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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Open accessAbstract
There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.
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Metadata
- Authors
- Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., Frei, R., Garbani, M., Globinska, A., Hess, L., Huitema, C., Kubo, T., Komlosi, Z., Konieczna, P., Kovacs, N., Kucuksezer, U. C., Meyer, N., Morita, H., Olzhausen, J., O'Mahony, L., Pezer, M., Prati, M., Rebane, A., Rhyner, C., Rinaldi, A., Sokolowska, M., Stanic, B., Sugita, K., Treis, A., van de Veen, W., Wanke, K., Wawrzyniak, M., Wawrzyniak, P., Wirz, O. F., Zakzuk, J. S., & Akdis, C. A.
- Affiliations
- University of Zurich (CH)
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 138
- Issue
- 4
- Pages
- 984-1010
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2517700447
- Cited by
- 912
- References
- 222
- Citations by year
- 2026: 57 · 2025: 117 · 2024: 102 · 2023: 108 · 2022: 119 · 2021: 128 · 2020: 97 · 2019: 75 · 2018: 64 · 2017: 39 · 2016: 4
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (acceptedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Swiss National Science Foundation (310030_156823, 320030-159870)
- Christine Kühne-Center for Allergy Research and Education (CK-CARE)
- PREDICTA
- European Commission's Seventh Framework programme (260895, 261357)
- GlaxoSmithKline
- European Academy of Allergy and Clinical Immunology
- Global Allergy and Asthma European Network (GA2LEN)
- International Society for Applied Biological Sciences
- Commission for Technology and Innovation
- Novartis
- MeDALL
- Christine Kühne-Center for Allergy Research and Education
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- interleukins, interferon, TGF-beta, TNF-α, cytokine receptors, cytokine signaling pathways, immune regulation, allergy, asthma, autoimmune disease, chronic infection, organ transplantation, carcinogenesis, gene-deficient mice, cytokine gene polymorphisms
- MeSH terms
- Animals, Humans, Immune System Diseases, Interferons, Interleukins, Tumor Necrosis Factor-alpha, Transforming Growth Factor beta, T-Lymphocytes, Regulatory
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