Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions
Abstract
Background This study compared brain white matter integrity in two groups of patients with DSM-IV anxiety disorders. Method Seventeen patients with posttraumatic stress disorder (PTSD), 20 with generalized anxiety disorder (GAD), and 28 healthy controls were assessed on diffusion tensor imaging. Results As compared to healthy controls, increased fractional anisotropy (FA) in left superior frontal gyrus in PTSD patients, and increased FA in right postcentral gyrus in GAD subjects were exhibited. Furthermore, patients with PTSD showed reduced FA in right anterior cingulate gyrus relative to GAD subjects. However, there was no significant correlation between the FA value of any altered region and the severity of PTSD or GAD. Limitations The sample studied can be considered small. Gender and educational level were not well-matched among the groups. Conclusions We tentatively speculate that abnormal white matter integrity of right anterior cingulate gyrus is an important neuroimaging marker of PTSD that distinguishes it from other anxiety disorders such as GAD.
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In survivors with PTSD following another disaster, reduced FA was found in the right subgenual region.
“Following another disaster, survivors with PTSD had reduced FA in the right subgenual region (Zhang et al., 2011).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Zhang et al., 2011
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
“Following another disaster, survivors with PTSD had reduced FA in the right subgenual region (Zhang et al., 2011).”
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White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.146 · Cited by 135 · see citing works
Neuroimaging and Anxiety: the Neural Substrates of Pathological and Non-pathological Anxiety
Taylor, J. M., & Whalen, P. J. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0586-9 · Cited by 58 · see citing works
- Authors
- Zhang, L., Zhang, Y., Li, L., Li, Z., Li, W., Ma, N., Hou, C., Zhang, Z., Zhang, Z., Wang, L., Duan, L., & Lu, G.
- Affiliations
- Second Xiangya Hospital of Central South University (CN)
- Chinese University of Hong Kong (HK)
- Peking University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Guangzhou Psychiatric Hospital (CN)
- Corresponding author
- Li, Lingjiang
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 133
- Issue
- 1-2
- Pages
- 294-299
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2006748710
- Cited by
- 81
- References
- 11
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30830046)
- Ministry of Education of the People's Republic of China (20090162110011)
- National Key Research and Development Program of China (2007CB512308, 2009CB918303)
- National Science and Technology Program during the Twelfth Five-year Plan Period (2007BAI17B02)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, generalized anxiety disorder, white matter integrity, fractional anisotropy, diffusion tensor imaging, anterior cingulate cortex, superior frontal gyrus, postcentral gyrus, neuroimaging biomarkers, anxiety disorders
- MeSH terms
- Adult, Anxiety Disorders, Brain, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Comorbidity, Case-Control Studies, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders, Stress Disorders, Traumatic, Acute, Young Adult
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