 · see citing works
A 2023 Update on Managing Insomnia in Primary Care
Rosenberg, R. P., Benca, R. M., Doghramji, P. P., & Roth, T. G. (2023) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.22nr03385 · Cited by 44 · see citing works
Prevalence And Spending Associated With Patients Who Have A Behavioral Health Disorder And Other Conditions
Thorpe, K., Jain, S., & Joski, P. (2017) · Health Affairs · doi:10.1377/hlthaff.2016.0875 · Cited by 41 · see citing works
Which mental disorders are associated with the greatest impairment in functioning?
Edlund, M. J., Wang, J., Brown, K., Forman‐Hoffman, V. L., Calvin, S., Hedden, S. L., & Bose, J. (2018) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-018-1554-6 · Cited by 43 · see citing works
Digital Interventions for People With Co-Occurring Depression and Problematic Alcohol Use: A Systematic Review and Meta-Analysis
Schouten, M. J. E., Christ, C., Dekker, J., Riper, H. M., Goudriaan, A. E., & Blankers, M. (2021) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa147 · Cited by 41 · see citing works
Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes
Cittaro, D., Lampis, V., Luchetti, A., Coccurello, R., Guffanti, A., Felsani, A., Moles, A., Stupka, E., D'Amato, F. R., & Battaglia, M. (2016) · Scientific Reports · doi:10.1038/srep25131 · Cited by 39 · see citing works
Nucleus accumbens volume as a predictor of anxiety symptom improvement following CBT and SSRI treatment in two independent samples
Burkhouse, K. L., Jimmy, J., DeFelice, N., Klumpp, H., Ajilore, O., Hosseini, B., Fitzgerald, K. D., Monk, C. S., & Phan, K. L. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0575-5 · Cited by 39 · see citing works
How Idiographic Methodologies Can Move the Clinical-Science Field Forward to Integrate Personalized Treatment Into Everyday Clinical Care and Improve Treatment Outcomes
Levinson, C. A., Christian, C., & Becker, C. B. (2024) · Clinical Psychological Science · doi:10.1177/21677026231217316 · Cited by 39 · see citing works
“Indeed, comorbidity is a rule rather than an exception in routine clinical practice (Gadermann et al., 2012).”
Agreement between pre-post measures of change and transition ratings as well as then-tests
Meyer, T., Richter, S., & Raspe, H. H. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-52 · Cited by 36 · see citing works
“Musculoskeletal and cardiovascular diseases often involve somatisation, functional impairments, and insomnia [22,23].”
Background
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms
Chen, X., Tang, J., Feng, S., Huang, H., Lu, F.-N., Lu, X., & Wang, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210111155110 · Cited by 36 · see citing works
“Patients with PTSD are often accompanied by comorbidities, such as anxiety and depression [2].”
Patient activation level and its associated factors in adults with chronic pain
Yao, F., Zheng, M., Wang, X., Ji, S., Li, S., Xu, G., & Zheng, Z. (2021) · Medicine · doi:10.1097/md.0000000000025929 · Cited by 36 · see citing works
“Mental health is impacted, with 54% of these patients experiencing depression, and over 50% reporting anxiety.([19]) It is a lifetime task for chronic pain patients to deal with the impacts (eg, depression and anxiety, poor sleep, reduced quality of life) of chronic pain.”
Fractures in the framework: limitations of classification systems inpsychiatry
Kapadia, M., Desai, M., & Parikh, R. M. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.1/rparikh · Cited by 34 · see citing works
Ideación suicida en estudiantes de medicina: prevalencia y factores asociados
Pinzón, A., Guerrero, S., Moreno, K., Landínez, C., & Pinzón, J. (2013) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2013.11.005 · Cited by 35 · see citing works
The Influence of Exposure to Natural Disasters on Depression and PTSD Symptoms among Firefighters
Pennington, M. L., Carpenter, T. P., Synett, S. J., Torres, V. A., Teague, J., Morissette, S. B., Knight, J., Kamholz, B. W., Keane, T. M., Zimering, R. T., et al. (2017) · Prehospital and Disaster Medicine · doi:10.1017/s1049023x17007026 · Cited by 32 · see citing works
“0%, respectively.(8) In addition, Shore and colleagues observed higher onset of depression and PTSD in subjects with high exposure to a volcanic eruption compared to those with low or no exposure.”
Background
The 18-item Swedish version of Ryff’s psychological wellbeing scale: psychometric properties based on classical test theory and item response theory
Garcia, D., Kazemitabar, M., & Asgarabad, M. H. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1208300 · Cited by 49 · see citing works
“…of the 18-item version was 10.3389/fpsyg.2023.1208300 Frontiers in Psychology 06 frontiersin.org examined using the equivalent of Cronbach’s alpha coefficient, which is based on polychoric correlation matrix rather than the Pearson correlation matrix (Zumbo et al., 2007; Gadermann et al., 2012).”
MethodInfluential
The Lingering Impact of Resolved PTSD on Subsequent Functioning
Bryant, R. A., McFARLANE, A. C., Silove, D. M., O'Donnell, M. L., Forbes, D., & Creamer, M. C. (2023) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.23021016 · Cited by 34 · see citing works
Impact of posttraumatic stress symptom dimensions on psychophysiological reactivity to threat and reward
Lieberman, L., Gorka, S. M., Funkhouser, C. J., Shankman, S. A., & Phan, K. L. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.04.002 · Cited by 30 · see citing works
“Focusing on only those individuals who are full syndromal PTSD also ignores individuals who are subthreshold e a group that is known to display functional impairment (Gadermann et al., 2012; Zlotnick et al., 2002).”
Background
Comorbidities in the first 2 years after arthroscopic hip surgery: substantial increases in mental health disorders, chronic pain, substance abuse and cardiometabolic conditions
Rhon, D., Greenlee, T. A., Marchant, B., Sissel, C. D., & Cook, C. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099294 · Cited by 28 · see citing works
Experiences of falling and depression: Results from the Korean Longitudinal Study of Ageing
Kim, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.026 · Cited by 31 · see citing works
Understanding the Evolution of Multimorbidity: Evidences from the North West Adelaide Health Longitudinal Study (NWAHS)
Ruel, G., Lévesque, J., Stocks, N., Sirois, C., Kröger, E., Adams, R. J., Doucet, M., & Taylor, A. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096291 · Cited by 31 · see citing works
Type of Multimorbidity and Complementary and Alternative Medicine Use among Adults
Alwhaibi, M., Bhattacharya, R., & Sambamoorthi, U. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/362582 · Cited by 30 · see citing works
“As the coexistence of chronic physical conditions and mental illnesses has been found to be associated with work absenteeism, functional disability, preventable hospitalization, and poor quality of life [14, 18–25], it is plausible that adults with chronic physical and mental illnesses are more likely to use CAM compa…”
Background
The panic disorder screener (PADIS): Development of an accurate and brief population screening tool
Batterham, P. J., Mackinnon, A. J., & Christensen, H. M. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.04.016 · Cited by 30 · see citing works
“Panic disorder accounts for a considerable proportion of disease burden in the general population (Eaton et al., 2008; Gadermann et al., 2012).”
Background
Are therapists uniformly effective across patient outcome domains? A study on therapist effectiveness in two different treatment contexts.
Nissen‐Lie, H. A., Goldberg, S. B., Hoyt, W. T., Falkenström, F., Holmqvist, R., Nielsen, S. L., & Wampold, B. E. (2016) · Journal of Counseling Psychology · doi:10.1037/cou0000151 · Cited by 30 · see citing works
Integrative mental healthcare White Paper: Establishing a new paradigm through research, education, and clinical guidelines
Sarris, J. J., Glick, R. M., Hoenders, R. H. J., Duffy, J., & Lake, J. (2013) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2012.12.002 · Cited by 30 · see citing works
Disease Burden Among Individuals with Severe Mental Illness in a Community Setting
Baughman, K. R., Bonfine, N., Dugan, S. E., Adams, R. E., Gallagher, M. S., Olds, R. S., Piatt, E., & Ritter, C. (2015) · Community Mental Health Journal · doi:10.1007/s10597-015-9973-2 · Cited by 27 · see citing works
“Similar to the study by Gadermann et al. (2012), we found a significant association between the number of chronic diseases and perceived health independent of the presence of chronic pain and persistent headaches.”
BackgroundMethodResultInfluential
Health-related quality of life of primary care patients with depressive disorders
Riihimäki, K., Sintonen, H., Vuorilehto, M. S., Jylhä, P. J., Saarni, S. I., & Isometsä, E. T. (2016) · European Psychiatry · doi:10.1016/j.eurpsy.2016.04.008 · Cited by 27 · see citing works
“Depressive disorders are also known to be highly comorbid both in the general population [15,16] and primary care patients [17], so in theory, poor HRQoL may well be a result of multiple cooccurring syndromes rather than depression alone.”
Background
Negative Life Events, Social Support, and Self-Efficacy in Anxious Adolescents
Raknes, S., Pallesen, S., Bjaastad, J. F., Wergeland, G. J., Hoffart, A., Dyregrov, K., Håland, Å. T., & Haugland, B. S. M. (2017) · Psychological Reports · doi:10.1177/0033294117699820 · Cited by 27 · see citing works
Protective and Risk Factors at the Intersection of Chronic Pain, Depression, Anxiety, and Somatic Amplification: A Latent Profile Approach
Kim, S., Lee, J., & Boone, D. (2022) · Journal of Pain Research · doi:10.2147/jpr.s340382 · Cited by 26 · see citing works
“While being older is typically associated with greater chronic pain symptoms, older age has also been associated with comorbid chronic pain and depression.(3,15) However, limited research has been conducted to examine the associations among age, chronic pain, and anxiety.”
Background
Neuroimmune mechanisms in fear and panic pathophysiology
McMurray, K. M. J., & Sah, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1015349 · Cited by 26 · see citing works
Challenges of creating synergy between global mental health and cultural psychiatry
de Jong, J. T. V. M. (2014) · Transcultural Psychiatry · doi:10.1177/1363461514557995 · Cited by 26 · see citing works
Concurrent varenicline and prolonged exposure for patients with nicotine dependence and PTSD: A randomized controlled trial.
Foa, E. B., Asnaani, A., Rosenfield, D., Zandberg, L. J., Gariti, P., & Imms, P. (2017) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000213 · Cited by 26 · see citing works
Post-Traumatic Stress Disorder among Survivors of the September 11, 2001 World Trade Center Attacks: A Review of the Literature
Hamwey, M. K., Gargano, L. M., Friedman, L., Leon, L. F., Petrsoric, L. J., & Brackbill, R. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17124344 · Cited by 26 · see citing works
“This mental health disorder can also result in both substantial individual and population burden of comorbid psychological and physical conditions [2,3].”
Background
A framework for indirect elicitation of the public health impact of gambling problems
Browne, M., Rawat, V., Newall, P. W. S., Begg, S. J., Rockloff, M., & Hing, N. (2020) · BMC Public Health · doi:10.1186/s12889-020-09813-z · Cited by 26 · see citing works
Relationship Between Self-Reported Concomitant Depressive and Anxiety Symptoms and the Post-Concussion Symptoms Scale (PCSS)
Thomas, G. A., Riegler, K. E., Guty, E. T., & Arnett, P. A. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s135561772100134x · Cited by 25 · see citing works
“While the current study examined athletes with elevated symptomatology rather than those with clinical disorders, these findings are inline with previous research showing that the burden of disease increases with each additional diagnosis, and that those with comorbid psychological disorders typically demonstrate poor…”
BackgroundResult
The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence
Muench, C., Schwandt, M. L., Jung, J., Cortes, C. R., Momenan, R., & Lohoff, F. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0184-9 · Cited by 25 · see citing works
Misuse of prescription opioids among chronic pain patients suffering from anxiety: A cross-sectional analysis
Feingold, D., Brill, S., Goor-Aryeh, I., Delayahu, Y., & Lev-Ran, S. (2017) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2017.04.006 · Cited by 24 · see citing works
What Physical Health Means to Me: Perspectives of People with Mental Illness
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Authors: Gadermann, A. M., Alonso, J., Vilagut, G., Zaslavsky, A. M., & Kessler, R. C.
Affiliations: Harvard University (US)
Universitat Pompeu Fabra (ES)
Corresponding author: Kessler, Ronald C.
ORCID: Gadermann, Anne M.
Alonso, Jordi
Vilagut, Gemma
Zaslavsky, Alan M.
Kessler, Ronald C.
Venue: Depression and Anxiety
Publisher: Wiley
Published: 2012-05-14
Volume: 29
Issue: 9
Pages: 797-806
ISSN: 1091-4269 (ISSN-L)
DOI: 10.1002/da.21924
PMC: PMC4005614
OpenAlex: W1928565634
Cited by: 210
References: 56
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 18 · 2022: 14 · 2021: 17 · 2020: 17 · 2019: 11 · 2018: 22 · 2017: 21 · 2016: 19 · 2015: 22 · 2014: 19 · 2013: 12 · 2012: 2
FWCI: 13.17
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1205 d)
Locations: Depression and Anxiety (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
Funders: National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
National Institute of Mental Health (R13-MH-066849, R01‐MH070884, U01-MH-60220, HHSN271200700030C, U01MH060220, R01‐MH069864)
National Institute on Drug Abuse (K05DA015799, R01DA016558)
Fogarty International Center (R03TW006481)
Topics: Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords: comorbidities, disease burden, mental illness, health perception, National Comorbidity Survey Replication, panic disorder, agoraphobia, bipolar disorder, post-traumatic stress disorder, major depressive disorder, chronic pain, diabetes mellitus, cardiovascular disease, arthritis, insomnia, social burden
MeSH terms: Adult, Aged, Aged, 80 and over, Mental Disorders, Chronic Disease, Female, Health Surveys, Humans, Male, Middle Aged, Regression Analysis, Self-Assessment, United States, Comorbidity, Prevalence, Cost of Illness, Diagnostic and Statistical Manual of Mental Disorders

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COMORBIDITY AND DISEASE BURDEN IN THE NATIONAL COMORBIDITY SURVEY REPLICATION (NCS-R): Research Article: Comorbidity and Disease Burden in the NCS-R

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