The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
Open accessAbstract
Background The mechanisms contributing to clinical immune tolerance remain incompletely understood. This study provides evidence for specific immune mechanisms that are associated with a model of operationally defined clinical tolerance. Objective Our overall objective was to study laboratory changes associated with clinical immune tolerance in antigen-induced T cells, basophils, and antibodies in subjects undergoing oral immunotherapy (OIT) for peanut allergy. Methods In a phase 1, single site study, we studied participants (n=23) undergoing peanut OIT and compared them to age-matched allergic controls (n=20) undergoing standard of care (abstaining from peanut) for 24 months. Participants were operationally defined as clinically immune tolerant (IT) if they had no detectable allergic reactions to a peanut oral food challenge after 3 months of therapy withdrawal (IT, n=7) while those that had an allergic reaction were categorized as non-tolerant (NT, n=13). Results Antibody and basophil activation measurements did not statistically differentiate between NT vs. IT. However, T-cell function and demethylation of FOXP3 CpG sites in antigen-induced Treg were significantly different between IT vs. NT participants. When IT participants were withdrawn from peanut therapy for an additional 3 months (total of 6 months); only 3 participants remained "immune tolerant" and 4 participants regained sensitivity along with increased methylation of FOXP3 CpG sites in antigen-induced Treg. Conclusion In summary, modifications at the DNA level of antigen-induced T-cell subsets may be predictive of a state of operationally-defined clinical "immune tolerance" during peanut OIT.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
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“Type 1 regulatory T (TR1) cells release IL-10(29,41,42) and express CD4, CD49, and lymphocyte activation gene 3 (LAG3) on their surfaces,(29,41,42) which differs from nTreg cell expression of CD4, CD25, CD127, and perhaps Helios on their surfaces.(25-27,43-46) We hypothesized that iTreg cells (CD4(1)CD25 cells prolife…”
BackgroundFoxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Regulatory T cells: mechanisms of differentiation and function
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Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
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Cited by
Sicherer, S. H., & Sampson, H. A. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.11.003 · Cited by 1,628
Food allergy: immune mechanisms, diagnosis and immunotherapy
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Self-citationShamji, M. H., Kappen, J. H., Akdis, M., Jensen‐Jarolim, E., Knol, E. F., Kleine‐Tebbe, J., Bohle, B., Chaker, A. M., Till, S. J., Valenta, R., et al. (2017) · Allergy · doi:10.1111/all.13138 · Cited by 382
Regulatory T cells in allergic diseases
Noval Rivas, M., & Chatila, T. A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.003 · Cited by 373
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Metadata
- Authors
- Syed, A., Garcia, M. A., Lyu, S.-C., Bucayu, R., Kohli, A., Ishida, S., Berglund, J. P., Tsai, M., Maecker, H., O’Riordan, G., Galli, S. J., & Nadeau, K. C.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 133
- Issue
- 2
- Pages
- 500-510.e11
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1969953062
- Cited by
- 490
- References
- 10
- FWCI
- 39.10
- Type
- journal article
- Language
- en
- Open access
- green
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