Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis
Open accessAbstract
Background The stratum corneum and tight junctions (TJs) form physical barriers in the epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture external antigens in mice. LCs and inflammatory dendritic epidermal cells (IDECs) are observed in the skin of patients with atopic dermatitis (AD). Objective We sought to investigate the characteristics of LCs and IDECs and the distribution of their antigen capture receptors in relation to TJs in normal and AD skin. Methods We characterized the interactions of LCs and IDECs with TJs and the expression patterns of langerin and FcεRI by using whole-mount epidermal sheets from healthy subjects and patients with AD, ichthyosis vulgaris, and psoriasis vulgaris. Results As in mouse skin, activated LCs penetrate TJs in human skin. The number of LCs with TJ penetration increased approximately 5-fold in erythematous lesional skin of patients with AD but not in nonlesional skin of patients with AD or lesions of patients with ichthyosis vulgaris or psoriasis. In contrast, IDECs localized in the lower part of the epidermis, and their dendrites extended horizontally without penetration through TJs. Although langerin accumulated on the tips of dendrites of activated LCs, FcεRI was expressed diffusely on the cell surfaces on LCs and IDECs in lesional skin from patients with AD. Conclusions These findings highlight interesting differences between LCs and IDECs in epidermis of patients with AD, where LCs, but not IDECs, extend dendrites through the TJs, likely to capture antigens from outside the TJ barrier with a polarized distribution of langerin but not FcεRI. These behavioral differences between skin dendritic cells might reflect an important pathophysiology of AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The mammalian skin consists of two sets of barriers: the stratum corneum and tight junctions in the stratum granulosum.
“The mammalian skin consists of two sets of barriers: one is the stratum corneum and the other is TJs in the stratum granulosum.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [17]
The stratum granulosum contains tight junctions that seal intercellular spaces and control the intercellular transport of water, solutes, and water-soluble molecules.
“The stratum granulosum contains tight junctions (TJs) that seal intercellular spaces and control the intercellular transport of water, solutes, and water-soluble morecules17.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [17]
Langerhans cells on the inside of the stratum spinosum can extend their dendrites to outside the tight junctions in the stratum granulosum to capture antigens.
“LCs on the inside of the stratum spinosum can extend their dendrites to outside the TJs in the stratum granulosum to capture antigens17, 19.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597 · see citing works
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works
Bieber, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra074081 · Cited by 1,780 · see citing works
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512 · see citing works
Self-citationLoss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works
One remarkable molecule: filaggrin
Brown, S. J., & Irwin McLean, W. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.393 · Cited by 527 · see citing works
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
Kubo, A., Nagao, K., Yokouchi, M., Sasaki, H., & Amagai, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091527 · Cited by 491 · see citing works
Self-citationLoss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
Brown, S., Asai, Y., Cordell, H. J., Campbell, L., Zhao, Y., Liao, H., Northstone, K., Henderson, J., Alizadehfar, R., Ben‐Shoshan, M., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.031 · Cited by 477 · see citing works
Sénéschal, J., Clark, R. A., Gehad, A. E., Baecher‐Allan, C., & Kupper, T. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.018 · Cited by 455 · see citing works
Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease
Rodríguez, E., Baurecht, H., Herberich, E., Wagenpfeil, S., Brown, S., Cordell, H. J., Irvine, A. D., & Weidinger, S. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.036 · Cited by 428 · see citing works
Wollenberg, A., Kraft, S., Hanau, D., & Bieber, T. R. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343596 · Cited by 414 · see citing works
The immunogenetics of asthma and eczema: a new focus on the epithelium
Cookson, W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1500 · Cited by 387 · see citing works
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
Kubo, A., Nagao, K., & Amagai, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57416 · Cited by 378 · see citing works
Self-citationMolecular Structure of Tight Junctions and Their Role in Epithelial Transport
Anderson, J. M. (2001) · Physiology · doi:10.1152/physiologyonline.2001.16.3.126 · Cited by 348 · see citing works
Nagao, K., Kobayashi, T., Moro, K., Ohyama, M., Adachi, T., Kitashima, D. Y., Ueha, S., Horiuchi, K., Tanizaki, H., Kabashima, K., et al. (2012) · Nature Immunology · doi:10.1038/ni.2353 · Cited by 319 · see citing works
Self-citationCOOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos
Chen, Y., Merzdorf, C., Paul, D. L., & Goodenough, D. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.891 · Cited by 302 · see citing works
Loss-of-Function Mutations in the Filaggrin Gene and Allergic Contact Sensitization to Nickel
Novak, N., Baurecht, H., Schäfer, T., Rodríguez, E., Wagenpfeil, S., Klopp, N., Heinrich, J., Behrendt, H., Ring, J., Wichmann, E., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701190 · Cited by 296 · see citing works
Roehr, C. C., Reibel, S., Ziegert, M., Sommerfeld, C., Wahn, U., & Niggemann, B. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112849 · Cited by 296 · see citing works
Darsow, U. G., Laifaoui, J., Kerschenlohr, K., Wollenberg, A., Bernhard Przybilla, A., Wüthrich, B., Borelli, S., Giusti, F., Seidenari, S., Drzimalla, K., et al. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00556.x · Cited by 274 · see citing works
Nakajima, S., Igyártó, B. Z., Honda, T., Egawa, G., Otsuka, A., Hara‐Chikuma, M., Watanabe, N., Ziegler, S. F., Tomura, M., Inaba, K., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.063 · Cited by 244 · see citing works
Phenotypic and functional characteristics of in vivo-activated Langerhans cells.
Aiba, S., & Katz, S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.9.2791 · Cited by 234 · see citing works
Filaggrin null mutations are associated with increased asthma severity in children and young adults
Palmer, C. N. A., Ismail, T., Lee, S. P., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Smith, F. J. D., McLean, W. H. I., & Mukhopadhyay, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.001 · Cited by 229 · see citing works
The filaggrin story: novel insights into skin-barrier function and disease
McGrath, J. A., & Uitto, J. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.10.006 · Cited by 224 · see citing works
Wollenberg, A., Oppel, T., Schottdorf, E.-M., Günther, S., Moderer, M., & Mommaas, M. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01665.x · Cited by 218 · see citing works
Novak, N., Valenta, R., Bohle, B., Laffer, S., Haberstok, J., Kraft, S., & Bieber, T. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.02.005 · Cited by 189 · see citing works
Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema
Nemoto‐Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I., & Shimizu, H. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.280 · Cited by 180 · see citing works
Self-citationWollenberg, A., Sharma, S., von Bubnoff, D., Geiger, E., Haberstok, J., & Bieber, T. R. M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112942 · Cited by 172 · see citing works
Langerhans cells are precommitted to immune tolerance induction
Shklovskaya, E., O’Sullivan, B., Ng, L. G., Roediger, B., Thomas, R., Weninger, W., & Groth, B. F. D. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110076108 · Cited by 166 · see citing works
Tight junctions form a barrier in human epidermis
Kirschner, N., Houdek, P., Fromm, M., Moll, I., & Brandner, J. M. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.07.010 · Cited by 139 · see citing works
Schuttelaar, M. L. A., Kerkhof, M., Jonkman, M. F., Koppelman, G. H., Brunekreef, B., de Jongste, J. C., Wijga, A. H., McLean, W. H. I., & Postma, D. S. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02080.x · Cited by 138 · see citing works
Kerschenlohr, K., Decard, S., Bernhard Przybilla, A., & Wollenberg, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1347 · Cited by 138 · see citing works
Ouchi, T., Kubo, A., Yokouchi, M., Adachi, T., Kobayashi, T., Kitashima, D. Y., Fujii, H., Clausen, B. E., Koyasu, S., Amagai, M., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20111718 · Cited by 129 · see citing works
Self-citationYoshida, K., Yokouchi, M., Nagao, K., Ishii, K., Amagai, M., & Kubo, A. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.04.021 · Cited by 115 · see citing works
Self-citationYuki, T., Hachiya, A., Kusaka, A., Sriwiriyanont, P., Visscher, M. O., Morita, K., Muto, M., Miyachi, Y., Sugiyama, Y., & Inoue, S. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.385 · Cited by 113 · see citing works
Bieber, T. R. M., Dannenberg, B., Prinz, J. C., Rieber, E. P., Stolz, W., Braun‐Falco, O., & Ring, J. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12277574 · Cited by 96 · see citing works
Hoetzenecker, W., Ecker, R., Kopp, T., Stuetz, A., Stingl, G., & Elbe‐Bürger, A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.011 · Cited by 94 · see citing works
van der Aar, A. M. G., Picavet, D. I., Muller, F. J. M., de Boer, L., van Capel, T. M. M., Zaat, S. A. J., Bos, J. D., Janssen, H., George, T. C., Kapsenberg, M. L., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.500 · Cited by 90 · see citing works
Langerhans' cell granule. An endocytotic organelle
Hashimoto, K. (1971) · Archives of Dermatology · doi:10.1001/archderm.104.2.148 · Cited by 89 · see citing works
Altered expression of occludin and tight junction formation in psoriasis
Yoshida, Y., Morita, K., Mizoguchi, A., Idé, C., & Miyachi, Y. (2001) · Archives of Dermatological Research · doi:10.1007/s004030100221 · Cited by 86 · see citing works
Bieber, T. R. M. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.03.001 · Cited by 70 · see citing works
Bieber, T. R. M., Ring, J., & Braun‐Falco, O. (1988) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1988.tb02432.x · Cited by 70 · see citing works
Immunoglobulin e-bearing antigen-presenting cells in atopic dermatitis
Novak, N., Bieber, T. R. M., & Kraft, S. (2004) · Current Allergy and Asthma Reports · doi:10.1007/s11882-004-0069-2 · Cited by 68 · see citing works
Schuller, E., Oppel, T., Bornhövd, E., Wetzel, S., & Wollenberg, A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.021 · Cited by 64 · see citing works
Uno, H., & Hanifin, J. M. (1980) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12521130 · Cited by 62 · see citing works
Basu, K., Palmer, C. N. A., Lipworth, B. J., McLean, W. H. I., Terron‐Kwiatkowski, A., Zhao, Y., Liao, H., Smith, F. J. D., Mitra, A. A., & Mukhopadhyay, S. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01660.x · Cited by 50 · see citing works
Dermatology in the Darwin anniversary. Part 1: Evolution of the integument
Schempp, C. M., Emde, M., & Wölfle, U. (2009) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2009.07193.x · Cited by 46 · see citing works
Ishida‐Yamamoto, A., Kishibe, M., Murakami, M., Honma, M., Takahashi, H., & Iizuka, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031641 · Cited by 38 · see citing works
The mode of topical immunomodulators in the immunological network of atopic dermatitis
Novak, N., Kwiek, B., & Bieber, T. R. M. (2005) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2005.01709.x · Cited by 32 · see citing works
Reynolds, N. J., YI, J. Y., Fisher, G. J., Cooper, K. D., Voorhees, J. J., & Griffiths, C. E. M. (1995) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb02611.x · Cited by 30 · see citing works
Goto, T., Soma, Y., Ra, C., Kawa, Y., Kubota, Y., & Mizoguchi, M. (2001) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00130-x · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Langan, S., Irvine, A. D., & Weidinger, S. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31286-1 · Cited by 1,943 · see citing works
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549 · see citing works
Noda, S., Suárez-Fariñas, M., Ungar, B., Kim, S. J., de Guzman Strong, C., Xu, H., Peng, X., Estrada, Y. D., Nakajima, S., Honda, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.015 · Cited by 657 · see citing works
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis
Dainichi, T., Kitoh, A., Otsuka, A., Nakajima, S., Nomura, T., Kaplan, D. H., & Kabashima, K. (2018) · Nature Immunology · doi:10.1038/s41590-018-0256-2 · Cited by 392 · see citing works
Self-citationNakatsuji, T., Chen, T. H., Two, A. M., Chun, K., Narala, S., Geha, R. S., Hata, T. R., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.127 · Cited by 365 · see citing works
Muraro, A. M., Lemanske, R. F., Hellings, P. W., Akdiş, C. A., Bieber, T. R. M., Casale, T. B., Jutel, M., Ong, P. Y., Poulsen, L. K., Schmid‐Grendelmeier, P., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.03.010 · Cited by 283 · see citing works
Pathogenesis of atopic dermatitis
Peng, W., & Novak, N. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12495 · Cited by 263 · see citing works
Epithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251 · see citing works
Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis
Beck, L. A., Cork, M. J., Amagai, M., Benedetto, A. D., Kabashima, K., Hamilton, J. D., & Rossi, A. B. (2022) · JID Innovations · doi:10.1016/j.xjidi.2022.100131 · Cited by 258 · see citing works
Self-citationThe role of tight junctions in skin barrier function and dermal absorption
Bäsler, K., Bergmann, S., Heisig, M., Nägel, A., Zorn‐Kruppa, M., & Brandner, J. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.08.007 · Cited by 245 · see citing works
Gorzelanny, C., Meß, C., Schneider, S. W., Huck, V., & Brandner, J. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070684 · Cited by 236 · see citing works
Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents
Luger, T. A., Amagai, M., Dréno, B., Dagnelie, M., Liao, W. J., Kabashima, K., Schikowski, T., Proksch, E., Elias, P. M., Simon, M., et al. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.04.007 · Cited by 217 · see citing works
Self-citationDavidson, W. F., Leung, D. Y. M., Beck, L. A., Berin, M. C., Boguniewicz, M., Busse, W. W., Chatila, T. A., Geha, R. S., Gern, J. E., Guttman‐Yassky, E., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.01.003 · Cited by 201 · see citing works
Cutaneous barrier dysfunction in allergic diseases
Leung, D. Y. M., Berdyshev, E., & Goleva, E. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.021 · Cited by 190 · see citing works
The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis
Otsuka, A., Nomura, T., Rerknimitr, P., Seidel, J. A., Honda, T., & Kabashima, K. (2017) · Immunological Reviews · doi:10.1111/imr.12545 · Cited by 185 · see citing works
Self-citationThe epithelial barrier theory and its associated diseases
Sun, N., Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Bu, X., Li, M., Zhu, X., Babayev, H., Ardıçlı, S., et al. (2024) · Allergy · doi:10.1111/all.16318 · Cited by 188 · see citing works
Wall Teichoic Acid in Staphylococcus aureus Host Interaction
van Dalen, R., Peschel, A., & van Sorge, N. M. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.05.017 · Cited by 139 · see citing works
Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
Bergmann, S., von Buenau, B., Vidal‐y‐Sy, S., Haftek, M., Wladykowski, E., Houdek, P., Lezius, S., Duplan, H., Bäsler, K., Dähnhardt‐Pfeiffer, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-58718-9 · Cited by 137 · see citing works
Skin barrier in atopic dermatitis: beyond filaggrin
Zaniboni, M. C., Samorano, L. P., Orfali, R. L., & Aoki, V. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164412 · Cited by 121 · see citing works
Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection
Rhodes, J. W., Tong, O., Harman, A. N., & Turville, S. G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01088 · Cited by 117 · see citing works
Dyjack, N. T., Goleva, E., Rios, C. L., Kim, B. E., Bin, L., Taylor, P. A., Bronchick, C., Hall, C. F., Richers, B. N., Seibold, M. A., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.10.046 · Cited by 121 · see citing works
Identification of HIV transmitting CD11c+ human epidermal dendritic cells
Bertram, K. M., Botting, R. A., Baharlou, H., Rhodes, J. W., Rana, H., Graham, J. D., Patrick, E., Fletcher, J., Plasto, T. M., Truong, N. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10697-w · Cited by 115 · see citing works
C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens
Mnich, M. E., van Dalen, R., & van Sorge, N. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00309 · Cited by 112 · see citing works
Tight junctions in skin inflammation
Bäsler, K., & Brandner, J. M. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1903-9 · Cited by 105 · see citing works
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903
Moosbrugger‐Martinz, V., Schmuth, M., & Dubrac, S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6786-5_8 · Cited by 99 · see citing works
Fujii, M. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00088 · Cited by 99 · see citing works
Otsuka, M., Egawa, G., & Kabashima, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01768 · Cited by 97 · see citing works
Roach, K. A., Stefaniak, A. B., & Roberts, J. R. (2019) · Journal of Immunotoxicology · doi:10.1080/1547691x.2019.1605553 · Cited by 85 · see citing works
Genetic and Immunological Pathogenesis of Atopic Dermatitis
Schuler, C. F., IV, Tsoi, L. C., Billi, A. C., Harms, P. W., Weidinger, S., & Gudjonsson, J. E. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.10.019 · Cited by 92 · see citing works
Emmert, H., Baurecht, H., Thielking, F., Stölzl, D., Rodríguez, E., Harder, I., Proksch, E., & Weidinger, S. (2020) · Experimental Dermatology · doi:10.1111/exd.14185 · Cited by 81 · see citing works
Maintenance of tight junction barrier integrity in cell turnover and skin diseases
Yokouchi, M., & Kubo, A. (2018) · Experimental Dermatology · doi:10.1111/exd.13742 · Cited by 79 · see citing works
Self-citationSimon, D., Page, B., Vogel, M., Bussmann, C., Blanchard, C., Straumann, A., & Simon, H. (2017) · Allergy · doi:10.1111/all.13244 · Cited by 77 · see citing works
Importance of Tight Junctions in Relation to Skin Barrier Function
Brandner, J. M. (2016) · Current problems in dermatology · doi:10.1159/000441541 · Cited by 75 · see citing works
Allergic Responses Induced by the Immunomodulatory Effects of Nanomaterials upon Skin Exposure
Yoshioka, Y., Kuroda, E., Hirai, T., Tsutsumi, Y. M., & Ishii, K. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00169 · Cited by 69 · see citing works
Self-citationElectrical aspects of skin as a pathway to engineering skin devices
Abe, Y., & Nishizawa, M. (2021) · APL Bioengineering · doi:10.1063/5.0064529 · Cited by 68 · see citing works
Telocyte dynamics in psoriasis
Manole, C. G., Gherghiceanu, M., & Simionescu, O. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12601 · Cited by 66 · see citing works
Park, S., Matte-Martone, C. C., Gonzalez, D. G., Lathrop, E., May, D. P., Pineda, C. M., Moore, J. L., Boucher, J. D., Marsh, E. D., Schmitter-Sánchez, A. D., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00670-5 · Cited by 60 · see citing works
Atopic Dermatitis: Collegium Internationale Allergologicum (CIA) Update 2019
Simon, D., Wollenberg, A., Renz, H. E., & Simon, H. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000497383 · Cited by 63 · see citing works
Role of Innate Immunity in Allergic Contact Dermatitis: An Update
Yamaguchi, H. L., Yamaguchi, Y., & Peeva, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612975 · Cited by 70 · see citing works
DUCA, E. D., He, H., Liu, Y., Pagan, A. D., David, E., Cheng, J., Carroll, B. E., Renert‐Yuval, Y., Bar, J., Estrada, Y. D., et al. (2023) · Allergy · doi:10.1111/all.15845 · Cited by 58 · see citing works
Fukuie, T., Hirakawa, S., Narita, M., Nomura, I., Matsumoto, K., TOKURA, Y., & Ohya, Y. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13408 · Cited by 57 · see citing works
Lung colonization by Aspergillus fumigatus is controlled by ZNF77
Gago, S., Overton, N. L. D., Ben-Ghazzi, N., Novak-Frazer, L., Read, N. D., Denning, D. W., & Bowyer, P. (2018) · Nature Communications · doi:10.1038/s41467-018-06148-7 · Cited by 51 · see citing works
The role of Langerhans cells in pathologies of the skin
Rajesh, A., Wise, L. M., & Hibma, M. H. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12253 · Cited by 50 · see citing works
The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review
Katsarou, S., Makris, M. P., Vakirlis, E., & Gregoriou, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041538 · Cited by 47 · see citing works
Sicherer, S. H., & Leung, D. Y. M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1906 · Cited by 44 · see citing works
Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells
Leitch, C. S., Natafji, E., Yu, C., Ghaffar, S. A., Madarasingha, N. P., Venables, Z. C., Chu, R., Fitch, P. M., Muinonen‐Martin, A., Campbell, L., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.040 · Cited by 43 · see citing works
Immunopathology and Immunotherapy of Inflammatory Skin Diseases
Song, A., Lee, S. E., & Kim, J. H. (2022) · Immune Network · doi:10.4110/in.2022.22.e7 · Cited by 46 · see citing works
Atopic dermatitis: pathogenesis and therapeutic intervention
Yue, C., Zhou, H., Wang, X., Yu, J., Hu, Y., Zhou, P., Zhao, F., Zeng, F., Li, G., Li, Y., et al. (2024) · MedComm · doi:10.1002/mco2.70029 · Cited by 50 · see citing works
Natsume, O., & Ohya, Y. (2017) · Allergology International · doi:10.1016/j.alit.2017.11.003 · Cited by 41 · see citing works
How dendritic cells sense and respond to viral infections
Marongiu, L., Valache, M., Facchini, F. A., & Granucci, F. (2021) · Clinical Science · doi:10.1042/cs20210577 · Cited by 41 · see citing works
Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)
Ahmad, F., Döbel, T., Schmitz, M., & Schäkel, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00948 · Cited by 41 · see citing works
Zhou, J., Liang, G., Liu, L., Feng, S., Zheng, Z., Wu, Y., Chen, X., Li, X., Wang, L., Wang, L., et al. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19256 · Cited by 37 · see citing works
Topical therapy of atopic dermatitis with a focus on pimecrolimus
Luger, T. A., Paller, A. S., Irvine, A. D., Sidbury, R., Eichenfield, L. F., Werfel, T., & Bieber, T. R. M. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17272 · Cited by 39 · see citing works
The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms
Smith, A. R., Knaysi, G. A., Wilson, J. M., & Wiśniewski, J. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0674-5 · Cited by 37 · see citing works
Monte, A. D., Olivieri, C.-V., Vitale, S., Bailleux, S., Castillo, L., Giordanengo, V., Maryanski, J. L., Segura, É., & Doglio, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00197 · Cited by 33 · see citing works
Management of Severe Atopic Dermatitis in Pediatric Patients
Mancuso, J., Lee, S. S., Paller, A. S., Ohya, Y., & Eichenfield, L. F. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.02.017 · Cited by 33 · see citing works
Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis
Tanei, R., & Hasegawa, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126682 · Cited by 33 · see citing works
Wang, X., Mao, D., Jia, J., & Zhang, J. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.027 · Cited by 33 · see citing works
Moosbrugger‐Martinz, V., Tripp, C. H., Clausen, B. E., Schmuth, M., & Dubrac, S. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12806 · Cited by 31 · see citing works
Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases
Itamura, M., & Sawada, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113445 · Cited by 30 · see citing works
Schafer, P. H., Adams, M., Horan, G. S. B., Truzzi, F., Marconi, A., & Pincelli, C. (2019) · Drugs in R&D · doi:10.1007/s40268-019-00284-1 · Cited by 30 · see citing works
Aeroallergens in atopic dermatitis and chronic urticaria
Chong, A. C., Chwa, W. J., & Ong, P. Y. (2022) · Current Allergy and Asthma Reports · doi:10.1007/s11882-022-01033-2 · Cited by 30 · see citing works
Type 2 immunity‐driven diseases: Towards a multidisciplinary approach
Hassoun, D., Malard, O., Barbarot, S., Magnan, A., & Colas, L. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.14029 · Cited by 30 · see citing works
Ouchi, T., Nakato, G., & Udey, M. C. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.04.005 · Cited by 27 · see citing works
Langerhans cells mediate the skin‐induced tolerance to ovalbumin via Langerin in a murine model
Luo, Y., Wang, S., Liu, X., Wen, H., Li, W., & Yao, X. (2019) · Allergy · doi:10.1111/all.13813 · Cited by 27 · see citing works
Oh, J.-S., Lee, S.-J., & Choung, S. (2021) · Nutrients · doi:10.3390/nu13093209 · Cited by 27 · see citing works
Morphological characteristics and notes of the skin in preclinical toxicity assessment
Moroki, T. (2023) · Journal of Toxicologic Pathology · doi:10.1293/tox.2022-0103 · Cited by 26 · see citing works
Zanella, S., Berti, E., Bonometti, A., & ONLUS, F. A. I. R. I. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19095 · Cited by 25 · see citing works
Knaysi, G. A., Smith, A. R., Wilson, J. M., & Wiśniewski, J. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0675-4 · Cited by 26 · see citing works
Langerhans cells: Central players in the pathophysiology of atopic dermatitis
Pan, Y., Hochgerner, M., Cichoń, M. A., Benezeder, T., Bieber, T. R. M., & Wolf, P. (2024) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.20291 · Cited by 26 · see citing works
Barrier Integrity and Immunity: Exploring the Cutaneous Front Line in Health and Disease
Fukuda, K., Ito, Y., & Amagai, M. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082323-030832 · Cited by 26 · see citing works
Self-citationMurai, H., Tadokoro, R., Sakai, K., & Takahashi, Y. (2015) · Development Growth & Differentiation · doi:10.1111/dgd.12201 · Cited by 23 · see citing works
IL-37 Targets TSLP-Primed Basophils to Alleviate Atopic Dermatitis
Hou, T., Tsang, M. S., Kan, L. L., Li, P., Chu, I. M., Lam, C. W.-K., & Wong, C. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147393 · Cited by 23 · see citing works
Zhang, Y. C., Du, W., Zhu, D., Li, M., Qu, L., Rao, G.-X., Lin, Y., Tong, X., Sun, Y., & Huang, F. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109102 · Cited by 23 · see citing works
Cutaneous Adverse Events Following Nemolizumab Administration: A Review
Mima, Y., Yamamoto, M., & Iozumi, K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14093026 · Cited by 23 · see citing works
Frombach, J., Unbehauen, M. L., Kurniasih, I., Schumacher, F., Volz, P., Hadam, S., Rancan, F., Blume‐Peytavi, U., Kleuser, B., Haag, R., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.028 · Cited by 22 · see citing works
Skin Barrier Function and Atopic Dermatitis
Rerknimitr, P., Otsuka, A., Nakashima, C., & Kabashima, K. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0232-y · Cited by 21 · see citing works
Effect of a Product Containing Xyloglucan and Pea Protein on a Murine Model of Atopic Dermatitis
Campolo, M., Casili, G., Paterniti, I., Filippone, A., Lanza, M., Ardizzone, A., Scuderi, S. A., Cuzzocrea, S., & Esposito, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103596 · Cited by 21 · see citing works
Hirai, K. E., Aarão, T. L. D. S., Silva, L. M., de Sousa, J. R., de Souza, J., Dias, L. B., Carneiro, F. R. O., Fuzii, H. T., & Quaresma, J. A. S. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.11.013 · Cited by 20 · see citing works
Enhancing tumor specific immune responses by transcutaneous vaccination
Saliba, H., Heurtault, B., Bouharoun‐Tayoun, H., Flacher, V., Frisch, B., Fournel, S., & Chamat, S. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1382357 · Cited by 20 · see citing works
Matsumoto, K., Mori, R., Miyazaki, C., Ohya, Y., & Saito, H. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.033 · Cited by 19 · see citing works
CD1a function in human skin disease
de Jong, A., & Ogg, G. S. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.006 · Cited by 19 · see citing works
Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis
Baran, W., Oehrl, S., Ahmad, F., Döbel, T., Alt, C., Buske-Kirschbaum, A., Schmitz, M., & Schäkel, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01352 · Cited by 18 · see citing works
Management of Infant Atopic Eczema to Prevent Severe Eczema and Food Allergy
Yamamoto‐Hanada, K., & Ohya, Y. (2024) · Clinical & Experimental Allergy · doi:10.1111/cea.14515 · Cited by 20 · see citing works
Möckel, M., Cruz, N. C. D. L., Rübsam, M., Wirtz, L., Tantcheva‐Poór, I., Malter, W., Zinser, M. J., Bieber, T. R. M., & Knebel-Mörsdorf, D. (2022) · Journal of Virology · doi:10.1128/jvi.00864-22 · Cited by 17 · see citing works
Mitsui, M., Shoda, T., Natsume, O., Nomura, I., Narita, M., Fukuda, A., Sakamoto, S., Kasahara, M., & Ohya, Y. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.04.013 · Cited by 17 · see citing works
Hong, C.-H., Lin, S.-H., Clausen, B. E., & Lee, C.-H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917479117 · Cited by 17 · see citing works
Xenobiotic Receptors and Their Mates in Atopic Dermatitis
Minzaghi, D., Pavel, P., & Dubrac, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174234 · Cited by 16 · see citing works
Relationship of skin barrier breakdown and eosinophilic esophagitis
Simon, D., & Simon, H. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.005 · Cited by 13 · see citing works
Role of skin management in the prevention of atopic dermatitis and food allergy
Tham, E. H., Yamamoto‐Hanada, K., Leung, A. S. Y., & Ohya, Y. (2024) · Pediatric Allergy and Immunology · doi:10.1111/pai.14094 · Cited by 13 · see citing works
Duality at the gate: Skin dendritic cells as mediators of vaccine immunity and tolerance
Nirschl, C. J., & Anandasabapathy, N. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1066050 · Cited by 13 · see citing works
Moran, M. C., Brewer, M. G., Schlievert, P. M., & Beck, L. A. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01684-23 · Cited by 13 · see citing works
Gonnet, J., Perrin, H., Hutton, A. J., Boccara, D., Bonduelle, O., Mimoun, M., Atlan, M., Soria, A., & Combadière, B. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16721 · Cited by 10 · see citing works
The roles of innate immune cells in atopic dermatitis
Pan, Y., Wang, Y., Xu, M., Zhong, M., Peng, X., Zeng, K., & Huang, X. (2024) · Journal of Innate Immunity · doi:10.1159/000539534 · Cited by 9 · see citing works
Food-induced anaphylaxis in two patients who were using soap containing foodstuffs
Tamagawa‐Mineoka, R., Masuda, K., Yagami, A., Nakamura, M., Sato, N., Matsunaga, K., & Katoh, N. (2018) · Allergology International · doi:10.1016/j.alit.2018.02.013 · Cited by 9 · see citing works
Horváth, D., Pénzes, Z., Molnár, P., Rebenku, I., Vereb, G., Szántó, M., Muzsai, S., Szegedi, A., Dajnoki, Z., Pázmándi, K., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1593141 · Cited by 7 · see citing works
Tanei, R., & Hasegawa, Y. (2021) · Dermatopathology · doi:10.3390/dermatopathology8030045 · Cited by 8 · see citing works
Whole‐Mount Preparation and Microscopic Analysis of Epidermis
Kubo, A., Aoki, S., & Fujita, H. (2022) · Current Protocols · doi:10.1002/cpz1.464 · Cited by 8 · see citing works
Self-citationThe Acari Hypothesis, III: Atopic Dermatitis
Retzinger, A. C., & Retzinger, G. S. (2022) · Pathogens · doi:10.3390/pathogens11101083 · Cited by 8 · see citing works
Matsumoto, K., & Saito, H. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.006 · Cited by 8 · see citing works
- Authors
- Yoshida, K., Kubo, A., Fujita, H., Yokouchi, M., Ishii, K., Kawasaki, H., Nomura, T., Shimizu, H., Kouyama, K., Ebihara, T., Nagao, K., & Amagai, M.
- Affiliations
- Keio University (JP)
- Toho University (JP)
- Hokkaido University (JP)
- Corresponding author
- Kubo, Akiharu
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 134
- Issue
- 4
- Pages
- 856-864
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2008105086
- Cited by
- 145
- References
- 51
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 16 · 2018: 13 · 2017: 20 · 2016: 17 · 2015: 6 · 2014: 1
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Keio University
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Cosmetology Research Foundation
- Japan Society for the Promotion of Science (25670507, 26293259, 26893260, 24390152)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- Langerhans cells, dendritic epidermal T cells, atopic dermatitis, tight junctions, antigen capture, Langerin, FcεRI, skin barrier, dendritic cell polarization, ichthyosis vulgaris, plaque psoriasis
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Dendritic Cells, Dermatitis, Atopic, Epidermis, Humans, Langerhans Cells, Microscopy, Electron, Scanning, Organ Culture Techniques, Psoriasis, Antigens, CD, Ichthyosis Vulgaris, Receptors, IgE, Antigen Presentation, Tight Junctions, Lectins, C-Type, Mannose-Binding Lectins, Mice, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
