The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Role of viral infections in the development and exacerbation of asthma in children
Open accessAbstract
&NA; Viral infections are closely linked to wheezing illnesses in children of all ages. Respiratory syncytial virus (RSV) is the main causative agent of bronchiolitis, whereas rhinovirus (RV) is most commonly detected in wheezing children thereafter. Severe respiratory illness induced by either of these viruses is associated with subsequent development of asthma, and the risk is greatest for young children who wheeze with RV infections. Whether viral illnesses actually cause asthma is the subject of intense debate. RSV‐induced wheezing illnesses during infancy influence respiratory health for years. There is definitive evidence that RSV‐induced bronchiolitis can damage the airways to promote airway obstruction and recurrent wheezing. RV likely causes less structural damage and yet is a significant contributor to wheezing illnesses in young children and in the context of asthma. For both viruses, interactions between viral virulence factors, personal risk factors (eg, genetics), and environmental exposures (eg, airway microbiome) promote more severe wheezing illnesses and the risk for progression to asthma. In addition, allergy and asthma are major risk factors for more frequent and severe RV‐related illnesses. Treatments that inhibit inflammation have efficacy for RV‐induced wheezing, whereas the anti‐RSV mAb palivizumab decreases the risk of severe RSV‐induced illness and subsequent recurrent wheeze. Developing a greater understanding of personal and environmental factors that promote more severe viral illnesses might lead to new strategies for the prevention of viral wheezing illnesses and perhaps reduce the subsequent risk for asthma.
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Cites
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The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611
The environmental microbiome, allergic disease, and asthma
Kelly, M. S., Bunyavanich, S., Phipatanakul, W., & Lai, P. S. (2022) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2022.06.006 · Cited by 47
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
Tang, H. H. F., Teo, S. M., Sly, P. D., Holt, P. G., & Inouye, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.026 · Cited by 43
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Alsayed, A. R., Abed, A., Khader, H. A., Hasoun, L., Al Maqbali, M., & Al Shawabkeh, M. J. (2024) · Libyan Journal of Medicine · doi:10.1080/19932820.2024.2307679 · Cited by 12
Metadata
- Authors
- Jartti, T., & Gern, J. E.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 140
- Issue
- 4
- Pages
- 895-906
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2760886426
- Cited by
- 474
- References
- 142
- FWCI
- 26.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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