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Cited by 38Pharmaceutical Practices and Patient OutcomesDementia and Cognitive Impairment ResearchIntensive Care Unit Cognitive Disorders

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Potentially inappropriate medication: Association between the use of antidepressant drugs and the subsequent risk for dementia.

Heser, Kathrin, Luck, Tobias, Röhr, Susanne, Wiese, Birgitt, Kaduszkiewicz, Hanna, Oey, Anke, Bickel, Horst, Mösch, Edelgard, Weyerer, Siegfried, Werle, Jochen, Brettschneider, Christian, König, Hans-Helmut, Fuchs, Angela, Pentzek, Michael, van den Bussche, Hendrik, Scherer, Martin, Maier, Wolfgang, Riedel-Heller, Steffi G., Wagner, Michael·2018·Journal of Affective Disorders
DOI 10.1016/j.jad.2017.09.016
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Abstract

Background Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia. Methods We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79.62) to compute Cox proportional hazards models. The risk for subsequent dementia was estimated over eight follow-ups up to 12 years depending on antidepressant intake and covariates. Results The intake of antidepressants was associated with an increased risk for subsequent dementia (HR = 1.53, 95% CI: 1.16-2.02, p = .003; age-, sex-, education-adjusted). PIM antidepressants (HR = 1.49, 95% CI: 1.06-2.10, p = .021), but not other antidepressants (HR = 1.04, 95% CI: 0.66-1.66, p = .863), were associated with an increased risk for subsequent dementia (in age-, sex-, education-, and depressive symptoms adjusted models). Significant associations disappeared after global cognition at baseline was controlled for. Limitations Methodological limitations such as selection biases and self-reported drug assessments might have influenced the results. Conclusions Only antidepressants considered as PIM were assoc…

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Metadata

Authors
Heser, K., Luck, T., Röhr, S., Wiese, B., Kaduszkiewicz, H., Oey, A., Bickel, H., Mösch, E., Weyerer, S., Werle, J., Brettschneider, C., König, H.-H., Fuchs, A., Pentzek, M., van den Bussche, H., Scherer, M., Maier, W., Riedel-Heller, S. G., & Wagner, M.
Affiliations
  • University of Bonn (DE)
  • Leipzig University (DE)
  • Medizinische Hochschule Hannover (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Technical University of Munich (DE)
  • Heidelberg University (DE)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Heinrich Heine University Düsseldorf (DE)
Corresponding author
Heser, Kathrin
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2018-01
Volume
226
Pages
28-35
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2017.09.016
OpenAlex
W2755554653
Cited by
38
References
3
Citations by year
2025: 5 · 2024: 9 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 5
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • DZNE Pub (submittedVersion)
Funders
  • German Federal Ministry of Education and Research (01GI0102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 01GI0434)
  • KNDD (01GI0710, 01GI0711, 01GI0712, 01GI0713, 01GI0714, 01GI0715, 01GI0716)
  • Health Service Research Initiative (01GY1322A, 01GY1322B, 01GY1322C, 01GY1322D, 01GY1322E, 01GY1322F, 01GY1322G)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
potentially inappropriate medications, antidepressants, dementia risk, PRISCUS list, elderly patients, anticholinergic effects, cognitive function, depression, primary care patients
MeSH terms
Potentially Inappropriate Medication List, Aged, Aged, 80 and over, Antidepressive Agents, Cognition, Dementia, Depression, Female, Humans, Male, Primary Health Care, Prospective Studies, Risk Factors, Proportional Hazards Models

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