The environmental microbiome, allergic disease, and asthma
Open accessAbstract
The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases and asthma. The environmental microbiome represents a ubiquitous, lifelong exposure to non-self antigens. During the critical window between birth and 1 year of life, interactions between our early immune system and the environmental microbiome have 2 consequences: our individual microbiome is populated by environmental microbes, and our immune system is trained regarding which antigens to tolerate. During this time, a diversity of exposures appears largely protective, dramatically decreasing the risk of developing allergic diseases and asthma. As we grow older, our interactions with the environmental microbiome change. While it continues to exert influence over the composition of the human microbiome, the environmental microbiome becomes increasingly a source for antigenic stimulation and infection. The same microbial exposure protective against disease development may exacerbate disease severity. Although much has been learned about the importance of the environmental microbiome in allergic disease, much more remains to be understood about these complicated interactions between our environment, our microbiome, our immune system, and disease.
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Altered microbiota, particularly in the gastrointestinal, respiratory tract, and skin, have emerged as mediators in the development and exacerbation of allergic diseases.
“Altered microbiota, particularly in the gastrointestinal, respiratory tract, and skin have emerged as mediators in the development and exacerbation of allergic diseases (73, 75, 76).”
From Indoor Allergen Interventions in Homes and Schools for Managing Asthma (2025) · cites this paper as [75]
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Self-citation
- Authors
- Kelly, M. S., Bunyavanich, S., Phipatanakul, W., & Lai, P. S.
- Affiliations
- Harvard University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Boston Children's Hospital (US)
- Corresponding author
- Lai, Peggy S.
- Venue
- The Journal of Allergy and Clinical Immunology: In Practice
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 10
- Issue
- 9
- Pages
- 2206-2217.e1
- ISSN
- 2213-2198 (ISSN-L)
- PMC
- PMC9704440
- OpenAlex
- W4283270814
- Cited by
- 47
- References
- 158
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 11 · 2023: 7 · 2022: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Journal of Allergy and Clinical Immunology In Practice (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R38HL150212)
- National Institute of Allergy and Infectious Diseases (U19AI136053, R01AI147028, U01AI110397, R01AI118833, K24AI106822, R01AI144119, U01AI160082)
- National Institute of Environmental Health Sciences (K23ES023700)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- environmental microbiome, allergic diseases, asthma, early life microbial exposure, immune tolerance, microbial diversity, disease severity, human microbiome, microbial metabolites
- MeSH terms
- Asthma, Environmental Exposure, Humans, Hypersensitivity, Microbiota
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