Cited by 134Treatment of Major DepressionStress Responses and CortisolDementia and Cognitive Impairment Research

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Hippocampus Atrophy and the Longitudinal Course of Late-life Depression

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Taylor, Warren D., McQuoid, Douglas R., Payne, Martha E., Zannas, Anthony S., MacFall, James R., Steffens, David C.·2014·The American Journal of Geriatric Psychiatry

DOI 10.1016/j.jagp.2013.11.004PMC PMC4031313

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Abstract

Objectives Smaller hippocampal volumes are observed in depression but it remains unclear how antidepressant response and persistent depression relate to changes in hippocampal volume. We examined the longitudinal relationship between hippocampal atrophy and course of late-life depression.Setting Academic medical center.Participants Depressed and never-depressed cognitively intact subjects age 60 years or older.Measurements Depression severity was measured every three months with the Montgomery-Asberg Depression Rating Scale (MADRS). Participants also completed cranial 1.5-T magnetic resonance imaging every 2 years. We compared 2-year change in hippocampal volume based on remission status, then in expanded analyses examined how hippocampal volumes predicted MADRS score.Results In analyses of 92 depressed and 70 never-depressed subjects, over 2 years the cohort whose depression never remitted exhibited greater hippocampal atrophy than the never-depressed cohort. In expanded analyses of a broader sample of 152 depressed elders, depression severity was significantly predicted by a hippocampus × time interaction where smaller hippocampus volumes over time were associated with greater depression severity.Conclusions Hippocampal atrophy is associated with greater and persistent depression severity. Neuropathological studies are needed to determine if this atrophy is related to the toxic effects of persistent depression or related to underlying Alzheimer disease.

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Authors: Taylor, W. D., McQuoid, D. R., Payne, M. E., Zannas, A. S., MacFall, J. R., & Steffens, D. C.
Affiliations: Vanderbilt University Medical Center (US)
Duke Medical Center (US)
UConn Health (US)
Corresponding author: Taylor, Warren D.
ORCID: Taylor, Warren D.
Zannas, Anthony S.
MacFall, James R.
Steffens, David C.
Venue: The American Journal of Geriatric Psychiatry
Publisher: Elsevier BV
Published: 2014-12
Volume: 22
Issue: 12
Pages: 1504-1512
ISSN: 1064-7481 (ISSN-L)
DOI: 10.1016/j.jagp.2013.11.004
PMC: PMC4031313
OpenAlex: W2013004783
Cited by: 134
References: 56
Citations by year: 2026: 9 · 2025: 14 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 5 · 2014: 1
FWCI: 4.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Geriatric Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIMH (R01 MH077745, R01 MH054846, K24 MH070027, P50 MH60451)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: hippocampal atrophy, geriatric depression, dysthymia, remission, hippocampal volume, depression severity, longitudinal course, older adults, antidepressant response, Alzheimer's disease
MeSH terms: Aged, Aged, 80 and over, Antidepressive Agents, Atrophy, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Recurrence, Remission Induction, Severity of Illness Index, Disease Progression

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Hippocampus Atrophy and the Longitudinal Course of Late-life Depression

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