Cited by 302Asthma and respiratory diseasesAllergic Rhinitis and SensitizationDermatology and Skin Diseases

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Environmental determinants of allergy and asthma in early life

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Burbank, Allison J., Sood, Amika K., Kesic, Matthew J., Peden, David B., Hernandez, Michelle L.·2017·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2017.05.010PMC PMC5675123

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Abstract

Allergic disease prevalence has increased significantly in recent decades. Primary prevention efforts are being guided by study of the exposome (or collective environmental exposures beginning during the prenatal period) to identify modifiable factors that affect allergic disease risk. In this review we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their effect on atopy development focused on microbial, allergen, and air pollution exposures. The abundance and diversity of microbial exposures during the first months and years of life have been linked with risk of allergic sensitization and disease. Indoor environmental allergen exposure during early life can also affect disease development, depending on the allergen type, dose, and timing of exposure. Recent evidence supports the role of ambient air pollution in allergic disease inception. The lack of clarity in the literature surrounding the relationship between environment and atopy reflects the complex interplay between cumulative environmental factors and genetic susceptibility, such that no one factor dictates disease development in all subjects. Understanding the effect of the summation of environmental exposures throughout a child's development is needed to identify cost-effective interventions that reduce atopy risk in children.

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Junge, K. M., Hörnig, F., Herberth, G., Röder, S. W., Kohajda, T., Rolle-Kampczyk, U. E., von Bergen�, M., Borte, M., Simon, J. C., Heroux, D., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.02.013 · Cited by 19
Early-life ozone exposure associated with asthma without sensitization in Latino children
Nishimura, K. K., Iwanaga, K., Oh, S. S., Pino-Yanes, M. D. M., Eng, C. S., Keswani, A., Roth, L. A., Nguyen, E. A., Thyne, S. M., Farber, H. J., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.03.058 · Cited by 19
Sensitization to mouse and cockroach allergens and asthma morbidity in urban minority youth
Fishbein, A. B., Lee, T. A., Cai, M., Oh, S. S., Eng, C. S., Hu, D., Huntsman, S., Farber, H. J., Serebrisky, D., Silverberg, J. I., et al. (2016) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2016.05.004 · Cited by 18
House dust mite sensitization in toddlers predict persistent wheeze in children between eight to fourteen years old
Llanora, G., Ming, L. J., Wei, L. M., & Bever, H. P. V. (2012) · Asia Pacific Allergy · doi:10.5415/apallergy.2012.2.3.181 · Cited by 16
Endotoxin exposure, serum vitamin D, asthma and wheeze outcomes
Mendy, A., Cohn, R. D., & Thorne, P. S. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.03.004 · Cited by 15
Correction: Relative Importance and Additive Effects of Maternal and Infant Risk Factors on Childhood Asthma
Wu, P., Feldman, A. S., Rosas‐Salazar, C., James, K. M., Escobar, G. J., Gebretsadik, T. S., Li, S. X., Carroll, K. N., Walsh, E. M., Mitchel, E. F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156473 · Cited by 6

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Air pollution and its effects on the immune system
Glencross, D. A., Ho, T.-R., Camiña, N., Hawrylowicz, C. M., & Pfeffer, P. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.179 · Cited by 726
The Burden of Pediatric Asthma
Ferrante, G., & Grutta, S. L. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00186 · Cited by 485
“These indoor allergens play an important role in eliciting asthma exacerbations, by increasing airway inflammation and bronchial hyper-responsiveness (24).”
Background
Macrophage polarization and allergic asthma
Saradna, A., Do, D. C., Kumar, S. A., Fu, Q.-L., & Gao, P. (2017) · Translational research · doi:10.1016/j.trsl.2017.09.002 · Cited by 441
“Allergic disease prevalence has increased significantly in recent decades.(1) The majority of school-age children and adults with asthma have concomitant allergic sensitization, which has been associated with asthma inception and severity.”
Background
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
Sözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 455
Environmental exposures and mechanisms in allergy and asthma development
Murrison, L. B., Brandt, E. B., Myers, J. M. B., & Hershey, G. K. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124612 · Cited by 406
“The inconsistencies in current research regarding the relationship between the environment and atopy reflect these complexities and the need for improved exposure assessment and rigorous study design (1, 2).”
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Authors: Burbank, A. J., Sood, A. K., Kesic, M. J., Peden, D. B., & Hernandez, M. L.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Hernandez, Michelle L.
ORCID: Burbank, Allison J.
Sood, Amika K.
Peden, David B.
Hernandez, Michelle L.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2017-07
Volume: 140
Issue: 1
Pages: 1-12
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2017.05.010
PMC: PMC5675123
OpenAlex: W2733928499
Cited by: 299
References: 155
Citations by year: 2026: 19 · 2025: 21 · 2024: 28 · 2023: 31 · 2022: 39 · 2021: 48 · 2020: 51 · 2019: 30 · 2018: 26 · 2017: 4
FWCI: 3.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: American Academy of Allergy Asthma and Immunology
National Institute of General Medical Sciences (T32GM086330)
National Institute of Environmental Health Sciences (R01ES023349, K23ES021745, P30ES010126)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: allergic diseases, asthma, exposome, prenatal exposure, early life exposure, atopy, allergen sensitization, microbial exposure, indoor allergens, ambient air pollution, environmental risk factors, genetic susceptibility, primary prevention
MeSH terms: Air Pollution, Allergens, Animals, Environmental Exposure, Humans, Hypersensitivity, Risk Factors, Microbiota

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Environmental determinants of allergy and asthma in early life

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