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Cited by 35Schizophrenia research and treatmentAging, Health, and DisabilityDementia and Cognitive Impairment Research

Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study.

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Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo +178 more·2019·Journal of Affective Disorders
DOI 10.1016/j.jad.2019.05.063
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Abstract

BACKGROUND: Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder. METHODS: We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder. RESULTS: Depression and cognitive impairment were positively associated (r = 0.24, p < 0.01) and both independently and negatively impacted on QoL (standardized β = -0.41 and β = -0.32, both p < 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively. LIMITATIONS: Because of the cross-sectional design of this study, measures of association do not imply causal associations. CONCLUSIONS: Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.

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  • Both severe positive symptoms and crisis-associated hospitalization are believed to contribute to secondary activation of negative symptoms and comorbid mood/anxiety disorders, resulting in increased chronification risk.

    “Both are believed to contribute to the secondary activation of negative symptoms such as poor rapport (83) and comorbid disorders like mood and anxiety disorders (84) resulting in an increased chronification risk (85).”

    From Developing a mechanism-based therapy for acute psychiatric inpatients with psychotic symptoms: an Intervention Mapping approach (2023) · cites this paper as [84]

    The Conclusions discuss comorbid depression in schizophrenia, supporting the mood-related example attached to citation 84. The cited paper does not establish comorbid anxiety disorders or say that severe positive symptoms or crisis-associated hospitalization secondarily activate those disorders. Its Discussion instead examines associations of depression and cognitive impairment with quality of life in older adults. (LLM, conf=0.82)

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Pascal de Raykeer, R., Hoertel, N., Blanco, C., Lavaud, P., Kaladjian, A., Blumenstock, Y., Cuervo-Lombard, C.-V., Peyre, H., Lemogne, C., Limosin, F., Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A. M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J. M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J. P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., Da Rin, D., Denis, J. B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, C., Haouzir, S., Hazif-Thomas, C., Heron, A., Hoertel, N., Hubsch, B., Jalenques, I., Januel, D., Kaladjian, A., Karnycheff, J. F., Kebir, O., Krebs, M. O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Limosin, F., Llorca, P. M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C. E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J. P., Samuelian, J. C., Scemama-Ammar, C., Schurhoff, F., Schuster, J. P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A. S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J. L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M. N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J. L., Wagermez, C., Walter, M., Yon, L., & Zendjidjian, X.
Affiliations
  • National Institute on Drug Abuse (US)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Centre National de la Recherche Scientifique (FR)
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Reims (FR)
  • Canadian Standards Association (CA)
  • Hôpital Corentin-Celton (FR)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2019-09
Volume
256
Pages
164-175
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2019.05.063
OpenAlex
W2946909991
Cited by
35
References
94
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 3
FWCI
3.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Affective Disorders (acceptedVersion, other-oa)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
  • HAL (submittedVersion)
Funders
Ministère des Affaires Sociales et de la Santé
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
schizophrenia spectrum disorders, older adults, depression, cognitive impairment, quality of life, schizoaffective disorder, mediation, depressive symptoms
MeSH terms
Aged, Aged, 80 and over, Cross-Sectional Studies, Depression, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Schizophrenia, Schizophrenic Psychology, Cohort Studies, Cognitive Dysfunction

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