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Cited by 216Curcumin's Biomedical ApplicationsTreatment of Major DepressionTryptophan and brain disorders

The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Lopresti, Adrian L., Maes, Michael, Maker, Garth L., Hood, Sean D., Drummond, Peter D.·2014·Journal of Affective Disorders
DOI 10.1016/j.jad.2014.06.001
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Abstract

Background Curcumin, the principal curcuminoid derived from the spice turmeric, influences several biological mechanisms associated with major depression, namely those associated with monoaminergic activity, immune-inflammatory and oxidative and nitrosative stress pathways, hypothalamus-pituitary-adrenal (HPA) axis activity and neuroprogression. We hypothesised that curcumin would be effective for the treatment of depressive symptoms in individuals with major depressive disorder.Methods In a randomised, double-blind, placebo-controlled study, 56 individuals with major depressive disorder were treated with curcumin (500 mg twice daily) or placebo for 8 weeks. The primary measure was the Inventory of Depressive Symptomatology self-rated version (IDS-SR30). Secondary outcomes included IDS-SR30 factor scores and the Spielberger State-Trait Anxiety Inventory (STAI).Results From baseline to week 4, both curcumin and placebo were associated with improvements in IDS-SR30 total score and most secondary outcome measures. From weeks 4 to 8, curcumin was significantly more effective than placebo in improving several mood-related symptoms, demonstrated by a significant group x time interaction for IDS-SR30 total score (F1, 53=4.22, p=.045) and IDS-SR30 mood score (F1, 53=6.51, p=.014), and a non-significant trend for STAI trait score (F1, 48=2.86, p=.097). Greater efficacy from curcumin treatment was identified in a subgroup of individuals with atypical depression.Conclusions Partial support is provided for the antidepressant effects of curcumin in people with major depressive disorder, evidenced by benefits occurring 4 to 8 weeks after treatment.Limitations Investigations with larger sample sizes, over extended treatment periods, and with varying curcumin dosages are required.

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  1. Milobedzka, 1910, Structure of curcumin, Ber. Dtsch. Chem. Ges., 43, 2163

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Metadata

Authors
Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D.
Affiliations
  • Murdoch University (AU)
  • Deakin University (AU)
  • The University of Western Australia (AU)
Corresponding author
Lopresti, Adrian L.
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2014-10
Volume
167
Pages
368-375
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2014.06.001
OpenAlex
W2048063648
Cited by
216
References
62
Citations by year
2026: 22 · 2025: 16 · 2024: 16 · 2023: 16 · 2022: 12 · 2021: 21 · 2020: 13 · 2019: 23 · 2018: 18 · 2017: 16 · 2016: 14 · 2015: 26 · 2014: 3
FWCI
8.99
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Murdoch University Research Portal (submittedVersion)
Funders
Arjuna Natural Extracts Limited
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
curcumin, major depressive disorder, antidepressant effects, atypical depression, depressive symptoms, anxiety, neuroinflammation, oxidative stress, hypothalamic-pituitary-adrenal axis, turmeric, natural product therapy
MeSH terms
Adult, Affect, Antidepressive Agents, Curcumin, Depressive Disorder, Major, Major Depressive Disorder, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Psychometrics, Surveys and Questionnaires, Western Australia

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