A critical review of pharmacotherapy for major depressive disorder.
Open accessAbstract
Newer generation antidepressant drugs, with improvements in safety and tolerability, have replaced tricyclic antidepressants as first-line treatment of depressive illness. However, no single antidepressant drug from any class has distinguished itself as the obvious first-line treatment of major depression. The choice of therapy is driven primarily by patient choice, with informed consent for the risks of adverse effects. Cost has become an additional factor in this decision as several of the newer antidepressant drugs are now available in generic form. Several augmentation and drug-switching strategies have demonstrated benefit in refractory illness. While no single strategy distinguished itself as superior to the others, some have been more rigorously tested. Ongoing efforts at improving effectiveness, time to response, and tolerability have led to novel drug therapies. Efforts at characterizing predictors of treatment outcomes now include pharmacogenetic studies.
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Self-citationBarbui, C., Hotopf, M. H., Freemantle, N., Boynton, J. R., Churchill, R. C., Eccles, M. P., Geddes, Hardy, R., Lewis, G., & Mason, J. M. (2006) · UCL Discovery (University College London) · Cited by 32 · see citing works
Posternak, M., Novak, S., Stern, R., Hennessey, J., Joffe, R., Prange, A., & Zimmerman, M. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007663 · Cited by 29 · see citing works
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Rapid Mood-Elevating Effects of Low Field Magnetic Stimulation in Depression
Rohan, M. L., Yamamoto, R. T., Ravichandran, C. T., Cayetano, K. R., Morales, O. G., Olson, D. P., Vitaliano, G., Paul, S. M., & Cohen, B. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.024 · Cited by 97 · see citing works
- Authors
- Dupuy, J. M., Ostacher, M. J., Huffman, J., Perlis, R. H., & Nierenberg, A. A.
- Affiliations
- Harvard University (US)
- Stanford Medicine (US)
- Corresponding author
- Dupuy, Jamie M.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-24
- Volume
- 14
- Issue
- 10
- Pages
- 1417-1431
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2168253623
- Semantic Scholar
- 0bec0446267ec5165ee973dcde50d9a3a9a0efe1
- Cited by
- 61
- References
- 102
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- Harvard University (UL1RR025758)
- Harvard Catalyst (UL1-RR025758)
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (K23AA016340)
- National Center for Research Resources (UL1RR025758, RR025758)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, antidepressants, pharmacotherapy, tricyclic antidepressants, first-line therapy, treatment-resistant depression, augmentation strategies, drug switching, adverse effects, cost, newer antidepressants, pharmacogenetics, predictors of treatment outcome
- MeSH terms
- Antidepressive Agents, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Humans, Pharmacogenetics, Drug Costs, Drugs, Generic, Treatment Outcome, Practice Guidelines as Topic, Risk Assessment, Patient Selection, Evidence-Based Medicine, Drug Substitution
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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