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Cited by 71Suicide and Self-Harm StudiesMental Health Treatment and AccessCardiac Health and Mental Health

Is excess mortality higher in depressed men than in depressed women? A meta-analytic comparison

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Cuijpers, Pim, Vogelzangs, Nicole, Twisk, Jos, Kleiboer, Annet, Li, Juan, Penninx, Brenda W.·2014·Journal of Affective Disorders
DOI 10.1016/j.jad.2014.03.003
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Abstract

Background It is not well-established whether excess mortality associated with depression is higher in men than in women. Methods We conducted a meta-analysis of prospective studies in which depression was measured at baseline, where mortality rates were reported at follow-up, and in which separate mortality rates for men and women were reported. We conducted systematic searches in bibliographical databases and calculated relative risks of excess mortality in men and women. Results Thirteen studies were included. Among the people with depression, excess mortality in men was higher than in women (RR=1.97; 1.63-2.37). Compared with non-depressed participants, excess mortality was increased in depressed women (RR=1.55; 95% CI: 1.32-1.82), but not as much as in men (RR=2.04; 95% CI: 1.76-2.37), and the difference between excess mortality in men was significantly higher than in women (p Conclusions Excess mortality related to depression is higher in men than in women. Although the exact mechanisms for this difference are not clear, it may point at differential or more intensified pathways leading from depression to increased mortality in depressed men compared to women.

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Authors
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., & Penninx, B. W.
Affiliations
  • Leuphana University of Lüneburg (DE)
  • Amsterdam Public Health (NL)
  • Chinese Academy of Sciences (CN)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2014-06
Volume
161
Pages
47-54
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2014.03.003
OpenAlex
W2097985079
Cited by
71
References
46
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 6
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
  • VU Research Portal (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • Multilingual Matters (Channel View Publications) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
depression, excess mortality, sex differences, men, women, mortality risk
MeSH terms
Adult, Depression, Depressive Disorder, Female, Humans, Male, Middle Aged, Prospective Studies, Risk, Sex Factors

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