The link between atopic dermatitis and asthma-immunological imbalance and beyond
Open accessAbstract
Atopic diseases are multifactorial chronic disturbances which may evolve one into another and have overlapping pathogenetic mechanisms. Atopic dermatitis is in most cases the first step towards the development of the atopic march and represents a major socio-economic burden in the industrialized countries. The treatment of atopic diseases is often long-lasting and in some cases with lower effectiveness than expected.In order to prevent the development of the atopic march, the links between the atopic diseases have to be understood. The aim of this review is to present some major points outlining the link between atopic dermatitis and asthma, through a research in the medical literature from recent years.Stratifying patient populations according to the clinical phenotype of their disease and according to specific measurable values (biomarkers) can help to establish the main etiopathogenetic mechanisms of the disease in these populations. This will add predictive value for the evolution of the disease, and will allow the use and research of more targeted therapy in order to stop this evolution and comorbidities.
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Shared immune dysregulation and inflammatory mechanisms are observed in both asthma and eczema.
“This is also supported by the shared immune dysregulation and inflammatory mechanisms observed in both conditions [72].”
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Zhang, M. J., Hou, K., Dey, K. K., Sakaue, S., Jagadeesh, K. A., Weinand, K., Taychameekiatchai, A., Rao, P., Pisco, A. O., Zou, J., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01167-z · Cited by 302 · see citing works
Hoskinson, C., Dai, D. L., Bel, K. L. D., Becker, A. B., Moraes, T. J., Mandhane, P. J., Finlay, B. B., Simons, E., Kozyrskyj, A. L., Azad, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40336-4 · Cited by 210 · see citing works
CCL17 / TARC in autoimmunity and inflammation—not just a T‐cell chemokine
Lupancu, T. J., Eivazitork, M., Hamilton, J. A., Achuthan, A. A., & Lee, M.-C. (2023) · Immunology and Cell Biology · doi:10.1111/imcb.12644 · Cited by 67 · see citing works
How the early life microbiome shapes immune programming in childhood asthma and allergies
Hoskinson, C., Petersen, C., & Turvey, S. E. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.12.005 · Cited by 28 · see citing works
The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation
Frey, A., Lunding, L. P., & Wegmann, M. (2023) · Cells · doi:10.3390/cells12182208 · Cited by 27 · see citing works
Atopic March or Atopic Multimorbidity—Overview of Current Research
Kobal, I. M., Plavec, D., Vlašić, Ž., Jerković, I., & Turkalj, M. (2023) · Medicina · doi:10.3390/medicina60010021 · Cited by 26 · see citing works
Factors associated with severity of atopic dermatitis – a Finnish cross‐sectional study
Salava, A., Salo, V., Leppänen, J., Lauerma, A., & Remitz, A. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18378 · Cited by 26 · see citing works
Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma
Wypych-Ślusarska, A., Grot, M., Kujawińska, M., Nigowski, M., Krupa-Kotara, K. H., Oleksiuk, K., Głogowska‐Ligus, J., & Grajek, M. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811180 · Cited by 18 · see citing works
Wallen-Russell, C., Pearlman, N., Wallen-Russell, S., Cretoiu, D., Thompson, D. C., & Voinea, S. C. (2023) · Microorganisms · doi:10.3390/microorganisms11112784 · Cited by 14 · see citing works
Kim, H., Kim, M. G., Kim, S., Lee, J., Byun, Y., Park, J., & Kim, K. (2024) · World Allergy Organization Journal · doi:10.1016/j.waojou.2024.100934 · Cited by 13 · see citing works
Infant lung function and early skin barrier impairment in the development of asthma at age 3 years
Färdig, M., Hoyer, A., Almqvist, C., Bains, K. E. S., Carlsen, K. C. L., Guðmundsdóttir, H., Granum, B. B., Haugen, G. N., Hedlin, G., Jonassen, C. M., et al. (2024) · Allergy · doi:10.1111/all.16024 · Cited by 10 · see citing works
Inferring skin–brain–skin connections from infodemiology data using dynamic Bayesian networks
Scutari, M., Kérob, D., & Salah, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-60937-3 · Cited by 10 · see citing works
Pereira, L., & Valado, A. (2024) · doi:10.37349/eaa.2024.00035 · Cited by 8 · see citing works
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT
Bradshaw, L. E., Wyatt, L. A., Brown, S., Haines, R., Montgomery, A. A., Perkin, M. R., Sach, T., Lawton, S., Flohr, C., Ridd, M. J., et al. (2024) · Health Technology Assessment · doi:10.3310/rhdn9613 · Cited by 8 · see citing works
Dore, M. P., Meloni, T., Bassu, I., & Pes, G. M. (2024) · Helicobacter · doi:10.1111/hel.13107 · Cited by 7 · see citing works
Chong, Y. Y., Kwan, J. Y. M., Yau, P. T., Cheng, H. Y., & Chien, W. T. (2023) · Healthcare · doi:10.3390/healthcare11202708 · Cited by 6 · see citing works
“This is also supported by the shared immune dysregulation and inflammatory mechanisms observed in both conditions [72].”
BackgroundThe burden of dermatitis from 1990–2019 in the Middle East and North Africa region
Safiri, S., Jaberinezhad, M., Mousavi, S. E., Asghari, K. M., Shamekh, A., Nejadghaderi, S. A., Sullman, M. J. M., Houshyar, Y., Behrangi, E., & Kolahi, A. (2024) · BMC Public Health · doi:10.1186/s12889-024-17836-z · Cited by 9 · see citing works
Identification of potential causal metabolites associated with atopic dermatitis
Jia, Y., Wang, R., Sun, L., Guo, D., Shi, M., Zhang, K., Yang, P., Wang, Y., Liu, F., Chen, G.-C., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad005 · Cited by 6 · see citing works
Huang, J. W., Gui, Y., Wu, J., & Xie, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.956850 · Cited by 6 · see citing works
Hsin, L., Hew, M. J., Aui, P. M., Deckert, K., Hogarth, P. M., O’Hehir, R. E., & van Zelm, M. C. (2025) · Allergy · doi:10.1111/all.16513 · Cited by 5 · see citing works
Haran, K., Kranyak, A. C., Johnson, C. E., Smith, P. L., Farberg, A. S., Bhutani, T., & Liao, W. J. (2024) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s478377 · Cited by 5 · see citing works
Astavans, A., Park, K. J., Murali, S., & Lee, R. J. (2025) · Journal of Pediatric Orthopaedics · doi:10.1097/bpo.0000000000003126 · Cited by 4 · see citing works
Asthma biomarkers in children. new opportunities, real practice and frontiers
Pampura, A. N., Kamaev, A. V., & Lebedenko, A. A. (2022) · Medical Herald of the South of Russia · doi:10.21886/2219-8075-2022-13-2-91-101 · Cited by 4 · see citing works
Jakovljević, S., Barjaktarović, I., Jakovljevic, D., Levakov, O., & Vujanović, L. (2025) · Clinics and Practice · doi:10.3390/clinpract15110192 · Cited by 3 · see citing works
Liao, K., Chen, P., Hung, Y.-T., Hsu, T.-J., Tsai, F., & Shen, T. (2024) · Journal of Epidemiology and Global Health · doi:10.1007/s44197-024-00230-8 · Cited by 3 · see citing works
Ni, X., Li, X., & Li, J. (2025) · Brain and Behavior · doi:10.1002/brb3.70512 · Cited by 3 · see citing works
Diagnostic value of serum thymus and activation-regulated chemokine (TARC) in fatal asthma
Yamada, A., Kiryu, K., Takashino, S., Yoshida, M., Takeichi, T., & Kitamura, O. (2024) · Forensic Science International · doi:10.1016/j.forsciint.2024.112276 · Cited by 2 · see citing works
Cheng, W., Borsos, K., Wang, Z., Ledanois, O., Gall, R., Small, M., & Humphreys, R. (2025) · Journal of Asthma · doi:10.1080/02770903.2025.2513059 · Cited by 2 · see citing works
Wu, J., Shen, D., He, Y., He, J., Lu, H., Xu, Y., Huang, H., Tang, W., & Ye, C. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118806 · Cited by 2 · see citing works
Lim, J. J., Huang, Z., Loo, E. X. L., Liu, M. H., & Chew, F. T. (2025) · Journal of Asthma and Allergy · doi:10.2147/jaa.s538254 · Cited by 2 · see citing works
The Research Progress on the Relationship Between Asthma and Skin Barrier Damage
Yuan, J., Yu, Z., Wang, X., Feng, L., Tang, J., & Li, Z. (2026) · British Journal of Hospital Medicine · doi:10.31083/bjhm50386 · Cited by 2 · see citing works
Sung, Y.-Y., Joo, Y. H., Kim, S.-H., & Kim, D.-S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41140 · Cited by 2 · see citing works
Herzig, M., Hove, M. V., Bertsche, A., Lipek, T., Kieß, W., Bertsche, T., Prenzel, F., & Neininger, M. P. (2025) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-025-00961-8 · Cited by 2 · see citing works
Whittaker, H. R., Jani, M., Pearce, F., Bell, S., Kallis, C., Hawcutt, D. B., Brown, S., Neves, A. L., Robson, J. C., Shi, T., et al. (2025) · The Lancet Primary Care · doi:10.1016/j.lanprc.2025.100080 · Cited by 1 · see citing works
Clinical and immunological features of the atopic dermatitis in children
Belan, E. B., Chueva, M. A., & Садчикова, Т. Л. (2022) · Allergology and Immunology in Pediatrics · doi:10.53529/2500-1175-2022-4-36-41 · Cited by 1 · see citing works
Wildfires and Atopic Diseases: A Review
Ha, A., Balmes, J. R., & Wei, M. L. (2026) · Allergy · doi:10.1111/all.70116
Diet therapy as support for the treatment of atopic dermatitis
Chrzanowska, E., Winiarska‐Mieczan, A., & Jachimowicz-Rogowska, K. (2023) · Aesthetic Cosmetology and Medicine · doi:10.52336/acm.2023.010
Role of Atopic March in the Development of Adult Asthma
Askari, S., Asadi, P., Hematyar, M., Hashemitari, S. K., & Darougar, S. (2023) · Immunoregulation · doi:10.32598/immunoregulation.5.2.2
KARAKTERISTIK DAN PERJALANAN DERMATITIS ATOPIK DENGAN RIWAYAT ASMA BRONKIAL
Abelia, A. D. (2023) · Surabaya Biomedical Journal · doi:10.30649/sbj.v3i1.85
Shiroshita, A., Katakoa, Y., Wang, Q., Kajita, N., Anan, K., Tajima, T., & Yajima, N. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4823357
王, 影. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1482217
Risteska-Nejasmic, V. (2024) · South East European Journal of Immunology · doi:10.3889/seejim.2024.6078
Factors of allergic disease progression in children (literature review)
Tikhonova, E. S., Зыблева, С. В., & Мартинков, В. Н. (2024) · Medical and Biological Problems of Life Activity · doi:10.58708/2074-2088.2024-1(31)-22-29
Corbacho-Cordero, C. F., & Arias-Orellana, D. L. (2024) · Revista Pediátrica Especializada · doi:10.58597/rpe.v3i4.86
Multimorbidity in adult patients diagnosed with atopic dermatitis
Mućka, S., Miodońska, M., Mróz, M., Źlik, A., Grzanka, A., Pawłowicz, R., & Bożek, A. (2025) · Dermatology Reports · doi:10.4081/dr.2025.10039
Modelling Asthma Treatment Dynamics: Insights from the g-Formula
Mommers, I., van Boven, J. F. M., Bos, J., Mubarik, S., Hak, E., & Bijlsma, M. J. (2025) · Clinical Epidemiology · doi:10.2147/clep.s486869
Evidence of Eczematous Skin Characteristics in Mild Allergic Asthma
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Pu, Y., Liu, J., Bennett, A. N., & Chan, K. H. K. (2025) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2025.100568
Safiri, S., Jaberinezhad, M., Mousavi, S. E., Asghari, K. M., Shamekh, A., Nejadghaderi, S. A., Sullman, M. J. M., Houshyar, Y., Behrangi, E., & Kolahi, A.-A. (2024) · Figshare · doi:10.6084/m9.figshare.26678024
Safiri, S., Jaberinezhad, M., Mousavi, S. E., Asghari, K. M., Shamekh, A., Nejadghaderi, S. A., Sullman, M. J. M., Houshyar, Y., Behrangi, E., & Kolahi, A.-A. (2024) · Figshare · doi:10.6084/m9.figshare.26678021
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Safiri, S., Jaberinezhad, M., Mousavi, S. E., Asghari, K. M., Shamekh, A., Nejadghaderi, S. A., Sullman, M. J. M., Houshyar, Y., Behrangi, E., & Kolahi, A.-A. (2024) · Figshare · doi:10.6084/m9.figshare.26678030
IMMUNE STATUS OF PATIENTS WITH CHRONIC MICROBIAL ECZEMA AND ELEVATED IGG4 LEVELS TO MOLD ALLERGENS
Popova, I. B., Kaidashev, I. P., Yemchenko, Y. О., Васильєва, К. В., Reznichenko, N. Y., Kameniev, V. I., & Ishcheikin, K. Y. (2025) · World of Medicine and Biology · doi:10.26724/2079-8334-2025-3-93-120-124
Formation of the SFPQ/S100A8 Protein Complex in Human Keratinocyte and Bronchial Cells
Lee, J.-S. (2025) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2025.31.4.389
Recognising and managing acute asthma attacks in adults in the emergency department
Colton, S. (2026) · Emergency Nurse · doi:10.7748/en.2026.e2250
Groenestein, S. F. F., Plag, S., Dubbeldeman, E. M., Vermeiren, R. R. J. M., Bussemaker, J., van der Pas, S., & Crone, M. R. (2026) · BMJ Public Health · doi:10.1136/bmjph-2024-002032
Liu, Y., Zeng, Y., & Fu, B. M. (2026) · Biology · doi:10.3390/biology15181668
- Authors
- Yaneva, M., & Darlenski, R.
- Affiliations
- Acibadem City Clinic (BG)
- Trakia University (BG)
- Corresponding author
- Yaneva, Martina
- Venue
- Asthma Research and Practice
- Published
- 2021-12
- Volume
- 7
- Issue
- 1
- Pages
- 16-16
- ISSN
- 2054-7064 (ISSN-L)
- PMC
- PMC8672460
- OpenAlex
- W4200410909
- Cited by
- 60
- References
- 83
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 24 · 2023: 10 · 2022: 7
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Asthma Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- atopic dermatitis, asthma, atopic march, immunological imbalance, atopic diseases, disease phenotypes, biomarkers, disease progression, comorbidities, targeted therapy
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