Cited by 913Cytokine Signaling Pathways and InteractionsAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways

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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

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Akdis, Mübeccel, Aab, Alar, Altunbulakli, Can, Azkur, Kursat, Costa, Rita A., Crameri, Reto, Duan, Su, Eiwegger, Thomas, Eljaszewicz, Andrzej, Ferstl, Ruth, Frei, Remo, Garbani, Mattia, Globinska, Anna, Hess, Lena, Huitema, Carly, Kubo, Terufumi, Komlosi, Zsolt, Konieczna, Patricia, Kovacs, Nora, Kucuksezer, Umut C., Meyer, Norbert, Morita, Hideaki, Olzhausen, Judith, O'Mahony, Liam, Pezer, Marija, Prati, Moira, Rebane, Ana, Rhyner, Claudio, Rinaldi, Arturo, Sokolowska, Milena, Stanic, Barbara, Sugita, Kazunari, Treis, Angela, van de Veen, Willem, Wanke, Kerstin, Wawrzyniak, Marcin, Wawrzyniak, Paulina, Wirz, Oliver F., Zakzuk, Josefina Sierra, Akdis, Cezmi A.·2016·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2016.06.033

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Abstract

There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.

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Authors: Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., Frei, R., Garbani, M., Globinska, A., Hess, L., Huitema, C., Kubo, T., Komlosi, Z., Konieczna, P., Kovacs, N., Kucuksezer, U. C., Meyer, N., Morita, H., Olzhausen, J., O'Mahony, L., Pezer, M., Prati, M., Rebane, A., Rhyner, C., Rinaldi, A., Sokolowska, M., Stanic, B., Sugita, K., Treis, A., van de Veen, W., Wanke, K., Wawrzyniak, M., Wawrzyniak, P., Wirz, O. F., Zakzuk, J. S., & Akdis, C. A.
Affiliations: University of Zurich (CH)
ORCID: Aab, Alar
Altunbulakli, Can
Costa, Rita A.
Eiwegger, Thomas
Eljaszewicz, Andrzej
Frei, Remo
Huitema, Carly
Kubo, Terufumi
Morita, Hideaki
Pezer, Marija
Rebane, Ana
Rhyner, Claudio
Rinaldi, Arturo
Sugita, Kazunari
Wawrzyniak, Marcin
Wawrzyniak, Paulina
Wirz, Oliver F.
Zakzuk, Josefina Sierra
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2016-10
Volume: 138
Issue: 4
Pages: 984-1010
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2016.06.033
OpenAlex: W2517700447
Cited by: 912
References: 222
Citations by year: 2026: 57 · 2025: 117 · 2024: 102 · 2023: 108 · 2022: 119 · 2021: 128 · 2020: 97 · 2019: 75 · 2018: 64 · 2017: 39 · 2016: 4
FWCI: 6.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 369 d)
Locations: Journal of Allergy and Clinical Immunology (acceptedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Swiss National Science Foundation (310030_156823, 320030-159870)
Christine Kühne-Center for Allergy Research and Education (CK-CARE)
PREDICTA
European Commission's Seventh Framework programme (260895, 261357)
GlaxoSmithKline
European Academy of Allergy and Clinical Immunology
Global Allergy and Asthma European Network (GA2LEN)
International Society for Applied Biological Sciences
Commission for Technology and Innovation
Novartis
MeDALL
Christine Kühne-Center for Allergy Research and Education
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: interleukins, interferon, TGF-beta, TNF-α, cytokine receptors, cytokine signaling pathways, immune regulation, allergy, asthma, autoimmune disease, chronic infection, organ transplantation, carcinogenesis, gene-deficient mice, cytokine gene polymorphisms
MeSH terms: Animals, Humans, Immune System Diseases, Interferons, Interleukins, Tumor Necrosis Factor-alpha, Transforming Growth Factor beta, T-Lymphocytes, Regulatory

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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

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