Effects of Imipramine on Individuals Varying in Level of Depression
Abstract
In the belief that studies with normal subjects are relevant to the assessment of psychotropic drugs for clinical use, the authors examined the antidepressant and anti-anxiety effects of imipramine in a group of nonhospitalized, asymptomatic subjects selected to differ in level of (nonclinical) depression. Although some of the results might be termed paradoxical, it was demonstrated that the antidepressant property of the drug, for which it is clinically utilized, is also evident in normal subjects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Imipramine induced an increase in depression in subjects with the lowest scores of depression.
“Imipramine induced an increase in depression in subjects with the lowest scores of depression.”
From May antidepressant drugs worsen the conditions they are supposed to treat? The clinical foundations of the oppositional model of tolerance (2020) · cites this paper as [27]
Cites
Mascio, A. D., Heninger, G. R., & Klerman, G. L. (1964) · Psychopharmacology · doi:10.1007/bf00441447 · Cited by 51 · see citing works
PERSONALITY FACTORS IN VARIABILITY OF RESPONSE TO PHENOTHIAZINES
Heninger, G. R., DiMascio, A., & Klerman, G. L. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.121.11.1091 · Cited by 50 · see citing works
Self-citationComparative Effects of Oxazepam in “High” and “Low” Anxious Student Volunteers
DiMascio, A., & Barrett, J. E. (1965) · Psychosomatics · doi:10.1016/s0033-3182(65)72241-x · Cited by 39 · see citing works
Self-citationP�ldinger, W. (1963) · Psychopharmacology · doi:10.1007/bf00408186 · Cited by 25 · see citing works
Untersuchungen über die besondere psychologische Wirkung des Thymolepticums Tofranil
Grünthal, E. (2008) · Psychiatria et Neurologia · doi:10.1159/000139575 · Cited by 22 · see citing works
Imipramine-desmethylimipramine
IDESTROM, C. M., & Cadenius, B. (1964) · Psychopharmacology · doi:10.1007/bf02193480 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Spielberger, C. D. (1972) · Anxiety · doi:10.1016/b978-0-12-657401-2.50009-5 · Cited by 1,102 · see citing works
The Efficacy of Antidepressant Drugs
Morris, J. B. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760110083010 · Cited by 354 · see citing works
Paykel, E. S., Hollyman, J. A., FREELING, P., & Sedgwick, P. M. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90075-4 · Cited by 273 · see citing works
Can long-term treatment with antidepressant drugs worsen the course of depression?
Fava, G. A. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0204 · Cited by 223 · see citing works
REM Sleep Reduction Effects on Depression Syndromes
Vogel, G. W. (1975) · Archives of General Psychiatry · doi:10.1001/archpsyc.1975.01760240093007 · Cited by 213 · see citing works
The mechanisms of tolerance in antidepressant action
Fava, G. A., & Offidani, E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.026 · Cited by 158 · see citing works
A Reevaluation of the Exclusion Criteria Used in Antidepressant Efficacy Trials
Posternak, M. A., Zimmerman, M. A., Keitner, G. I., & Miller, I. W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.191 · Cited by 97 · see citing works
Rational Use of Antidepressant Drugs
Fava, G. A. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000362803 · Cited by 95 · see citing works
Oxman, T. E., & Sengupta, A. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200205000-00004 · Cited by 87 · see citing works
Fava, G. A. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320970325 · Cited by 84 · see citing works
Tardive dysphoria: The role of long term antidepressant use in-inducing chronic depression
El‐Mallakh, R. S., Gao, Y., & Roberts, R. J. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.01.020 · Cited by 73 · see citing works
Stimulus properties of antidepressants in the rat
Jones, C. N., Howard, J. L., & McBennett, S. T. (1980) · Psychopharmacology · doi:10.1007/bf00431964 · Cited by 71 · see citing works
Tachyphylaxis in major depressive disorder: A review of the current state of research
Kinrys, G., Gold, A. K., Pisano, V. D., Freeman, M. P., Papakostas, G. I., Mischoulon, D., Nierenberg, A. A., & Fava, M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.357 · Cited by 45 · see citing works
Sexual dysfunction resulting from drug side effects
Story, N. L. (1974) · The Journal of Sex Research · doi:10.1080/00224497409550840 · Cited by 35 · see citing works
Self-evaluations of antidepressants
McNair, D. M. (1974) · Psychopharmacology · doi:10.1007/bf00428915 · Cited by 34 · see citing works
Potential Sensitising Effects of Antidepressant Drugs on Depression
Fava, G. A. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00001 · Cited by 23 · see citing works
Ethnic Variations in Drug Response
Murphy, H. B. M. (1969) · Transcultural Psychiatric Research Review · doi:10.1177/136346156900600101 · Cited by 23 · see citing works
Depression in the Elderly. II. Possible Drug Etiologies; Differential Diagnostic Criteria*
Salzman, C., & Shader, R. I. (1978) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1978.tb01340.x · Cited by 21 · see citing works
Psychopharmacologic Investigations in Healthy Elderly Volunteers: MMPI Depression Scale†
Harmatz, J. S., & Shader, R. I. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00325.x · Cited by 21 · see citing works
Effects of Antianxiety Drug and Personality on Stress‐Inducing Psychomotor Performance Test
Nakano, S., Ogawa, N., Kawazu, Y., & Osato, E. (1978) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1978.tb02432.x · Cited by 19 · see citing works
Discriminative stimulus control with imipramine: Transfer to other anti-depressants
Schechter, M. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90074-6 · Cited by 17 · see citing works
Clinical pharmacology in the development of new antidepressants: the challenges
Alexander, R., & Preskorn, S. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.016 · Cited by 15 · see citing works
Vocal indicators of psychoactive drug effects
Helfrich, H., Standke, R., & Scherer, K. R. (1984) · Speech Communication · doi:10.1016/0167-6393(84)90019-0 · Cited by 13 · see citing works
Behavioral Treatment of Affective Disorders
Rubeis, R. J. D., & Hollon, S. D. (1981) · Springer eBooks · doi:10.1007/978-1-4613-3243-5_6 · Cited by 13 · see citing works
Katz, M. M. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00065-7 · Cited by 10 · see citing works
Methodological Considerations in Evaluating Antianxiety Drugs
Hollister, L. E. (1970) · The Journal of Clinical Pharmacology · doi:10.1177/009127007001000103 · Cited by 10 · see citing works
Chemotherapy of Manic-Depressive Disorder
Shopsin, B., & Gershon, S. (1971) · Advances in behavioral biology · doi:10.1007/978-1-4684-3057-8_22 · Cited by 7 · see citing works
Toxicology and Side-Effects of Anxiolytics
Lr, H. (1981) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-67767-0_7 · Cited by 7 · see citing works
Behavioral Toxicity of Psychiatric Drugs
Perl, M., Hall, R. C. W., & Gardner, E. R. (1980) · Psychiatric Presentations of Medical Illness · doi:10.1007/978-94-011-7677-4_18 · Cited by 6 · see citing works
The effect of level of depression on the use of visual analogue scales by normal volunteers.
Peet, M., Ellis, S., & Yates, R. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01197.x · Cited by 6 · see citing works
Tardive dysphoria: antidepressant-induced chronic depression
El‐Mallakh, R. S., Roberts, R. J., Swann, A. C., Rutherford, P. R., & Surja, A. (2011) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700011976 · Cited by 6 · see citing works
Lehmann, E., & Hopes, H. (1977) · Progress in Neuro-Psychopharmacology · doi:10.1016/0364-7722(77)90038-8 · Cited by 5 · see citing works
Human pharmacology of antidepressives.
LADER, M. H. (1977) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1977.tb05740.x · Cited by 4 · see citing works
Musch, B., Hindmarch, I., & Saletu, B. (1990) · doi:10.1007/978-1-349-10705-6_30 · Cited by 1 · see citing works
Nakano, S., 暢也, 小., 河津, 雄., & 大里, 栄. (1971) · Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics · doi:10.3999/jscpt.2.376 · Cited by 1 · see citing works
Limits and Usefulness of Clinical Psychopharmacology
Musch, B., & Morselli, P. L. (1985) · Springer eBooks · doi:10.1007/978-1-4899-5049-9_35
Hollister, L. E. (1981) · Springer eBooks · doi:10.1007/978-1-4615-7740-9_4
Gründer, G. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21199-7.00001-5
Les manifestations cliniques associées à la toxicité comportementale
Fava, G. A., & Peretti, C.-S. (2024) · Elsevier eBooks · doi:10.1016/b978-2-294-77932-9.00003-0
- Authors
- DIMASCIO, A., MEYER, R. E., & STIFLER, L.
- ORCID
- MEYER, ROGER E.
- Venue
- American Journal of Psychiatry
- Published
- 1968-02
- Volume
- 124
- Issue
- 8S
- Pages
- 55-58
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2056635799
- Cited by
- 39
- References
- 6
- Citations by year
- 2024: 2 · 2020: 1 · 2018: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- imipramine, antidepressant effects, anxiolytic effects, asymptomatic patients, normal subjects, tricyclic antidepressants
- MeSH terms
- Adult, Anxiety, Depression, Humans, Imipramine, Male, MMPI, Placebos
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
