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Hippocampus Atrophy and the Longitudinal Course of Late-life Depression
Open accessAbstract
Objectives Smaller hippocampal volumes are observed in depression but it remains unclear how antidepressant response and persistent depression relate to changes in hippocampal volume. We examined the longitudinal relationship between hippocampal atrophy and course of late-life depression.Setting Academic medical center.Participants Depressed and never-depressed cognitively intact subjects age 60 years or older.Measurements Depression severity was measured every three months with the Montgomery-Asberg Depression Rating Scale (MADRS). Participants also completed cranial 1.5-T magnetic resonance imaging every 2 years. We compared 2-year change in hippocampal volume based on remission status, then in expanded analyses examined how hippocampal volumes predicted MADRS score.Results In analyses of 92 depressed and 70 never-depressed subjects, over 2 years the cohort whose depression never remitted exhibited greater hippocampal atrophy than the never-depressed cohort. In expanded analyses of a broader sample of 152 depressed elders, depression severity was significantly predicted by a hippocampus × time interaction where smaller hippocampus volumes over time were associated with greater depression severity.Conclusions Hippocampal atrophy is associated with greater and persistent depression severity. Neuropathological studies are needed to determine if this atrophy is related to the toxic effects of persistent depression or related to underlying Alzheimer disease.
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“longitudinal work has shown that hippocampal and mPFC volume reductions become more pronounced when depressive symptoms do not remit (35,38).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [35]
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“and non-remission/treatment resistance (28,31–38).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [35]
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Metadata
- Authors
- Taylor, W. D., McQuoid, D. R., Payne, M. E., Zannas, A. S., MacFall, J. R., & Steffens, D. C.
- Affiliations
- Vanderbilt University Medical Center (US)
- Duke Medical Center (US)
- UConn Health (US)
- Corresponding author
- Taylor, Warren D.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 22
- Issue
- 12
- Pages
- 1504-1512
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC4031313
- OpenAlex
- W2013004783
- Cited by
- 134
- References
- 56
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 5 · 2014: 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIMH (R01 MH077745, R01 MH054846, K24 MH070027, P50 MH60451)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- hippocampal atrophy, geriatric depression, dysthymia, remission, hippocampal volume, depression severity, longitudinal course, older adults, antidepressant response, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Antidepressive Agents, Atrophy, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Recurrence, Remission Induction, Severity of Illness Index, Disease Progression
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