Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: neural correlates of generalized emotional response
Abstract
Previous evidence from functional magnetic resonance imaging (fMRI) studies has shown that amygdala responses to emotionally neutral pictures are exaggerated at a group level in patients with severe post-traumatic stress disorder (PTSD) [Hendler T, Rotshtein P, Yeshurun Y, Weizmann T, Kahn I, Ben-Bashat D, Malach R, Bleich A (2003) Neuroimage 19(3):587-600]. The present fMRI study tested the hypothesis that amygdala responses are elevated not only in response to negative pictures but also to neutral pictures as a function of disease severity in patients with mild symptoms and in subjects who did not develop symptoms. To this end, fMRI scans were performed in 10 patients with mild PTSD and 10 healthy controls (both victims of a bank robbery), during the execution of a visuo-attentional task in which they were asked to observe emotionally negative or neutral pictures. Control subjects showed enhanced amygdala responses to emotionally negative stimuli compared to neutral stimuli. On the contrary, PTSD patients were characterized by high amygdala responses to both neutral and emotional pictures, with no statistically significant difference between the two classes of stimuli. In the entire group, we found correlations among the severity of the PTSD symptoms, task performance, and amygdala activation during the processing of neutral stimuli. Results of this study suggest that amygdala responses and the selectivity of the emotional response to neutral stimuli are elevated as a function of disease severity in PTSD patients with mild symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A previous study showed elevated amygdala responses towards neutral pictures in PTSD patients compared with trauma-exposed controls.
“Indeed, a previous study showed elevated amygdala responses towards neutral pictures in PTSD patients compared with trauma-exposed controls (Brunetti et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Brunetti et al, 2010
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923 · see citing works
Movement‐Related effects in fMRI time‐series
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350312 · Cited by 3,774 · see citing works
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · see citing works
International Affective Picture System (IAPS) : Technical Manual and Affective Ratings
Lang, P. J. (1995) · Medical Entomology and Zoology · Cited by 2,870 · see citing works
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859 · see citing works
Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1
Boynton, G., Engel, S., Glover, G., & Heeger, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04207.1996 · Cited by 2,522 · see citing works
The Body Keeps the Score: Memory and the Evolving Psychobiology of Posttraumatic Stress
van der Kolk, B. A. (1994) · Harvard Review of Psychiatry · doi:10.3109/10673229409017088 · Cited by 1,367 · see citing works
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00828-3 · Cited by 1,111 · see citing works
Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., Peters, P. M., Metzger, L. J., Dougherty, D. D., Cannistraro, P. A., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.2.168 · Cited by 790 · see citing works
Bremner, J. D., Narayan, M., Staib, L. H., Southwick, S. M., McGlashan, T., & Charney, D. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1787 · Cited by 701 · see citing works
Statistical methods of estimation and inference for functional MR image analysis
Bullmore, E. T., Brammer, M. J., Williams, S., Rabe‐Hesketh, S., Janot, N., David, A. S., Mellers, J. D. C., Howard, R. J., & Sham, P. C. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350219 · Cited by 683 · see citing works
A direct brainstem–amygdala–cortical ‘alarm’system for subliminal signals of fear.
Liddell, B. J., Brown, K. J., Kemp, A. H., Barton, M. J., Das, P., Peduto, A., Gordon, E., & Williams, L. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.016 · Cited by 670 · see citing works
Shin, L. M., McNally, R. J., Kosslyn, S. M., Thompson, W. L., Rauch, S. L., Alpert, N. M., Metzger, L. J., Lasko, N. B., Orr, S. P., & Pitman, R. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.575 · Cited by 647 · see citing works
Brain activation in PTSD in response to trauma-related stimuli
Liberzon, I., Taylor, S. F., Amdur, R., Jung, T. D., Chamberlain, K. R., Minoshima, S., Koeppe, R. A., & Fig, L. M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00246-7 · Cited by 635 · see citing works
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., & Tancer, M. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.012 · Cited by 539 · see citing works
Artifacts due to stimulus correlated motion in functional imaging of the brain
Hajnal, J. V., Myers, R., Oatridge, A., Schwieso, J. E., YOUNG, I. R., & Bydder, G. M. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310307 · Cited by 486 · see citing works
Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala
Gläscher, J., & Adolphs, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10274.2003 · Cited by 457 · see citing works
A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation
Lanius, R. A., Bluhm, R., Lanius, U., & Pain, C. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.007 · Cited by 380 · see citing works
Chapter 26 Emotional networks and motor control: a fearful view
(1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61880-4 · Cited by 364 · see citing works
Trauma modulates amygdala and medial prefrontal responses to consciously attended fear
Williams, L. M., Kemp, A. H., Felmingham, K., Barton, M., Olivieri, G., Peduto, A., Gordon, E., & Bryant, R. A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.047 · Cited by 351 · see citing works
Neural Processing of Fearful Faces: Effects of Anxiety are Gated by Perceptual Capacity Limitations
Bishop, S. J., Jenkins, R., & Lawrence, A. D. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl070 · Cited by 343 · see citing works
Neural Mechanisms Underlying Selective Attention to Threat
Bishop, S. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.016 · Cited by 330 · see citing works
Does "subthreshold" posttraumatic stress disorder have any clinical relevance?
Zlotnick, C., Franklin, C. L., & Zimmerman, M. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.35900 · Cited by 283 · see citing works
Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery
Britton, J. C., Phan, K. L., Taylor, S. F., Fig, L. M., & Liberzon, I. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.025 · Cited by 265 · see citing works
Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity
Admon, R., Lubin, G., Stern, O., Rosenberg, K., Lee, S.-L., Ben-Ami, H., & Hendler, T. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0903183106 · Cited by 250 · see citing works
Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study
Pissiota, A., Frans, Ö., Fernandez, M., von Knorring, L., Fischer, H., & Fredrikson, M. (2002) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060200014 · Cited by 228 · see citing works
Sensing the invisible: differential sensitivity of visual cortex and amygdala to traumatic context
Hendler, T., Rotshtein, P., Yeshurun, Y., Weizmann, T., Kahn, I., Bashat, D. B., Malach, R., & Bleich, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00141-1 · Cited by 228 · see citing works
Bryant, R. A., Felmingham, K. L., Kemp, A. H., Barton, M., Peduto, A. S., Rennie, C., Gordon, E., & Williams, L. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.021 · Cited by 211 · see citing works
Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (2011) · PsycTESTS Dataset · doi:10.1037/t00072-000 · Cited by 177 · see citing works
Yang, P., Wu, M.-T., Hsu, C.-C., & Ker, J.-H. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.07.033 · Cited by 138 · see citing works
Emotional enhancement effect of memory: removing the influence of cognitive factors.Preprint
Sommer, T., Gläscher, J., Moritz, S., & Büchel, C. (2008) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.995108 · Cited by 53 · see citing works
Catani, C., Adenauer, H., KEIL, J. E., Aichinger, H., & Neuner, F. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0006-4 · Cited by 49 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452 · see citing works
Functional neuroimaging studies of post-traumatic stress disorder
Hughes, K. C., & Shin, L. M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.198 · Cited by 290 · see citing works
Learning models of PTSD: Theoretical accounts and psychobiological evidence
Lissek, S. M., & van Meurs, B. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.11.006 · Cited by 244 · see citing works
Functional Neuroanatomy of Emotion and Its Regulation in PTSD
Fitzgerald, J. M., DiGangi, J. A., & Phan, K. L. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000185 · Cited by 177 · see citing works
Stark, E. A., Parsons, C. E., Van Hartevelt, T. J., Charquero-Ballester, M., McManners, H., Ehlers, A., Stein, A., & Kringelbach, M. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.007 · Cited by 152 · see citing works
Does Reconsolidation Occur in Humans?
Schiller, D., & Phelps, E. A. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00024 · Cited by 211 · see citing works
Garrett, A. S., Carrion, V., Kletter, H., Karchemskiy, A., Weems, C. F., & Reiss, A. (2012) · Depression and Anxiety · doi:10.1002/da.21892 · Cited by 131 · see citing works
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 119 · see citing works
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Goodman, J., Leong, K.-C., & Packard, M. G. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0049 · Cited by 97 · see citing works
BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure
Angelucci, F., Ricci, V., Gelfo, F., Martinotti, G., Brunetti, M., Sepede, G., Signorelli, M. S., Aguglia, E., Pettorruso, M., Vellante, F., et al. (2013) · Brain and Cognition · doi:10.1016/j.bandc.2013.11.012 · Cited by 93 · see citing works
Self-citationApplication of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders
Bremner, J. D., Gurel, N. Z., Wittbrodt, M. T., Shandhi, M. M. H., Rapaport, M. H., Nye, J. A., Pearce, B. D., Vaccarino, V., Shah, A. J., Park, J., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030119 · Cited by 93 · see citing works
Ayers, L. W., Missig, G., Schulkin, J. A., & Rosen, J. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.138 · Cited by 87 · see citing works
Shvil, E., Rusch, H. L., Sullivan, G. M., & Neria, Y. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0358-3 · Cited by 86 · see citing works
The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray
Terpou, B. A., Harricharan, S., McKinnon, M. C., Frewen, P., Jetly, R., & Lanius, R. A. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24447 · Cited by 82 · see citing works
Fischer, B. L., Parsons, M. W., Durgerian, S., Reece, C., Mourany, L., Lowe, M. J., Beall, E. B., Koenig, K. A., Jones, S. E., Newsome, M. R., et al. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2877 · Cited by 82 · see citing works
Piqueras‐Fiszman, B., Kraus, A. A., & Spence, C. J. (2014) · Appetite · doi:10.1016/j.appet.2014.03.029 · Cited by 81 · see citing works
Atypical visual processing in posttraumatic stress disorder
Mueller‐Pfeiffer, C., Schick, M., Schulte-Vels, T., Tuura, R., Michels, L., Martin-Söelch, C., Blair, J., Rufer, M., Schnyder, U., Zeffiro, T. A., et al. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.08.009 · Cited by 79 · see citing works
Zhang, L., Zhang, Y., Li, L., Li, Z., Li, W., Ma, N., Hou, C., Zhang, Z., Zhang, Z., Wang, L., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.040 · Cited by 81 · see citing works
White matter integrity alterations in post‐traumatic stress disorder
O'Doherty, D. C. M., Ryder, W., Paquola, C., Tickell, A. M., Chan, C., Hermens, D. F., Bennett, M. R., & Lagopoulos, J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23920 · Cited by 71 · see citing works
Strong, P. V., Christianson, J. P., Loughridge, A. B., Amat, J., Maier, S. F., Fleshner, M., & Greenwood, B. N. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.041 · Cited by 61 · see citing works
Thermal signature of fear conditioning in mild post traumatic stress disorder
Giacinto, A. D., Brunetti, M., Sepede, G., Ferretti, A., & Merla, A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.009 · Cited by 56 · see citing works
Self-citationWhite matter abnormalities in Gulf War veterans with posttraumatic stress disorder: A pilot study
Bierer, L. M., Ivanov, I., Carpenter, D. M., Wong, E. W., Golier, J. A., Tang, C. Y., & Yehuda, R. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.007 · Cited by 50 · see citing works
Vásquez, C. E., Riener, R. M., Reynolds, E., & Britton, G. B. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.09.007 · Cited by 49 · see citing works
Sambuco, N., Bradley, M. M., Herring, D. R., Hillbrandt, K., & Lang, P. J. (2019) · Psychophysiology · doi:10.1111/psyp.13349 · Cited by 47 · see citing works
Cisler, J. M., Esbensen, K., Sellnow, K. A., Ross, M. C., Weaver, S. S., Sartin‐Tarm, A., Herringa, R. J., & Kilts, C. D. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.08.014 · Cited by 44 · see citing works
BDNF concentration and impulsiveness level in post-traumatic stress disorder.
Martinotti, G., Sepede, G., Brunetti, M., Ricci, V., Gambi, F., Chillemi, E., Vellante, F., Signorelli, M., Pettorruso, M., Risio, L. D., et al. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.07.085 · Cited by 39 · see citing works
Self-citationChu, D. A., Bryant, R. A., Gatt, J. M., & Harris, A. W. F. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.006 · Cited by 37 · see citing works
Neural correlates of trauma-unrelated emotional processing in war veterans with PTSD
van Rooij, S. J. H., Rademaker, A. R., Kennis, M., Vink, M., Kahn, R. S., & Geuze, E. (2015) · Psychological Medicine · doi:10.1017/s0033291714001706 · Cited by 36 · see citing works
Effects of stress on AMPA receptor distribution and function in the basolateral amygdala
Hubert, G. W., Li, C., Rainnie, D. G., & Muly, E. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0557-z · Cited by 36 · see citing works
Narrative imagery: Emotional modulation in the default mode network
Sambuco, N., Bradley, M. M., & Lang, P. J. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.108087 · Cited by 37 · see citing works
Zhang, L., Li, W., Shu, N., Zheng, H., Zhang, Z., Zhang, Y., He, Z., Hou, C., Li, Z., Liu, J., et al. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00580.x · Cited by 35 · see citing works
Cisler, J. M., Privratsky, A. A., Smitherman, S., Herringa, R. J., & Kilts, C. D. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.12.001 · Cited by 30 · see citing works
McCurry, K. L., Frueh, B. C., Chiu, P. H., & King‐Casas, B. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.09.006 · Cited by 31 · see citing works
Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse
Ayash, S., Lingner, T., Ramisch, A., Ryu, S., Kalisch, R., Schmitt, U., & Müller, M. B. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205576120 · Cited by 28 · see citing works
Maldonado, N. M., Espejo, P. J., Martijena, I. D., & Molina, V. A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.10.005 · Cited by 28 · see citing works
On the basis of sex: Differences in safety discrimination vs. conditioned inhibition
Krueger, J. N., & Sangha, S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113024 · Cited by 27 · see citing works
Outhred, T., Das, P., Felmingham, K. L., Bryant, R. A., Nathan, P. J., Malhi, G. S., & Kemp, A. H. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130118 · Cited by 27 · see citing works
Resilience and cross-network connectivity: A neural model for post-trauma survival
Brunetti, M., Marzetti, L., Sepede, G., Zappasodi, F., Pizzella, V., Sarchione, F., Vellante, F., Martinotti, G., & Giannantonio, M. D. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.010 · Cited by 26 · see citing works
Self-citationYang, X., Kendrick, K. M., Wu, Q., Chen, T., Lama, S., Cheng, B., Li, S., Huang, X., & Gong, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063151 · Cited by 24 · see citing works
Cognitive load and emotional processing in psoriasis: a thermal imaging study
Panasiti, M. S., Ponsi, G., Monachesi, B., Lorenzini, L., Panasiti, V., & Aglioti, S. M. (2018) · Experimental Brain Research · doi:10.1007/s00221-018-5416-y · Cited by 22 · see citing works
van den Heuvel, M. I., Henrichs, J., Donkers, F. C. L., & den Bergh, B. R. H. V. (2017) · Developmental Science · doi:10.1111/desc.12612 · Cited by 22 · see citing works
Childhood maltreatment influences autonomic regulation and mental health in college students
Dale, L. P., Kolacz, J., Mazmanyan, J., Leon, K. G., Johonnot, K., Bossemeyer Biernacki, N., & Porges, S. W. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.841749 · Cited by 21 · see citing works
Nilsen, A. S., Blix, I., Leknes, S., Ekeberg, Ø., Skogstad, L., Endestad, T., Østberg, B. C., & Heir, T. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01173 · Cited by 22 · see citing works
Salivary biomarkers of neural hypervigilance in trauma-exposed women
Yoon, S. A., & Weierich, M. R. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.007 · Cited by 20 · see citing works
Kraus, J., Frick, A., Fischer, H., Howner, K., Fredrikson, M., & Furmark, T. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.08.012 · Cited by 21 · see citing works
Lee, M., Anumagalla, P., & Pavuluri, M. N. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00303-9 · Cited by 20 · see citing works
Recovery from anorexia nervosa includes neural compensation for negative body image
Pruis, T. A., Keel, P. K., & Janowsky, J. S. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.22034 · Cited by 18 · see citing works
An Experimental-Psychological Approach for the Development of Character Computing
Herbert, C. (2020) · Human-computer interaction series · doi:10.1007/978-3-030-15954-2_2 · Cited by 18 · see citing works
Fitzgerald, J. M., Belleau, E. L., Miskovich, T. A., Pedersen, W. S., & Larson, C. L. (2020) · Brain and Behavior · doi:10.1002/brb3.1707 · Cited by 17 · see citing works
Campanella, C., & Bremner, J. D. (2016) · Wiley eBooks · doi:10.1002/9781118356142.ch12 · Cited by 17 · see citing works
Opmeer, E. M., Kortekaas, R., van Tol, M., van der Wee, N. J. A., Woudstra, S., van Buchem, M. A., Penninx, B. W. J. H., Veltman, D. J., & Aleman, A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst025 · Cited by 16 · see citing works
The Neurocircuitry of Fear and PTSD
VanElzakker, M. B., Staples-Bradley, L. K., & Shin, L. M. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_10 · Cited by 17 · see citing works
Bryant, R. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803457-6.00013-1 · Cited by 16 · see citing works
McCunn, P., Richardson, J. A., Jetly, R., & Dunkley, B. T. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113797 · Cited by 16 · see citing works
Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
Dagnino‐Subiabre, A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0079 · Cited by 15 · see citing works
Hinojosa, C. A., VanElzakker, M. B., Hughes, K. C., Offringa, R., Sangermano, L., Spaulding, I. G., Staples-Bradley, L. K., Whitman, E. T., Lasko, N. B., Rauch, S. L., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.049 · Cited by 13 · see citing works
Facco, E., Mendozzi, L., Bona, A., Motta, A., Garegnani, M., Costantini, I., Dipasquale, O., Cecconi, P., Menotti, R., Coscioli, E., et al. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109274 · Cited by 15 · see citing works
Heilicher, M. O., Crombie, K. M., & Cisler, J. M. (2022) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2022.859792 · Cited by 12 · see citing works
Amygdala activation in response to 2D and 3D emotion-inducing stimuli
Dores, A. R., Barbosa, F., Monteiro, L. M. C., Reis, M., Coelho, C. M., Ribeiro, E., Leitão, M., Carvalho, I. P., de Sousa, L., & Castro‐Caldas, A. (2022) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.26537/r4983 · Cited by 12 · see citing works
Brunetti, M., Sepede, G., Ferretti, A., Mingoia, G., Romani, G. L., & Babiloni, C. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.03.001 · Cited by 11 · see citing works
Self-citationAge and cortisol levels modulate judgment of positive and negative facial expressions
Feeney, J. C., Gaffney, P. R., & O’Mara, S. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.015 · Cited by 11 · see citing works
Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders
Etami, Y., Lildharrie, C., Manza, P., Wang, G., & Volkow, N. D. (2023) · Genes · doi:10.3390/genes14122113 · Cited by 11 · see citing works
Identification of a stress-responsive subregion of the basolateral amygdala in male rats
Aukema, R. J., Petrie, G. N., Matarasso, A. K., Baglot, S. L., Molina, L. A., Füzesi, T., Kadhim, S., Nastase, A. S., Reyes, I. R., Bains, J. S., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01927-x · Cited by 10 · see citing works
Liu, M., Tian, X.-Y., Fang, T., Wu, N., Li, H., & Li, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03312-z · Cited by 10 · see citing works
Civilian Moral Injury and Amygdala Functional Connectivity During Attention to Threat
Fulton, T. M., Lathan, E. C., Karkare, M. C., Guelfo, A., Eghbalzad, L., Ahluwalia, V., Ely, T. D., Turner, J. A., Turner, M. D., Currier, J. M., et al. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.07.006 · Cited by 10 · see citing works
Teixeira, R. J., & Pereira, M. G. (2013) · European Journal of Cancer Care · doi:10.1111/ecc.12102 · Cited by 9 · see citing works
Women and men managers in pharmacy: gender issues.
Cockerill, R. W., Tanner, J., Barnsley, J. R., & Williams, A. P. (1999) · PubMed · Cited by 6 · see citing works
Tamman, A. J. F., Abdallah, C. G., Dunsmoor, J. E., & Cisler, J. M. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.02.015 · Cited by 4 · see citing works
Sex Differences in the Effects of Cognitive Reappraisal Training on Conditioned Fear Responses
Liao, S., Xiao, W., & Wang, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315837 · Cited by 4 · see citing works
Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD
Roeckner, A. R., Lin, E. R.-H., Hinrichs, R. C., Harnett, N. G., Lebois, L. A. M., van Rooij, S. J. H., Ely, T. D., Jovanović, T., Murty, V. P., Bruce, S. E., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02115-1 · Cited by 4 · see citing works
Moe, A. M., Phan, K. L., Fournier, J. C. J., Jimmy, J., & Gorka, S. M. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111618 · Cited by 4 · see citing works
Guerra, L. T. L., Rocha, J. M., Osório, F. D. L., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2023) · Biological Psychology · doi:10.1016/j.biopsycho.2023.108660 · Cited by 3 · see citing works
Chazan, R. (1989) · University of California Press eBooks · doi:10.1525/9780520407022-011 · Cited by 3 · see citing works
Sambuco, N., Bradley, M. M., & Lang, P. J. (2025) · Psychophysiology · doi:10.1111/psyp.70027 · Cited by 3 · see citing works
Goldstein, B. L., Arciero, O., Santos, S., Grasso, D. J., Eigsti, I., Hoeft, F., Williams, C. J., Mohan, A., Mohler, E., McCarthy, K. J., et al. (2025) · Developmental Psychobiology · doi:10.1002/dev.70045 · Cited by 1 · see citing works
The aftermath of trauma on resting state source-level MEG microstate dynamics
Bertoli, M., Croce, P., Zappasodi, F., Matteo, R. D., Vellante, F., Pettorruso, M., Martinotti, G., & Brunetti, M. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2520638 · Cited by 1 · see citing works
Self-citationDunkley, B. T., Wong, S. M., Jetly, R., Pang, E. W., & Taylor, M. J. (2019) · Journal of Military Veteran and Family Health · doi:10.3138/jmvfh.2017-0047 · Cited by 1 · see citing works
Brunetti, M., Martinotti, G., Sepede, G., Vellante, F., Fiori, F., Sarchione, F., & Giannantonio, M. D. (2017) · Archives of Trauma Research · doi:10.4103/atr.atr_12_17 · Cited by 1 · see citing works
Self-citationIsaeva, O. L., Boronenko, M., & Boronenko, Y. (2021) · International Conference on Computer and Communication Systems (ICCCS) · doi:10.1109/icccs52626.2021.9449315 · Cited by 1 · see citing works
Posttraumatische Belastungsstörung
Regenbogen, C., & Pauly, K. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-29800-4_45 · Cited by 1 · see citing works
Shiba, Y. (2013) · Apollo (University of Cambridge) · doi:10.17863/cam.28 · Cited by 1 · see citing works
Rumball, F. (2013) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 1 · see citing works
Strong, P. V. (2012) · CU Scholar (University of Colorado Boulder)
Research Progress of Brain Function Magnetic Resonance Imaging in Post-Traumatic Stress Disorder
张, 红. (2017) · Advances in Psychology · doi:10.12677/ap.2017.711165
Neural Hypervigilance in Trauma-exposed Women
Yoon, S. A. (2018) · CUNY Academic Works (City University of New York)
Research Progress of Cognitive Impairment in Post-Traumatic Stress Disorder
Luo, L., Yan-hai, K., Zeng, F., Lin, Y., Feng, Y. R., Li, M., & Li, F. (2021) · Health · doi:10.4236/health.2021.132014
Experimental methods of pupillographic analysis based on high-speed video recording devices
Isaeva, O. L., & Boronenko, M. (2021) · Вестник Югорского государственного университета · doi:10.17816/byusu20210359-67
P.213 Sustained attention in patients with post traumatic stress disorder
Lorusso, M., Sepede, G., Gambi, F., Brunetti, M., Vellante, F., Spano, M. C., Miuli, A., & Giannantonio, M. D. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.09.256
Self-citationTranscutaneous Vagal Nerve Stimulation in Trauma Spectrum Psychiatric Disorders
Bremner, J. D., Wittbrodt, M. T., Gurel, N. Z., Shandhi, M. M. H., Gazi, A. H., Park, J., & Inan, O. T. (2023) · Neuromethods · doi:10.1007/978-1-0716-3465-3_8
Lawrence, A. J., Lawrence‐Wood, E., Aidman, E., Spencer-Merris, P., Felmingham, K. L., & McFARLANE, A. C. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.02.033
Schwert, H., Salur, E., Richard, M., Pöllmann, M., Lesch, K., Asan, E., & Schmitt-Böhrer, A. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.07.680627
Imaging Studies of Anxiety Disorders
Mann, J. J., & Yin, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00120-2
Teixeira, R., & Pereira, M. G. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Ramos-Rolón, A. P., Langleben, D. D., Lynch, K. G., Wiers, C. E., & Shi, Z. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113066
Santistevan, A. C., Natraj, N., Yack, L. M., Felmingham, K. L., Woodward, S., Mathalon, D. H., Neylan, T. C., & Richards, A. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.27.714805
State and trait anxiety modulate hemodynamic amygdala responses to innocuous auditory stimulationPreprint
Kartsaki, D., Cinca-Tomás, M. T., Kosteletou-Kassotaki, E., Cean, M., Lombardo, D., & Domínguez‐Borràs, J. (2026) · Research Square · doi:10.21203/rs.3.rs-10360357/v1
Functional brain imaging in posttraumatic stress disorder: a review
Bremner, J. D. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03228-7
Schwert, H., Salur, E., Richard, M., Pöllmann, M., Lesch, K., Asan, E., & Schmitt-Böhrer, A. G. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03224-x
- Authors
- Brunetti, M., Sepede, G., Mingoia, G., Catani, C., Ferretti, A., Merla, A., Del Gratta, C., Romani, G. L., & Babiloni, C.
- Affiliations
- University of Chieti-Pescara (IT)
- Bielefeld University (DE)
- University of Foggia (IT)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 168
- Issue
- 3
- Pages
- 670-679
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2088502524
- Semantic Scholar
- 310cee15d6a617a0ed5e079eb8b85cad5f3cf016
- Cited by
- 101
- References
- 38
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 13 · 2012: 6
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Publikationen an der Universität Bielefeld (Universität Bielefeld) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- post-traumatic stress disorder, amygdala, neutral stimuli, disease severity, emotional face processing
- MeSH terms
- Adult, Amygdala, Emotions, Fear, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Photic Stimulation, Severity of Illness Index, Stress Disorders, Post-Traumatic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
