White Matter Integrity in Highly Traumatized Adults With and Without Post-Traumatic Stress Disorder
Open accessAbstract
Prior structural imaging studies of post-traumatic stress disorder (PTSD) have observed smaller volumes of the hippocampus and cingulate cortex, yet little is known about the integrity of white matter connections between these structures in PTSD samples. The few published studies using diffusion tensor imaging (DTI) to measure white matter integrity in PTSD have described individuals with focal trauma rather than chronically stressed individuals, which limits generalization of findings to this population; in addition, these studies have lacked traumatized comparison groups without PTSD. The present DTI study examined microstructural integrity of white matter tracts in a sample of highly traumatized African-American women with (n=25) and without (n=26) PTSD using a tract-based spatial statistical approach, with threshold-free cluster enhancement. Our findings indicated that, relative to comparably traumatized controls, decreased integrity (measured by fractional anisotropy) of the posterior cingulum was observed in participants with PTSD (p<0.05). These findings indicate that reduced microarchitectural integrity of the cingulum, a white matter fiber that connects the entorhinal and cingulate cortices, appears to be associated with PTSD symptomatology. The role of this pathway in problems that characterize PTSD, such as inadequate extinction of learned fear, as well as attention and explicit memory functions, are discussed.
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Hippocampus function, structure, and functional connectivity with other regions is compromised in individuals with PTSD, GAD, and PD.
“The hippocampus is another brain structure within the medial temporal lobe whose function, structure, and functional connectivity with other regions is comprised in individuals with PTSD, GAD, and PD (Cui et al, 2016;Fani et al, 2012b;Woon et al, 2010).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Fani et al, 2012b
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496 · see citing works
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 6,805 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Hua, K., Zhang, J., Wakana, S., Jiang, H., Li, X., Reich, D. S., Calabresi, P. A., Pekar, J. J., van Zijl, P. C. M., & Mori, S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.053 · Cited by 1,507 · see citing works
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339 · see citing works
Axonal pathology in traumatic brain injury
Johnson, V. E., Stewart, W., & Smith, D. H. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.013 · Cited by 1,273 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
A meta-analysis of structural brain abnormalities in PTSD
KARL, A., SCHAEFER, M., MALTA, L., DORFEL, D., ROHLEDER, N., & WERNER, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.004 · Cited by 881 · see citing works
Traumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738 · see citing works
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684 · see citing works
Self-citationBradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., Gillespie, C. F., Berg, T., Evces, M., Newport, D. J., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.26 · Cited by 643 · see citing works
Self-citationDe Bellis, M. D., Keshavan, M. S., Shifflett, H., Iyengar, S., Beers, S. R., Hall, J., & Moritz, G. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01459-2 · Cited by 632 · see citing works
Trauma exposure and stress-related disorders in inner city primary care patients
Gillespie, C. F., Bradley, B., Mercer, K., Smith, A. K., Conneely, K. N., Gapen, M., Weiss, T., Schwartz, A. C., Cubells, J. F., & Ressler, K. J. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.05.003 · Cited by 504 · see citing works
Self-citationChanging Fear: The Neurocircuitry of Emotion Regulation
Hartley, C. A., & Phelps, E. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.121 · Cited by 489 · see citing works
Childhood neglect is associated with reduced corpus callosum area
Teicher, M. H., Dumont, N. L., Ito, Y., Vaituzis, C., Giedd, J. N., & Andersen, S. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.016 · Cited by 484 · see citing works
Impaired fear inhibition is a biomarker of PTSD but not depression
Jovanovic, T., Norrholm, S. D., Blanding, N. Q., Davis, M., Duncan, E., Bradley, B., & Ressler, K. J. (2010) · Depression and Anxiety · doi:10.1002/da.20663 · Cited by 444 · see citing works
Self-citationHow the Neurocircuitry and Genetics of Fear Inhibition May Inform Our Understanding of PTSD
Jovanović, T., & Ressler, K. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09071074 · Cited by 441 · see citing works
Self-citationWoon, F. L., Sood, S., & Hedges, D. W. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.016 · Cited by 410 · see citing works
(1993) · Behavior Therapy · Cited by 409 · see citing works
Norrholm, S. D., Jovanovic, T., Olin, I. W., Sands, L. A., Karapanou, I., Bradley, B., & Ressler, K. J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.013 · Cited by 397 · see citing works
Self-citationHippocampal involvement in contextual modulation of fear extinction
Ji, J., & Maren, S. (2007) · Hippocampus · doi:10.1002/hipo.20331 · Cited by 297 · see citing works
Fani, N., Tone, E. B., Phifer, J., Norrholm, S. D., Bradley, B., Ressler, K. J., Kamkwalala, A., & Jovanovic, T. (2012) · Psychological Medicine · doi:10.1017/s0033291711001565 · Cited by 266 · see citing works
Self-citationPhan, K. L., Orlichenko, A., Boyd, E., Angstadt, M., Coccaro, E. F., Liberzon, I., & Arfanakis, K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.028 · Cited by 226 · see citing works
Jackowski, A. P., Douglas-Palumberi, H., Jackowski, M., Win, L., Schultz, R. T., Staib, L. W., Krystal, J. H., & Kaufman, J. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.08.006 · Cited by 206 · see citing works
Neuroimaging Studies of Emotional Responses in PTSD
LIBERZON, I., & MARTIS, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.009 · Cited by 198 · see citing works
Posttraumatic Stress Disorder Among African Americans in an Inner City Mental Health Clinic
Schwartz, A. C., Bradley, R. G., Sexton, M., Sherry, A. R., & Ressler, K. J. (2005) · Psychiatric Services · doi:10.1176/appi.ps.56.2.212 · Cited by 193 · see citing works
Self-citationDiffusion tensor imaging and cognitive function in older adults with no dementia
Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31822313dc · Cited by 182 · see citing works
Huang, H., Fan, X., Williamson, D. E., & Rao, U. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.199 · Cited by 174 · see citing works
Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04754blu · Cited by 173 · see citing works
Genetics of microstructure of cerebral white matter using diffusion tensor imaging
Kochunov, P., Glahn, D. C., Lancaster, J. L., Winkler, A. M., Smith, S. M., Thompson, P. M., Almasy, L. A., Duggirala, R., Fox, P. T., & Blangero, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.078 · Cited by 158 · see citing works
Schuff, N. W., Zhang, Y., Wang, Z., Lenoci, M., Ching, C. R. K., Boreta, L. C., Mueller, S. G., Wang, Z., Marmar, C. R., Weiner, M. W., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.024 · Cited by 155 · see citing works
Neural correlates of attention bias to threat in post-traumatic stress disorder
Fani, N., Jovanovic, T., Ely, T. D., Bradley, B., Gutman, D., Tone, E. B., & Ressler, K. J. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.03.001 · Cited by 150 · see citing works
Self-citationDisease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage
Drago, V., Babiloni, C., Bartrés‐Faz, D., Caroli, A., Bosch, B., Hensch, T., Didic, M., Klafki, H., Pievani, M., Jovicich, J., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0043 · Cited by 138 · see citing works
Fox, R. J., Sakaie, K., Lee, J.-C., Debbins, J. P., Liu, Y., Arnold, D. L., Melhem, E. R., Smith, C. H., Philips, M. D., Lowe, M., et al. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2844 · Cited by 137 · see citing works
Abe, O., Yamasue, H., Kasai, K., Yamada, H., Aoki, S., Iwanami, A., Ohtani, T., Masutani, Y., Kato, N., & Ohtomo, K. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.004 · Cited by 129 · see citing works
White matter tracts in first-episode psychosis: A DTI tractography study of the uncinate fasciculus
Price, G. W., Cercignani, M., Parker, G. J. M., Altmann, D. R., Barnes, T. R. E., Barker, G. J., Joyce, E. M., & Ron, M. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.012 · Cited by 120 · see citing works
Keedwell, P. A., Chapman, R., Christiansen, K., Richardson, H., Evans, J., & Jones, D. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.022 · Cited by 106 · see citing works
Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?
Shin, L. M., & Handwerger, K. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20442 · Cited by 102 · see citing works
Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
Kim, S. J., Jeong, D.-U., Sim, M. E., Bae, S. C., Chung, A., Kim, M. J., Chang, K. H., Ryu, J., Renshaw, P. F., & Lyoo, I. K. (2006) · Neuropsychobiology · doi:10.1159/000098262 · Cited by 102 · see citing works
Hippocampal Regulation of Aversive Memories
Goosens, K. A. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.04.003 · Cited by 95 · see citing works
Baur, V., Brühl, A. B., Herwig, U., Eberle, T., Rufer, M., Delsignore, A., Jäncke, L., & Hänggi, J. (2011) · Human Brain Mapping · doi:10.1002/hbm.21447 · Cited by 88 · see citing works
Morell, P., & Norton, W. T. (1980) · Scientific American · doi:10.1038/scientificamerican0580-88 · Cited by 86 · see citing works
Molecular Specificity of Multiple Hippocampal Processes Governing Fear Extinction
Radulović, J., & Tronson, N. C. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.1.1 · Cited by 82 · see citing works
Zhang, L., Zhang, Y., Li, L., Li, Z., Li, W., Ma, N., Hou, C., Zhang, Z., Zhang, Z., Wang, L., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.040 · Cited by 81 · see citing works
Altered white matter connectivity in never-medicated patients with schizophrenia
Mandl, R. C. W., Rais, M., van Baal, G. C. M., van Haren, N. E. M., Cahn, W., Kahn, R. S., & Pol, H. E. H. (2012) · Human Brain Mapping · doi:10.1002/hbm.22075 · Cited by 68 · see citing works
Disrupted white matter tract integrity of anterior cingulate in trauma survivors
Kim, M. J., Lyoo, I. K., Kim, S. J., Sim, M., Kim, N., Choi, N., Jeong, D. U., Covell, J., & Renshaw, P. F. (2005) · Neuroreport · doi:10.1097/00001756-200507130-00004 · Cited by 68 · see citing works
Soderblom, L. A. (1980) · Scientific American · doi:10.1038/scientificamerican0180-88 · Cited by 61 · see citing works
Tavanti, M., Battaglini, M., Borgogni, F., Bossini, L., Calossi, S., Marino, D., Vatti, G., Pieraccini, F., Federico, A., Castrogiovanni, P., et al. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0659-4 · Cited by 53 · see citing works
Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors
Chen, L., Lui, S., Wu, Q., Zhang, W., Zhou, D., Chen, H., Huang, X., Kuang, W., Chan, R. C. K., Mechelli, A., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21438 · Cited by 40 · see citing works
Chiang, M.-C., Avedissian, C., Marina Barysheva, A., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., Wright, M. J., & Thompson, P. M. (2009) · Lecture notes in computer science · doi:10.1007/978-3-642-04271-3_62 · Cited by 27 · see citing works
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Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
Self-citationAkiki, T. J., Averill, C. L., & Abdallah, C. G. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0840-4 · Cited by 365 · see citing works
Stevens, J. S., Jovanovic, T., Fani, N., Ely, T. D., Glover, E. M., Bradley, B., & Ressler, K. J. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.031 · Cited by 293 · see citing works
Self-citationA Review of Mental Health and Mental Health Care Disparities Research: 2011-2014
Cook, B. L., Hou, S. S., Lee‐Tauler, S. Y., Progovac, A. M., Samson, F. L., & Román, M. J. S. (2018) · Medical Care Research and Review · doi:10.1177/1077558718780592 · Cited by 178 · see citing works
Jenkins, L. M., Barba, A., Campbell, M. L., Lamar, M., Shankman, S. A., Leow, A., Ajilore, O., & Langenecker, S. A. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.09.001 · Cited by 147 · see citing works
Krystal, J. H., Abdallah, C. G., Averill, L. A., Kelmendi, B., Harpaz-Rotem, I., Sanacora, G., Southwick, S. M., & Duman, R. S. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0829-z · Cited by 145 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0631-x · Cited by 108 · see citing works
Self-citationThe nature of white matter abnormalities in blast-related mild traumatic brain injury
Hayes, J. P., Miller, D. R., Lafleche, G., Salat, D. H., & Verfaellie, M. H. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.04.001 · Cited by 103 · see citing works
Zaba, M., Kirmeier, T., Ionescu, I. A., Wollweber, B., Buell, D. R., Gall-Kleebach, D. J., Schubert, C. F., Novak, B., Huber, C., Köhler, K., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.02.005 · Cited by 101 · see citing works
Siehl, S., King, J. A., Burgess, N., Flor, H., & Nees, F. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.05.013 · Cited by 102 · see citing works
Moreno-López, L., Ioannidis, K., Askelund, A. D., Smith, A., Schueler, K., & van Harmelen, A. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.008 · Cited by 93 · see citing works
Aberrant structural connectivity in childhood maltreatment: A meta-analysis
Lim, L. L., Howells, H., Raduà, J., & Rubia, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.004 · Cited by 82 · see citing works
Fani, N., King, T. Z., Shin, J., Srivastava, A., Brewster, R. C., Jovanovic, T., Bradley, B., & Ressler, K. J. (2016) · Depression and Anxiety · doi:10.1002/da.22483 · Cited by 80 · see citing works
Self-citationKoch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160129 · Cited by 80 · see citing works
Towards new approaches to disorders of fear and anxiety
Dias, B. G., Banerjee, S. B., Goodman, J. V., & Ressler, K. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.013 · Cited by 79 · see citing works
Self-citationNeurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction
Al’Absi, M., Ginty, A. T., & Lovallo, W. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108519 · Cited by 80 · see citing works
White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event
Li, L., Lei, D., Li, L., Huang, X., Suo, X., Xiao, F., Kuang, W., Li, J., Bi, F., Lui, S., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.012 · Cited by 75 · see citing works
White matter integrity alterations in post‐traumatic stress disorder
O'Doherty, D. C. M., Ryder, W., Paquola, C., Tickell, A. M., Chan, C., Hermens, D. F., Bennett, M. R., & Lagopoulos, J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23920 · Cited by 71 · see citing works
Treatment Outcome-Related White Matter Differences in Veterans with Posttraumatic Stress Disorder
Kennis, M., van Rooij, S. J. H., Tromp, D., Fox, A. S., Rademaker, A. R., Kahn, R. S., Kalin, N. H., & Geuze, E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.94 · Cited by 75 · see citing works
White matter abnormalities associated with military PTSD in the context of blast TBI
Davenport, N. D., Lim, K. O., & Sponheim, S. R. (2015) · Human Brain Mapping · doi:10.1002/hbm.22685 · Cited by 68 · see citing works
FKBP5 Genotype and Structural Integrity of the Posterior Cingulum
Fani, N., King, T. Z., Reiser, E., Binder, E. B., Jovanović, T., Bradley, B., & Ressler, K. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.322 · Cited by 68 · see citing works
Self-citationReuveni, I., Bonne, O. B., Giesser, R., Shragai, T., Lazarovits, G., Isserles, M., Schreiber, S., Bick, A. S., & Levin, N. (2015) · Human Brain Mapping · doi:10.1002/hbm.23051 · Cited by 65 · see citing works
Physical neglect during childhood alters white matter connectivity in healthy young males
Tendolkar, I., Mårtensson, J., Kühn, S., Klumpers, F., & Fernández, G. (2017) · Human Brain Mapping · doi:10.1002/hbm.23916 · Cited by 61 · see citing works
Fani, N., King, T. Z., Brewster, R. C., Srivastava, A., Stevens, J. S., Glover, E. M., Norrholm, S., Bradley, B., Ressler, K., & Jovanović, T. (2014) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2014.11.006 · Cited by 62 · see citing works
Self-citationLong, Z., Duan, X., Xie, B., Du, H., Li, R., Xu, Q., Wei, L., Zhang, S., Wu, Y., Gao, Q. C., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.03.004 · Cited by 54 · see citing works
White matter abnormalities in Gulf War veterans with posttraumatic stress disorder: A pilot study
Bierer, L. M., Ivanov, I., Carpenter, D. M., Wong, E. W., Golier, J. A., Tang, C. Y., & Yehuda, R. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.007 · Cited by 50 · see citing works
Olson, E. A., Cui, J., Fukunaga, R., Nickerson, L. D., Rauch, S. L., & Rosso, I. M. (2017) · Depression and Anxiety · doi:10.1002/da.22615 · Cited by 52 · see citing works
Ju, Y., Ou, W., Su, J., Averill, C. L., Liu, J., Wang, M., Wang, Z., Zhang, Y., Liu, B., Li, L., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.047 · Cited by 51 · see citing works
Costanzo, M. E., Jovanović, T., Pham, D. L., Leaman, S. C., Highland, K. B., Norrholm, S. D., & Roy, M. J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.041 · Cited by 49 · see citing works
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Self-citationHan, K.-M., Won, E., Kang, J., Choi, S., Kim, A., Lee, M.-S., Tae, W.-S., & Ham, B.-J. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.05.010 · Cited by 46 · see citing works
Choi, S., Han, K., Kang, J. C., Won, E., Chang, H. S., Tae, W., Son, K. R., Kim, S. J., Lee, M.-S., & Ham, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164301 · Cited by 45 · see citing works
Reframing postconcussional syndrome as an interface disorder of neurology, psychiatry and psychology
Clark, C. N., Edwards, M. J., Ong, B. E., Goodliffe, L., Ahmad, H., Dilley, M. D., Betteridge, S., Griffin, C., & Jenkins, P. O. (2022) · Brain · doi:10.1093/brain/awac149 · Cited by 45 · see citing works
Fani, N., King, T. Z., Clendinen, C., Hardy, R. A., Surapaneni, S., Blair, J., White, S. F., Powers, A. D., Ely, T. D., Jovanović, T., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.098 · Cited by 45 · see citing works
Self-citationKeifer, O. P., Gutman, D. A., Hecht, E. E., Keilholz, S. D., & Ressler, K. J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.047 · Cited by 44 · see citing works
Self-citationZhu, X., Suarez‐Jimenez, B., Zilcha‐Mano, S., Lazarov, A., Arnon, S., Lowell, A. L., Bergman, M., Ryba, M., Hamilton, A. J., Hamilton, J. F., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25360 · Cited by 46 · see citing works
Hu, H., Zhou, Y., Wang, Q., Su, S., Qiu, Y., Ge, J., Wang, Z., & Xiao, Z. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.044 · Cited by 37 · see citing works
Sydnor, V. J., Sylvain Bouix, A., Pasternak, O., Härtl, E., Levin-Gleba, L., Reid, B. E., Tripodis, Y., Guenette, J. P., Kaufmann, D., Makris, N., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102190 · Cited by 41 · see citing works
Main, K., Soman, S., Pestilli, F., Furst, A. J., Noda, A. M., Hernandez, B., Kong, J., Cheng, J. J., Fairchild, J. K., Taylor, J. L., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.06.031 · Cited by 36 · see citing works
Lopez, K. C., Leary, J. B., Pham, D. L., Chou, Y., Dsurney, J., & Chan, L. E. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4323 · Cited by 35 · see citing works
Structural connectivity and risk for anhedonia after trauma: A prospective study and replication
Fani, N., Michopoulos, V., van Rooij, S. J. H., Clendinen, C., Hardy, R. A., Jovanović, T., ROTHBAUM, B. O., Ressler, K. J., & Stevens, J. S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.009 · Cited by 35 · see citing works
Self-citationStress: The roots of resilience
HUGHES, V. A. (2012) · Nature · doi:10.1038/490165a · Cited by 34 · see citing works
Slavova, D., Ortiz, V., Blaise, M., Bairachnaya, M., Bruno Giros, A., & Isingrini, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105925 · Cited by 36 · see citing works
Structural brain correlates of resilience to traumatic stress in Dutch police officers
van der Werff, S. J. A., Elzinga, B. M., Smit, A. S., & van der Wee, N. J. A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.08.019 · Cited by 31 · see citing works
Stress, trauma and PTSD: translational insights into the core synaptic circuitry and its modulation
Bennett, M. R., Hatton, S. N., & Lagopoulos, J. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1056-1 · Cited by 33 · see citing works
Fujii, T., Ota, M., Hori, H., Hattori, K., Teraishi, T., Sasayama, D., Higuchi, T., & Kunugi, H. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.009 · Cited by 31 · see citing works
Lei, D., Li, L., Li, L., Suo, X., Huang, X., Lui, S., Li, J., Bi, F., Kemp, G. J., & Gong, Q. (2015) · Scientific Reports · doi:10.1038/srep08933 · Cited by 31 · see citing works
Lischke, A., Domín, M., Freyberger, H. J., Grabe, H. J., Mentel, R., Bernheim, D., & Lotze, M. (2015) · Psychological Medicine · doi:10.1017/s0033291715001142 · Cited by 30 · see citing works
Current and future functional imaging techniques for post-traumatic stress disorder
Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., & Gartia, M. R. (2019) · RSC Advances · doi:10.1039/c9ra03562a · Cited by 32 · see citing works
Okeke, O., Elbasheir, A., Carter, S. E., Powers, A. D., Mekawi, Y., Gillespie, C. F., Schwartz, A. C., Bradley, B., & Fani, N. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.05.004 · Cited by 29 · see citing works
Self-citationBen‐Zion, Z., Fine, N. B., Keynan, J. N., Admon, R., Halpern, P., Liberzon, I., Hendler, T., & Shalev, A. Y. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1683941 · Cited by 30 · see citing works
Siehl, S., Wicking, M., Pohlack, S. T., Winkelmann, T., Zidda, F., Steiger-White, F., King, J. A., Burgess, N., Flor, H., & Nees, F. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102424 · Cited by 27 · see citing works
DeRosse, P., Ikuta, T., Peters, B. D., Karlsgodt, K. H., Szeszko, P. R., & Malhotra, A. K. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.09.001 · Cited by 27 · see citing works
Resilience and White Matter Integrity in Geriatric Depression
Vlasova, R. M., Siddarth, P., Krause, B., Leaver, A. M., Laird, K. T., St Cyr, N., Narr, K. L., & Lavretsky, H. (2018) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.04.004 · Cited by 25 · see citing works
Herrold, A., Kletzel, S., Harton, B., Chambers, R., Jordan, N., & Pape, T.-B. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.143408 · Cited by 25 · see citing works
Waltzman, D., Soman, S., Hantke, N. C., Fairchild, J. K., Kinoshita, L. M., Wintermark, M., Ashford, J. W., Yesavage, J. A., Williams, L. M., Adamson, M. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170564 · Cited by 25 · see citing works
Tomas, C. W., Belleau, E. L., Pedersen, W. S., Miskovich, T. A., & Larson, C. L. (2018) · Chronic Stress · doi:10.1177/2470547018807134 · Cited by 25 · see citing works
Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder
Averill, C. L., Averill, L. A., Wrocklage, K. M., Scott, J. C., Akiki, T. J., Schweinsburg, B. C., Southwick, S. M., Krystal, J. H., & Abdallah, C. G. (2018) · Complex Psychiatry · doi:10.1159/000490464 · Cited by 22 · see citing works
Brain structural connectivity and context‐dependent extinction memory
Hermann, A., Stark, R. M., Blecker, C. R., Milad, M. R., & Merz, C. J. (2017) · Hippocampus · doi:10.1002/hipo.22738 · Cited by 23 · see citing works
Cortical complexity in world trade center responders with chronic posttraumatic stress disorder
Kritikos, M., Clouston, S., Huang, C., Pellecchia, A. C., Mejia‐Santiago, S., Carr, M. A., Kotov, R., Lucchini, R. G., Gandy, S., Bromet, E. J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01719-7 · Cited by 23 · see citing works
Spadoni, A. D., Huang, M., & Simmons, A. N. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_35 · Cited by 23 · see citing works
A Physarum Centrality Measure of the Human Brain Network
Kwon, H., Choi, Y. H., & Lee, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-42322-7 · Cited by 23 · see citing works
Microstructural white matter alterations in borderline personality disorder: A minireview
Grottaroli, M., Delvecchio, G., Bressi, C., Moltrasio, C., Soares, J. C., & Brambilla, P. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.12.033 · Cited by 23 · see citing works
Wong, S., Lebois, L. A. M., Ely, T. D., van Rooij, S. J. H., Bruce, S. E., Murty, V. P., Jovanović, T., House, S. L., Beaudoin, F. L., An, X., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02012-3 · Cited by 21 · see citing works
Self-citationAlmli, L. M., Srivastava, A., Fani, N., Kerley, K. A., Mercer, K. B., Feng, H., Bradley, B., & Ressler, K. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.017 · Cited by 21 · see citing works
Self-citationHarrington, D. L., Hsu, P., Theilmann, R. J., Angeles‐Quinto, A., Robb, A., Nichols, S., Song, T., Le, L., Rimmele, C. T., Matthews, S. C., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12040987 · Cited by 18 · see citing works
Kennis, M., van Rooij, S. J. H., Kahn, R. S., Geuze, E., & Leemans, A. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2016.03.022 · Cited by 18 · see citing works
The neurobiology of brain recovery from traumatic stress: A longitudinal DTI study
Meng, L., Chen, Y., Xu, X. Y., Chen, T., Lui, S., Huang, X., Sweeney, J. A., Li, K., & Gong, Q. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.075 · Cited by 17 · see citing works
Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice
Corne, R., Leconte, C., Ouradou, M., Fassina, V., Zhu, Y., Déou, E., Besson, V. C., Plotkine, M., Marchand‐Leroux, C., & Mongeau, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.07.023 · Cited by 17 · see citing works
Kim, G. S., & Uddin, M. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00288-6 · Cited by 17 · see citing works
McCunn, P., Richardson, J. A., Jetly, R., & Dunkley, B. T. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113797 · Cited by 16 · see citing works
Dennis, E. L., Disner, S. G., Fani, N., Salminen, L. E., Logue, M. W., Clarke‐Rubright, E. K., Haswell, C. C., Averill, C. L., Baugh, L. A., Bomyea, J. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/677153 · Cited by 16 · see citing works
Self-citationLiu, J., Likhtik, E., Shereen, A. D., Dennis‐Tiwary, T. A., & Casaccia, P. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.587053 · Cited by 15 · see citing works
Bottari, S. A., Lamb, D. G., Murphy, A. J., Porges, E. C., Rieke, J. D., Harciarek, M., Datta, S., & Williamson, J. B. (2021) · Brain Injury · doi:10.1080/02699052.2021.1927186 · Cited by 15 · see citing works
Personality and neuroimaging measures differentiate PTSD from mTBI in veterans
Davenport, N. D., Lim, K. O., & Sponheim, S. R. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9371-y · Cited by 15 · see citing works
Webb, E. K., Ely, T. D., Rowland, G. E., Lebois, L. A. M., van Rooij, S. J. H., Bruce, S. E., Jovanović, T., House, S. L., Beaudoin, F. L., An, X., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.34483 · Cited by 14 · see citing works
Self-citationThe Corpus Callosum and PTSD Severity
Graziano, R. C., Bruce, S. E., & Paul, R. H. (2019) · Journal of Interpersonal Violence · doi:10.1177/0886260519835007 · Cited by 15 · see citing works
Romaniuk, M., Xia, Y., Fisher, G., Pannek, K., Fripp, J., Evans, J., & Rose, S. (2022) · Military Medical Research · doi:10.1186/s40779-022-00413-z · Cited by 16 · see citing works
Liu, Y., Lian, J., Fu, Y., Wang, S., Liu, Y., Zhang, R., & Han, H. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100762 · Cited by 12 · see citing works
Scene Construction and Spatial Processing in Post-traumatic Stress Disorder
Marlatte, H., Beaton, D., Adler-Luzon, S., Abo-Ahmad, L., & Gilboa, A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.888358 · Cited by 12 · see citing works
Cingulate and hippocampal subregion abnormalities in combat-exposed veterans with PTSD
Szeszko, P. R., Bierer, L. M., Bader, H. N., Chu, K.-W., Tang, C. Y., Murphy, K. M., Hazlett, E. A., Flory, J. D., & Yehuda, R. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.081 · Cited by 11 · see citing works
Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms
Tomas, C. W., Huggins, A. A., Miskovich, T. A., Fitzgerald, J. M., Bennett, K. P., Krukowski, J. L., Webb, E. K., deRoon‐Cassini, T. A., & Larson, C. L. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.742198 · Cited by 11 · see citing works
Early life adversity and white matter microstructural organization—a systematic review
Mitchell, O., Roddy, D. W., & Connaughton, M. (2025) · Brain Imaging and Behavior · doi:10.1007/s11682-025-01007-8 · Cited by 10 · see citing works
Treatment outcome of posttraumatic stress disorder: A white matter tract analysis
Graziano, R. C., Vuper, T. C., Yetter, M. A., & Bruce, S. E. (2021) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2021.102412 · Cited by 11 · see citing works
Saar‐Ashkenazy, R., Shalev, H., Kanthak, M. K., Guez, J., Friedman, A., & Cohen, J. E. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.05.015 · Cited by 10 · see citing works
White matter microstructure in trauma‐exposed children: Associations with pubertal stage
Fani, N., Stenson, A. F., van Rooij, S. J. H., Barrie, D. L. L., & Jovanović, T. (2021) · Developmental Science · doi:10.1111/desc.13120 · Cited by 9 · see citing works
Self-citationYoon, S. A., & Weierich, M. R. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.015 · Cited by 8 · see citing works
Guo, Y., Liu, S., Poletti, S., Liu, W., Liu, Y., Zhao, J., Xiong, Q., Zheng, H., Wei, D., Li, J., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725100780 · Cited by 7 · see citing works
Hanson, K. L., Avino, T. A., Taylor, S. L., Murray, K. D., & Schumann, C. M. (2025) · Molecular Autism · doi:10.1186/s13229-025-00684-y · Cited by 7 · see citing works
The Influence of Social Exclusion on Posttraumatic Stress Reactions in Older Adult Veterans
Olson, M. D. (2020) · Social Work · doi:10.1093/sw/swaa008 · Cited by 7 · see citing works
Uldall, S. W., Lundell, H., Baaré, W. F. C., Siebner, H. R., Rostrup, E., & Carlsson, J. M. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102929 · Cited by 7 · see citing works
Cho, H., Likhtik, E., & Dennis‐Tiwary, T. A. (2021) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-020-00855-9 · Cited by 7 · see citing works
White Matter Abnormalities in Patients With Typhoon-Related Posttraumatic Stress Disorder
Chen, H., Qi, R., Ke, J., Qiu, J., Xu, Q., Zhong, Y., Lu, G., & Chen, F. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.665070 · Cited by 6 · see citing works
Translational In Vivo Assays in Behavioral Biology
Withey, S. L., Pizzagalli, D. A., & Bergman, J. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-093711 · Cited by 4 · see citing works
Zhang, Y., Chen, H., Qi, R., Ke, J., Xu, Q., Zhong, Y., Wu, Y., Guo, Y., Lu, G., & Chen, F. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00755-1 · Cited by 5 · see citing works
Mohamed, A. Z., Lagopoulos, J., Nasrallah, F. A., & Shan, Z. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.03.029 · Cited by 5 · see citing works
Brain Structural Abnormalities in Posttraumatic Stress Disorder and Relations with Sleeping Problems
Liberzon, I., Wang, X., & Xie, H. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_12 · Cited by 5 · see citing works
White matter correlates of dissociation in a diverse sample of trauma-exposed women
Kondas, A., McDermott, T. J., Ahluwalia, V., Haller, O. C., Karkare, M. C., Guelfo, A., Daube, A., Bradley, B., Powers, A. D., Stevens, J. S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116231 · Cited by 4 · see citing works
Self-citationRodriguez, A., Petropoulos, H., Sanjuan, P. M., Wang, Y., Wilson, T. W., Calhoun, V. D., & Stephen, J. M. (2025) · Stresses · doi:10.3390/stresses5010019 · Cited by 4 · see citing works
- Authors
- Fani, N., King, T. Z., Jovanovic, T., Glover, E. M., Bradley, B., Choi, K., Ely, T., Gutman, D. A., & Ressler, K. J.
- Affiliations
- Emory University (US)
- Georgia State University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fani, Negar
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2012-08-08
- Volume
- 37
- Issue
- 12
- Pages
- 2740-2746
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3473340
- OpenAlex
- W2007304263
- Cited by
- 135
- References
- 54
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 18 · 2020: 11 · 2019: 15 · 2018: 8 · 2017: 15 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 1
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Burroughs Wellcome Fund
- Georgia Institute of Technology
- Georgia State University
- National Institutes of Health (UL1TR000454, RR025008)
- Center for Advanced Brain Imaging
- National Institute of Mental Health (R21MH098212, R01MH096764, R01MH071537, F32MH095456)
- National Institute of General Medical Sciences (K12GM000680)
- National Center for Research Resources (UL1RR025008, RR025008)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, white matter integrity, posterior cingulum, fractional anisotropy, African American women, entorhinal cortex, cingulate cortex, fear extinction, declarative memory, attention
- MeSH terms
- Adult, Black or African American, Brain, Depression, Female, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Surveys and Questionnaires, Rape, Risk Factors, Stress Disorders, Post-Traumatic, Violence, Wounds and Injuries, Models, Statistical, Cluster Analysis, Anisotropy, Young Adult, Diffusion Tensor Imaging
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