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Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes
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“Indeed, levels of SCF and consequently, mast cell numbers are lower in the skin of germ‐free compared to conventionally housed mice. 83”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [83]
In the citing paper
“They are, however, also reduced and appear less mature in the skin of germ‐free mice. 83”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [83]
In the citing paper
“SCF can be produced by a range of non‐immune cells including fibroblasts and keratinocytes, and dermal mast cells are absent in mice in which SCF is specifically ablated in keratinocytes. 83”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [83]
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Citations
Cites
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The microbiome extends to subepidermal compartments of normal skin
Nakatsuji, T., Chiang, H.-I., Jiang, S. B., Nagarajan, H., Zengler, K., & Gallo, R. L. (2013) · Nature Communications · doi:10.1038/ncomms2441 · Cited by 450 · cited 1×
“This contact allows normal commensal bacteria to directly communicate with dermal cells in a site previously thought to be sterile.(11) The gram-positive Actinobacteria phylum constitutes the majority of the skin microbiota.”
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Analysis of Gut Microbiota in Patients with Parkinson’s Disease
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., et al. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3700-7 · Cited by 487
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Metadata
- Authors
- Wang, Z., Mascarenhas, N., Eckmann, L., Miyamoto, Y., Sun, X., Kawakami, T., & Di Nardo, A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 139
- Issue
- 4
- Pages
- 1205-1216.e6
- ISSN
- 0091-6749
- PMC
- PMC5385284
- Cited by
- 117
- References
- 2
- Language
- en
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