A Meta-Analysis of Cognitive Remediation in Schizophrenia
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OBJECTIVE: This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia. METHOD: A meta-analysis was conducted of 26 randomized, controlled trials of cognitive remediation in schizophrenia including 1,151 patients. RESULTS: Cognitive remediation was associated with significant improvements across all three outcomes, with a medium effect size for cognitive performance (0.41), a slightly lower effect size for psychosocial functioning (0.36), and a small effect size for symptoms (0.28). The effects of cognitive remediation on psychosocial functioning were significantly stronger in studies that provided adjunctive psychiatric rehabilitation than in those that provided cognitive remediation alone. CONCLUSIONS: Cognitive remediation produces moderate improvements in cognitive performance and, when combined with psychiatric rehabilitation, also improves functional outcomes.
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Neurocognitive interventions for schizophrenia reliably improve neurocognitive functioning.
“neurocognitive interventions for schizophrenia have been shown to reliably improve neurocognitive functioning”
From Improving Outcomes for Youth with ADHD: A Conceptual Framework for Combined Neurocognitive and Skill-Based Treatment Approaches (2014) · cites this paper as McGurk, Twamley, Sitzer, McHugo, & Mueser, 2007
Combining neurocognitive interventions with evidence-based psychosocial skill-based interventions for schizophrenia leads to greater transfer of effects to functional outcomes that persists over time.
“when neurocognitive interventions are combined with evidence-based psychosocial skill-based interventions (e.g., vocational therapy), there appears to be greater transfer of effects to functional outcomes for adults with schizophrenia that persists over time (McGurk et al., 2007; Wykes, Huddy, Cellard, McGurk, & Czobor, 2011).”
From Improving Outcomes for Youth with ADHD: A Conceptual Framework for Combined Neurocognitive and Skill-Based Treatment Approaches (2014) · cites this paper as McGurk et al., 2007
Neurocognitive interventions for schizophrenia have limited impact on functional outcomes.
“studies suggest limited impact of these interventions on functional outcomes (McGurk, Twamley, Sitzer, McHugo, & Mueser, 2007).”
From Improving Outcomes for Youth with ADHD: A Conceptual Framework for Combined Neurocognitive and Skill-Based Treatment Approaches (2014) · cites this paper as McGurk, Twamley, Sitzer, McHugo, & Mueser, 2007
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- Authors
- McGurk, S. R., Twamley, E. W., Sitzer, D. I., McHugo, G. J., & Mueser, K. T.
- Affiliations
- Dartmouth Psychiatric Research Center (US)
- Venue
- American Journal of Psychiatry
- Published
- 2007-12
- Volume
- 164
- Issue
- 12
- Pages
- 1791-1802
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3634703
- OpenAlex
- W2168340793
- Cited by
- 1,214
- References
- 58
- Citations by year
- 2026: 23 · 2025: 26 · 2024: 34 · 2023: 26 · 2022: 47 · 2021: 48 · 2020: 57 · 2019: 122 · 2018: 69 · 2017: 64 · 2016: 91 · 2015: 79 · 2014: 75 · 2013: 99 · 2012: 102
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (H133 GO 50230)
- National Institute of Mental Health (MH 77210, R01MH077210, K23MH066011)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- cognitive remediation, schizophrenia, cognitive performance, psychosocial functioning, psychiatric rehabilitation, symptom improvement, functional outcome
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Cognition Disorders, Humans, Middle Aged, Neuropsychological Tests, Psychotherapy, Rehabilitation, Vocational, Schizophrenia, Schizophrenic Psychology, Social Adjustment, Therapy, Computer-Assisted, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Employment, Supported, Treatment Outcome
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