The DOI matches its Crossref record; 154 of the 155 references it cites were found in a registry or an index.
Environmental determinants of allergy and asthma in early life
Open accessAbstract
Allergic disease prevalence has increased significantly in recent decades. Primary prevention efforts are being guided by study of the exposome (or collective environmental exposures beginning during the prenatal period) to identify modifiable factors that affect allergic disease risk. In this review we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their effect on atopy development focused on microbial, allergen, and air pollution exposures. The abundance and diversity of microbial exposures during the first months and years of life have been linked with risk of allergic sensitization and disease. Indoor environmental allergen exposure during early life can also affect disease development, depending on the allergen type, dose, and timing of exposure. Recent evidence supports the role of ambient air pollution in allergic disease inception. The lack of clarity in the literature surrounding the relationship between environment and atopy reflects the complex interplay between cumulative environmental factors and genetic susceptibility, such that no one factor dictates disease development in all subjects. Understanding the effect of the summation of environmental exposures throughout a child's development is needed to identify cost-effective interventions that reduce atopy risk in children.
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“Allergic diseases, including asthma, are increasingly understood as multifactorial complex outcomes of genetic predisposition, environmental exposures, shaped by inflammatory and metabolic processes, host-microbiota interactions, and even epigenetic modifications (67–73).”
From Indoor Allergen Interventions in Homes and Schools for Managing Asthma (2025) · cites this paper as [67]
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Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Atopic Dermatitis: Global Epidemiology and Risk Factors
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Wild, C. P. (2005) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0456 · Cited by 2,562
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children
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The effect of air pollution on lung development from 10 to 18 years of age
Gauderman, W. J., Avol, E., Gilliland, F., Vora, H., Thomas, D., Berhane, K., McConnell, R., Kuenzli, N., Lurmann, F., Rappaport, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040610 · Cited by 1,440
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
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Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
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Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
The Burden of Pediatric Asthma
Ferrante, G., & Grutta, S. L. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00186 · Cited by 485
“These indoor allergens play an important role in eliciting asthma exacerbations, by increasing airway inflammation and bronchial hyper-responsiveness (24).”
BackgroundMacrophage polarization and allergic asthma
Saradna, A., Do, D. C., Kumar, S. A., Fu, Q.-L., & Gao, P. (2017) · Translational research · doi:10.1016/j.trsl.2017.09.002 · Cited by 441
“Allergic disease prevalence has increased significantly in recent decades.(1) The majority of school-age children and adults with asthma have concomitant allergic sensitization, which has been associated with asthma inception and severity.”
BackgroundSözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 455
Environmental exposures and mechanisms in allergy and asthma development
Murrison, L. B., Brandt, E. B., Myers, J. M. B., & Hershey, G. K. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124612 · Cited by 406
“The inconsistencies in current research regarding the relationship between the environment and atopy reflect these complexities and the need for improved exposure assessment and rigorous study design (1, 2).”
BackgroundInfluential
Metadata
- Authors
- Burbank, A. J., Sood, A. K., Kesic, M. J., Peden, D. B., & Hernandez, M. L.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Hernandez, Michelle L.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 140
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC5675123
- OpenAlex
- W2733928499
- Cited by
- 299
- References
- 155
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 28 · 2023: 31 · 2022: 39 · 2021: 48 · 2020: 51 · 2019: 30 · 2018: 26 · 2017: 4
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- American Academy of Allergy Asthma and Immunology
- National Institute of General Medical Sciences (T32GM086330)
- National Institute of Environmental Health Sciences (R01ES023349, K23ES021745, P30ES010126)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- allergic diseases, asthma, exposome, prenatal exposure, early life exposure, atopy, allergen sensitization, microbial exposure, indoor allergens, ambient air pollution, environmental risk factors, genetic susceptibility, primary prevention
- MeSH terms
- Air Pollution, Allergens, Animals, Environmental Exposure, Humans, Hypersensitivity, Risk Factors, Microbiota
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