Tachyphylaxis in major depressive disorder: A review of the current state of research
Open accessAbstract
Background Patients with major depressive disorder (MDD) often experience a re-emergence or worsening of symptoms despite ongoing treatment with previously effective antidepressant pharmacotherapy. This lost or reduced antidepressant response during maintenance, referred to as tachyphylaxis, negatively impacts treatment outcomes and quality of life for patients with MDD. This review assesses the prevalence of antidepressant tachyphylaxis as well as the evidence for interventions to manage it.Methods We searched PubMed/Medline for the relevant clinical trials and meta-analyses on antidepressant tachyphylaxis up to January 2017. Search terms included "depression" paired with "treatment" (n = 186,674), "tachyphylaxis" paired with "depression" (n = 112), "tachyphylaxis" paired with "major depressive disorder" (n = 21), and "antidepressant" paired with "tachyphylaxis" (n = 68). Studies were included if they reported on a clinical trial or meta-analysis exploring tachyphylaxis in MDD and were excluded if the sample population did not have a primary DSM diagnosis of MDD.Results Rates of tachyphylaxis varied from 9% to 57% depending on the patient population and duration of follow-up. Limited evidence suggests potentially beneficial strategies for managing tachyphylaxis, including change in antidepressant dosing, switch of class of antidepressant medication, augmentation or combination pharmacotherapy, and psychotherapy.Limitations Studies of antidepressant tachyphylaxis are largely heterogeneous in nature and employ strict inclusion/exclusion criteria; thus, these findings may not be generalizable to all depressed populations.Conclusion Few established treatment strategies exist to manage antidepressant tachyphylaxis. Further interventional research is needed to provide symptomatic relief for patients with tachyphylaxis in MDD.
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The phenomenon of loss of treatment efficacy is not generalized, since it involves a segment of the treated population that increases progressively over time.
“However, this possibility runs counter the fact that the phenomenon is not generalized, since it involves a segment of the treated population that increases progressively over time.”
From May antidepressant drugs worsen the conditions they are supposed to treat? The clinical foundations of the oppositional model of tolerance (2020) · cites this paper as [12]
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Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works
Self-citationDiagnosis and definition of treatment-resistant depression
Fava, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00231-2 · Cited by 1,380 · see citing works
Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression
Goodwin, F. K., & Jamison, K. R. (2007) · Medical Entomology and Zoology · Cited by 1,325 · see citing works
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh, B. T., Seidman, S. N., Sysko, R., & Gould, M. (2002) · JAMA · doi:10.1001/jama.287.14.1840 · Cited by 1,109 · see citing works
Multiple recurrences of major depressive disorder
Solomon, D. A., Keller, M. B., Leon, A. C., Mueller, T. I., Lavori, P. W., Shea, M. T., Coryell, W., Warshaw, M., Turvey, C., Maser, J. D., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.229 · Cited by 835 · see citing works
(1997) · PubMed · Cited by 727 · see citing works
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601 · see citing works
Sackeim, H. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00271-8 · Cited by 568 · see citing works
Brunoni, A. R., Chaimani, A., Moffa, A. H., Razza, L. B., Gattaz, W. F., Daskalakis, Z. J., & Carvalho, A. F. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3644 · Cited by 520 · see citing works
Rush, A. J., Trivedi, M. H., Stewart, J. W., Nierenberg, A. A., D, M. F. M., Kurian, B. T., Warden, D., Morris, D. W., Luther, J. F., Husain, M. M., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111645 · Cited by 372 · see citing works
Self-citationPredictors of Relapse in Major Depressive Disorder
Keller, M. B. (1983) · JAMA · doi:10.1001/jama.1983.03340240025024 · Cited by 304 · see citing works
Texas Medication Algorithm Project
Gilbert, D. A., Altshuler, K. Z., Rago, W. V., Shon, S. P., Crismon, M. L., Toprac, M. G., & Rush, A. J. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0702 · Cited by 264 · see citing works
Crismon, M. L., Trivedi, M., Pigott, T. A., Rush, A. J., Hirschfeld, R. M. A., Kahn, D. A., DeBattista, C., Nelson, J. C., Nierenberg, A. A., Sackeim, H. A., et al. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0302 · Cited by 250 · see citing works
Self-citationCrossley, N. A., & Bauer, M. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0617 · Cited by 246 · see citing works
Papakostas, G. I., Shelton, R. C., Smith, J., & D, M. F. M. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0602 · Cited by 242 · see citing works
Self-citationKarp, J. F., Butters, M. A., Begley, A. E., Miller, M. D., Lenze, E. J., Blumberger, D. M., Mulsant, B. H., & Reynolds, C. F. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08725 · Cited by 191 · see citing works
Chandler, G. M., Iosifescu, D. V., Pollack, M. H., Targum, S. D., & Fava, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00102.x · Cited by 158 · see citing works
Clinical Evidence and Potential Neurobiological Underpinnings of Unresolved Symptoms of Depression
Trivedi, M. H., Hollander, E., Nutt, D., & Blier, P. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0211 · Cited by 153 · see citing works
Loss of Antidepressant Efficacy During Maintenance Therapy: Possible Mechanisms and Treatments
Byrne, S. E., & Rothschild, A. J. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0602 · Cited by 149 · see citing works
Rapaport, M. H., Gharabawi, G. M., Canuso, C. M., Mahmoud, R. A., Keller, M. B., Bossie, C. A., Turkoz, I., Lasser, R. A., Loescher, A., Bouhours, P., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301113 · Cited by 148 · see citing works
Outcome of patients with chronic affective disorder: a five-year follow- up
Coryell, W. H., Endicott, J., & Keller, M. B. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.12.1627 · Cited by 125 · see citing works
Lee, E. E., Della Selva, M. P., Liu, A., & Himelhoch, S. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.003 · Cited by 124 · see citing works
Ketamine as a promising prototype for a new generation of rapid‐acting antidepressants
Abdallah, C. G., Averill, L. A., & Krystal, J. H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12718 · Cited by 121 · see citing works
Brunelin, J., Jalenques, I., Trojak, B., Attal, J., Székely, D. L., Gay, A., Januel, D., Haffen, É., Schott, A., Brault, C., et al. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.07.040 · Cited by 120 · see citing works
Keller, M. B., Trivedi, M. H., Thase, M. E., Shelton, R. C., Kornstein, S. G., Nemeroff, C. B., Friedman, E. S., Gelenberg, A. J., Kocsis, J. H., Dunner, D. L., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0812 · Cited by 116 · see citing works
Sehatzadeh, S., Tu, H., Palimaka, S., Yap, B., O’Reilly, D. J., & Bowen, J. M. (2016) · Cited by 102 · see citing works
Rapid Mood-Elevating Effects of Low Field Magnetic Stimulation in Depression
Rohan, M. L., Yamamoto, R. T., Ravichandran, C. T., Cayetano, K. R., Morales, O. G., Olson, D. P., Vitaliano, G., Paul, S. M., & Cohen, B. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.024 · Cited by 97 · see citing works
Alexopoulos, G. S., Canuso, C. M., Gharabawi, G. M., Bossie, C. A., Greenspan, A. J., Turkoz, I., & Reynolds, C. F. (2007) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31813546f2 · Cited by 97 · see citing works
Gálvez, V., Li, A., Huggins, C., Glue, P., Martin, D., Somogyi, A. A., Alonzo, A., Rodgers, A., Mitchell, P. B., & Loo, C. K. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118760660 · Cited by 85 · see citing works
Leykin, Y., Amsterdam, J. D., DeRubeis, R. J., Gallop, R., Shelton, R. C., & Hollon, S. D. (2007) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.75.2.267 · Cited by 82 · see citing works
Nierenberg, A. A., Petersen, T., & Alpert, J. E. (2003) · PubMed · Cited by 80 · see citing works
Self-citationRachid, F. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.09.009 · Cited by 79 · see citing works
MAOI efficacy and safety in advanced stage treatment-resistant depression—A retrospective study
Amsterdam, J. D., & Justine Shults, A. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.06.011 · Cited by 78 · see citing works
Do Antidepressant and Antianxiety Drugs Increase Chronicity in Affective Disorders?
Fava, G. A. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288880 · Cited by 73 · see citing works
Tachyphylaxis in unipolar major depressive disorder
Solomon, D. A., Leon, A. C., Mueller, T. I., Coryell, W., Teres, J. J., Posternak, M. A., Judd, L. L., Endicott, J., & Keller, M. B. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0302 · Cited by 71 · see citing works
Amsterdam, J. D., & Justine Shults, A. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318166c4e6 · Cited by 71 · see citing works
Further evidence that a placebo response to antidepressants can be identified
Quitkin, F. M., Stewart, J. W., McGrath, P. J., Nunes, E. F., Ocepek‐Welikson, K., TRICAMO, E., Rabkin, J. G., & Klein, D. F. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.566 · Cited by 69 · see citing works
Posternak, M. A., & Zimmerman, M. A. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0605 · Cited by 67 · see citing works
Management of recurrent depression.
Kupfer, D. J. (1993) · PubMed · Cited by 65 · see citing works
Reynolds, C. F., Frank, E., Perel, J. M., Mazumdar, S., Dew, M. A., Begley, A. E., Houck, P. R., Hall, M. H., Mulsant, B. H., Shear, M. K., et al. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.11.1418 · Cited by 64 · see citing works
Relapse in patients on long-term fluoxetine treatment: response to increased fluoxetine dose.
D, M. F. M., Rappe, S., Pava, J. A., Nierenberg, A. A., Alpert, J. E., & Rosenbaum, J. F. (1995) · PubMed · Cited by 63 · see citing works
Self-citationTreatment Approaches to Major Depressive Disorder Relapse
Schmidt, M. E., Fava, M., Zhang, S., Gonzales, J., Raute, N. J., & Judge, R. (2002) · Psychotherapy and Psychosomatics · doi:10.1159/000063643 · Cited by 60 · see citing works
Repetitive transcranial magnetic stimulation in psychiatry
Praharaj, S. K., Mishra, B., Sarkar, S., Mehta, V. S., Diwedi, S., & Nizamie, S. (2011) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.91935 · Cited by 58 · see citing works
Relapse and Recurrence of Depression
Thase, M. E., & Sullivan, L. R. (1995) · CNS Drugs · doi:10.2165/00023210-199504040-00004 · Cited by 57 · see citing works
Mischoulon, D., Hylek, L., Yeung, A., Clain, A. J., Baer, L., Cusin, C., Ionescu, D. F., Alpert, J. E., Soskin, D. P., & D, M. F. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.029 · Cited by 55 · see citing works
Self-citationAltamura, A. C., & Percudani, M. (1993) · PubMed · Cited by 54 · see citing works
Tachyphylaxis in Epidural Analgesia: I. Augmentation and Decay of Local Anesthesia
Bromage, P. R., Pettigrew, R. T., & Crowell, D. E. (1969) · The Journal of Clinical Pharmacology · doi:10.1177/009127006900900106 · Cited by 52 · see citing works
Meta-Analysis of Placebo Rates in Major Depressive Disorder Trials
Stolk, P., ten Berg, M. J., Hemels, M. E. H., & Einarson, T. R. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d172 · Cited by 52 · see citing works
Cain, J. W. (1992) · PubMed · Cited by 49 · see citing works
The Role of pH in the Development of Tachyphylaxis to Local Anesthetic Agents
Cohen, E. N., Levine, D. A., COLLISS, J. E., & Günther, R. (1968) · Anesthesiology · doi:10.1097/00000542-196809000-00027 · Cited by 48 · see citing works
Clinical Usefulness of Therapeutic Neuromodulation for Major Depression
McGirr, A., & Berlim, M. T. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.04.009 · Cited by 45 · see citing works
Continuation and Maintenance Therapy of Early-Onset Major Depressive Disorder
Emslie, G. J., Mayes, T. L., & Ruberu, M. (2005) · Pediatric Drugs · doi:10.2165/00148581-200507040-00001 · Cited by 42 · see citing works
Updates on Transcranial Magnetic Stimulation Therapy for Major Depressive Disorder
Garnaat, S. L., Yuan, S., Wang, H., Philip, N. S., & Carpenter, L. L. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.04.006 · Cited by 41 · see citing works
Amsterdam, J. D., Williams, D., Michelson, D., Adler, L. A., Dunner, D. L., Nierenberg, A. A., Reimherr, F. W., & Schatzberg, A. F. (2009) · Neuropsychobiology · doi:10.1159/000226611 · Cited by 39 · see citing works
Self-citationEffects of Imipramine on Individuals Varying in Level of Depression
DIMASCIO, A., MEYER, R. E., & STIFLER, L. (1968) · American Journal of Psychiatry · doi:10.1176/ajp.124.8s.55 · Cited by 39 · see citing works
Desseilles, M., Witte, J. M., Chang, T. E., Iovieno, N., Dording, C. M., Ashih, H., Nyer, M., Freeman, M. P., D, M. F. M., & Mischoulon, D. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11ac07225 · Cited by 37 · see citing works
Self-citationManagement of depression relapse: Re-initiation of duloxetine treatment or dose increase
D, M. F. M., Detke, M. J., Balestrieri, M., WANG, F., Raskin, J., & David, P. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.06.005 · Cited by 36 · see citing works
Mann, J. J. (1983) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198312000-00007 · Cited by 35 · see citing works
Massachusetts General Hospital SAFER Criteria for Clinical Trials and Research
Desseilles, M., Witte, J. M., Chang, T. E., Iovieno, N., Dording, C. M., Ashih, H., Nyer, M., Freeman, M. P., D, M. F. M., & Mischoulon, D. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e3182a75cc7 · Cited by 35 · see citing works
Self-citationGuidelines for the long-term treatment of depression.
Hirschfeld, R. M. A. (1994) · PubMed · Cited by 35 · see citing works
Maintenance Ketamine Therapy for Treatment-Resistant Depression
Archer, S., Chrenek, C., & Swainson, J. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000894 · Cited by 33 · see citing works
Is There a Placebo Problem in Antidepressant Trials?
Yang, H., Cusin, C., & Fava, M. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/156802605774297092 · Cited by 32 · see citing works
Self-citationPerlis, R. H., Alpert, J. E., Nierenberg, A. A., Mischoulon, D., Yeung, A., Rosenbaum, J. F., & D, M. F. M. (2003) · Acta Psychiatrica Scandinavica · doi:10.1046/j.0001-690x.2003.00168.x · Cited by 31 · see citing works
Self-citationZimmerman, M., & Thongy, T. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0814 · Cited by 31 · see citing works
D, M. F. M., Freeman, M. P., Flynn, M., Hoeppner, B. B., Shelton, R. C., Iosifescu, D. V., Murrough, J. W., Mischoulon, D., Cusin, C., Rapaport, M. H., et al. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.09.010 · Cited by 30 · see citing works
Self-citationLieb, J., & Balter, A. (1984) · Medical Hypotheses · doi:10.1016/0306-9877(84)90018-5 · Cited by 30 · see citing works
Assessing Past Treatment History
Posternak, M. A., Young, D., Sheeran, T. F., Chelminski, I., Franklin, C. L., & Zimmerman, M. A. (2004) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000110280.19284.47 · Cited by 28 · see citing works
Relapse of depressed patients after effective continuation therapy
Georgotas, A., & McCue, R. E. (1989) · Journal of Affective Disorders · doi:10.1016/0165-0327(89)90038-4 · Cited by 28 · see citing works
Psychiatrists' responses to failure of maintenance therapy with antidepressants
Byrne, S., & Rothschild, A. J. (1997) · Psychiatric Services · doi:10.1176/ps.48.6.835 · Cited by 27 · see citing works
Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?
Peckham, A. M., Cruz, A. D. L., & Dufresne, R. L. (2018) · Mental Health Clinician · doi:10.9740/mhc.2018.07.175 · Cited by 25 · see citing works
Continuous epidural analgesia: experience with mechanical injection devices
Spoerel, W. E., Thomas, A., & Gerula, G. R. (1970) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03004526 · Cited by 22 · see citing works
(2009) · PubMed · Cited by 20 · see citing works
Rothschild, A. J., Dunlop, B. W., Dünner, D. L., Friedman, E. S., Gelenberg, A. J., Holland, P. J., Kocsis, J. H., Kornstein, S. G., Shelton, R. C., Trivedi, M. H., et al. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4086 · Cited by 20 · see citing works
Storosum, J. G., Elferink, A. J. A., van Zwieten, B. J., van den Brink, W., & Huyser, J. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-815472 · Cited by 18 · see citing works
Tachyphylaxis/ tolerance to antidepressive medications: a review.
Katz, G. (2011) · PubMed · Cited by 18 · see citing works
The Rothschild scale for antidepressant tachyphylaxis: reliability and validity
Rothschild, A. J. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.03.002 · Cited by 15 · see citing works
Current Trends in Identifying Rapidly Acting Treatments for Depression
Ionescu, D., & Papakostas, G. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0075-4 · Cited by 13 · see citing works
Self-citationFabrazzo, M., Perris, F., Monteleone, P., Esposito, G., Catapano, F., & Maj, M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.06.006 · Cited by 12 · see citing works
Recurrent vital depressions. A follow-up study of 56 female and 28 male patients.
van Scheyen, J. D. (1973) · PubMed · Cited by 12 · see citing works
Possible therapeutic window for serotonin reuptake inhibitors.
Fichtner, C. G., Jobe, T. H., & Braun, B. G. (1994) · PubMed · Cited by 10 · see citing works
Tolerance to amoxapine antidepressant effects.
Zetin, M., Aden, G. C., & Moldawsky, R. J. (1983) · PubMed · Cited by 7 · see citing works
Reply to It looks like "Bradyphylaxis" to Me
Solomon, D. A. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0818g · Cited by 1 · see citing works
Flagged first, then by citations
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Burch, R. C. (2019) · Current Treatment Options in Neurology · doi:10.1007/s11940-019-0557-2 · Cited by 108 · see citing works
Fava, G. A. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320970325 · Cited by 84 · see citing works
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Jiang, Y., Du, Z., Shen, Y., Zhou, Q., & Zhu, H. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01732-5 · Cited by 61 · see citing works
Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression
Andreescu, C., Ajilore, O., Aizenstein, H. J., Albert, K. M., Butters, M. A., Landman, B. A., Karim, H. T., Krafty, R. T., & Taylor, W. D. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.07.016 · Cited by 56 · see citing works
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Trunnell, E. R., Baines, J., Farghali, S., Jackson, T. A., Jayne, K., Smith, R., & Stibbe, T. (2024) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2024.105666 · Cited by 42 · see citing works
Borgiani, G., Possidente, C., Fabbri, C., Oliva, V., Bloemendaal, M., Vásquez, A. A., Dinan, T. G., Vieta, E., Menchetti, M., Ronchi, D. D., et al. (2024) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000533 · Cited by 42 · see citing works
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Markowitz, J. C., Wright, J. H., Peeters, F., Thase, M. E., Kocsis, J. H., & Sudak, D. M. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21050535 · Cited by 41 · see citing works
Stein, M. B., Jain, S., Simon, N. M., West, J. C., Marvar, P. J., Bui, É., He, F., Benedek, D. M., Cassano, P., Griffith, J. L., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.012 · Cited by 36 · see citing works
Cohen, Z. D., DeRubeis, R. J., Hayes, R., Watkins, E. R., Lewis, G., Byng, R., Byford, S., Crane, C., Kuyken, W., Dalgleish, T., et al. (2023) · Clinical Psychological Science · doi:10.1177/21677026221076832 · Cited by 25 · see citing works
Montano, C. B., Jackson, W., Vanacore, D., & Weisler, R. H. (2023) · Postgraduate Medicine · doi:10.1080/00325481.2023.2189868 · Cited by 24 · see citing works
Kamp, C. B., Petersen, J. J., Faltermeier, P., Juul, S., Siddiqui, F., Moncrieff, J., Horowitz, M. A., Hengartner, M. P., Kirsch, I., Gluud, C. N., et al. (2024) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796024000520 · Cited by 22 · see citing works
Kamp, C. B., Petersen, J. J., Faltermeier, P., Juul, S., Siddiqui, F., Barbateskovic, M., Kristensen, A. T., Moncrieff, J., Horowitz, M. A., Hengartner, M. P., et al. (2024) · BMJ Mental Health · doi:10.1136/bmjment-2023-300730 · Cited by 21 · see citing works
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Thom, R. P., Alexander, J. L., Baron, D. A., Garakani, A., Gross, L. S., Pine, J. H., Radhakrishnan, R., Slaby, A. E., & Sumner, C. R. (2021) · Journal of Psychiatric Practice · doi:10.1097/pra.0000000000000578 · Cited by 21 · see citing works
Treating depression in clinical practice: new insights on the multidisciplinary use of trazodone
Albert, U., Tomasetti, C., Marra, C., Neviani, F., Pirani, A., Taddeo, D., Zanetti, O. O., & Maina, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1207621 · Cited by 18 · see citing works
Early Response to Antidepressant Medications in Adults With Major Depressive Disorder
Belanger, H. G., Lee, C. M., Poliacoff, Z., Gupta, C., & Winsberg, M. E. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001638 · Cited by 13 · see citing works
Xiao, C., Zhou, J. L., Li, A., Zhang, L., Zhu, X., Zhou, J., Hu, Y., Zheng, Y., Liu, J., Deng, Q., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.28817 · Cited by 12 · see citing works
Antidepressant Discontinuation Syndrome
Kim, S. H., Kim, Y. S., & Kang, U. G. (2024) · 신경정신의학 · doi:10.4306/jknpa.2024.63.2.104 · Cited by 12 · see citing works
Kamp, C. B., Petersen, J. J., Faltermeier, P., Juul, S., Sillassen, C. D. B., Siddiqui, F., Andersen, R. K., Moncrieff, J., Horowitz, M. A., Hengartner, M. P., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-024-06396-6 · Cited by 11 · see citing works
Svensson, C. K. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000978 · Cited by 9 · see citing works
Hoisington, A. J., Stearns‐Yoder, K. A., Stamper, C. E., Simonetti, J. A., Oslin, D. W., & Brenner, L. A. (2024) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20220221 · Cited by 7 · see citing works
Mundula, T., Baldi, S., Gerace, E., & Amedei, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020550 · Cited by 7 · see citing works
Siddiqui, F., Petersen, J. J., Juul, S., Kamp, C. B., Barbateskovic, M., Moncrieff, J., Horowitz, M. A., Maagaard, M., Katakam, K. K., Gluud, C. N., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2023-082853 · Cited by 6 · see citing works
Sridharan, K. (2025) · European Journal of Hospital Pharmacy · doi:10.1136/ejhpharm-2024-004353 · Cited by 5 · see citing works
Ormel, J., Bosker, F. J., Hollon, S. D., & Ruhé, H. G. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.86 · Cited by 5 · see citing works
Freeman, M. P. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3637 · Cited by 4 · see citing works
Self-citationHarris, D. R., & Machek, S. B. (2021) · Journal of Exercise and Nutrition · doi:10.53520/jen2021.10397 · Cited by 3 · see citing works
Risk factors for treatment resistance among women with postpartum depression in a nationwide study
Chen, Y., Bränn, E., Bendix, M., Joyce, E. E., Fransson, E., Lu, Y., Skalkidou, A., & Lu, D. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00587-8 · Cited by 2 · see citing works
Xiao, Z., Liu, C., Duan, J., Zhou, T., Liu, X., Lu, S., Yang, Z., & Xu, F. (2020) · International Journal of Pharmacology · doi:10.3923/ijp.2020.500.513 · Cited by 2 · see citing works
Zhang, H., Hu, Z., TONG, J. J., Hu, J., Wang, X., & Wang, B. (2024) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2024.102773 · Cited by 2 · see citing works
Behavioral effects of a low molecular weight peptide fraction from Phaseolus vulgaris in rats
Graziani, D., Ribeiro, J. V. V., Turones, L. C., Costa, É. A., Reis‐Silva, L. L., de Araújo, E. G., de Paula, L. G. F., Ferreira-Junior, M. D., Gomes, R. M., Campos, H. M., et al. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e12314 · Cited by 1 · see citing works
Niu, J.-D., Yang, J., He, Z.-Y., & Wang, T. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121332 · Cited by 1 · see citing works
Brain Stimulation Therapeutic Interventions in Neuropsychiatry: A Cambrian Explosion
Sackeïm, H. A., & George, M. S. (2026) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20260691 · Cited by 1 · see citing works
Depression: Third Wave Case Conceptualization
Zuo, Z., & Segal, Z. V. (2022) · Springer eBooks · doi:10.1007/978-3-031-11677-3_17
Mihalik-Wenger, A. C., Suryadevara, U., Wenger, J., Nuthi, M., Hitching, R., & Fenn, H. H. (2024) · Springer eBooks · doi:10.1007/978-3-031-53976-3_11
Introduction to Deprescribing Psychiatric Medications
(2024) · Wiley eBooks · doi:10.1002/9781394291052.mdg001
Safe Deprescribing of Antidepressants
(2024) · Wiley eBooks · doi:10.1002/9781394291052.mdg002
Les manifestations cliniques associées à la toxicité comportementale
Fava, G. A., & Peretti, C.-S. (2024) · Elsevier eBooks · doi:10.1016/b978-2-294-77932-9.00003-0
Guo, K., Li, H., Wang, W., Cheng, L., Du, W., & Zhang, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328191
Stopping antidepressants safely
Horowitz, M. A., & Perry, T. L. (2026) · African Journal of Primary Health Care & Family Medicine · doi:10.4102/phcfm.v18i1.5431
Potential effect of the short-acting GLP-1 agonist exenatide on copeptin in healthy adults
Baumann, S., Leibnitz, S., Atila, C., Romberg, C., Hepprich, M., Antwi, K., Christ, E., & Crain, M. C. (2026) · Obesity and Endocrinology · doi:10.1093/obendo/wjag006
Paribello, P., Isayeva, U., Lazzardi, S., Pinna, M. A., Contu, M., Meloni, A., Pisanu, C., Squassina, A., Baune, B. T., & Manchia, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1819237
The Promise of Psychoeducation in Relieving the Societal Burden of Psychopathology
Strayhorn, J. M., Chai, K. Y. Y., & Zhang‐James, Y. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-92-0922-4
Can Drugs Relieve the Societal Burden of Psychopathology?
Strayhorn, J. M., Chai, K. Y. Y., & Zhang‐James, Y. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-92-0922-4_4
- Authors
- Kinrys, G., Gold, A. K., Pisano, V. D., Freeman, M. P., Papakostas, G. I., Mischoulon, D., Nierenberg, A. A., & Fava, M.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Kinrys, Gustavo
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 245
- Pages
- 488-497
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2898517662
- Cited by
- 45
- References
- 81
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 4
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Affective Disorders (acceptedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- tachyphylaxis, major depressive disorder, antidepressant response, antidepressant non-response, maintenance therapy, antidepressant switching, augmentation therapy, combination pharmacotherapy, psychotherapy, prevalence
- MeSH terms
- Antidepressive Agents, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Drug Therapy, Combination, Humans, Longitudinal Studies, Psychotherapy, Research, Tachyphylaxis, Treatment Outcome
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