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Cited by 385Dementia and Cognitive Impairment ResearchMental Health Treatment and AccessAging, Health, and Disability

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

10-year trajectories of depressive symptoms and risk of dementia: a population-based study

Open access
Mirza, Saira Saeed, Wolters, Frank J, Swanson, Sonja A, Koudstaal, Peter J, Hofman, Albert, Tiemeier, Henning, Ikram, M Arfan·2016·The Lancet Psychiatry
DOI 10.1016/s2215-0366(16)00097-3
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Abstract

Background Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. Such an approach neglects the course of depression, which, given its remitting and relapsing nature, might provide further insights into the complex association of depression with dementia. We therefore repeatedly measured depressive symptoms in a population of adults over a decade to study the subsequent risk of dementia. Methods Our study was embedded in the Rotterdam Study, a population-based study of adults aged 55 years or older in Rotterdam (Netherlands), ongoing since 1990. The cohort is monitored continuously for major events by data linkage between the study database and general practitioners. We examined a cohort of participants who were free from dementia, but had data for depressive symptoms from at least one examination round in 1993-95, 1997-99, or 2002-04. We assessed depressive symptoms with the validated Dutch version of the Center for Epidemiology Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale-Depression. We used these data to identify 11-year trajectories of depressive symptoms by latent class trajectory modelling. We screened participants for dementia at each examination round and followed up participants for 10 years for incident dementia by latent trajectory from the third examination round to 2014. We calculated hazard ratios (HR) for dementia by assigned tra…

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  • In a population-based study with a mean follow-up of 8 years, the incidence of dementia was 13% among older adults with depression, similar to our findings.

    “However, in a population-based study with a mean follow-up of 8 years, the incidence of dementia was 13% among older adults with depression, [39] similar to our findings.”

    From Association between first-line antidepressant use and risk of dementia in older adults: a retrospective cohort study (2023) · cites this paper as [39]

  • Late life depression is thought to be an early symptom of dementia, whereas studies of whether midlife depression is a risk factor for later life dementia have had mixed findings.

    “In particular, late life depression is thought to be an early symptom of dementia,18 19 whereas studies of whether midlife depression is a risk factor for later life dementia have had mixed findings.20 21”

    From Anticholinergic drugs and risk of dementia: case-control study (2018) · cites this paper as [19]

Citations

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Research works printed but not linked: 29

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Metadata

Authors
Mirza, S. S., Wolters, F. J., Swanson, S. A., Koudstaal, P. J., Hofman, A., Tiemeier, H., & Ikram, M. A.
Affiliations
Erasmus MC (NL)
Corresponding author
Ikram, M Arfan
ORCID
Venue
The Lancet Psychiatry
Publisher
Elsevier BV
Published
2016-07
Volume
3
Issue
7
Pages
628-635
ISSN
2215-0366 (ISSN-L)
DOI
10.1016/s2215-0366(16)00097-3
OpenAlex
W2342525617
Cited by
385
References
4
Citations by year
2026: 42 · 2025: 58 · 2024: 52 · 2023: 55 · 2022: 22 · 2021: 33 · 2020: 44 · 2019: 22 · 2018: 28 · 2017: 18 · 2016: 9
FWCI
17.71
Type
journal article
Language
en
Open access
Licence
Locations
  • The Lancet Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Funders
Vidi (grant 017.106.370)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
depressive symptoms, dementia risk, geriatric depression, depression trajectories, Alzheimer's disease, incident dementia, APOE ε4, competing risk of death, older adults, Rotterdam Study, antidepressant use, cognitive function, anxiety comorbidity, primary care follow-up
MeSH terms
Aged, Aged, 80 and over, Dementia, Depression, Female, Humans, Male, Netherlands, Psychiatric Status Rating Scales, Risk Factors, Cohort Studies

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